1,184 research outputs found
Wenting, Li
No full textTese de Doutoramento em Didática das Línguas - Multilinguismo e Educação para a Cidadania Global em associação com a Faculdade de Ciências Sociais e Humanas da Universidade Nova de Lisboa, apresentada à Universidade AbertaApós a entrada no novo século, o processo de democratização do ensino superior
acelerou, ao mesmo tempo que se estreitou a relação entre o ensino superior e o
desenvolvimento socioeconómico.
O crescente acesso ao ensino superior na China conduziu a uma mudança fundamental
nas oportunidades de emprego dos detentores de um grau universitário, nomeadamente
com cursos de línguas estrangeiras, que enfrentam uma pressão crescente no mercado
de trabalho. A sociedade chinesa tem demonstrado particular preocupação com grupos
especiais, criando por exemplo escolas de formação profissional de línguas estrangeiras.
Na base da sua própria experiência no ensino de português na China, a autora pretende
contribuir para a evolução profissional na área da educação e ensino desta língua. Neste
contexto, deixa algumas sugestões para a reforma dos cursos de Língua Portuguesa nos
Institutos de Línguas Estrangeiras de Formação Profissional, área da sua especialização
académica.After the entry into the new century, the process of democratization of higher education
accelerated, and the relationship between higher education and socio-economic
development became even closer.
Increasing access to higher education in China has led to a fundamental change in the
job opportunities of college graduates, notably of the foreign language courses, which
face increasing pressure on the labor market. Chinese society has been particularly
concerned about special groups, for example by setting up vocational training schools for
foreign languages.
Based on her own experience in teaching Portuguese in China, the author intends to
contribute to the professional development of the Portuguese language education and
teaching. In this context, she gives some suggestions for the reform of Portuguese
Language courses at the Foreign Language Institutes of Vocational Training, her area of
academic specialization.N/
Nao he sheng zhi qi guan biao da ji yin BRE zai xiao shu cheng xian wei xi bao zhong de gong neng yan jiu
No full textShi, Wenting.Thesis Ph.D. Chinese University of Hong Kong 2016.Includes bibliographical references (leaves 136-159).Abstracts also in Chinese.Title from PDF title page (viewed on 04, January, 2017).Shi, Wenting
sj-pdf-1-jcb-10.1177_0271678X231167924 - Supplemental material for Preceding transient ischemic attack was associated with functional outcome after stroke thrombectomy: A propensity score matching study
No full textSupplemental material, sj-pdf-1-jcb-10.1177_0271678X231167924 for Preceding transient ischemic attack was associated with functional outcome after stroke thrombectomy: A propensity score matching study by Jiali Xu, Wenting Guo, Jin Ma, Qingfeng Ma, Jian Chen, Haiqing Song, Changhong Ren, Sijie Li, Yuchuan Ding, Wenbo Zhao and Xunming Ji in Journal of Cerebral Blood Flow & Metabolism</p
Fluoride increases the susceptibility of developmental dysplasia of the hip via increasing capsular laxity triggered by cell apoptosis and oxidative stress in vivo and in vitro
No full textThe etiology of developmental dysplasia of the hip (DDH) is multifactorial, including breech presentation and hip capsular laxity. In particular, hip laxity is the main contributor to DDH by changing the ratio and distribution of collagens. Also, fluoride (F) affects collagens from various tissue besides bone and tooth. To investigate the association of DDH and excessive F intake, we conducted this research in lab on cell and animal model simultaneously. We established animal model of combination of DDH and F toxicity. The incidence of DDH in each group was calculated, and hip capsules were collected for testing histopathological and ultrastructural changes. The primary fibroblasts were further extracted from hip capsule and treated with F. The expression of collagen type I and III was both examined in vivo and in vitro, and the level of oxidative stress and apoptosis was also tested identically. We revealed that the incidence of DDH increased with F concentration. Furthermore, the oxidative stress and apoptosis levels of hip capsules and fibroblasts both increased after F exposure. Therefore, this study shows that excessive F intake increases susceptibility to DDH by altering hip capsular laxity in vivo and in vitro respectively. We believe that F might be a risk factor for DDH by increasing hip laxity induced by triggering fibroblast oxidative stress and apoptosis
What is common may be as important as what is different: examining the general factor shared by dispositional shame and guilt using bi-factor models
No full textPrevious research on shame and guilt has tended to focus on their unique associations with other variables. It has become commonplace to eliminate the substantial shared variance with shame when examining guilt, and to eliminate shared variance with guilt when examining shame. What previous research has typically not done is to examine the variance shared by shame and guilt. In a series of three studies, we addressed this issue by employing bi-factor models to examine the general factor shared by shame and guilt, and its relationship to several important personality traits and two broad liability factors of psychopathology (i.e., externalizing and internalizing psychopathology). As hypothesized, the general factor shared by shame and guilt was strongly and positively associated with personality traits associated with moral emotions (empathy, agreeableness and conscientiousness), and strongly but inversely associated with both self-reported and informant-reported externalizing psychopathology. The general factor was also associated with self-consciousness, but not with self-criticism, vulnerable narcissism or neuroticism. The implications of these findings are discussed regarding the conceptualization of shame and guilt.Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2020-08-01The student, Wenting Mu, accepted the attached license on 2018-04-13 at 09:14.The student, Wenting Mu, submitted this Dissertation for approval on 2018-04-13 at 09:24.This Dissertation was approved for publication on 2018-04-17 at 17:21.DSpace SAF Submission Ingestion Package generated from Vireo submission #12229 on 2018-09-27 at 11:15:30Made available in DSpace on 2018-09-27T16:27:59Z (GMT). No. of bitstreams: 2
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Previous issue date: 2018-04-17Embargo set by: Seth Robbins for item 107730
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Reason: Author requested U of Illinois access only (OA after 2yrs) in Vireo ETD systemU of I Only Restriction Lifted for Item 107730 on 2020-09-28T09:15:07Z
Parallel session 8 : Teaching and learning innovations
No full textPresented Titles: Pros and Cons of Online Learning: Some Evidence from Chinese Primary School Students [Authors: Wenting Chen; Ada Hiu-kan Wong; Liutan Ying] More Self-directed Learning and Better Employability? How Home-returning Graduate Students Go Through Synchronous Online Courses and Future Career Planning during COVID-19 Lockdowns in Taiwan? [Author: Louise Yi-ning Tsai] Levelling the Playing Field: COVID-19, Educational Inequalities and the Transition to Online and Hybrid Teaching and Learning among Rural-based Tertiary Students in Ghana [Authors: Kwaku Abrefa Busia; Alice Amegah] ELT Online: Conducting a Language Class Online under the Shadow of COVID-19 [Author: Bosco Li
Efficient checkpoint and recovery scheme in a fast in-memory database
No full textThesis: M. Eng., Massachusetts Institute of Technology, Department of Electrical Engineering and Computer Science, 2014.This electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections.Cataloged from student-submitted PDF version of thesis.Includes bibliographical references (pages 61-62).Multicore in-memory databases for modern machines can support extraordinarily high transaction rates for online transaction processing workloads. A potential weakness of such databases, however, is recovery from crash failures. We show that techniques for disk-based persistence can be ecient enough to keep up with current systems' huge memory sizes and fast transaction rates, be smart enough to avoid additional contention, and provide fast recovery. This thesis presents SiloR, a persistence system built for a very fast multicore database system called Silo. We show that naive logging and checkpoints make normal-case execution slower, but that careful design of the persistence system allows us to keep up with many workloads without negative impact on runtime performance. We design the checkpoint and logging system to utilize multicore's resources to its fullest extent, both during runtime and during recovery. Parallelism allows the system to recover fast. Experiments show that a large database (~~ 50 GB) can be recovered in under five minutes.by Wenting Zheng.M. Eng
A nanobar-supported lipid bilayer system for the study of membrane curvature sensing proteins in vitro
No full textMembrane curvature plays important roles in various essential processes of cells, such as cell migration, cell division, and vesicle trafficking. It is not only passively generated by cellular activities, but also actively regulates protein interactions and is involved in many intracellular signaling. Thus, it is of great value to examine the role of membrane curvature in regulating the distribution and dynamics of proteins and lipids. Recently, many techniques have been developed to study the relationship between the curved membrane and protein in vitro. Compared to traditional techniques, the newly developed nanobar-supported lipid bilayer (SLB) offers both high-throughput and better accuracy in membrane curvature generation by forming a continuous lipid bilayer on patterned arrays of nanobars with a pre-defined membrane curvature and local flat control. Both the lipid fluidity and protein sensitivity to curved membranes can be quantitatively characterized using fluorescence microscopy imaging. Here, a detailed procedure on how to form a SLB on fabricated glass surfaces containing nanobar arrays and the characterization of curvature-sensitive proteins on such SLB are introduced. In addition, protocols for nanochip reusing and image processing are covered. Beyond the nanobar-SLB, this protocol is readily applicable to all types of nanostructured glass chips for curvature sensing studies.Ministry of Education (MOE)Nanyang Technological UniversityPublished versionThis work is funded by the Singapore Ministry of Education (MOE) (W. Zhao, RG112/20, RG95/21, and MOE-T2EP30220-0009), the Institute for Digital Molecular Analytics and Science (IDMxS) supported by MOE funding under the Research Centres of Excellence scheme (W. Zhao), the Human Frontier Science Program Foundation (W. Zhao, RGY0088/2021), the NTU Start-up Grant (W. Zhao), School of Chemical and Biomedical Engineering NTU for the research scholarship (X. Miao), and China Scholarship Council for the research scholarship (J. Wu)
Measurement of Soil Water Content with Dielectric Dispersion Frequency
No full textFrequency domain reflectometry (FDR) is an inexpensive and attractive methodology for repeated measurements of soil water content (θ). Although there are some known measurement limitations for dry soil and sand, a fixed-frequency method is commonly used with commercially available FDR probes. The purpose of our study was to determine if the soil dielectric spectrum could be used to measure changes in θ. A multifrequency FDR probe was constructed with a 6-mm diameter, and a soil dielectric spectrum was obtained. Using the dielectric spectrum, the dielectric dispersion frequency (fd) was determined. It was discovered that changes in fd were highly correlated with changes in θ, and a third-order polynomial equation (R2 = 0.96) was developed describing the relationship. The effectiveness of fd for θ measurement was evaluated for three soils and a sand across a range of θ. The effects of soil temperature and soil salinity were also evaluated. Accurate measurements of θ were obtained even in dry soil and sand. The root mean square error of the θ estimated by the fdmeasurement was 0.021. The soil temperature and soil salinity had no measureable effects on θ determination. The use of fd for θ determination should be an effective and accurate methodology, especially when dry soils, soil temperature, and/or soil salinity could potentially cause problems with the θ measurements.This article is published as Xu, Jinghui, Sally D. Logsdon, Xiaoyi Ma, Robert Horton, Wenting Han, and Ying Zhao. "Measurement of Soil Water Content with Dielectric Dispersion Frequency." Soil Science Society of America Journal 78, no. 5 (2014): 1500-1506. doi: 10.2136/sssaj2013.10.0429. Posted with permission.</p
Investigating the functional roles of microRNA-29b and microRNA-146a in prion diseases
No full text© 2018 Dr Wenting ZhaoNeurodegenerative diseases such as Alzheimer’s disease and prion disease are closely related with specific gene and protein dysfunction. Prion diseases, also known as transmissible spongiform encephalopathies (TSEs), are characterized by the structural transformation of the cellular prion protein (PrPC) to the disease associated isoform (PrPSc). One hallmark of Alzheimer’s disease is the accumulation of beta amyloid (Aβ) plaques in the brain, resulting from the pathological cleavage of the amyloid precursor protein (APP) by β-secretase (BACE1) and the γ-secretase complex. MicroRNAs (miRNAs) are a class of small non-coding RNAs that regulate gene or protein expression by targeting mRNAs and triggering either translational repression or mRNA degradation. Distinct expression levels of miRNAs, including miR-29b and miR-146a, have been detected in various biological fluids and tissues from prion disease and Alzheimer’s disease patients, as well as in cell and animal models. These miRNAs could be potential diagnostic biomarkers of these diseases, suggesting that investigating the miRNA functional roles and miRNA-target regulation pathways will improve our understanding of the disease regulation networks.
The first aspect of the thesis utilized CRISPR/Cas9 gene editing to knockdown miR-29b and miR-146a respectively in a number of cell lines, and cell clones with stable miRNA knockdown were generated. Off-target analysis of the cell clones revealed the high specificity of CRISPR/Cas9 editing of miRNAs. Common and distinct pathways and novel targets of miR-29b were also identified in two cell lines using transcriptome profiling, and potential miR-29b targets in Alzheimer’s and prion diseases were revealed. In the second aspect of the thesis, miR-29b was shown to positively regulate prion protein levels in both miR-29b stable knockdown cell clones and miR-29b overexpressed cells. This regulation is not mediated through miR-29b target SP1 or potential target PPP2CA, which can interact with prion protein or was implicated in prion pathogenesis. miR-29b could further affect PrPSc generation through regulating prion protein levels and potentially affect prion progression. miR-29b was also revealed to regulate APP and BACE1, the two key proteins in Alzheimer’s disease, in in vitro models. Lastly, the dual roles of miR-146a in regulating prion protein and inflammatory pathways were revealed in prion disease. miR-146a can upregulate prion protein levels in both overexpressed and stably downregulated cell models, as well as in miR-146a transgenic mice generated using CRISPR/Cas9 gene editing. miR-146a overexpression also resulted in the decreased formation of PrPSc in prion cell models. The miR-29b/miR-146a-PrP-PrPSc pathways possibly share a similar mechanism involving the interaction of prion protein with Argonaute protein – the key component of miRNA induced silencing complex (miRISC). Prion protein was demonstrated to be a direct target of miR-146a. miR-146a can also target inflammatory regulator TRAF6 in both prion infected cell models and in miR-146a transgenic mice.
The findings from this thesis have important implications for the comprehensive understanding of prion disease pathogenesis. The miR-29b/miR-146a-PrP-PrPSc pathways and miR-146a mediated inflammatory pathway are added to the regulation network of prion disease. miRNAs represent novel regulators in prion diseases and other neurodegenerative disorders and hold promise to be future therapeutics to cure prion disease
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