11,088 research outputs found
Involvement of adrenoceptors, dopamine receptors and AMPA receptors in antidepressant-like action of 7-O-ethylfangchinoline in mice
No full textAim: 7-O-ethylfangchinoline (YH-200) is a bisbenzylisoquinoline derivative. The aim of this study was to investigate the antidepressant-like action and underlying mechanisms of YH-200 in mice. Methods: Mice were treated with YH-200 (15, 30, and 60 mg/kg, ig) or tetrandrine (30 and 60 mg/kg, ig) before conducting forced swimming test (FST), tail suspension test (TST), or open field test (OFT). Results: YH-200 (60 mg/kg) significantly decreased the immobility time in both FST and TST, and prolonged the latency to immobility in FST. YH-200 (60 mg/kg) was more potent than the natural bisbenzylisoquinoline alkaloid tetrandrine (60 mg/kg) in FST. Pretreatment with alpha(1)-adrenoceptor antagonist prazosin (1 mg/kg), beta-adrenoceptor antagonist propranolol (2 mg/kg), dopamine D-1/D-5 receptor antagonist SCH23390 (0.05 mg/kg), dopamine D-2/D-3 receptor antagonist haloperidol (0.2 mg/kg) or AMPA receptor antagonist NBQX (10 mg/kg) prevented the antidepressant-like action of YH-200 (60 mg/kg) in FST. In contrast, pretreatment with alpha(2) adrenoceptor antagonist yohimbine (1 mg/kg) augmented the antidepressant-like action of YH-200 (30 mg/kg) in FST. Chronic administration of YH-200 (30 and 60 mg/kg for 14 d) did not produce drug tolerance; instead its antidepressant-like action was strengthened. Chronic administration of YH-200 did not affect the body weight of mice compared to control mice. Conclusion: YH-200 exerts its antidepressant-like action in mice via acting at multi-targets, including alpha(1), alpha(2) and beta-adrenoceptors, D-1/D-5 and D-2 /D-3 receptors, as well as AMPA receptors.National Natural Science Foundation of China [81173031, 81202511, 81302746]SCI(E)PubMed中国科技核心期刊(ISTIC)中国科学引文数据库(CSCD)[email protected]
Mechanism and pharmacological rescue of berberine-induced hERG channel deficiency [Corrigendum]
No full textYan M, Zhang KP, Shi YH, Feng LF, Lv L, Li BX. Drug Des Devel Ther. 2015 Oct 22;9:5737–5747.On page 5742, Figure 3C, an incorrect Western blot image is shown.Read the original article
HIGH RESOLUTION FOURIER TRANSFORM EMISSION SPECTROSCOPY OF YH AND YD.
No full textAuthor Institution: Department of Chemistry, University of Arizona; Department of Chemistry, University of WaterlooThe electronic emission spectrum of YH and YD has been investigated in the 690 nm to 3 spectral region using a Fourier transform spectrometer. The YH and YD bands were excited in an yttrium hollow cathode lamp operated with neon gas and a trace of of The observed bands have been classified into three different electronic transitions; and . The transition of YD could not be identified due to its very weak intensity. The rotational analysis of several bands of the transition (up to for YH and for YD) provides improved equilibrium vibrational and rotational constants for the ground state of YH and YD. The excited state is involved in several perturbations
FACTORIZATION OF INTEGERS WITH MULTI-PATH OPTICAL INTERFERENCE
No full textWe introduce a new factorization algorithm based on the optical computation by multi-path interference of the periodicity of a "factoring" function given by exponential sums at continuous arguments. We demonstrate that this algorithm allows, in principle, the prime number decomposition of several large numbers by exploiting a remarking rescaling property of this periodic function. Such a function is recorded by measuring optical interferograms with a multi-path Michelson interferometer, a polychromatic light source and a spectrometer. The information about factors is encoded in the location of the inteferogram maxima
The YH database: the first Asian diploid genome database
No full textThe YH database is a server that allows the user to easily browse and download data from the first Asian diploid genome. The aim of this platform is to facilitate the study of this Asian genome and to enable improved organization and presentation large-scale personal genome data. Powered by GBrowse, we illustrate here the genome sequences, SNPs, and sequencing reads in the MapView. The relationships between phenotype and genotype can be searched by location, dbSNP ID, HGMD ID, gene symbol and disease name. A BLAST web service is also provided for the purpose of aligning query sequence against YH genome consensus. The YH database is currently one of the three personal genome database, organizing the original data and analysis results in a user-friendly interface, which is an endeavor to achieve fundamental goals for establishing personal medicine. The database is available at http://yh.genomics.org
New factorization algorithm based on a continuous representation of truncated Gauss sums
No full textIn this paper, we will describe a new factorization algorithm based on the continuous representation of Gauss sums, generalizable to orders j > 2. Such an algorithm allows one, for the first time, to find all the factors of a number N in a single run without precalculating the ratio N/l, where l are all the possible trial factors. Continuous truncated exponential sums turn out to be a powerful tool for distinguishing factors from non-factors (we also suggest, with regard to this topic, to read an interesting paper by S. Wölk et al. also published in this issue [Wölk, Feiler, Schleich, J. Mod. Opt. in press]) and factorizing different numbers at the same time. We will also describe two possible M-path optical interferometers, which can be used to experimentally realize this algorithm: a liquid crystal grating and a generalized symmetric Michelson interferometer
Factorization algorithm based on the periodicity measurement of a CTES
No full textWe introduce a new factorization algorithm based on the measurement of the periodicity of a determined function, similar to Shor's algorithm. In particular, such a function is given by a generalized continuous truncated exponential sum (CTES). The CTES interference pattern satisfies a remarkable scaling property, which allows one to plot the interferogram as a function of a suitable continuous variable depending on the number to factorize. This allows one, in principle, to factorize arbitrary numbers with a single interferogram. In particular, information about the factors is encoded in the location of the interference maxima, which repeat periodically in the interferogram. A possible analogue computer for the implementation of such an algorithm can be realized using multi-path optical interferometers, with polychromatic light sources and a high-resolution spectrometer. The experimental accuracy in the realization of the CTES interferogram and the bandwidth of the polychromatic sources determine the largest number Nmax factorable. Once the CTES interferogram is recorded, all the numbers with value up to Nmax can be factorable, without performing any further measurement
<i>De novo</i> assembly of the YH genome.
No full text<p>(A), The YH scaffold N50 (green bar) and N90 (blue bar) sizes were dramatically improvement with the addition of long-range PE information (from 2 kb to 35 kb). The trends of improvement are shown as a dashed line. (B), Alignment between the assembled YH scaffolds (y-axis) and the reference human genome (NCBI build 37, x-xis) on chr8. Local repeat level in the reference chr8 (calculated in a 1-kb window) is showed in color along the chromosome at the top-up bar. The white blocks in the bar represent the gaps in the reference genome. (C), Alignment of the YH scaffold 320 onto the reference chr8. Local repeat level on the region of the reference chr8 is also shown in color along the sequence (calculated in a 1-kb window).</p
Isolation and evaluation of Pediococcus acidilactici YH-15 from cat milk: Potential probiotic effects and antimicrobial properties
No full textThe study aimed to screen for the possible presence of lactic acid bacteria (LAB) in cat milk in order to evaluate their probiotic properties. The isolates were characterized by biochemical identification, morphological tests and 16S rDNA sequencing. Afterward, gastrointestinal passage, in vitro safety and probiotic properties were evaluated. The results showed that the isolates had 10 strains of Pediococcus acidilactici permitted in the feed additive catalog. The high survival rate in the acid and bile salt resistance test reflected the good strain tolerance of the isolates to the simulated gastrointestinal conditions of the host in vitro. The mean inhibitory diameters of the 10 strains against chloramphenicol and tetracycline were 23.6 mm and 17.4 mm, respectively; none of the hemolytic tests showed α/β hemolytic ring. The bacteriostatic test showed that P. acidilactici YH-9, YH-14 and YH-15 had inhibitory effects on four common pathogenic bacteria, including Escherichia coli, Salmonella typhimurium, Staphylococcus aureus and Streptococcus. The adhesion test showed that P. acidilactici YH-15 had good adhesion to HT-29 cells. Based on these results, we concluded that P. acidilactici YH-15 extracted from cat milk has potential application as a clinical probiotic therapy and health care product
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