18,377 research outputs found
ORIGINAL ARTICLES Influence of paeonol on expression of COX-2 and p27 in HT-29 cells
No full textAuthor contributions: Ye JM performed the majority of experiments and wrote the manuscript, Zhang JB cultured the HT-29 cell line; Deng T designed the study, participated in writing and editing the manuscript
Plexin-B1 TM-JM trimer RMSD values comparing TM only and TM-JM structures before and after MD.
No full text<p>RMSD values between the TM regions in the TM only trimers, comparing initial and final structures (a) and RMSD between the TM in the TM only and in the TM-JM structure, both with respect to their own initial (b.1) and with respect to each others final structures (b.2). We also compare the total deviation of the TM-JM structure (initial vs. final) (c) and similarly to a) compare the RMSD of the JM region between initial and final structures (d).</p><p>Plexin-B1 TM-JM trimer RMSD values comparing TM only and TM-JM structures before and after MD.</p
The SSC of the Generalised Jahangir’s Graph Jm,k and its Algebraic Characterizations
No full textIn this article, we present important combinatorial and algebraicproperties of spanning simplicial complex (SSC) of the generalised Jahangir’sgraph Jm,k. We describe the relation to find f−vectors associatedto Δs(Jm,k) and determine the Hilbert series for the SR-ring KΔs(Jm,k).In the end, we present the associated primes of the facet ideal IF(Δs(Jm,k))and the Cohen-Macaulay characterization of the SR-ring of Δs(Jm,k).AMS (MOS) Subject Classification Codes: Primary 13-P10, Secondary 13-F20, 13-C14, 13-H10.Corresponding Author: Agha KashifKey Words: Simplicial Complexes, f-vectors, Spanning Trees, Face Ring, Hilbert Series, CohenMacaulay
To <i>JM</i> on Its 75th Anniversary
No full text This article discusses how Journal of Marketing ( JM) has influenced marketing science and practice by publishing articles on substantive topics relevant to customers, managers, organizations, markets, and society. The journal's 75th anniversary coincides with the 50th anniversary of the Marketing Science Institute (MSI). Frequently, JM and MSI have collaborated to address important substantive marketing issues identified in MSI's Research Priorities. The author highlights seminal articles on brand equity; business-to-business marketing (including sales force management); connecting marketing information, metrics, and strategy; consumer behavior; innovation, new product development. and product management; marketing orientation and capabilities; and market research, methodology and services. She also draws attention to articles that have won the Sheth Foundation/ JM Award and the H. Paul Root Award. The article describes how JM‘s knowledge dissemination is amplified by powerful social network effects. Ideas in JM articles diffuse through the business community, influencing the mind-set of managers worldwide. </jats:p
Plexin-C1 TM-JM RMSD values comparing TM only and TM-JM structures before and after MD.
No full text<p>See Legend for <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0121513#pone.0121513.t003" target="_blank">Table 3</a>.</p><p>Plexin-C1 TM-JM RMSD values comparing TM only and TM-JM structures before and after MD.</p
Model structures and dynamics of plexin-B1 TM-JM 9trimers.
No full text<p>a) Two TM-JM trimer models for plexin-B1; structures are shown before MD refinement. Final structures are shown in Fig. B in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0121513#pone.0121513.s001" target="_blank">S1 File</a>. Left: extended clock-anticlock; Right: helix connected anticlock-anticlock. Distances of the JM C-terminal region from the membrane are plotted in Fig. F in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0121513#pone.0121513.s001" target="_blank">S1 File</a>. b) RMSF and c) 2> for these plexin-B1 TM-JM trimers plotted as a function of sequence for the same simulations.</p
Neuromuscular and perceptual mechanisms of fatigue accompanying task failure in response to moderate-, heavy-, severe-, and extreme-intensity cycling
No full textA comprehensive characterization of neuromuscular and perceptual mechanisms of fatigue at task failure following exercise across the entire intensity spectrum is lacking. This study evaluated the extent of peripheral and central fatigue, and corresponding perceptual attributes, at task failure following cycling within the moderate-(MOD), heavy-(HVY), severe-(SVR), and extreme-(EXT) intensity domains. After a ramp-incremental test, 11 young males performed four constant-power output trials to the limit of tolerance (Tlim) at 4 distinct domain-specific workloads. These trials were preceded and followed by 5-s knee-extension maximal voluntary contractions (MVCs) and femoral nerve electrical stimuli to quantify peripheral and central fatigue. In addition, perceptual measures including ratings of global fatigue, legs pain, dyspnea, and perceived effort (RPE) were also collected. At Tlim, reductions in MVC were independent of intensity (P > 0.05). However, peripheral fatigue was greater following EXT and SVR and progressively, but distinctively, lower following HVY and MOD (P < 0.05). Central fatigue was similar after SVR, HVY, and MOD, but absent after EXT (P < 0.05). At Tlim, subjective ratings of global fatigue were progressively higher with lower exercise intensities, whereas ratings of legs pain and dyspnea were progressively higher with higher exercise intensities. On the other hand, RPE was maximal following HVY, SVR, and EXT, but not MOD. The findings demonstrate that at Tlim, the extent of peripheral fatigue is highly domain-specific, whereas the extent of central fatigue is not. Sensations such as fatigue, pain, and dyspnea may integrate with mechanisms of sense of effort to determine task failure in a manner specific to each intensity domain
Some theoretical aspects of strain localization analysis of multiphase porous media with regularized constitutive models
No full textThis paper discusses some theoretical aspects of strain localiza-
tion analysis in multiphase porous media, particularly when reg-
ularized constitutive models such as the gradient-dependent and
rate-dependent models are used. Stability and hyperbolicity of the governing equations are studied and the relations between permeability and the wave number where a real wave speed exists are investigated numerically. Particular attention is focused on the two cases of wave number K=0 and K→∞ of the perturbation waves.
The interaction between the different internal length scale parameters during dynamic strain localization in multiphase porous materials is also studied. It is pointed out that the consideration of fluid interaction is necessary for the prediction of the internal length in a multiphase porous medium when regularization through a constitutive model is introduced in the numerical model to overcome mesh dependence in a finite element solution
JM-20, a Benzodiazepine-Dihydropyridine Hybrid Molecule, Inhibits the Formation of Alpha-Synuclein-Aggregated Species
No full text\ua9 2022, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.Studies showed that JM-20, a benzodiazepine-dihydropyridine hybrid molecule, protects against rotenone and 6-hydroxydopamine neurotoxicity. However, its protective effects against cytotoxicity induced by endogenous neurotoxins involved in Parkinson’s disease (PD) pathogenesis have never been investigated. In this study, we evaluated the ability of JM-20 to inhibit alpha-synuclein (aSyn) aggregation. We also evaluated the interactions of JM-20 with aSyn by molecular docking and molecular dynamics and assessed the protective effect of JM-20 against aminochrome cytotoxicity. We demonstrated that JM-20 induced the formation of heterogeneous amyloid fibrils, which were innocuous to primary cultures of mesencephalic cells. Moreover, JM-20 reduced the average size of aSyn positive inclusions in H4 cells transfected with SynT wild-type and synphilin-1-V5, but not in HEK cells transfected with synphilin-1-GFP. In silico studies showed the interaction between JM-20 and the aSyn-binding site. Additionally, we showed that JM-20 protects SH-SY5Y cells against aminochrome cytotoxicity. These results reinforce the potential of JM-20 as a neuroprotective compound for PD and suggest aSyn as a molecular target for JM-20
A heavy Metals Morphology Prediction Modelling Method based on JM-GEP
No full textIn this paper, an improved GEP (Gene Expression Programming based on Jumping Genes, JM-GEP) is proposed in consideration of the morphology of heavy metals (HM) changed over time, on which a new heavy metal prediction method has been put forward. Jumping operator is the key point to JM-GEP, in which the jumping operators use self-adaptive jumping probability to keep population diversity and study the convergence property of the optimal retention strategy. Aiming at the improved GEP, we raised a heavy metals modelling method based on JM-GEP. The simulation results show that the new model, compared with traditional methods, has excellent goodness of fit to HMFT characteristic function, and find out its global optimal. The new method proved to be widely used for researching other time sequences problems
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