23 research outputs found
Evodiamine alleviates kidney ischemia reperfusion injury in rats: A biochemical and histopathological study
No full textRenal ischemia/reperfusion (I/R) injury resulting in acute renal failure, is a major clinical problem due to its high mortality rate. Renal I/R increases the reactive oxygen species, secretion of inflammatory cytokines, chemokines and other factors. This suggests that initiating the apoptosis process in the presence of oxidative stress may play a role in life-threatening conditions, such as ischemia. Ischemia reperfusion-induced renal damage can result in renal failure and death. Although many treatment procedures have been carried out to reduce or destroy renal I/R damage in experimental models, so far, a routine method of treatment has not yet been found. For this reason, the current study was planned to investigate the possible protective effects of evodiamine on tissue damage caused by ischemia-reperfusion in kidney tissue in rats and an experimental renal I/R model was used for this purpose. Four groups were formed in the study: the control, sham control, ischemia reperfusion (I/R), and evodiamine (10 mg/kg) + I/R groups. The effects of evodiamine against kidney I/R injury were investigated. TAS (total oxidant status), TOS (total oxidant status), interleukin-1 beta (IL-1 beta), IL-6, IL-10 and tumor necrosis factor-alpha levels were determined by enzyme-linked immunosorbent assay. The oxidative stress index was calculated from TAS and TOS levels. In addition, the renal ischemia reperfusion injury was examined histopathologically. The IL-10 and TAS levels in the I/R group decreased when compared with the control and Sham groups, while these levels increased in the evodiamine group. Histopathologic examination revealed that caspase 3 and nuclear factor-kappa B levels decreased in the evodiamine group compared with the I/R group. The application of evodiamine significantly reduced ischemia reperfusion-induced kidney damage due to its antioxidant, anti-inflammatory and antiapoptotic properties
A content analysis of scientific studies on recreation on disabled individuals in Turkey (2001-2020)
No full textBu çalışma Türkiye'de rekreasyon alanında engelli gruplar üzerine yapılan bilimsel çalışmaların analiz edilmesi ve analiz sonucunda hangi alanlarda eksikliğin olduğunu tespit etmek amacıyla yapılmıştır. Araştırmada kaynak taraması yöntemi kullanılmıştır. Türkiye'de 25 ilde yapılmış toplamda 83 akademik çalışma (15 doktora tezi, 48 yüksek lisans tezi ve 20 makale) incelenmiştir. İncelenen çalışmaların 41'i nicel, 37'si nitel ve 5'i karma desen çalışmalarıdır. Yapılan incelemede, 2003 öncesi herhangi bir çalışmanın olmadığı ve çalışmaların büyük bir bölümünün (%77,14) 2010 ve sonraki yıllarda yapıldığı tespit edilmiştir. İncelenen çalışmalarda örneklem büyüklüğü ise ağırlıklı olarak 40 ve altı (%66,25) katılımcının olduğu saptanmıştır. Yapılan incelemede yazar sayısına göre dağılımı incelendiğinde ağırlıklı olarak (%83,14) bir yazarlı olduğu tespit edilmiştir. İncelenen çalışmalar sonucunda genel olarak engelli bireylere yönelik yapılan rekreatif ve sportif etkinlikler engelli bireylerin başta sağlık problemlerini azaltmada, kendini zinde hissetmede ve en önemli olgu olarak yaşam kalitelerini arttırmada pozitif yönlü katkı sağladığı görülmektedir. Araştırmanın sonucunda; yapılan çalışmaların büyük çoğunluğunun son yıllarda olduğu, en fazla tek yazarlı çalışmalar ve yüksek lisans tezi olduğu, nicel ve nitel yöntemin dengeli sayıda olmasının yanında karma yöntemin çok az kullanıldığı, yapılan çalışmaların büyük çoğunluğunun Beden Eğitimi ve Spor Ana Bilim Dalı'nda yapıldığı ve zihinsel engelliler üzerine olduğu görülmüştür.This study was carried out in order to analyze the scientific studies on disabled groups in the field of recreation in Turkey and to determine in which areas there are deficiencies as a result of the analysis. Source scanning method was used in the research. A total of 83 academic studies (15 doctoral dissertations, 48 master's theses and 20 articles) conducted in 25 provinces in Turkey were examined. 41 of the examined studies are quantitative, 37 qualitative and 5 mixed design studies. In the examination, it was determined that there was no study before 2003 and that most of the studies (77,14%) were carried out in 2010 and later years. The sample size of the studies examined was predominantly 40 and below (66.25%) participants. When the distribution according to the number of authors is examined, it has been determined that there is predominantly (83.14%) one author. As a result of the studies examined, it is seen that the recreational and sportive activities made for disabled individuals in general contribute positively to reducing the health problems of the disabled individuals, making them feel fit and increasing their quality of life as the most important phenomenon. As a result of the research; Most of the studies are in recent years, mostly single-authored studies and master's thesis, quantitative and qualitative methods are balanced in number, mixed method is used very little, most of the studies are done in the Department of Physical Education and Sports, and people with mental disabilities are mentally handicapped. Was found on
Bortezomibin sıçan kalbinde yaptığı histopatolojik değişiklikler ve beta glukanın bu değişikliklere etkisi
No full textNicotinamide Riboside Preserves Ovarian Injury in Experimental Sepsis Model in Rats
No full textObjective: The aim of the study is to investigate the protective effects of nicotinamide riboside on oxidative stress in an experimental sepsis model created by cecal ligation and puncture. Materials and Methods: Rats were divided into 3 groups randomly: sham-operated (control) group, sepsis group, and nicotinamide riboside-treated group. Sepsis model-induced cecal ligation and puncture was applied to sepsis group rats. Animals in the nicotinamide riboside-treated group were administered nicotinamide riboside intraperitoneally (500 mg/kg). Tissue specimens from rats were biochemically calculated for their activities of catalase, superoxide dismutase, glutathione peroxidase, myeloperoxidase, and malondialdehyde levels. Ovarian tissues of all rats were histopathologically evaluated. Results: Catalase, superoxide dismutase, and glutathione peroxidase activities were lower in the sepsis group compared to the sham-operated (control) group. Superoxide dismutase activity was significantly higher in the nicotinamide riboside-treated group than in control and sepsis group (P < .05). Myeloperoxidase activities and mean malondialdehyde concentration of ovarian tissue were lower in nicotinamide riboside-treated group than in sepsis group (P < .05). The light microscopic assessment revealed that ovarian tissue was protected, and inflammation and interstitial edema decreased in nicotinamide riboside-treated group. The follicular damage findings were notably decreased in nicotinamide riboside-treated group in comparison to sepsis group (P<0.05). Conclusion: Our findings indicated that nicotinamide riboside diminished ovarian injury in sepsis via inhibiting tissue infiltration and increasing endogenous antioxidant capacity. Nicotinamide riboside administration may represent a new treatment approach for the prevention of sepsis-induced ovarian injury
Deneysel diyabetin postmenopozal dönemdeki ratların tiroid bezi üzerindeki etkilerinin belirlenmesi histopatolojik sterolojik inceleme
No full textEffects of Menopause and Diabetes on the Rat Thyroid Gland A Histopathological and Stereological Examining
No full textA classification of 1-well-covered graphs
No full textA graph is well-covered if all its maximal independent sets have the same size. If a graph is well-covered and remains well-covered upon removal of any vertex, then it is called 1-well-covered graph. It is well-known that [n/2] + 1 = 1 and vertical bar G vertical bar = n. We further present some combinatorial properties of such graphs. In particular, we provide a tight upper bound on the size of those graphs in terms of k, namely vertical bar G vertical bar <= 10k - 2, also we show that Delta(G) <= 2k + 1 and alpha(G) <= min{4k - 1,n - 2k}. This particularly enables us to obtain a characterization of such graphs for k = 1, which settles a problem of Levit and Mandrescu [14].TUBITAK (The Scientific and Technological Research Council of Turkey) [121F018]This research has been supported by TUBITAK (The Scientific and Technological Research Council of Turkey) under the project number 121F018. The author would like to thank the anonymous referee for useful suggestions that improved the presentation of this work. The author also would like to thank Mehmet Akif Yetim for many helpful discussions
