1,720,960 research outputs found
Targeted molecular therapies (cetuximab and bevacizumab) do not induce additional hepatotoxicity: Preliminary results of a case-control study
No full textAims: To analyse the effects of the preoperative targeted molecular therapy (cetuximab (cetu) or bevacizumab (beva)) on non-tumorous liver parenchyma, and the clinical and biological outcome after liver resection for colorectal liver metastases (CLM). Methods: Between January 2005 and December 2007, 36 patients receiving preoperatively cetu (n = 15) or beva (n = 21) were, respectively, matched to a control group of patients who did not receive targeted molecular therapy. They were matched on the basis of age, gender, body mass index, extent of hepatectomy, and type and number of neoadjuvant chemotherapy. Liver function tests, postoperative outcome and histopathology of the resected liver were compared. Results: There was no mortality. Postoperative morbidity and perioperative bleeding rates were similar in both groups. In the beva group, liver function tests showed higher serum bilirubin level on postoperative day (POD) 1 (p = 0.001) and POD 3 (p = 0.01), higher serum aspartate aminotransferase on POD 1 (p = 0.004), and lower prothrombin time on POD 5 (p = 0.02). In both groups, cetu and beva, the postoperative peaks of gamma-glutamyl transpeptidase and alkaline phosphatase were statistically higher than in the control groups. Interestingly, the prevalence of sinusoidal injury and fibrosis was lower in patients receiving cetu (p = 0.04), while the prevalence of steatohepatitis was lower in patients receiving beva (p = 0.04). Conclusion: The addition of beva or cetu to the neoadjuvant chemotherapy regimens does not appear to increase the morbidity rates after hepatectomy for CLM. The pathological examination did not show additional injury to the non-tumorous liver parenchyma. (C) 2010 Elsevier Ltd. All rights reserved
Značaj obradivih površina u Srbiji za ishranu fazana i zeca i brojnost populacija
Full text linkIn this review paper has been shown how the specific feeding brown hares and pheasant, the structure of arable land in the hunting grounds of Serbia and its importance as a nutrient base for the number of populations of these species. The spatial distribution and abundance of brown hares and pheasants primarily affect natural factors (climate, disease and predators) and to some extent, extent and anthropogenic factors (agricultural work, transportation, hunting ...). Hunting grounds in Serbia occupy a total area of 8,828,528.29 hectares, of which the fields and fields 3,787,836.13 hectares or 42.9%. This structure in the hunting area (the area under cereals in particular) have a major impact on the number of brown hares and pheasants, which in recent years has the trend. In contrast, the recorded increase in the percentage of killing relative to base stock of game, which the hardest in 2008. amounted to 18.02% and 45.78% for the pheasants. Based on the literature review it is evident that the intensification of agriculture and reducing the natural diversity of food are of great importance for the number of hares and pheasant populations. A partial solution to this problem is in the preservation of 'green oasis' and found a 'green corridor' between large areas of monoculture, organic vegetable production, control the number of predators and offspring production in the rabbit and pheasant farm. .U radu su na revijalan način prikazane specifičnosti ishrane fazana i zeca, struktura obradivih površina u lovištima Srbije i njihov značaj kao hranidbene baze za brojnost populacija ovih vrsta divljači. Na prostornu distribuciju i brojnost fazana i zeca utiču prvenstveno prirodni faktori (klima, bolesti i predatori) a u značajnoj meri i antropogeni faktori (poljoprivredni radovi, saobraćaj, lov...). Lovišta u Srbiji zauzimaju ukupnu površinu od 8.828.528,29 ha, od čega je pod njivama i oranicama 3.787.836,13 ha, odnosno 42,9%. Ovakva struktura površina u lovištima (naročito površina pod cerealijama) ima veliki uticaj na brojnost populacija zeca i fazana, koja zadnjih godina ima trend smanjenja. Nasuprot tome, beleži se povećanje procenta odstrela u odnosu na matični fond divljači, koji za zeca u 2008. godini iznosi 18,02% a za fazana 45,78%. Na osnovu pregleda literature evidentno je da intenzifikacija poljoprivrede i smanjenje raznovrsnosti prirodne ishrane imaju veliki značaj za brojnost populacija zeca i fazana. Delimično rešenje ovog problema je u: očuvanju 'zelenih oaza' i zasnivanje 'zelenih koridora' između velikih površina sa monokultura, organskoj biljnoj proizvodnji, kontroli brojnosti predatora i proizvodnji podmlatka zeca i fazana u odgajivalištima. . PR Projekat Ministarstva nauke Republike Srbije, br. TR-31009
Use of BiClamp decreased the severity of hypocalcemia after total thyroidectomy compared with LigaSure: A prospective study
No full textBackground Postoperative hypocalcemia is the most common complication after thyroidectomy. New surgical devices have been propose to achieve vessel sealing and hemostasis. However, the risk of parathyroid glands damage has not been fully elucidated. This prospective study was designed to evaluate the severity of hypocalcemia after total thyroidectomy by using two different sealing devices. Methods Between January 2005 and December 2006, 86 patients underwent total thyroidectomy by using BiClamp (R) (n = 46) or LigaSure (R) (n = 40) devices in our institution. The severity of postoperative hypocalcemia was analyzed. Results No mortality or recurrent laryngeal nerve palsy was observed. Patients characteristics were similar in both groups. The mean operation time was significantly shorter in the BiClamp group (142 +/- 35 minutes versus 170 +/- 57 minutes, P = 0.023). Eleven patients had symptomatic hypocalcemia. Hypocalcemia (< 2 mmol/l) at postoperative day 1 was more frequent in the LigaSure group than in the BiClamp group (P = 0.034). Significantly more patients in the LigaSure group required oral calcium supplementation than in the BiClamp group (67.5% versus 34.7% respectively; P = 0.002). Conclusion The present prospective study suggests that total thyroidectomy can be performed safely with both surgical devices. However, BiClamp reduced the operative time and the severity of postoperative hypocalcemia
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
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