323,406 research outputs found

    D-2867: 696 Canyon Road, Logan, Utah, Albert and Frieda S. Zbinden residence

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    D-2867: 696 Canyon Road, Logan, Utah, Albert and Frieda S. Zbinden residenc

    Cardiovascular risk factors impair native collateral development and may impair efficacy of therapeutic interventions

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    Animal and early clinical studies of gene therapy for tissue ischaemia suggested that this approach might provide benefit to patients with coronary artery disease not amenable to traditional revascularization. This enthusiasm was then tempered by the subsequent disappointing results of randomized clinical trials and led researchers to develop strategies using progenitor cells as an alternative to improve collateral function. However, the recent publication of several randomized clinical trials reporting either negative or weakly positive results using this approach have led to questions regarding its effectiveness. There are several factors that need to be considered in explaining the discordance between the positive studies of such treatments in animals and the disappointing results seen in randomized patient trials. Aside from the practical issues of arteriogenic therapies, such as effective delivery, vascular remodelling is an extraordinarily complex process, and the administration of a single agent or cell in the hope that it would lead to lasting physiological effects may be far too simplistic an approach. In addition, however, evidence now suggests that many of the traditional cardiovascular risk factors-such as age and hypercholesterolemia-may impair the host response not only to ischaemia but, critically, also to treatment as well. This review discusses the evidence and mechanisms for these observations and highlights future directions that might be taken in an effort to provide more effective therapies

    Diffusive author(s), cohesive author: Analysis of S/N (1994)

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    This study indicates the ways in which various aspects of the author(s) are brought forth in Dumb type’s performance art, the S/N production. Previous research has suggested a non-hierarchical organization of Dumb type and the absence of a “privileged author” in Dumb type’s collaborative work, S/N. However, the results that I have investigated from member’s interviews on the creative process of S/N along with my analysis of the recorded images of S/N, indicate a different aspect of the author(s). First, S/N was created through, so to speak, the collective ideas of the members of Dumb type. Further, S/N has at least nine quotations from previous performances, installations, and printed writings, besides the work-in-progress technique. Explicating one of the “author functions” as given by Michel Foucault, each text has plural subjects of the author. However, it has been revealed from members’ interviews that Teiji Furuhashi had a decision-making role in selecting the members’ ideas within the performance. Since then, S/N has had plural subjects of creation; however, Furuhashi is one of the subjects of creation along with the “privileged author.” S/N has plural authors (diffusive authors) yet at the same time, it has a “privileged author,” Teiji Furuhashi (cohesive author)

    Going Beyond Counting First Authors in Author Co-citation Analysis

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    The present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed

    Congruence patients - thérapeutes et dropout en psychiatrie ambulatoire publique

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    Danielle Goerg, Eric Zbinden, Biaise Duvanel: Patient-therapist congruence and treatment dropouts in public outpatient psychiatry. This study, which was undertaken in a public outpatient psychiatrie service, concerning new patients and their therapists, shows that the probability of treatment being abandoned is greater when the patients do not share the values of the psychiatrie institution and when there is poor congruence between patients and therapists concerning the definition of the problems and expectations. The findings that a number of patients however do stay in treatment in spite of the absence of congruence should probably be analyzed in terms that are structural rather than cultural.Résumé. L'étude entreprise dans un service de psychiatrie ambulatoire publique auprès de patients nouveaux cas et de leurs thérapeutes montre que les probabilités d'abandon de traitement sont plus grandes lorsque les patients ne partagent pas les valeurs de l'institution psychiatrique et lorsque la congruence est faible entre patients et thérapeutes dans les définitions des problématiques et des attentes. La constatation qu'un certain nombre de patients restent cependant en traitement malgré une absence de congruence devrait s'analyser sans doute en termes plus structurels que culturels.Danielle Goerg, Eric Zbinden, Biaise Duvanel : Congruencia entre pacientes y terapeutas en relación al abandono de la terapéutica en la siquiatría pública ambulatoria. El estudio realizado en un servicio público de siquiatría, a partir de pacientes considerados como casos nuevos y de sus terapeutas, demuestra que las probabilidades de abandono del tratamiento crecen cuando los pacientes no comparten los valores de la institu- ciôn siquiâtrica y cuando pacientes y terapeutas poco concuerdan en sus definiciones de las problemâticas y expectativas. S in embargo, es probable que el hecho de que un cierto numéro de pacientes siguen el tratamiento aûn cuando no haya congruencia, tenga que ser analizado en términos mâs estructurales que culturales. tas, demuestra que las probabilidades de abandono del tratamiento crecen cuando los pacientes no comparten los valores de la institución siquiátrica y cuando pacientes y terapeutas poco concuerdan en sus definiciones de las problemáticas y expectativas. Sin embargo, es probable que el hecho de que un cierto número de pacientes siguen el tratamiento aún cuando no haya congruencia, tenga que ser analizado en términos más estructurales que culturales.Goerg Danielle, Zbinden Eric, Duvanel Blaise. Congruence patients - thérapeutes et dropout en psychiatrie ambulatoire publique. In: Sciences sociales et santé. Volume 8, n°3, 1990. pp. 49-71

    Dispelling the Myths Behind First-author Citation Counts

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    We conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more sophisticated methods
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