362 research outputs found
Claes Oldenburg : Raw Notes : Documents and Spirits of the Performances : "Stars", "Moveyhouse", "Massage", "The Typewriter" with Annotations by the Author
No full textReproduces Oldenburg's complete unaltered collection of documents (including scripts, notes, instructions, theory) relating to four performances dating from 1963-1968, transcribed from their original form. Includes annotations by the author and examples of the original manuscripts
Protocol for analyzing protein-protein interactions by split-luciferase complementation assays in human cell lysates
No full textSummary: Here, we present a lysate-based split-luciferase assay for examining protein-protein interactions (PPIs) in HEK293T cell lysates, exemplified by interactions between subunits of protein phosphatase PP1. We describe steps for storing and re-using lysates, sensor design, assay setup/optimization, and high-throughput screening of compound libraries. We then detail procedures for applying the assay as a research tool to characterize the dynamics of PPIs, which we illustrate with specific examples.For complete details on the use and execution of this protocol, please refer to Claes and Bollen.1 : Publisher’s note: Undertaking any experimental protocol requires adherence to local institutional guidelines for laboratory safety and ethics
Lease of land from Hilletje Jans, widow of Ide Cornelius Van Vorst, to her son-in-law Jan Ariense Sip, 1694
No full textDocument in which Hilletje Jans, widow, asserts that she has leased a tract of land to her son in law Jan Arianse Sip, and agrees to continue the lease until her death, at which point all of her land is to be divided among her heirs, with certain exceptions detailed in document. Deed recorded by Town Clerk Claes Arentse Toers.Deed in Colonial Dutch from 1694, with transcription and translatio
DNA fusion gene vaccination mobilizes effective anti-leukemic cytotoxic T lymphocytes from a tolerized repertoire
No full textThe majority of known human tumor-associated antigens derive from non-mutated self proteins. T cell tolerance, essential to prevent autoimmunity, must therefore be cautiously circumvented to generate cytotoxic T cell responses against these targets. Our strategy uses DNA fusion vaccines to activate high levels of peptide-specific CTL. Key foreign sequences from tetanus toxin activate tolerance-breaking CD4+ T cell help. Candidate MHC class Ibinding tumor peptide sequences are fused to the C terminus for optimal processing and presentation. To model performance against a leukemia-associated antigen in a tolerized setting, we constructed a fusion vaccine encoding an immunodominant CTL epitopederived from Friend murine leukemia virus gag protein (FMuLVgag) and vaccinated tolerant FMuLVgag-transgenic (gag-Tg) mice. Vaccination with the construct induced epitopespecificIFN-c-producing CD8+ T cells in normal and gag-Tg mice. The frequency and avidity of activated cells were reduced in gag-Tg mice, and no autoimmune injury resulted. However, these CD8+ T cells did exhibit gag-specific cytotoxicity in vitro and in vivo. Also, epitope-specific CTL killed FBL-3 leukemia cells expressing endogenous FMuLVgag antigen and protected against leukemia challenge in vivo. These results demonstrate a simple strategy to engage anti-microbial T cell help to activate epitope-specific polyclonal CD8+ T cell responses from a residual tolerized repertoire
The Fragility of Liberalism: David Hume and the Problem of Virtue
No full textDegree awarded: Ph.D. Politics. The Catholic University of AmericaThe Fragility of Liberalism: David Hume and the Problem of VirtueNong Cheng, Ph.D. Director: Claes G. Ryn, Ph.D. David Hume has often been seen as a representative of interest-based liberalism, as distinct from, for example, Lockean, rights-based liberalism or Kantian, autonomy-based liberalism. This dissertation considerably revises or qualifies this interpretation by demonstrating that in Hume's political theory virtues play a significant role in motivating compliance with rules.The dissertation shows the importance of a distinction between interest as justifying rationale and interest as direct motive. Hume's argument for liberal institutions is essentially based on considerations of self-interest. However, he has deep reservations about self-interest being the motive for action. Given Hume's theory of reason and passion, he cannot expect people to be always clearheaded and to be constantly calculating relative advantage. Only preexisting, unreflective dispositional tendencies can ensure and explain strict rule-following. These dispositions form the core of liberal virtues.What is special about Hume's account of liberal virtues is that he juxtaposes the self-interest motive and the virtuous motive and has to explain their relationship. The typical liberal idea of the self-interest motive, understood as involving autonomous rational agency and reflective calculation, conflicts with the dispositional view of the virtuous motive. But Hume's notion of the self-interest motive is context-dependent, and the interests in the concrete contexts are diverse and heterogeneous. This particularized sense of interest is more like an unreflective tendency than a reflective calculation. As such it plays a major role in the formation of the corresponding virtuous motive and gradually gives place to the latter. The dissertation brings out that a stable liberal order cannot rely on either voluntary commitment or rational calculation, but depends on virtuous tendencies widely possessed by a people. These virtuous tendencies are shaped primarily through habituation, and their formation involves a protracted historical development and a particular way of life.Made available in DSpace on 2011-06-24T17:11:28Z (GMT). No. of bitstreams: 1
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Ekonomistyrning i småföretag : En fallstudie av ett israeliskt och ett svenskt småföretag
No full textSammanfattning Kandidatuppsats i företagsekonomi inom ekonomistyrning. Ekonomihögskolan Linneuniversitetet Vårterminen 2012. Författare: Claes Lindberg Handledare: Jan Alpenberg Titel: Ekonomistyrning i småföretag Syfte: Syftet med denna studie är: Att bidra till ökad förståelse för användningen av ekonomistyrsystemen i ett tillverkande småföretag i Israel och jämföra med dito i Sverige. Att beskriva användandet av ekonomistyrsystemen samt analysera olikheter och likheter emellan dem. Metod: Jag har i den här undersökningen valt att göra en fallstudie med två företag, ett israeliskt och ett svenskt. Den metod som jag använt definierar jag som en fallstudieteknik med en kvalitativ metod som enligt Yins dimensioner faller under multipel fallstudie med ett holistiskt tillvägagångssätt. Själva analysen har utförts med hjälp av ”contingency theory”. Slutsats: I studien har framkommit att det är stor skillnad i hur de två företagen har använt sina ekonomistyrsystem. Det är stor skillnad i hur man ser på ekonomistyrsystemen och vilket mervärde de tillför organisationen. Det svenska företaget har ett ekonomistyrningssystem som är väldigt traditionellt uppbyggt och där det anses viktigt för att leda företaget på effektivt sätt. Dessa skillnader har troligtvis uppkommit både på grund av skillnader i omgivningen men också av skillnader i företagens affärsidé, koncept och också pga. skillnader i VD/ägares personlighet. Vi kan dock konstatera att båda dessa företag har verkat under längre tid med god lönsamhet trots sina olika sätt att använda de traditionella ekonomistyrsystemen. Abstract Title Management Control Systems in Small Businesses Author Claes Lindberg Supervisor Jan Alpenberg Course Bachelor Thesis in Business Administration 15 ECts Purpose The purpose of the thesis is to: Add understanding to the use of management control systems in a small producing business in Israel and compare it to a similar business in Sweden. Describe the use of the management control systems and analyze the differences and differences between them. Methodology The methodology used in this thesis is a qualitative multiple case study that according to Yins dimensions would be characterized as a holistic case study. The relevant theory for analyzing the result is contingency theory. Conclusions The study has found that there is a big difference in how the two companies are using their management control systems and a big difference in how management see the added value to the organization from these control systems. The Swedish company has a control system that is very traditional in the type of segment where they operate and they consider the system as an important tool to lead the company in the right direction. The Israeli company on the other hand has a system that gives a more general picture and is less complicated and exact compared to the Swedish one. These differences are probably due to differences in the surroundings but also in business concept, customer demands and also difference in character and leader style of company owners. We can conclude that both these companies have been successful for 25 plus years with a profit level way above their competitors despite their different ways of using the traditional management control systems.
Ekonomistyrning i småföretag : En fallstudie av ett israeliskt och ett svenskt småföretag
No full textSammanfattning Kandidatuppsats i företagsekonomi inom ekonomistyrning. Ekonomihögskolan Linneuniversitetet Vårterminen 2012. Författare: Claes Lindberg Handledare: Jan Alpenberg Titel: Ekonomistyrning i småföretag Syfte: Syftet med denna studie är: Att bidra till ökad förståelse för användningen av ekonomistyrsystemen i ett tillverkande småföretag i Israel och jämföra med dito i Sverige. Att beskriva användandet av ekonomistyrsystemen samt analysera olikheter och likheter emellan dem. Metod: Jag har i den här undersökningen valt att göra en fallstudie med två företag, ett israeliskt och ett svenskt. Den metod som jag använt definierar jag som en fallstudieteknik med en kvalitativ metod som enligt Yins dimensioner faller under multipel fallstudie med ett holistiskt tillvägagångssätt. Själva analysen har utförts med hjälp av ”contingency theory”. Slutsats: I studien har framkommit att det är stor skillnad i hur de två företagen har använt sina ekonomistyrsystem. Det är stor skillnad i hur man ser på ekonomistyrsystemen och vilket mervärde de tillför organisationen. Det svenska företaget har ett ekonomistyrningssystem som är väldigt traditionellt uppbyggt och där det anses viktigt för att leda företaget på effektivt sätt. Dessa skillnader har troligtvis uppkommit både på grund av skillnader i omgivningen men också av skillnader i företagens affärsidé, koncept och också pga. skillnader i VD/ägares personlighet. Vi kan dock konstatera att båda dessa företag har verkat under längre tid med god lönsamhet trots sina olika sätt att använda de traditionella ekonomistyrsystemen. Abstract Title Management Control Systems in Small Businesses Author Claes Lindberg Supervisor Jan Alpenberg Course Bachelor Thesis in Business Administration 15 ECts Purpose The purpose of the thesis is to: Add understanding to the use of management control systems in a small producing business in Israel and compare it to a similar business in Sweden. Describe the use of the management control systems and analyze the differences and differences between them. Methodology The methodology used in this thesis is a qualitative multiple case study that according to Yins dimensions would be characterized as a holistic case study. The relevant theory for analyzing the result is contingency theory. Conclusions The study has found that there is a big difference in how the two companies are using their management control systems and a big difference in how management see the added value to the organization from these control systems. The Swedish company has a control system that is very traditional in the type of segment where they operate and they consider the system as an important tool to lead the company in the right direction. The Israeli company on the other hand has a system that gives a more general picture and is less complicated and exact compared to the Swedish one. These differences are probably due to differences in the surroundings but also in business concept, customer demands and also difference in character and leader style of company owners. We can conclude that both these companies have been successful for 25 plus years with a profit level way above their competitors despite their different ways of using the traditional management control systems.
Model Predictive Control of a Combined EGR/SCR HD Diesel Engine
No full textMaterials Noise, Vibration and Harshness Parts and Components Power and Propulsion Quality, Reliability and Durability Safety Tests and Testing Transportation Systems Vehicles and Performance Other Options Papers by Event SAE Home > Papers> By Event> SAE 2010 World Congress & Exhibition Model Predictive Control of a Combined EGR/SCR HD Diesel Engine Date Published: 2010-04-12Paper Number: 2010-01-1175 DOI: 10.4271/2010-01-1175 Author(s): Claes Westerlund - Scania CV AB Bjorn Westerberg - Scania CV AB Ingemar Odenbrand - Lund Univ. Rolf Egnell - Lund Univ. View All CollapseAbstract Achieving upcoming HD emissions legislation, Euro VI / EPA 10, is a challenge for all engine manufacturers. A likely solution to meet the NO x limit is to use a combination of EGR and SCR. Combining these two technologies poses new challenges and possibilities when it comes to optimization and calibration
Helping Students Develop Information Skills is Everyone's Business: Examining Information Contexts
No full textInformation literacy (IL) is both a discipline and transdisciplinary skill (ACRL, 2015). Its transdisciplinary and context-dependant application, as well as its theoretical underpinnings, make it a natural fit within the Scholarship of Teaching and Learning (SoTL). IL is broadly defined as the ability to search for, select, critically evaluate and use information for solving problems in various contexts (ACRL Framework, 2015; SCONUL 7 Pillars, 2015). Previous decades of expansion and diversification in higher education - with a growing interest in research on teaching and learning (e.g. SoTL), along with the rapidly changing information landscape – has highlighted IL as an important academic skill. IL is a vital skill for graduates’ employability, lifelong learning, and for being an engaged and informed citizen. Today, this conversation has been reinvigorated due to the rapid misinformation spread via social networks and the Internet. This panel is comprised of three librarians from three countries who will talk about how IL is viewed in different national contexts in North America and Europe. The panelists will outline how different national and institutional contexts affect how IL is viewed, highlight the importance of disciplinary context and how faculty approach IL, discuss how IL can be embedded into curriculum, and point to the dominant IL frameworks currently being used. The panelists will also summarize some of the common critiques of IL instruction and make an argument for why IL can be enhanced through SoTL research approaches. Time will be set aside, near the start of the panel, for participants to discuss how information works in their discipline (including creation, distribution, and evaluation) and how they teach IL skills in their classroom. Following an overview of the dominant IL frameworks and different national contexts, the panelists will lead a more general discussion about how these frameworks apply or do not apply to the participants’ disciplinary contexts. Constructivist approaches on learning IL have replaced instrumental pedagogical views inspired by behaviorism and its focus on generic and decontextualized skills. Learning is seen as constructed from learners’ own experiences and understandings of the object of teaching/learning. A social and contextual constructivist pedagogical view is put forward by researchers such as Vygotsky (1962) and Lave and Wenger (1991) who argue that learning is embedded in and part of social, ideological and physical contexts, situations and environments (e.g., academic disciplines). In IL research, such communities of practice are studied in information and learning practices (Limberg, Sundin & Talja, 2013) stressing IL as a context-bound and transdisciplinary skill and not only as a discipline in itself. The specific practices of both information and learning mean that instructors can reinforce the separateness of information and not support a cohesive understanding of information practices and environments. Much of the discourse around IL revolves around the situational context in which these skills are taught. There is evidence that curriculum embedded IL instruction is more likely to promote long-term skill development (Rosman, Mayer, & Krampen, 2016). Learning can be maximized when information literacy is underpinned by theory and taught contextually. This means that instruction needs to be tailored to the program, course, and assignments. While there are established threshold concepts (Christensen, 2015; Townsend, Hofer, Hanick, & Brunetti, 2016), a critique of IL scholarship is the overabundance of local, institutionally specific, and practice-based studies not rooted in theoretical literature. Through a SoTL lens, IL and its influence on learning is better understood. Furthermore, IL research can be strengthened by borrowing some of the established methodologies and linking research to theory. From this panel presentation, audience members will learn about the variance in approaches to IL instruction and why national, institutional, and disciplinary context is so important. Through discussion, participants will connect how SoTL studies can help faculty understand the nature of IL in their context and what IL skills their students possess and still need to learn. Studying IL through a SoTL lens has the potential to greatly aid the higher education learning community in understanding differences in how IL is contextualized, based on the differing international information landscapes. Panel session learning objectives:
1) Define information literacy in the context of their discipline;
2) Develop ideas for how information literacy could be integrated into their discipline and taught;
3) Identify how approaches and practices in SoTL can support and undergird information literacy theory and skills in various learning cultures.
Finding and evaluating information is a critical skill in higher education, regardless of the disciplinary, institutional, and national learning contexts. This panel session will provide an argument why teaching information literacy skills is everyone's business, and will get participants to think about how how information literacy is relevant to their own disciplinary context. Throughout the session, participants will have opportunities for dialogue and discussion about information literacy in their discipline and cultural context. Specifically, time will be set aside, near the start of the panel, for participants to discuss how information works in their discipline (including creation, distribution, and evaluation) and how they teach IL skills in their classroom. Following an overview of the dominant IL frameworks and different national contexts, the panelists will lead a more general discussion about how these frameworks apply or do not apply to the participants’ disciplinary contexts. By rooting information literacy skills within SoTL, attendees will develop new ideas for integrating and teaching information literacy skills
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