1,720,958 research outputs found
Add-on quetiapine in the treatment of major depressive disorder in elderly patients with cerebrovascular damage
No full textMDQ positive people's searching for effective and ineffective treatments for bipolar disorders: a screening study in France
No full textINTRODUCTION:
The objective was to estimate the rate of subjects who tested positive at a screening for bipolar disorders among the people insured by a French Health Company, and subsequently to measure treatment patterns.
METHODS:
Cross-sectional postal survey on the "Mutuelle Générale de l'Education Nationale" (MGEN) policyholders. A self-rated questionnaire was sent by mail to 20,099 individuals randomly selected among MGEN policyholders. Tools: questionnaire on socio-demographic variables and health-care use; Mood Disorder Questionnaire (MDQ); Composite International Diagnostic Interview Short Form Self-Administered (CIDI-SA).
RESULTS:
Responders were 10,288 (53%). The prevalence of MDQ positivity (MDQ(+)) was 3.6%. The respondents older than 65 showed the lowest frequencies. High frequencies were recorded by the people who had left work because of long term sickness and by people with invalidity. Subjects having a diagnosis of ICD-10 major depression were found to be at risk. Positive subjects had no more contacts with general practitioners than negative subjects; on the contrary they had more contacts with psychiatrists, alternative medicine professionals, psychologists, psychoanalysts, spiritual guides or welfare workers. MDQ+ subjects had a higher risk to use all kinds of psychodrugs, including antidepressants (27.7%, OR=2.7, CI95% 1.9-3.9).
DISCUSSION:
The prevalence of MDQ(+) was similar to the surveys in the USA and Italy. The use of ADs in people with MDQ(+) and MDD diagnosis needs to be taken into account when managing the public health-care system. A large rate of positive subjects reported to have used ineffective treatments for bipolar disorders.
LIMITS:
Relative low response rate and observational design
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
An open label follow-up study on amisulpride in the add-on treatment of bipolar I patients
Full text linkBackground: Atypical antipsychotics are widely used in the treatment of bipolar disorders.Amisulpride is an atypical antipsychotic that has been proven to be effective in treatment ofschizophrenia, major depressive disorder and, more recently, acute mania. At the moment,however, no study has assessed the effectiveness of this compound in maintenance therapy ofbipolar disorders. The purpose of this study was to assess the long-term effectiveness ofamisulpride in combination with standard treatments in patients with bipolar I disorder who haveshown inadequate responses to ongoing standard therapies.Methods: The study enrolled fourteen bipolar I outpatients, not responding to ongoing standard therapy.Three patients discontinued treatment but 11 were followed-up for 11.7 ± 8.2 months before(range 3-24 months) and 5.2 ± 2.7 months after the introduction of amisulpride (range 3-9months). Relapse rates before and during treatment with amisulpride were calculated inaccordance to an increase of 1 or more in Clinical Global Impressions Scale-Bipolar Version (CGI-BP) score that was accompanied by a change in therapy or to an exacerbation of the symptomsthat required hospitalization.Results: A statistically significant decrease in overall relapse rate was observed during the periodof amisulpride therapy compared with months previous to the introduction of amisulpride. Therelative risk of relapse in the absence of amisulpride therapy was 3.1 (χ2 = 4.2, P < 0.05). Similarly,the rates of manic/mixed and depressive relapse were decreased but only manic episodes reachedstatistical significance (RR = 5.3, χ2 = 5.2, P < 0.02).Discussion and conclusion: This open-label study suggests that long-term therapy withamisulpride may benefit patients by improving global symptoms of bipolar disorder and reducingthe rate of manic/mixed relapses. Large, randomized, double-blind, placebo-controlled studies areneeded to explore the benefits of adding long-term amisulpride to standard therapies for bipolardisorder.Published: 24 August 2006Clinical Practice and Epidemiology in Mental Health 2006, 2:19doi:10.1186/1745-0179-2-19Received: 18 April 2006Accepted: 24 August 2006This article is available from: http://www.cpementalhealth.com/content/2/1/19© 2006 Carta et al; licensee BioMed Central Ltd.This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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