252,551 research outputs found

    ee-Reduced rings in terms of the Zhou radical

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    Let RR be a ring, ee an idempotent of RR and δ(R)\delta(R) denote the intersection of all essential maximal right ideals of RR which is called Zhou radical. In this paper, the Zhou radical of a ring is applied to the ee-reduced property of rings. We call the ring RR {\it Zhou right} (resp. {\it left}) {\it ee-reduced} if for any nilpotent aa in RR, we have aeδ(R)ae\in \delta(R) (resp. eaδ(R))ea\in \delta(R)). Obviously, every ring is Zhou 00-reduced and a ring RR is Zhou right (resp., left) 11-reduced if and only if N(R)δ(R)N(R)\subseteq \delta(R). So we assume that the idempotent ee is nonzero. We investigate basic properties of Zhou right ee-reduced rings. Furthermore, we supply some sources of examples for Zhou right ee-reduced rings. In this direction, we show that right ee-semicommutative rings (and so right ee-reduced rings and ee-symmetric rings), central semicommutative rings and weak symmetric rings are Zhou right ee-reduced. As an application, we deal with some extensions of Zhou right ee-reduced rings. Full matrix rings need not be Zhou right ee-reduced, but we present some Zhou right ee-reduced subrings of full matrix rings over Zhou right ee-reduced rings

    Unveiling the Therapeutic Potential of Berberine in Rheumatoid Arthritis: A Comprehensive Study of Network Pharmacology, Metabolomics, and Intestinal Flora [Erratum]

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    Li B, Liu J, He C, Deng Z, Zhou X, Peng R. J Inflamm Res. 2024;17:10849—10869. The authors have advised the second listed corresponding author, Zhou Deng, is incorrect. The correct corresponding author is Xiaohong Zhou. The remaining details are correct. This error was introduced by the Editorial staff during the publication process

    Appropriate Similarity Measures for Author Cocitation Analysis

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    We provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis

    An Explanation for the Ternary Relation R in the Relational Semantics of Relevance Logic

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    Relational semantics is one of the most popular forms of semantics for relevance logic. However, this semantics, especially the ternary relation R lacks intuition, and that is why there are various interpretations for R. The original motivation for creating relevance logic is to give a better description of inference, thus if an interpretation for R could match this motivation better, then it will be more intuitive than the relational semantics and other interpretations. Therefore, this paper focuses on inference semantics, which could be viewed as a relational semantics with a ternary relation R, and R represents a relation among rules, premises and conclusions. These two forms of semantics are equivalent with respect to the relevance logic system R+. Actually, relational semantics could be regarded as a characterization of the formal structure of inference, and relevance logic may be defined as the logic of some kind of inference.CPCI-S(ISTP)CPCI-SSH(ISSHP)[email protected]; [email protected]

    Angiotensin II induces soluble fms-Like tyrosine kinase-1 release via calcineurin signaling pathway in pregnancy

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    Maternal endothelial dysfunction in preeclampsia is associated with increased soluble fms-like tyrosine kinase-1 (sFlt-1), a circulating antagonist of vascular endothelial growth factor and placental growth factor. Angiotensin II (Ang II) is a potent vasoconstrictor that increases concomitant with sFlt-1 during pregnancy. Therefore, we speculated that Ang II may promote the expression of sFlt-1 in pregnancy. Here we report that infusion of Ang II significantly increases circulating levels of sFlt-1 in pregnant mice, thereby demonstrating that Ang II is a regulator of sFlt-1 secretion in vivo. Furthermore, Ang II stimulated sFlt-1 production in a dose- and time-dependent manner from human villous explants and cultured trophoblasts but not from endothelial cells, suggesting that trophoblasts are the primary source of sFlt-1 during pregnancy. As expected, Ang II-induced sFlt-1 secretion resulted in the inhibition of endothelial cell migration and in vitro tube formation. In vitro and in vivo studies with losartan, small interfering RNA specific for calcineurin and FK506 demonstrated that Ang II-mediated sFlt-1 release was via Ang II type 1 receptor activation and calcineurin signaling, respectively. These findings reveal a previously unrecognized regulatory role for Ang II on sFlt-1 expression in murine and human pregnancy and suggest that elevated sFlt-1 levels in preeclampsia may be caused by a dysregulation of the local renin/angiotensin system

    Phospholipid meets all-Trans-retinal: The making of RPE bisretinoids

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    The lipid phase of the photoreceptor outer segment membrane is essential to the photon capturing and signaling functions of rhodopsin. Rearrangement of phospholipids in the bilayer accompanies the formation of the active intermediates of rhodopsin following photon absorption. Furthermore, evidence for the formation of a condensation product between the photolyzed chromophore all-trans-retinal and phosphatidylethanolamine indicates that phospholipid may also participate in the movement of the retinoid in the membrane. The downside of these interactions is the formation of bisretinoid-phosphatidylethanolamine compounds that accumulate in retinal pigment epithelial cells with age and that are particularly abundant in some retinal disorders. The propensity of these compounds to negatively impact on the cells has been linked to the pathogenesis of some retinal disorders including juvenile onset recessive Stargardt disease and age-related macular degeneration.-Sparrow, J. R., Y. Wu, C. Y. Kim, and J. Zhou. Phospholipid meets all-trans-retinal: the making of RPE bisretinoids. Copyright �� 2010 by the American Society for Biochemistry and Molecular Biology, Inc

    "Closing the R&D Gap, Evaluating the Sources of R&D Spending"

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    Both spending and tax policies have been implemented in the United States with the goal of stimulating private sector research and development (R&D). Karier questions whether current R&D policy, especially the research and experimentation tax credit, can contribute to closing the gap between nondefense expenditures on R&D in the United States and such expenditures in other countries, such as Japan and Germany. He also explores possible changes to our current R&D policy to make it more effective.

    Going Beyond Counting First Authors in Author Co-citation Analysis

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    The present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed

    MR-JTI implementation

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    Please cite: Zhou, D., Jiang, Y., Zhong, X., Cox, N. J., Liu, C., & Gamazon, E. R. (2020). A unified framework for joint-tissue transcriptome-wide association and Mendelian randomization analysis. Nature Genetics. (https://www.nature.com/articles/s41588-020-0706-2) .Zhou, D. & Gamazon, E. R. (2020). MR-JTI implementation (Version 1). Zenodo. http://doi.org/10.5281/zenodo.416474
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