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Relación entre las concentraciones hormonales y microlitiasis con la expresión de proteínas de pluripotencialidad y las alteraciones histológicas testiculares en pacientes con criptorquidia
Get PDFIntroduction. CO or undescended testicle, is a risk factor for testicular neoplasia. It is proposed that non-invasive methods such as the determination of MT characterized by microcalcifications in the seminiferous tubules and the hormonal concentrations associated with cells expressing pluripotentiality proteins, could be considered markers of cancer development risk. Objective. To determine in the testicle of patients with CO, the histopathological characteristics, the presence of MT, the expression of pluripotential proteins and the hormonal profile. Materials and methods. 23 children with CO from the National Institute of Pediatrics were studied. Peripheral blood was obtained to determine the concentrations of FSH, Inhibin B and estradiol. During the orchidopexy a testicular biopsy was taken for histological analysis and the determination of pluripotential proteins (SALL4, AP2γ, PLAP, c-kit and OCT3/4) by immunohistochemistry. All variables were correlated by a Pearson test (p<0.05). Results. In all patients a positive correlation between IH, MT and MC was observed; the number of germ cells the LB and the expression of SALL4; and the IH and the MT. There was a positive correlation in patients with inguinal CO between SALL4 expression, MC, MT and IH. Also in patients with CO who presented MT in histology, in the concentrations of Inhibin B and the degree of MT, age and MC, age and IH, LB and IH and SALL4 with age. It was observed that, of the 23 patients, 8 of them representing 35% presented MT in histology and 6 of them presented at least the expression of a pluripotentiality protein. One of the patients showed the expression of 4 of 5 pluripotentiality proteins and low concentrations of Inhibin B with concentrations of up to 50% lower compared to men of the age.
Conclusion. There is a positive correlation between the expression of SALL4 (a pluripotentiality protein) with MT in patients with CO. This supports the presence of MT added to CO, as a risk factor for malignancyIntroducción. La criptorquidia (CO) o testículo no descendido, es un factor de riesgo para la neoplasia testicular. Se propone que métodos no invasivos como la determinación de microlitiasis (MT) caracterizada por microcalcificaciones en los túbulos seminíferos y las concentraciones hormonales asociadas a células que expresan proteínas de pluripotencialidad, podría considerarse marcadores de riesgo a desarrollo de cáncer. Objetivo. Determinar en el testículo de pacientes con CO, las características histopatológicas, la presencia de MT, la expresión de proteínas de pluripotencialidad y el perfil hormonal. Materiales y métodos. Se estudiaron 23 niños con CO provenientes del Instituto Nacional de Pediatría. Se obtuvo sangre periférica para determinar las concentraciones de FSH, Inhibina B y estradiol. Durante la orquidopexia se tomó una biopsia testicular para el análisis histológico y la determinación de proteínas de pluripotencialidad (SALL4, AP2γ, PLAP, c-kit y OCT3/4) por inmunohistoquímica. Se correlacionaron todas las variables mediante una prueba de Pearson (p<0.05). Resultados. En todos los pacientes se observó, correlación positiva entre la IH, MT y MC; el número de células germinales la LB y la expresión de SALL4; y el IH y la MT. Se presentó correlación positiva en los pacientes con CO inguinal entre la expresión de SALL4, la MC, MT y el IH. También en los pacientes con CO que presentaron MT en la histología, en las concentraciones de Inhibina B y el grado de MT, edad y MC, edad e IH, LB e IH y SALL4 con la edad. Se pudo observar que, de los 23 pacientes, 8 de ellos que representan el 35% presentaron MT en la histología y 6 de ellos presentaron al menos la expresión de una proteína de pluripotencialidad. Uno de los pacientes mostró la expresión de 4 de 5 proteínas de pluripotencialidad y concentraciones bajas de Inhibina B con concentraciones de hasta 50% más bajas en comparación con varones de la edad.
Conclusión. Existe una correlación positiva entre la expresión de SALL4 (una proteína de pluripotencialidad) con la MT en los pacientes con CO. Esto apoya la presencia de MT sumado a la CO, como un factor de riesgo de malignidad
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Get PDFWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
Author Under Sail The Imagination of Jack London, 1893-1902
No full textIn Author Under Sail, Jay Williams offers the first complete literary biography of Jack London as a professional writer engaged in the labor of writing. It examines the authorial imagination in London's work, the use of imagination in both his fiction and nonfiction, and the ways he defined imagination in the creative process in his business dealings with his publishers, editors, and agents. In this first volume of a two-volume biography, Williams traverses the years 1893 to 1902, from London's "Story of a Typhoon" to The People of the Abyss. The Jack London who emerges in the pages of Author Under Sail is a writer whose partnership with publishers, most notably his productive alliance with George Brett of Macmillan, was one of the most formative in American literary history. London pioneered many author models during the heyday of realism and naturalism, blurring the boundaries of these popular genres by focusing on absorption and theatricality and the representation of the seen and unseen. London created an impassioned, sincere, and extremely personal realism unlike that of other American writers of the time. Author Under Sail is a literary tour de force that reveals the full range of London as writer, creative citizen, and entrepreneur at the same time it sheds light on the maverick side of machine-age literature.Intro -- Title Page -- Copyright Page -- Dedication -- Contents -- Acknowledgments -- Introduction -- 1. Spirit Truth -- 2. From Absorption to Theatricality and Back Again -- 3. "I Will Build a New Present" -- 4. Sons as Authors -- 5. Fathers as Publishers -- 6. The Daughter as Author -- 7. Lovers as Authors -- 8. At Sea with the Family -- 9. Yellow News, Yellow Stories -- 10. The Return Home -- Notes -- Bibliography -- Index -- About Jay WilliamsIn Author Under Sail, Jay Williams offers the first complete literary biography of Jack London as a professional writer engaged in the labor of writing. It examines the authorial imagination in London's work, the use of imagination in both his fiction and nonfiction, and the ways he defined imagination in the creative process in his business dealings with his publishers, editors, and agents. In this first volume of a two-volume biography, Williams traverses the years 1893 to 1902, from London's "Story of a Typhoon" to The People of the Abyss. The Jack London who emerges in the pages of Author Under Sail is a writer whose partnership with publishers, most notably his productive alliance with George Brett of Macmillan, was one of the most formative in American literary history. London pioneered many author models during the heyday of realism and naturalism, blurring the boundaries of these popular genres by focusing on absorption and theatricality and the representation of the seen and unseen. London created an impassioned, sincere, and extremely personal realism unlike that of other American writers of the time. Author Under Sail is a literary tour de force that reveals the full range of London as writer, creative citizen, and entrepreneur at the same time it sheds light on the maverick side of machine-age literature.Description based on publisher supplied metadata and other sources.Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, YYYY. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries
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