1,721,472 research outputs found
The long-term safety and efficacy of fibrates in patients with hypertriglyceridemia: Real-life data from a lipid clinic cohort
Full text linkNegative Allosteric Modulators of A2AR: A New Weapon for Cancer Immunotherapy?
Full text linkAdenosine-mediated activation of A(2A)R drives immunosuppressive signaling in high-adenosine tumor microenvironments (TMEs), impeding anticancer immunity. Targeting A(2A)R with negative allosteric modulators (NAMs) is a promising approach for cancer immunotherapy: unlike the orthosteric antagonists currently in use, which face competitive and off-target limitations, NAMs leverage a noncompetitive, saturable mechanism that enhances receptor selectivity. The development of a novel series of A(2A)R NAMs demonstrates potent activity within high-adenosine TMEs, underscoring a significant translational potential in oncology
Il dilemma di Jørgensen e il paradosso di Ross alla luce della teoria dei modelli mentali
No full textLo scopo di questo articolo è quello di utilizzare la teoria dei modelli mentali per lo studio di alcuni problemi di logica deontica, cioè il dilemma di Jørgensen e il paradosso di Ross. Nella prima parte, dopo alcuni brevi cenni alla semantica cognitiva, viene fornita una descrizione generale della teoria dei modelli mentali. Nella seconda parte viene descritta l'applicazione della teoria dei modelli mentali agli enunciati prescrittivi. Infine, nella terza parte, il dilemma di Jørgensen e il paradosso di Ross vengono descritti e poi analizzati attraverso la teoria dei modelli mentali.The aim of this paper is to use the mental models theory to study some problems of deontic logic, namely Jørgensen's dilemma and Ross' paradox. In the first part, after some brief remarks about cognitive semantics, a general description of the mental models theory is given. In the second part the application of the mental models theory to normative sentences is described. Finally, in the third part, Jørgensen's dilemma and Ross' paradox are described and then analyzed through the mental models theory
Chapter 5: Supercritical Fluid Pasteurization and Food Safety
No full textProcesses based on supercritical fluids, especially carbon dioxide, have been extensively investigated for their utility in pasteurizing milk, fruit and vegetable juices, raw vegetables, meat, and fish. This chapter initially reviews current issues in food pasteurization, then presents the thermodynamic fundamentals of supercritical fluid behavior and how SCFs can be utilized for pasteurization. The chapter includes possible mechanisms and models for the inactivation of a variety of hazardous microorganisms. This is followed by a comprehensive overview of specific studies of applications to a wide range of foodstuffs. Finally, the commercial viability of SCF pasteurization and the recent patent literature is discussed. The goal of this chapter is to enable both researchers and process developers to understand the scientific fundamentals behind the use of supercritical fluids for food pasteurization and assess the breadth of applications that have been considered
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Lo studio ACCORD: contestualizzazione ed intepretazione clinica.
No full textAnalisi critica dello Studio ACCOR
Vibration analysis of super-yachts: Validation of the Holden Method and estimation of the structural damping
Full text linkThe hull excitation generated by marine propellers constitutes one of the most significant vibration sources affecting comfort on passenger ships. Consequently, the evaluation of the propeller-generated excitation through reliable numerical tools during the preliminary stage of ship design is fundamental. The Holden Method (HM) is an empirical tool utilized to calculate the propeller-induced pressure distribution on a ship hull. The present paper validates the HM, which is applied to a twin-screw, 54-m super-yacht. Finite Element Analysis (FEA) is used to benchmark the HM numerical predictions against a set of full-scale vibration measures. The outcomes show that the magnitude of the propeller-induced dynamic excitation predicted by the HM is overestimated. Thereafter, the calibrated propeller-induced forces and the diesel engine excitation are applied to the FE model to perform a series of forced vibration analyses and estimate the global structural damping coefficient of the super-yacht. The study highlights the necessity of developing new empirical methodologies, analogous to the HM, to be applied to modern small luxury vessels
On microstructural development and inclusion generation in a continuosly cast resulphurised steel
No full textRed Yeast Rice for Hypercholesterolemia: JACC Focus Seminar
Full text linkThe extracts of red yeast rice (RYR) are currently the most effective cholesterol-lowering nutraceuticals. This activity is mainly due to monacolin K, a weak reversible inhibitor of 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase, whose daily consumption causes a reduction in low-density lipoprotein (LDL)-cholesterol plasma levels up to 15% to 25% within 6 to 8 weeks. The decrease in LDL-cholesterol is accompanied by a proportional decrease in total and non-high-density lipoprotein cholesterol, plasma apolipoprotein B, and high-sensitivity C-reactive protein. Some trials suggest that RYR use is associated with improvement in endothelial function and arterial stiffness, whereas a long-term study supports its role in the prevention of cardiovascular events. Despite the statin-like mechanism of action, the risk related to 3 to 10 mg monacolin K taken per day is minimal (mild myalgia in previously severely statin-intolerant subjects). RYR could represent a therapeutic tool to support lifestyle improvement in managing mild to moderate hypercholesterolemia in low-risk patients, including those who cannot be treated with statins or other LDL-cholesterol-lowering therapies
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