1,720,959 research outputs found
Circulating microparticles and hypercoagulability in obesity
Full text linkObesity has been associated with hypercoagulability and increased risk of both arterial and venous thromboembolic events. Many different and complex changes in plasma coagulation factors have been described in patients with obesity. Conventional plasma recalcification times don’t assess the entire process in physiological and holistic manner.
In a case-control study, the presence of hypercoagulability was evaluated in free of metabolic syndrome overweight and obese patients by measuring different subtypes of microparticles (MPs), thrombin generation, whole blood rotation thromboelastometry (ROTEM®) and impedance aggregometry (Multiplate®). Furthermore, the levels of MPs were prospectively measured in a group of 20 III degree obese patients before and after 12 months bariatric surgery in order to investigate the effect of weight loss.
Twenty overweight patients (body mass index [BMI] range 25–29.9 kg/m2), 20 with I degree (30-34.9 kg/m2), 20 with II degree (35–39.9 kg/m2) and 20 with III degree obesity (< 40 kg/m2) were enrolled and compared to 40 age and gender-matched normal weight individuals.
Microparticles: a significant increase in median levels of all MP subtypes was observed in the three degrees of obese patients compared to controls. All MPs, except for endothelial-derived MP, all MPs subtypes had significantly decreased at T12. Thrombin generation: obese patients had a significantly shorter median lag time, higher median peak thrombin and increased median endogenous thrombin potential compared to controls. Thromboelastometry: in INTEM and EXTEM tests MCF and AUC were significantly increased in III degree obese compared with controls; MCF in FIBTEM was significantly higher in I, II and III degree obesity than controls. Impedance aggregometry: a significant difference in platelet aggregation was found between III degree obese subjects and healthy controls in each of the tests considered.
We conclude that obesity is associated with overproduction of procoagulant MP and increase thrombin generation. A relationship between hypercoagulability detected by whole blood thromboelastometry and aggregometry and increased fat mass is shown. Assessment of global hemostasis tests may be helpful in the early characterization of the prothrombotic state in obese patients
Lung cancer and paraneoplastic neurologic syndromes. Case report and review of the literature
No full textHypercoagulability detected by whole blood thromboelastometry (ROTEM®) and impedance aggregometry (MULTIPLATE®) in obese patients
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Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Hypercoagulability in overweight and obese subjects who are asymptomatic for thrombotic events
No full textDispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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