64 research outputs found
Plasma xanthine oxidoreductase activity in Japanese patients with type 2 diabetes across hospitalized treatment
No full textYusuke Kawachi; Yuya Fujishima; Hitoshi Nishizawa; Hirofumi Nagao; Takashi Nakamura; Seigo Akari; Takayo Murase; Naohiro Taya; Kazuo Omori; Akimitsu Miyake; Shiro Fukuda; Mitsuyoshi Takahara; Shunbun Kita; Naoto Katakami; Norikazu Maeda; Iichiro Shimomura. Plasma xanthine oxidoreductase activity in Japanese patients with type 2 diabetes across hospitalized treatment. J Diabetes Investig. 2020.Aims/Introduction: Xanthine oxidoreductase (XOR) is an enzyme that catalyzes hypoxanthine and xanthine to xanthine and uric acid, respectively. Plasma XOR activity has recently been measured in humans. However, limited information is known about plasma XOR activity in patients with type 2 diabetes mellitus, and its changes after short-term glycemic control treatment. Materials and Methods: We enrolled 28 Japanese patients (10 men/18 women) with type 2 diabetes mellitus who were hospitalized to undergo medical treatment for diabetes. Plasma XOR activity, quantified using triple quadrupole mass spectrometry and liquid chromatography, and other clinical parameters were examined at admission and 2 weeks after treatment during hospitalization. Changes in plasma XOR activity after treatment during hospitalization and associated clinical parameters were assessed. Results: At the time of admission, the median plasma XOR activity was 83.1 pmol/h/mL, with a wide range of 14.4–1150 pmol/h/mL. Multiple regression analysis identified serum aspartate transaminase and alanine transaminase levels as significant and independent factors correlating with the baseline plasma XOR. Two weeks of treatment during hospitalization was associated with a significant decrease in plasma XOR activity. Changes in serum aspartate transaminase were also the only significant and independent factor correlating with changes in plasma XOR activity. Conclusions: A close relationship was observed between plasma XOR activity and liver transaminases in patients with type 2 diabetes mellitus, cross-sectionally, and also across treatment during hospitalization
Plasma xanthine oxidoreductase activity in Japanese patients with type2 diabetes across hospitalized treatment
No full textYusuke Kawachi; Yuya Fujishima; Hitoshi Nishizawa; Hirofumi Nagao; Takashi Nakamura; Seigo Akari; Takayo Murase; Naohiro Taya; Kazuo Omori; Akimitsu Miyake; Shiro Fukuda; Mitsuyoshi Takahara; Shunbun Kita; Naoto Katakami; Norikazu Maeda; Iichiro Shimomura. Plasma xanthine oxidoreductase activity in Japanese patients with type 2 diabetes across hospitalized treatment. J Diabetes Investig. 2020.Aims/Introduction: Xanthine oxidoreductase (XOR) is an enzyme that catalyzes hypoxanthine and xanthine to xanthine and uric acid, respectively. Plasma XOR activity has recently been measured in humans. However, limited information is known about plasma XOR activity in patients with type2 diabetes mellitus, and its changes after short-term glycemic control treatment. Materials and Methods: We enrolled 28 Japanese patients (10 men/18 women) with type2 diabetes mellitus who were hospitalized to undergo medical treatment for diabetes. Plasma XOR activity, quantified using triple quadrupole mass spectrometry and liquid chromatography, and other clinical parameters were examined at admission and 2weeks after treatment during hospitalization. Changes in plasma XOR activity after treatment during hospitalization and associated clinical parameters were assessed. Results: At the time of admission, the median plasma XOR activity was 83.1pmol/h/mL, with a wide range of 14.4–1150pmol/h/mL. Multiple regression analysis identified serum aspartate transaminase and alanine transaminase levels as significant and independent factors correlating with the baseline plasma XOR. Two weeks of treatment during hospitalization was associated with a significant decrease in plasma XOR activity. Changes in serum aspartate transaminase were also the only significant and independent factor correlating with changes in plasma XOR activity. Conclusions: A close relationship was observed between plasma XOR activity and liver transaminases in patients with type2 diabetes mellitus, cross-sectionally, and also across treatment during hospitalization
Effect of Glucagon-Like Peptide 1 Receptor Agonists on Visceral Fat Adiposity, Appetite, and Food Preference
No full textPlasma xanthine oxidoreductase activity in Japanese patients with type2 diabetes across hospitalized treatment
No full textYusuke Kawachi; Yuya Fujishima; Hitoshi Nishizawa; Hirofumi Nagao; Takashi Nakamura; Seigo Akari; Takayo Murase; Naohiro Taya; Kazuo Omori; Akimitsu Miyake; Shiro Fukuda; Mitsuyoshi Takahara; Shunbun Kita; Naoto Katakami; Norikazu Maeda; Iichiro Shimomura. Plasma xanthine oxidoreductase activity in Japanese patients with type 2 diabetes across hospitalized treatment. J Diabetes Investig. 2020.Aims/Introduction: Xanthine oxidoreductase (XOR) is an enzyme that catalyzes hypoxanthine and xanthine to xanthine and uric acid, respectively. Plasma XOR activity has recently been measured in humans. However, limited information is known about plasma XOR activity in patients with type2 diabetes mellitus, and its changes after short-term glycemic control treatment. Materials and Methods: We enrolled 28 Japanese patients (10 men/18 women) with type2 diabetes mellitus who were hospitalized to undergo medical treatment for diabetes. Plasma XOR activity, quantified using triple quadrupole mass spectrometry and liquid chromatography, and other clinical parameters were examined at admission and 2weeks after treatment during hospitalization. Changes in plasma XOR activity after treatment during hospitalization and associated clinical parameters were assessed. Results: At the time of admission, the median plasma XOR activity was 83.1pmol/h/mL, with a wide range of 14.4–1150pmol/h/mL. Multiple regression analysis identified serum aspartate transaminase and alanine transaminase levels as significant and independent factors correlating with the baseline plasma XOR. Two weeks of treatment during hospitalization was associated with a significant decrease in plasma XOR activity. Changes in serum aspartate transaminase were also the only significant and independent factor correlating with changes in plasma XOR activity. Conclusions: A close relationship was observed between plasma XOR activity and liver transaminases in patients with type2 diabetes mellitus, cross-sectionally, and also across treatment during hospitalization
Pharmacological HIF-1 activation upregulates extracellular vesicle production synergistically with adiponectin through transcriptional induction and protein stabilization of T-cadherin
No full textFujii K., Fujishima Y., Kita S., et al. Pharmacological HIF-1 activation upregulates extracellular vesicle production synergistically with adiponectin through transcriptional induction and protein stabilization of T-cadherin. Scientific Reports 14, 3620 (2024); https://doi.org/10.1038/s41598-024-51935-6.Pharmacological activation of hypoxia-inducible factor 1 (HIF-1), a hypoxia-responsive transcription factor, has attracted increasing attention due to its efficacy not only in renal anemia but also in various disease models. Our study demonstrated that a HIF-1 activator enhanced extracellular vesicle (EV) production from cultured endothelial cells synergistically with adiponectin, an adipocyte-derived factor, through both transcriptional induction and posttranscriptional stabilization of an adiponectin binding partner, T-cadherin. Increased EV levels were observed in wild-type mice but not in T-cadherin null mice after consecutive administration of roxadustat. Adiponectin- and T-cadherin-dependent increased EV production may be involved in the pleiotropic effects of HIF-1 activators
Pharmacological HIF-1 activation upregulates extracellular vesicle production synergistically with adiponectin through transcriptional induction and protein stabilization of T-cadherin
No full textFujii K., Fujishima Y., Kita S., et al. Pharmacological HIF-1 activation upregulates extracellular vesicle production synergistically with adiponectin through transcriptional induction and protein stabilization of T-cadherin. Scientific Reports 14, 3620 (2024); https://doi.org/10.1038/s41598-024-51935-6.Pharmacological activation of hypoxia-inducible factor 1 (HIF-1), a hypoxia-responsive transcription factor, has attracted increasing attention due to its efficacy not only in renal anemia but also in various disease models. Our study demonstrated that a HIF-1 activator enhanced extracellular vesicle (EV) production from cultured endothelial cells synergistically with adiponectin, an adipocyte-derived factor, through both transcriptional induction and posttranscriptional stabilization of an adiponectin binding partner, T-cadherin. Increased EV levels were observed in wild-type mice but not in T-cadherin null mice after consecutive administration of roxadustat. Adiponectin- and T-cadherin-dependent increased EV production may be involved in the pleiotropic effects of HIF-1 activators
Discharge operation of single-stage buck bi-directional AC/DC converter
No full textTainan, Taiwan, 3-6 November 2013conference pape
Large-scale web-based survey on eating behaviour in the Japanese general population using a dietary behaviour questionnaire
No full textFujii K., Fujishima Y., Kimura Y., et al. Large-scale web-based survey on eating behaviour in the Japanese general population using a dietary behaviour questionnaire. Diabetes, Obesity and Metabolism 27, 5737 (2025); https://doi.org/10.1111/dom.16626.Aims: Identifying habitual patterns of eating behaviour underlying obesity is essential for effective weight loss interventions. This study aimed to clarify differences in eating behaviours among obese individuals in a large-scale Japanese population. Materials and Methods: We analysed data from an online survey completed by 17 766 individuals aged 20–69 years. Eating behaviours were assessed using the Dietary Behaviour Questionnaire from the Japan Society for the Study of Obesity. Differences in the seven eating behaviour domains were examined by sex (Wilcoxon rank-sum test), age (Steel test with the 20s as the reference), and BMI category (Steel–Dwass test), classified as normal weight (18.5 to <25 kg/m²), overweight (25 to <30 kg/m²), or obese (≥30 kg/m²). Results: Among the normal-weight subjects, females scored higher than males in all domains except ‘Way of Eating’ and ‘Dietary Content’, whereas the eating behaviour scores declined with age across all of the domains in both sexes. Across the BMI categories, scores for all of the domains significantly increased with increasing obesity levels in both sexes. Particularly in males, significant differences were also observed between overweight and obese subjects. Additionally, age-related declines in scores were less pronounced among obese individuals. Furthermore, significant positive correlations between scores for all domains and BMI were observed in both sexes, even after adjusting for age. Conclusions: Our findings revealed significant differences in a wide range of eating behaviours across sex, age, and obesity levels. These results may contribute to the development of evidence-based strategies for the treatment of obesity disease
Influence of Crack Orientation of ASR Expansion Under Restraint Condition on Compressive Behavior Evaluated by Mesoscale Discrete Model
No full textInternational audienceThe influence of crack orientation in concrete due to the alkali–silica reaction (ASR) under restraint conditions on the change in compressive behavior is numerically evaluated. In the analysis, aggregates and mortar are modeled separately using a 3D rigid-body spring model. The mechanism of generating expansion pressure inside aggregates is described using the expansion model. ASR expansion under various restraint directions is simulated to reproduce the crack orientation due to ASR and then uniaxial compressive loading is performed. It is observed that crack orientation is parallel to the restraint direction and also affected the compressive behavior. Expansion cracks perpendicular to the loading axis caused a large reduction in compressive strength and elastic modulus. Furthermore, the stress distribution in a cross section during loading indicates that cracks parallel to the loading axis do not strongly affect compressive stress transfer, whereas perpendicular cracks prevent compressive stress transfer
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