28 research outputs found
Evidence for the Importance of Resonance Scattering in X‐Ray Emission Line Profiles of the O Star ζ Puppis
No full textTHE EFFECT OF STUDENT PERCEPTION ON ACADEMIC QUALITY VARIABLES TOWARD STUDENT PERFORMANCE ( Case study: International and Regular Program)
No full textABSTRAK
Masalah kualitas sekarang menjadi tema penting dalam manajemen pendidikan tinggi. Penelitian ini menyelidiki pengaruh Persepsi Mahasiswa tentang Variabel Kualitas Akademik terhadap Kinerja Mahasiswa Program Internasional dan Reguler, di Fakultas Ekonomi, Universitas Andalas. Berdasarkan tinjauan pustaka ada 4 jenis persepsi mahasiswa tentang kualitas akademik: Instruksi Akademik, Kehidupan Kampus, Bimbingan dan Pengakuan. Sebanyak 150 responden di Program Internasional dan Reguler, Fakultas Ekonomi, Universitas Andalas disurvei dalam penelitian ini tetapi hanya 135 responden yang dapat dianalisis untuk distribusi frekuensi, sementara itu 98 responden dapat dianalisis dengan regresi linier berganda. Temuan ini memiliki beberapa hasil yang menarik. Berdasarkan persepsi mahasiswa dalam program internasional, temuan menunjukkan bahwa bimbingan memiliki hubungan yang signifikan dengan kinerja mahasiswa, dan berdasarkan persepsi mahasiswa tentang program reguler, temuan menunjukkan bahwa instruksi akademik memiliki hubungan yang signifikan dengan kinerja mahasiswa
Specificity and cross-reactivity of IgM anti-EV71 in control subjects.
No full text<p>Specificity and cross-reactivity of IgM anti-EV71 in control subjects.</p
Bringing it all back home; social inclusion through advanced technologies in the home
No full textEThOS - Electronic Theses Online ServiceGBUnited Kingdo
The influence of aerated hydration seed treatment on seed longevity as assessed by the viability equations
No full textSupplementary materials and methods from A HER2-Targeting Antibody–Drug Conjugate, Trastuzumab Deruxtecan (DS-8201a), Enhances Antitumor Immunity in a Mouse Model
No full textSupplementary materials and methods</p
Supplementary Figures S1-S7 from A HER2-Targeting Antibody–Drug Conjugate, Trastuzumab Deruxtecan (DS-8201a), Enhances Antitumor Immunity in a Mouse Model
No full textSupplementary Figure S1. The chemical structure of DS-8201a. Supplementary Figure S2. Importance of targeted delivery by the ADC. Supplementary Figure S3. Reduced antitumor effect of DS-8201a in an immunocompromised mouse model. Supplementary Figure S4. Cell growth inhibition activity of DS-8201a and DXd. Supplementary Figure S5. Increased CD8+ cell infiltration into tumors. Supplementary Figure S6. Reduced antitumor effect of DS-8201a by CD8 depletion. Supplementary Figure S7. DXd, the payload of DS-8201a directly increased expression of MHC class I.</p
Pharmacokinetics of trastuzumab deruxtecan (T-DXd), a novel anti-HER2 antibody-drug conjugate, in HER2-positive tumour-bearing mice
No full textTrastuzumab deruxtecan (T-DXd, DS-8201a) is an antibody-drug conjugate (ADC), comprising an anti-HER2 antibody (Ab) at a drug-to-Ab ratio of 7–8 with the topoisomerase I inhibitor DXd. In this study, we investigated the pharmacokinetics (PK), biodistribution, catabolism, and excretion profiles of T-DXd in HER2-positive tumour-bearing mice.Following intravenous (iv) administration of T-DXd, the PK profiles of T-DXd and total Ab (the sum of conjugated and unconjugated Ab) were almost similar, indicating that the linker is stable during circulation. Biodistribution studies using radiolabelled T-DXd demonstrated tumour-specific distribution and long-term retention. DXd was the main catabolite released from T-DXd in tumours, with exposure levels at least five times higher than those in normal tissues and seven times higher than those achieved by non-targeted control ADC. Following iv administration of DXd, it was rapidly cleared from the circulation (T1/2; 1.35 h) and excreted mainly through faeces as its intact form.The PK profiles reveal that T-DXd effectively delivers the expected payload, DXd, to tumours, while minimising payload exposure to the systemic circulation and normal tissues. The released DXd is rapidly cleared from systemic circulation, presumably via the bile with negligible metabolism, and excreted through the faeces. Trastuzumab deruxtecan (T-DXd, DS-8201a) is an antibody-drug conjugate (ADC), comprising an anti-HER2 antibody (Ab) at a drug-to-Ab ratio of 7–8 with the topoisomerase I inhibitor DXd. In this study, we investigated the pharmacokinetics (PK), biodistribution, catabolism, and excretion profiles of T-DXd in HER2-positive tumour-bearing mice. Following intravenous (iv) administration of T-DXd, the PK profiles of T-DXd and total Ab (the sum of conjugated and unconjugated Ab) were almost similar, indicating that the linker is stable during circulation. Biodistribution studies using radiolabelled T-DXd demonstrated tumour-specific distribution and long-term retention. DXd was the main catabolite released from T-DXd in tumours, with exposure levels at least five times higher than those in normal tissues and seven times higher than those achieved by non-targeted control ADC. Following iv administration of DXd, it was rapidly cleared from the circulation (T1/2; 1.35 h) and excreted mainly through faeces as its intact form. The PK profiles reveal that T-DXd effectively delivers the expected payload, DXd, to tumours, while minimising payload exposure to the systemic circulation and normal tissues. The released DXd is rapidly cleared from systemic circulation, presumably via the bile with negligible metabolism, and excreted through the faeces.</p
