243 research outputs found
Alternative Muslim modernities: Bosnian intellectuals in the Ottoman and Habsburg Empires
No full textThe Habsburg takeover of Ottoman Bosnia Herzegovina (1878–1918) is conventionally considered the entry of this province into the European realm and the onset of its modernization. Treating the transition from one empire to another not as a radical break, but as in many respects continuity, reveals that the imperial context provided for the existence of overlapping affiliations that shaped the means by which modernity was mediated and embodied in the local experience. Drawing on Bosnian and Ottoman sources, this article analyzes Bosnian intellectuals’ conceptions of their particular Muslim modernity in a European context. It comparatively evaluates the ways in which they integrated the modernist discourse that developed in the Ottoman Empire and the broader Muslim world, and how they also contributed to that discourse. I show that their concern with modernity was not abstract but rather focused on concrete solutions that the Muslim modernists developed to challenges in transforming their societies. I argue that we must incorporate Islamic intellectual history, and cross-regional exchanges within it, to understand southeastern Europe's past and present, and that studies of Europe and the Middle East need to look beyond geohistorical and disciplinary divisions.Peer reviewe
Synthesis and anticancer activity of some 1,2,3-trisubstituted pyrazinobenzimidazole derivatives
No full textWOS: 000345518000007PubMed ID: 24456294The synthesis of some new pyrazino[1,2-a]benzimidazole derivatives and investigation of their anticancer activities were aimed in this work. Thus, 2-acetylbenzimidazole was reacted with appropriate alpha-bromoacetophenones and potassium carbonate in acetone to give 2-(2-acetyl-1H-benzimidazol-1-yl)-1-phenylethanone derivatives (3a-d). These diketone compounds were reacted with varied benzylamines in acetic acid to obtain 2-benzyl-1-methylidene-3-aryl-1,2-dihydropyrazino[1,2-a]benzimidazole derivatives (4a-t). The structures of the obtained compounds were elucidated by using IR, H-1-NMR, C-13-NMR, MS spectral data and elemental analyses results. Anticancer activities of the selected compounds were investigated in National Cancer Institute, Bethesda, MD. 3c and 4n showed remarkable anticancer activity comparing with standard drugs, melphalan and cisplatin
A GODDESS ON STAGE – LEYLA GENCER, A FLUTTERING HEART
No full textBir “Çılgın Türk” ün, bir “Prima Donna”nın, ünlü sopranomuz Leyla Gencer'in yaşamı, sanat dünyasındaki olağanüstü başarısı, otuz üç yıllık sanat yaşamı keyifle okunan yaşamöyküsel bir romana konu olmuş. Kitabın yazarı, gazeteci Zeynep Oral romanına çok emek vermiş, satırlarına renk ve ses katmış nerdeyse. Anlatının dokusunu, sanatçılarla, Türk ve İtalyan sanat dünyasından ünlü kişilerle yapılan söyleşiler, sanatçının hakkında özellikle yurt dışında yayımlanan dergi ve gazete makalelerinde yeralan övgüler, sanatçıya gelen sayısız mektup ve fotoğraflar oluşturuyor. Yazımız gerçek bir tutkunun, başarının ve azmin öyküsünü irdeliyor. Leyla Gencer çok değişik ve zengin opera, arya repertuvarı ile Türk kadınının “Ben Anadoluyum, ben Türk’üm” diye dünyaya seslenişini biz okurlara bir kez daha anımsatıyor.The life of Leyla Gencer, our well-known soprano, a “Crazy Turk”, a “Prima Donna”, her great success in the world of art, and her thirty-three years of artistic experience have been the subject of a biographical novel. Zeynep Oral, the author of the novel, has given a colourful touch to the work with her own style. She has built up her narrative with the interviews of famous artists, tributes from various journals and articles from Italy and Turkey, and numerous letters and photographs received by the artist. Our paper explores the real story of passion, achievement, and ambition. With her rich repertory of opera and aria, Leyla Gencer reminds of Turkish woman’s strength once again by crying out “I am Anatolia, I am Turk!”
Leyla Erbil's storyelling in the context of sociology of literature
No full textYalçın, Seda, "Edebiyat Sosyolojisi Bağlamında Leylâ Erbil'in Öykücülüğü", Yüksek Lisans Tezi, Kırıkkale, 2019. 1950 kuşağı öykücülerinden olan Leylâ Erbil, yayımladığı öykü, roman ve diğer türlerdeki eserleriyle toplumsal meselelere ve toplumu ilgilendiren siyasi, sosyal olaylara eserlerinde ki yaklaşımı açısından edebiyatımızda önemli bir yerdedir. Bu çalışmada edebiyat sosyolojisinin dünyada ve Türkiye'deki gelişimi üzerine bilgi verilecek olup, bu bilgiler ışığında Leylâ Erbil'in öykülerinin edebiyat sosyolojisi bağlamında incelenmesine yer verilmiştir. Öykülerini edebiyat sosyolojisi bağlamında incelediğimiz yazar, yayımladığı üç öykü kitabında da toplumsal meselelere yer vermiş, eserin kaleme alınma sürecinde yaşanan siyasi, sosyal ve kültürel hayata kayıtsız kalmamış aynı zamanda kendi hayatından izdüşümleri de eserlerine konu etmiştir. Bu bakımdan edebiyat sosyolojisi açısından eserleri toplum ve insanın etkileşimi üzerine bilgi vermesi yönüyle ayna niteliğindedir. Anahtar Sözcükler: Leylâ Erbil, Edebiyat Sosyolojisi, Öykü, Edebiyat.Yalçın, Seda, "Leyla Erbil's Storytelling In the Context of Sociology of Literature", Master Thesis, Kırıkkale, 2019. Leyla Erbil, one of the story writers of the 1950s, published stories, novels and trials. The importance of her writings in Turkish Language and Literature is the social issues she mentioned in those genres. In this study, the development of literary sociology in Turkey and in the world was mentioned and the stories of Leyla Erbil were examined in this context. The author, whose stories are examined in the context of the sociology of literature, has included social problems in three short stories she has published. She was also influenced by the period of political, cultural and social perspective in which she lived. In this regard, her stories are obviously contain elements belonging to the sociology of literature. It is said to be the stories of Leyla Erbil serve as mirrors as they reflect the social and political problems of the period in which she lived. Key Words: Leyla Erbil, Sociology of literatüre, story, literatür
Synthesis and Antimicrobial Activity of Some New N-(1H-benzimidazol-2- yl)-2-mercaptoacetamide Derivatives
No full text
Background:
Due to multi-drug, extended-drug, and pandrug resistance phenotypes,
bacterial resistance to antibiotics and fungal infections are a general health issue. Particulary,
increase of fungal infections due to secondary cause of human diseases have been observed. An
extensive variety of benzimidazole derivatives have been characterized for their chemotherapeutic
significance. Benzimidazole derivatives have received important attention because of pharmacological
significance during current years, especially antimicrobial, anti-fungal, antitubercular, antioxidant,
anti-Alzheimer's disease and antihypertension activities.
Methods:
Some N-(1H-benzimidazol-2-yl)-2-mercaptoacetamide derivatives (2a-h) were
synthesised and evaluated for their antimicrobial activity. The title compounds were gained by
reacting N-(1H-benzimidazol-2-yl)-2-chloroacetamide with some substituted 2-mercapto heterocyclic
rings. The synthesised compounds were investigated for their antimicrobial activities against
C. albicans (ATCC 24433), C. krusei (ATCC 6258), C. glabrata (ATCC90030), C. parapsilosis
(ATCC 22019), E. coli (ATCC 25922), E. coli (ATCC 35218), E. feacalis (ATCC 51299),
E. feacalis (ATCC 29212), S. aureus (ATCC 25923), K. pneumoniae (ATCC 700603),
P. aeruginosa (ATCC 27853).
Results:
The compounds showed high antifungal activity when compared with standard drug
ketoconazole. In addition, all compounds (MIC 100 µg/mL) showed inhibitor activity against
P. aeruginosa at two fold concentration of chloramphenicol (MIC 50 µg/mL). Also, compounds 2a,
2c and 2e (MIC: 50 µg/mL) have equal effect against E. coli (ATCC 35218) and more effective
than other compounds (MIC of chloramphenicol: 100 µg/mL).
Conclusıon:
All compounds showed notable activity. Compounds have determined to possess higher
antifungal activity than antibacterial activity. Additionally, compounds 2a with 1-methyltetrazole,
2c with benzothiazole and 2e with 6-chlorobenzothiazole moieties were found as the most active
compounds.</jats:sec
Deux ou trois choses que l'on sait de lui
No full textTwo or Three Things We Know About Him.
In 1977, Jacques Lefrere found an Iliad in Spanish which contained a statement of ownership by Isidore Ducasse, Count of Lautréamont, which reveals possession of another book. Its analysis, combined with a remarkable synthesis of the criticism, provides great insight in locating the work — and the author, to some degree.Perrone-Moisès Leyla. Deux ou trois choses que l'on sait de lui. In: Littérature, n°117, 2000. La mise à distance. pp. 18-37
Dal Convivio alla Monarchia: quale Livio per Dante?
No full textIn questo contributo si prendono in considerazione il riferimento a Livio in Convivio
IV.v, 11 e alcuni dei riferimenti allo storico romano ritenuti maggiormente significativi nel secondo libro della Monarchia. Si dimostra che il rimando a Livio nel primo trattato è introdotto in riferimento a una ripresa probabilmente dal suo abbreviatore Floro e in apertura di un passaggio in cui si utilizza una tradizione storiografica più articolata e complessa, comprendente anche Agostino. Si propone, di conseguenza, che il rimando a Livio non si basi su una conoscenza diretta dello storico latino ma si fondi sulla sintesi realizzata da Floro. Si dimostra poi che, contrariamente all’opinione vulgata, alcuni riferimenti a Livio nella Monarchia, particolarmente quello programmatico di II.iii, 6, non sono riconducibili
in toto alla tradizione indiretta e quindi sembrerebbero suggerire che Dante avesse avuto accesso a questo autore entro la composizione del suo trattato politico.This essay focuses on Dante’s references to Livy in Convivio IV.v, 11 as well as on some particularly important references to the Roman historian in the second book of the De Monarchia. The author argues that the first reference is most likely derived from the epitome compiled by Livy’s abbreviator Florus, and shows how it is placed at the beginning of a passage that refers to several different historiographical sources, including Agustine. The author therefore suggests that this reference to Livy in the Convivio is not based on Dante’s direct knowledge of the work of the Roman historian, but rather on the information contained in the synthesis by Florus. She also challenges the scholarly consensus on this
topic by showing that some references to Livy in the De Monarchia – especially the “programmatic” one in II.iii, 6 – do not appear in the indirect tradition and can only be traced back directly to Livy. This suggests that Dante likely accessed the work of Livy before the composition of his political treatise
Microwave supported synthesis of some novel 1,3-Diarylpyrazino[1,2-a] benzimidazole derivatives and investigation of their anticancer activities
No full textWOS: 000286905400048PubMed ID: 21122952The syntheses of 1,3-diarylpyrazino[1,2-a]benzimidazole derivatives and the investigation of their anticancer activities were studied. For this, 2-aryloylbenzimidazole derivatives were reacted with 2-bromoacetophenones in acetone to give 1-(2-aryl-2-oxoethyl)-2-aryloylbenzimidazoles. The resulting materials were reacted with ammonium acetate in acetic acid to obtain the aimed compound. In this reaction, microwave irradiation method was applied as the reaction conditions. Anticancer activities of the compounds obtained were investigated. It was observed that some of the compounds showed remarkable anticancer activities
New N’-Arylidene-2-[(4-Nitrophenyl)Piperazın-1-yl]Acetohydrazide Derivatives: Synthesis and Anticancer Activity Investigation
No full textWOS: 000405935700007Background: Compounds bearing ortho-hydroxy N-acyl hydrazone moiety have been reported with high anticancer activity acting by increasing the enzymatic activity of procaspase-3 in cancer cells and therefore inducing apoptosis in some tumour models. Methods: Considering this subunit's proclivity for anticancer activity we have synthesized novel N'-arylidene-2-[(4-nitrophenyl) piperazin-1-yl] acetohydrazide derivatives (3a-3n) including N-acyl hydrazone moiety with a well-known three step synthetic procedure. The antiproliferative activity of the compounds were investigated using MTT method and xCELLigence real time cell analysis system against NIH/3T3 (Mouse embryo fibroblast cell line) as healthy cell line and A549 (Human lung adenocarcinoma ephitelial cell line) as tumour cell line. Results and Conclusion: The IC50 values of final compounds were determined for 24h and 48h incubation periods. As a second stage, flow cytometric analysis was performed for selected highly active compounds (3g, 3i, 3j, 3n) on A549 cell line. Compound 3i bearing 3-chlorophenyl moiety was detected to cause apoptosis in a ratio of 54.7 %
Per la biblioteca di Ugo Foscolo: Thomson, Wieland, André.
No full textIl contributo individua alcuni testi che avrebbero inluenzato l’estetica foscoliana in generale e specialmente l’incompiuto poemetto Alle Grazie. In due elenchi di libri compilati durante il soggiorno fiorentino (1812-1813), Foscolo attesta di avere con sé ben due edizioni delle Seasons di Thomson, una in francese (con l’originale inglese a fronte) e l’altra in italiano. Nella lista dei libri lasciati a Milano partendo per l’esilio è poi incluso un Musarion, che potrebbe essere la versione francese o addirittura italiana dell’omonima opera di Wieland. Inine, nel giovanile Piano di studi Foscolo menziona un certo André, che si deve identificare in Yves-Marie André autore di un fortunato Essai sur le Beau, ripreso talvolta alla lettera da Leopoldo Cicognara nel suo saggio Del Bello. Cicognara diventò il teorico dell’arte canoviana e fu a Firenze nell’agosto-settembre del 1812, soggiornando nello stesso albergo di Foscolo. Dietro al progetto foscoliano di un carme intitolato alle Grazie, quindi, non agiva soltanto la sua profonda conoscenza dei classici, ma si può avvertire l’eco della cultura europea sviluppatasi fra Sette e Ottocento: dalla poesia campestre di Thomson, alla grazia galante e rococò di Wieland, fino al neoclassicismo canoviano.This paper deals with some works which might have influenced Ugo Foscolo’s aesthetic thought and in particular his unfinished poem Le Grazie. In two lists of books dating at his stay in Florence (1812-1813), Foscolo registers his possession of two editions of Thomson’s Seasons, a French one (accompanied by the original English text) and an Italian one. In another list, which records the books he left in Milan before going into exile, we can also ind a Musarion, which could be a French, or even the Italian translation of Wieland’s work of the same title. Finally, in his youth Piano di studi, Foscolo names an André, who has to be identified with Yves-Marie André, the author of a famous Essai sur le Beau. This essay was quoted sometimes literally by Leopoldo Cicognara in his book Del Bello. The promoter of Canova’s art, Cicognara was in August-September 1812 at the same Florentine hotel where Foscolo lived. Therefore, Foscolo’s plan of a poem to the Graces must have benefitted not only of the poet’s deep knowledge of Classical literature but also of the influence of the whole European culture between xviii and xix century: from Thomson’s bucolic poetry, to Wieland’s galant and Rococo grace, until Canova’s Neoclassicism
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