108,476 research outputs found
Cost effectiveness of Mohs micrographic surgery for non-melanoma skin cancer: a systematic review protocol
No full textReview question/objective
The overall research question for this systematic review is: what is the cost effectiveness of Mohs micrographic surgery for non-melanoma skin cancer?
More specifically, the objectives are to:
Examine the evidence on the cost effectiveness, cost benefit, cost minimization, and cost utility of Mohs micrographic surgery, compared to other surgical/ablative interventions such as excisional surgery and radiation therapy, as well as non-surgical/chemotherapeutic interventions such as topical 5-fluorouracil and imiquimod immunotherapy, for non-melanoma skin cancer clinical care outcomes;
Determine the cost effectiveness, cost benefit, cost minimization and cost utility of Mohs micrographic surgery from the patient, provider, healthcare system and societal perspectives in order to elucidate the economic and clinical benefits of the procedure at these various levels;
Provide a comprehensive assessment of the relative economic and clinical effectiveness of this procedure for patients with non-melanoma skin cancer in different contexts globally.
Inclusion criteria
Types of participants
This review will consider studies that include participants with an established diagnosis of non-melanoma skin cancer. For the purposes of this review, an established diagnosis of non-melanoma skin cancer will consist of either squamous cell carcinoma or basal cell carcinoma , confirmed histologically or clinically or both, by a healthcare provider trained to do so.
Types of intervention(s)/phenomena of interest
This review will consider studies that evaluate Mohs micrographic surgery as a treatment for non-melanoma skin cancer.
Types of outcomes
This review will consider studies that measured any clinical care outcomes related to non-melanoma skin cancer, including but not limited to mortality, quality of life, quality-adjusted life years , incidence and recurrence of non-melanoma skin cancer lesions, and frequency of adverse events. However, to be considered for inclusion, studies must also provide an economic evaluation of the relative costs of using Mohs micrographic surgery as a therapeutic modality when compared to other known treatment modalities.Peer reviewedThe definitive version is available at http://www.joannabriggslibrary.org/index.php/index
Letter, [Author unclear] to Paulina T. Merritt
No full textHandwritten letter to Paulina Merritt from an unknown author, October 1, 1876.
Characterization of the gravitaxis-related protein Yuri Gagarin through genetic and biochemical approaches
No full textThe Drosophila melanogaster gene yuri gagarin was first identified in a screen for aberrant behavioral responses to the mechanosensory stimulus provided by the force of gravity. This novel gene encodes Yuri isoforms of four sizes; the three larger isoforms are predicted to be composed largely of coil-forming domains, which are common protein interaction domains. The four isoforms are expressed in varying ratios throughout the animal, at all stages of development. Notably, Yuri is present in muscle tissue, localized to Actin-containing regions of the sarcomere.
A male-sterile deletion allele of yuri, yuriF64, was identified and sequenced. This deletion removes roughly 500 base pairs of sequence upstream of the Yuri coding region; in these animals, the mid-sized Yuri isoforms are not expressed in any tissue, and the smallest isoform is no longer expressed in the testis. In wild-type animals, Yuri protein is present throughout the testis, and it assumes a dynamic microtubule-dependent nuclear localization pattern during the process of nuclear condensation, appearing to be a component of the "dense complex" described in ultrastructural studies of spermatogenesis. A previously undescribed filamentous Actin network co-localizes with Yuri on the nuclear surface; Yuri may act as a linker between the Actin and microtubule cytoskeletons.
In yuriF64 homozygotes, no Yuri-staining or filamentous Actin structures are detected on the condensing sperm nuclei, and the basal body and centriolar adjunct are mis-localized or absent. Axonemal defects are apparent in heterozygotes and homozygotes, and the Actin-dependent sperm individualization does not take place, leaving immature sperm bound in bundles of 64.
Yuri physically interacts with components of the Actin cytoskeleton (Actin, Tropomyosin 1, and Troponin T) in an in vivo pull-down assay. Tropomyosin 1 (Tm1) is the interacting protein purified in greatest abundance in the assay, suggesting that it and Yuri interact directly; this coil-forming molecule wraps actin filaments, stabilizes them against enzymatic or physical degradation, and blocks the interaction of the filament with other proteins. Tm1 is present on the condensing sperm nucleus, and Yuri co-localizes with it in muscle tissue. Thus, the defects seen in yuriF64 animals may reflect aberrant Actin dynamics arising from a lack of Yuri-Tm1 interaction
Handwritten biographical information on Paulina T. McClung Merritt
No full textA handwritten biography of Paulina T. McClung Merritt by an unknown author, 1892.
Heterogeneous and tissue-specific regulation of effector T cell responses by IFN-gamma during Plasmodium berghei ANKA infection.
Get PDFIFN-γ and T cells are both required for the development of experimental cerebral malaria during Plasmodium berghei ANKA infection. Surprisingly, however, the role of IFN-γ in shaping the effector CD4(+) and CD8(+) T cell response during this infection has not been examined in detail. To address this, we have compared the effector T cell responses in wild-type and IFN-γ(-/-) mice during P. berghei ANKA infection. The expansion of splenic CD4(+) and CD8(+) T cells during P. berghei ANKA infection was unaffected by the absence of IFN-γ, but the contraction phase of the T cell response was significantly attenuated. Splenic T cell activation and effector function were essentially normal in IFN-γ(-/-) mice; however, the migration to, and accumulation of, effector CD4(+) and CD8(+) T cells in the lung, liver, and brain was altered in IFN-γ(-/-) mice. Interestingly, activation and accumulation of T cells in various nonlymphoid organs was differently affected by lack of IFN-γ, suggesting that IFN-γ influences T cell effector function to varying levels in different anatomical locations. Importantly, control of splenic T cell numbers during P. berghei ANKA infection depended on active IFN-γ-dependent environmental signals--leading to T cell apoptosis--rather than upon intrinsic alterations in T cell programming. To our knowledge, this is the first study to fully investigate the role of IFN-γ in modulating T cell function during P. berghei ANKA infection and reveals that IFN-γ is required for efficient contraction of the pool of activated T cells
Dispelling the Myths Behind First-author Citation Counts
Get PDFWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
Pelevin’s Trinity in the novel “t”: author – protagonist – reader
No full textThe article attempts to interpret Pelevin's artistic strategy in the novel "T" by exploring its subject organization and addressing the key problems of the author, the protagonist, and the reader as they are seen by the researcher. The article analyzes the peculiarities of constructing the narrative reality in the novel "T", and goes on to discuss Pelevin's philosophic models of the development of the humankind, and the emergence of his new anthropology
Global Well-Posedness for Eddy-Mean Vorticity Equations on
No full textWe consider the two-dimensional, -plane, vorticity equations for an
incompressible flow, where the zonally averaged flow varies on scales much
larger than the perturbation. We prove global existence and uniqueness of the
solution to the equations on periodic settings
Measuring industry-science links through inventor-author relations: A profiling method
Get PDFIn this pilot study we examine the performance of text-based profiling in recovering a set of validated inventor-author links. In a first step we match patents and publications solely based on their similarity in content. Next, we compare inventor and author names on the highest ranked matches for the occurrence of name matches. Finally, we compare these candidate matches with the names listed in a validated set of inventor-author names. Our text-based profile methodology performs significantly better than a random matching of patents and publications, suggesting that text-based profiling is a valuable complementary tool to the name searches used in previous studies.innovation; industry-science links; text-based profiling;
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