21,459 research outputs found
Requirement for a core 1 galactosyltransferase in the Drosophila nervous system:
No full textGlycosylation is important in a lot of fundamental biological processes, including cell recognition, cell adhesion, and cell signaling. Mucin-type O-glycosylation involves the synthesis of glycoproteins, expressed in mucous secretions and as transmembrane proteins on the cell surfaces. However, the biological functions of mucin-type O-glycans remain incompletely understood. I have pursued genetic and biochemical studies to understand their importance during development in Drosophila.
Mucin-type O-glycosylation is initiated by the attachment of N-acetylgalactosamine (GalNAc) to Ser or Thr residues, and then elongated by additional sugars. To examine the requirements for mucin-type glycosylation in Drosophila, I characterized the expression and phenotypes of core 1 galactosyltransferases (core 1 GalTs), which elongate O-GalNAc by adding galactose in a β1, 3 linkage. Among Drosophila core 1 GalTs, CG9520 (C1GalTA) is expressed in the amnioserosa and central nervous system. A null mutation in C1GalTA is lethal. The mutant animals show a morphogenetic defect in their central nervous system in which the ventral nerve cord is greatly elongated and the brain hemispheres are distorted. Lectin staining and blotting experiments confirmed that C1GalTA is required for the synthesis of Gal-ß1,3-GalNAc in vivo. Our observations establish a role for mucin-type O-glycosylation during neural development in Drosophila.
Overexpression of C1GalTA causes a wing blistering phenotype, which occurs when adhesion between the two ventral and dorsal surfaces of the wing blade is lost, and is also commonly seen in integrin mutants. This result implicates mucin-type O-glycans in cell adhesion in the Drosophila wing blade.
Altogether, these results suggest a role of mucin-type O-glycosylation in Drosophila development, including the morphogenesis of central nervous system and the formation of the wing blade.Ph.D.Includes bibliographical references (p. 90-94)by Yuh-Ru Li
Dr. Lin Sun, CAU, March 2013
No full textThis video is a conversation with Dr. Lin Sun. Dr. Sun talks about an exhibit at the Woodruff Library titled "At The Boundary." Jordan Moore, AUC Woodruff Library, is the interviewer
An Analysis of <i>Judge Lin</i>
No full textBiography of Lin Wen Zhong Gong has another way to call, that is Judge Lin. The leading character is Lin Ze-Xu. This book is based on functionary experience of Lin Ze-Xu, with the captivating plots of court case, helping by highly skilled military attach\uc3\ua9s and chivalrous knights, and the history facts of Opium War. It makes Lin Ze-Xu\ue2s Confucian temperament and tragic mood more, also contrasts with author\ue2s sorrow and furiousness for the politics at the time. History, court case, martial arts\ue2\ua6\ue2\ua6etc. are essence of this book and it broadens the way of this writing style.
The topic of the thesis is \ue2An Analysis of Judge Lin\ue2. The following thesis will be divided into six different chapters. The introduction is Chapter one of the thesis, which is including researching motive and purpose, literature review of predecessors, researching version by existing information, raising questions, choosing research methods and arranging chapters. In chapter Two, I discuss the study of characters of Lin Ze-Xu, also makes a deep analysis of author\u27s purpose of writing him. In chapter Three, I analyze supporting actors and actress. Meanwhile, I illustrate author\u27s purpose of writing supporting actress because the author had different manner to describe supporting actress. Moving to the Chapter Four, I mainly focus on the plots of Judge Lin, and organize cases of Lin Ze-Xu and his subordinates to understand features of cases. In Chapter Five, I represent the causes of Opium War. China and England had difference of opinions of opium. Therefore, it is easier to comprehend what the author\u27s purpose is. In the last chapter I summarize the main points of the preceding chapters and confirm particularity of Judge Lin
Effect of red mold rice on antifatigue and exercise-related changes in lipid peroxidation in endurance exercise
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sj-pdf-1-ajs-10.1177_03635465211030295 – Supplemental material for Use of Platelet-Rich Plasma Plus Suramin, an Antifibrotic Agent, to Improve Muscle Healing After Injuries
No full textSupplemental material, sj-pdf-1-ajs-10.1177_03635465211030295 for Use of Platelet-Rich Plasma Plus Suramin, an Antifibrotic Agent, to Improve Muscle Healing After Injuries by Wen-Chung Tsai, Tung-Yang Yu, Gwo-Jyh Chang, Hsiang-Ning Chang, Li-Ping Lin, Miao-Sui Lin and Jong-Hwei S. Pang in The American Journal of Sports Medicine</p
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