2,327 research outputs found
RIC-HSCT for MF/SS
No full textAdvanced-stage mycosis fungoides and Sezary syndrome (MF/SS) have a poor prognosis. Allogeneic hematopoietic stem cell transplantation (HSCT), particularly using a reduced-intensity conditioning (RIC) regimen, is a promising treatment for advanced-stage MF/SS. We performed RIC-HSCT in nine patients with advanced MF/SS. With a median follow-up period of 954days after HSCT, the estimated 3-year overall survival was 85.7% (95% confidence interval, 33.4-97.9%) with no non-relapse mortality. Five patients relapsed after RIC-HSCT; however, in four patients whose relapse was detected only from the skin, persistent complete response was achieved in one patient, and the disease was manageable in other three patients by the tapering of immunosuppressants and donor lymphocyte infusion, suggesting that graft-versus-lymphoma effect and "down-staging" effect from advanced stage to early stage by HSCT improve the prognosis of advanced-stage MF/SS. These results suggest that RIC-HSCT is an effective treatment for advanced MF/SS
MF-OAMP-Based Joint Channel Estimation and Data Detection for OTFS Systems
No full textTo overcome the low spectral efficiency issue caused by large guard space adopted in conventional channel estimation schemes for orthogonal time frequency space (OTFS) systems, superimposed pilot-data placement schemes without the use of guard space have been considered in the literature. However, it is still an open problem for efficient joint channel estimation and OTFS symbol detection based on superimposed pilot-data placement schemes. In this work, an orthogonal approximate message passing (OAMP) based joint channel estimation and detection algorithm with the aid of mean-field (MF) message passing is proposed. In particular, soft information corresponding to the effective channel matrix and data symbols are fed OAMP-based symbol detector and channel estimator via MF, respectively. Thanks to the MF message passing rules, enhanced error performance is brought by iterative information exchange between the OTFS detector and the channel estimator. Numerical results demonstrate that the proposed iterative algorithm can efficiently detect the data symbols without the use of guard space.</p
Preparation of mono-sized epoxy/MF microcapsulesin the appearance of polyvinyl alcohol as co-emulsifier
No full textFor epoxy microcapsules embedded in concrete as mechanic-triggered self-healing adhesive, globular shape with uniform size is the basic requirement to ensure the solid shell broken and the liquid core released at a designed stress. In this paper, monodispersed melamine\u96formaldehyde (MF) resin-walled epoxy E-51 microcapsules were successfully fabricated in an in situ polycondensation process, in which a certain amount of polyvinyl alcohol (PVA) solution was added as coemulsifier to control the microcapsules\u92 shape and size. Detail investigation shows, with the cooperation of PVA, the microcapsule morphologies and size distribution were ease to be adjusted by the parameters such as emulsifying agents, agitation rate, pH value and acidification time
Exploit Security for Low-Altitude Economy: A SWIPT-Driven Strategy With UAV-Mounted MF-RIS
No full textThe low-altitude economy (LAE) is emerging as a critical enabler for next-generation (6 G) networks. In this correspondence, we propose a secure and energy-efficient simultaneous wireless information and power transfer (SWIPT) system enabled by a UAV-mounted multifunctional reconfigurable intelligent surface (MF-RIS) tailored for LAE applications. By integrating MF-RIS on UAVs, the system leverages UAV mobility and the dual-mode operation of MF-RIS, performing signal amplification for enhanced legitimate communication and energy harvesting (coupled with signal reflection) to enhance secrecy energy efficiency (SEE). To address the associated non-convex, coupled optimization challenges, we develop a fully cooperative multi-agent soft actor-critic (mSAC) algorithm that jointly optimizes the UAV trajectory, BS transmit beamforming, and MF-RIS reflection coefficient matrix. Simulation results confirm that the proposed mSAC algorithm significantly enhances the SEE, paving the way for secure, green, and sustainable low-altitude networks
ACT Family Violence Intervention Program review
No full textThis paper reports on a review of the Australian Capital Territory’s Family Violence Intervention Program, which provides an interagency response to family violence matters.
The scope of the review was to analyse the program’s activities and outcomes using 2007–08 data provided by participating agencies, supported by in-depth interviews with key stakeholders including victims whose matters had been finalised in court. After the completion of this report, additional data from 2008–09 and 2009–10 was made available by some Family Violence Intervention Program (FVIP) participating agencies. Although not within the scope of this evaluation, these data pointed to some preliminary improvements in the FVIP
NF membrane fouling by aluminum and iron coagulant residuals after coagulation-MF pretreatment
No full textThe effects of coagulant residuals on fouling of a nanofiltration (NF) membrane were investigated. Experiments were carried out with a laboratory-scale microfiltration (MF)-NF setup and a pilot MF-NF plant. In the laboratory-scale experiments, NF feed water was pretreated with poly-aluminum chloride (PACl) or alum followed by MF. NF membrane permeability declined when the feed water contained residual aluminum at 18 μg/L or more, but not when it was lower than 9 μg/L. When pretreated with ferric chloride, no substantial decline of NF membrane permeability was observed: residual iron did not affect the permeability. When SiO2 was added to the water before the pretreatment with PACl, the NF membrane permeability declined at about double the speed. Thermodynamic calculations and elemental analysis of foulants recovered from the membranes indicated that the majority of inorganic foulants were compounds composed of aluminum, silicate, and possibly potassium. In the pilot plant, NF feed was pretreated by PACl. Transmembrane pressure for NF doubled over 4.5 months of operation. Although the aluminum concentration in the NF feed was not high (30 μg/L), analysis of membrane foulants revealed excessive accumulation of aluminum and silicate, also suggesting that aluminum residuals caused the membrane fouling by alumino-silicates or aluminum hydroxide
Revisiting the natural history of chronic hepatitis B: Impact of new concepts on clinical management
No full textAppropriate treatment for chronic hepatitis B (CHB) to prevent disease progression and clinical complications requires an accurate knowledge of the natural history of this disorder. In patients who acquire the disease in early life, as is the situation in Asian CHB patients, complications of CHB continue to develop because of the prolonged insidious damage to the liver, even in the low viremic phase. Hepatitis B e antigen seroconversion with hepatitis B virus (HBV) DNA levels just below 105 copies/mL may not be an adequate treatment endpoint for Asian CHB patients. Furthermore, it has been shown that patients with mild elevation of alanine aminotransferase (ALT) levels are already at considerable risk of development of complications. More recent studies have shown that in order to move towards a better disease outcome, CHB patients should have HBV DNA levels at least less than 103 copies/mL, with ALT levels preferably in the range of less than 0.5 times the upper limit of the normal range. Therefore, prolonged, adequate suppression of viral replication should be the practical goal for the treatment of CHB disease in the Asian population. © 2007 The Author.link_to_subscribed_fulltex
Presence of biopsy-proven histologic damage (necroinflammation and fibrosis) is common even when ALT is less than 2x ULN in patients with chronic hepatitis B (CHB)
No full textCorrection Factor on Dynamic Force in a Marsh Funnel Test for Tunneling
No full textThis paper presents an improvement on a previous model for predicting the Marsh funnel (MF) test that is used in slurry shield tunneling for evaluating the rheological properties of bentonite slurries. The improvement focuses on the prediction of the dynamic part for fluids with small MF times. The velocity profile of the Herschel-Bulkley fluid in a laminar pipe flow condition is first investigated and a correction factor is introduced in the improved model. Comparisons of results from experiments and calculations with the previous model confirm the improved performance over the existing model. The rheological parameters obtained from the improved model show good resemblance to those obtained from a laboratory viscometer. The work also provides a reference to similar applications such as fluid transportation through pipelines where dynamic pressure dominates and therefore should be correctly predicted considering its velocity profile in a laminar condition.Green Open Access added to TU Delft Institutional Repository 'You share, we take care!' - Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Offshore and Dredging Engineerin
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