1,721,262 research outputs found
Upland rice from technological validation areas and community banks of seeds in Nicaragua
No full textThis dataset contains 438 crop cycles for upland rice in 22 departments of Nicaragua that were collected with INTA (Instituto Nacional de Tecnología Agropecuaria) in the period 2016 – 2020. In the dataset, 100 and 338 records came from technological validation areas and community banks of seeds, respectively. Each location was georeferenced. Variables such as cultivar, planting practices, harvest date, and region were also recorded. Finally, Worclim and soil data layers from INETER (Instituto Nicaragüense de Estudios Territoriales) were used to integrated weather and soil information for each crop cycl
Politics Remains but Economics Leads and Peace Follows: Making a Case for India-Pakistan Peace Process in line with China Model
Full text linkThe paper traces the causal links of Indo-Pakistan conflict with trade, military expenditure and democracy under multivariate time series framework from 1950-2005. We find that higher exports to outside world and increased bilateral trade have high propensity to reduce hostilities between both nations. Furthermore, historically high military expenditures in Pakistan have been a direct outcome of continued hostilities in its Eastern borders whereas Indian military expenditure is weakly related with the conflict. Political orientation of both countries does not seem to significantly affect the conflict either. Overall, the findings support the case for liberal (economic) peace than political (democratic) peace.Inter-state conflict and trade; democracy and conflict; conflict and economic development
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Evolution of the microstructure and tribological performance of Ti-6Al-4V cladding with TiN powder
No full textVariations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
Effect of Leptin on Growth of Breast Cancer Cells
No full text乳癌是女性最普遍的惡性腫瘤之一，為台灣婦女癌症的第二大年發生率，且近十年來，罹患率和死亡率有逐年增加的趨勢。臨床資料發現肥胖與乳癌的發生有極密切的關係，肥胖為乳癌發生之危險因子。脂肪細胞為乳房主要的基質細胞之一，乳腺被豐富之脂肪細胞所包圍，一般認為脂肪細胞會分泌脂肪細胞素調節乳腺細胞生理弁遄A但是何種細胞素目前尚不清楚。瘦體素 (leptin) 為ob(obese) 基因所表現，主要係由脂肪細胞生成，其濃度與體內脂肪含量成正比，負責調控攝食行為及能量代謝，有研究指出，瘦體素和瘦體素受體皆可在正常乳腺細胞及乳癌腫瘤中表現。所以瘦體素可能可以藉由paracrine 和autocrine的機轉來刺激腫瘤細胞增生及分化。利用細胞計數，MTT分析和Brdu incorporation分析，觀察細胞生長情形。發現經瘦體素處理後，乳癌細胞株 (T-47 D 和ZR-75-1) 有明顯細胞增生。以反轉錄聚合鍊反應（RT-PCR）及西方墨點法（Western Blotting Assay）分析特異蛋白質及轉錄因子表現的增減及活化情形。關於細胞週期的調控因子方面，本研究的重要貢獻在於首次發現瘦體素調控了細胞週期中重要進程因子(cyclin D1, p21, p53)，增加致癌蛋白(c-Myc)的表現，也增加了抗細胞凋亡因子 (Bcl-2和Bcl-xL)的表現。特別的是瘦體素也可能以藉由endocrine，paracrine 和autocrine的作用機轉，同時促進細胞週期和抑制細胞凋亡，因而刺激乳癌細胞株的增殖。本實驗的結果，將可以提供肥胖何以會促使乳癌之發生及惡化的作用機制以及解釋臨床乳癌治療上何以肥胖患者預後差，又部分患者對於雌性素療法反應不佳，或是經HER-2/neu的人類單株抗體（trastuzumab）藥物治療仍會失敗的原因。若是瘦體素對於乳癌細胞的作用機轉和訊息途徑被更明暸，和其它已知致癌路徑間的交互作用被更清楚研究。可供研發對抗乳癌新療法之標的或是在乳癌預防上重要的著力點。如此，乳癌的治療就能更為完備。Breast cancer is the most prevalent malignant tumor in women and accounting for leading cause of cancer death among women. Obesity has been recognized as a risk factor for many cancers including breast cancer. The adipocyte represents one of the most abundant cell types surrounding breast cancer cells and the cytokines secreted from adipocytes may prove to be players in a paracrine manner. Leptin is an adipocyte derived cytokine. Leptin and leptin receptors expression has also been detected in normal and tumoral human mammary epithelial cells. Besides the classical function in regulating food intake and body weight, leptin may play a putative role in breast cancer cell growth through an autocrine and paracrine mechanism. By cell counting, MTT assay and Brdu incorporation, we demonstrated cell growth with leptin treatment in ZR-75-1 cells and T-47 D cells. Semiquantitative RT-PCR, Western blotting were use to detect the expression of specific proteins and transcription factors responsible to regulate the cell proliferation. We first found that c-myc, the oncogen from the hell, was upregulated following leptin exposure. We also confirmed theat cyclin D, the possible converge target of oncogenic pathway of estrogen and HER-2/neu, was also upregulated. At the same time, leptin could drive cell cycle progression by downregulation of expression of p53 and p21. Important findings are now emerging that give hope for the development of candidate drug molecules that are directed against a specific oncoprotein. We propose that leptin is a direct stimulating agent in breast cancer growth and play important role in “fail safe mechanism” of breast cancer when treated with antiestrogen and monoclonal antibody to HER-2/neu receptor (trastuzumab). Consequently, the leptin pathway should be further studied as a target for interventions to treat and/or prevent breast cancer.目錄
頁次
一、中文摘要 7
二、緒論 8
三、研究材料與方法 25
四、結果 28
五、討論 31
六、展望 34
七、英文簡述 35
八、參考文獻36
九、圖表 4
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