72,785 research outputs found
Rethinking Import-substituting Industrialization: Development Strategies and Institutions in Taiwan and China
Get PDFimport-substituting industrialization, export-oriented industrialization, development strategies, institutions
Effects of inotilone on inflammation and inflammation-associated tumorigenesis
No full textInflammation, a complex process, involving numerous mediators of cellular and plasma origins, is considered to be a critical factor in many human diseases and conditions, including obesity, cardiovascular diseases, diabetes, aging, and cancers. Inotilone, a secondary metabolite recently found in the dietary Inonotus mushroom, has been reported as a potent inflammatory inhibitor in test tube. However, its inhibitory effect at cellular level as well as in animal model remain unclear. The anti-inflammatory effects of inotilone were investigated in vitro using lipopolysaccharide (LPS)-stimulated murine macrophage. Inotilone was shown to inhibit nitric oxide (NO) and prostaglandin E2 (PGE2) production through modulating inducible nitric oxide synthase (iNOS) expression and cyclooxygenase 2 (COX 2) enzyme activity, respectively. It is also found that inotilone can only suppressed the expression of iNOS but not COX 2. This divergence may origin from the differential effect of inotilone on transcription factors, nuclear factor κB (NF κB) and CCAAT enhancer-binding protein (C/EBP). However, this differential effect was not found in the in vivo study employing 12 O tetradecanoylphorbol 13 acetate (TPA)-treated mouse skin. This finding suggested that the effects of inotilone on C/EBPβ expression may be cell type- or stimuli-specific. The inhibitory effects of inotilone were also observed on the activation of phosphatidylinositol 3-kinase/Akt (PI3K/Akt), extracellular signal-regulated protein kinase 1/2 (ERK1/2) and p38 mitogen-activated protein kinase (MAPK) signaling pathways both in vitro and in vivo. Furthermore, the ability of inotilone to prevent inflammation-associated tumorigenesis was also evaluated using a classical two-stage mouse skin carcinogenesis model. After initiation of 7,12 dimethylbenz[a]nthracene (DMBA), applying inotilone topically before each TPA treatment was found to reduce the incidence and multiplicity of papillomas at 20th week. Taken together, the results suggest that inotilone has potential to be developed into an effective chemopreventive agent for the treatment of a variety of inflammatory diseases, especially the prevention and treatment of epithelial skin cancer.Ph.D.Includes bibliographical referencesIncludes vitaby Yu-Ching Ku
Theoretical analysis of transient waves in a simply-supported Timoshenko beam by ray and normal mode methods
No full textTransient wave analysis of a cantilever Timoshenko beam subjected to impact loading by Laplace transform and normal mode methods
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Jo-Ching Peng Flute Recital Program Notes
No full textThis document is the program notes of Jo-Ching Peng\ue2s Flute Recital, which was performed on December 17, 2020. The repertoire of this recital includes five famous flute compositions from the Baroque period, the Romantic period, and the twentieth century. It will be divided into five chapters to discuss about the life of the composers, the background of the compositions, the analysis, and interpretation of these masterpieces.
The first chapter describes the concept of the repertoire in the recital, and puts forward the research limitations and methods in this document. The second chapter is Grande fantaisie sur Mignon pour fl\uc3\ubbte et piano, composed by Paul Taffanel in the Romantic period. The third chapter discusses Frank Martin\ue2s Ballade for flute and piano in the twentieth century. The fourth chapter refers to Nocturne et Allegro Scherzando by Philippe Gaubert, who was Taffanel\ue2s outstanding pupil. Sonata in E major for flute and basso continuo, BWV 1035 by Johann Sebastian Bach in the Baroque period will be the main topic of the fifth chapter. Finally, the sixth chapter is related with Robert Muczynski\ue2s Sonata for Flute and Piano, Op. 14 in the twentieth century
Supplemental_Table_20180618_Final – Supplemental material for Choices for long-term hypertensive control in patients after first-ever hemorrhagic stroke: a nationwide cohort study
No full textSupplemental material, Supplemental_Table_20180618_Final for Choices for long-term hypertensive control in patients after first-ever hemorrhagic stroke: a nationwide cohort study by Chi-Hung Liu, Yu-Sheng Lin, Ching-Chi Chi, Chia-Wei Liou, Jiann-Der Lee, Tsung-I Peng and Tsong-Hai Lee in Therapeutic Advances in Neurological Disorders</p
Copy of letter form Kuan Yu-Shan to Lu, Hui Ching (August 15, 1948)
No full textThis is a two-page typewritten copy of a letter written by Kuan Yu-Shan to Lu Hui Ching. The letter is dated August 15, 1948. In the letter Kuan discusses Lu's proposal to set up a Physical Education and Health Education research and training Institute in China.For more information about Lu Hui-chʻing, see:https://springfield.as.atlas-sys.com/agents/people/97
Appropriations of Irish drama by modern Korean nationalist theatre : a focus on the influence of Sean O’Casey in a colonial context
Get PDFMy thesis explores how a translated author on the periphery of the host culture’s
translated repertoire can be at once subversive and innovative on the colonial scene,
using as an example the case of Sean O’Casey in colonial Korea. It explores the
importation of Irish drama in modern Korean theatre during the colonial period and
examines the appropriations of O’Casey’s plays by a central Korean playwright, Yu
Chi-jin, in creating his own plays. Under Japanese colonial rule in the early twentieth
century, intellectuals perceived the supreme task for the Korean people to be the
recovery of national sovereignty and independence. The modern Korean theatre
movement which rose among Korean intellectuals and dramatists during the colonial
period was to play a major part in this task. The ultimate goal of this movement was
to establish a modern national theatre promoting Korean culture and educating the
people, thereby recovering national independence. As their modernised dramatic
polysystem was still "young", Korean intellectuals and dramatists who were
involved in the theatre movement had to borrow dramatic models from other
countries. One of the models they chose was Irish playwrights, especially those who
were involved in the Irish dramatic movement. They published or staged the works
of W.B. Yeats, Lord Dunsany [Edward John Moreton Drax Plunkett], Augusta
Gregory, J.M. Synge, St. J. Ervine, T.C. Murray and Sean O'Casey. Although
O'Casey was considered an important dramatist in the Irish dramatic movement, he
was a playwright on the periphery in the list of translated Irish dramatists in Korea
due to the colonisers’ censorship. However, he remained as a subversive and
innovative playwright on the colonial scene by virtue of being appropriated by Yu
Chi-jin who used O’Casey’s plays as models when creating his own works. In
discussing the subject matter of my thesis, I use Even Zohar’s polysystems theory as
a starting point in looking at ideological issues surrounding translation and extend
the discussion to offer a postcolonial perspective. While most translation in a
colonial context was considered as "an expression of the cultural power of the
colonisers," my thesis shifts the focus to translation as an expression of the cultural
power of the colonised. I explore how the colonised uses another colonised culture to
subvert the colonisers’ power
Fig. 5 in Triterpene glycosides and phenylpropane derivatives from Staurogyne concinnula possessing anti-angiogenic activity
No full textFig. 5. Inhibition of FAK/paxillin/MMP signaling pathway treated with 4.Published as part of Vo, Thanh-Hoa, Lin, Yu-Chi, Liaw, Chia-Ching, Pan, Wen-Pin, Cheng, Jing-Jy, Lee, Ching-Kuo & Kuo, Yao-Haur, 2021, Triterpene glycosides and phenylpropane derivatives from Staurogyne concinnula possessing anti-angiogenic activity, pp. 1-9 in Phytochemistry (112666) 184 on page 8, DOI: 10.1016/j.phytochem.2021.112666, http://zenodo.org/record/829216
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