2,093 research outputs found
Chun qiu bie dian: [15 juan]. v.1
No full text薛虞畿撰.綫裝, 1函.出版年據伍元薇跋.框18.1 x 14.1公分, 11行22字, 小字雙行同, 黑口, 雙魚尾, 四周單邊. 版心中鐫卷次.Xue Yuji zhuan.Xian zhuang, 1 han.Chu ban nian ju Wu Yuanwei ba.Kuang 18.1 x 14.1 gong fen, 11 xing 22 zi, xiao zi shuang xing tong, hei kou, shuang yu wei, si zhou dan bian. Ban xin zhong juan juan ci
sj-tif-1-jor-10.1177_20551169221074964 – Supplemental material for Skeletal radiographic manifestations of GM2 gangliosidosis variant 0 (Sandhoff disease) in two Japanese domestic cats
No full textSupplemental material, sj-tif-1-jor-10.1177_20551169221074964 for Skeletal radiographic manifestations of GM2 gangliosidosis variant 0 (Sandhoff disease) in two Japanese domestic cats by Yoshihiko Yu, Daisuke Hasegawa, Yuji Hamamoto, Shunta Mizoguchi, Toshiki Fujimori, Yoshiaki Kubo, Md Shafiqul Islam and Osamu Yamato in Journal of Feline Medicine and Surgery Open Reports</p
sj-tif-2-jor-10.1177_20551169221074964 – Supplemental material for Skeletal radiographic manifestations of GM2 gangliosidosis variant 0 (Sandhoff disease) in two Japanese domestic cats
No full textSupplemental material, sj-tif-2-jor-10.1177_20551169221074964 for Skeletal radiographic manifestations of GM2 gangliosidosis variant 0 (Sandhoff disease) in two Japanese domestic cats by Yoshihiko Yu, Daisuke Hasegawa, Yuji Hamamoto, Shunta Mizoguchi, Toshiki Fujimori, Yoshiaki Kubo, Md Shafiqul Islam and Osamu Yamato in Journal of Feline Medicine and Surgery Open Reports</p
sj-docx-1-jor-10.1177_20551169221074964 – Supplemental material for Skeletal radiographic manifestations of GM2 gangliosidosis variant 0 (Sandhoff disease) in two Japanese domestic cats
No full textSupplemental material, sj-docx-1-jor-10.1177_20551169221074964 for Skeletal radiographic manifestations of GM2 gangliosidosis variant 0 (Sandhoff disease) in two Japanese domestic cats by Yoshihiko Yu, Daisuke Hasegawa, Yuji Hamamoto, Shunta Mizoguchi, Toshiki Fujimori, Yoshiaki Kubo, Md Shafiqul Islam and Osamu Yamato in Journal of Feline Medicine and Surgery Open Reports</p
Strong Coupling Superconductivity in the Vicinity of the Structural Quantum Critical Point in (CaxSr1-x)3Rh4Sn13
No full textThe family of the superconducting quasiskutterudites (CaxSr1?x)3Rh4Sn13 features a structural quantum critical point at xc=0.9, around which a dome-shaped variation of the superconducting transition temperature Tc is found. Using specific heat, we probe the normal and the superconducting states of the entire series straddling the quantum critical point. Our analysis indicates a significant lowering of the effective Debye temperature on approaching xc, which we interpret as a result of phonon softening accompanying the structural instability. Furthermore, a remarkably large enhancement of 2?/kBTc and ?C/?Tc beyond the Bardeen-Cooper-Schrieffer values is found in the vicinity of the structural quantum critical point. The phase diagram of (CaxSr1?x)3Rh4Sn13 thus provides a model system to study the interplay between structural quantum criticality and strong electron-phonon coupling superconductivity
Diaphragmatic excursion is correlated with the improvement in exercise tolerance after pulmonary rehabilitation in patients with chronic obstructive pulmonary disease
No full text近畿大学Kindai University博士（医学）主査：光冨徹哉 教授 学内授与番号：医第1377号
Masashi Shiraishi, Yuji Higashimoto, Ryuji Sugiya, Hiroki Mizusawa, Yu Takeda, Shuhei Fujita, Osamu Nishiyama, Shintarou Kudo, Tamotsu Kimura, Yasutaka Chiba, Kanji Fukuda, Yuji Tohda & Hisako Matsumoto "Diaphragmatic excursion is correlated with the improvement in exercise tolerance after pulmonary rehabilitation in patients with chronic obstructive pulmonary disease" Respiratory Research volume 22, Article number: 271 (2021)
https://doi.org/10.1186/s12931-021-01870-1 掲載application/pdfdoctoral thesi
Author response image 1.
No full textNeurotransmitter is released at synapses by fusion of synaptic vesicles with the plasma membrane. To sustain synaptic transmission, compensatory retrieval of membranes and vesicular proteins is essential. We combined capacitance measurements and pH-imaging via pH-sensitive vesicular protein marker (anti-synaptotagmin2-cypHer5E), and compared the retrieval kinetics of membranes and vesicular proteins at the calyx of Held synapse. Membrane and Syt2 were retrieved with a similar time course when slow endocytosis was elicited. When fast endocytosis was elicited, Syt2 was still retrieved together with the membrane, but endocytosed organelle re-acidification was slowed down, which provides strong evidence for two distinct endocytotic pathways. Strikingly, CaM inhibitors or the inhibition of the Ca2+-calmodulin-Munc13-1 signaling pathway only impaired the uptake of Syt2 while leaving membrane retrieval intact, indicating different recycling mechanisms for membranes and vesicle proteins. Our data identify a novel mechanism of stimulus-and Ca2+-dependent regulation of coordinated endocytosis of synaptic membranes and vesicle proteins
Reestablishment of Energy Balance in a Male Mouse Model With POMC Neuron Deletion of BMPR1A
No full textThe regulation of energy balance involves complex processes in the brain, including coordination by hypothalamic neurons that contain pro-opiomelanocortin (POMC). We previously demonstrated that central bone morphogenetic protein (BMP) 7 reduced appetite. Now we show that a type 1 BMP receptor, BMPR1A, is colocalized with POMC neurons and that POMC-BMPR1A-knockout (KO) mice are hyperphagic, revealing physiological involvement of BMP signaling in anorectic POMC neurons in the regulation of appetite. Surprisingly, the hyperphagic POMC-BMPR1A-KO mice exhibited a lack of obesity, even on a 45% high-fat diet. This is because the brown adipose tissue (BAT) of KO animals exhibited increased sympathetic activation and greater thermogenic capacity owing to a reestablishment of energy balance, most likely stemming from a compensatory increase of BMPR1A in the whole hypothalamus of KO mice. Indeed, control animals given central BMP7 displayed increased energy expenditure and a specific increase in sympathetic nerve activity (SNA) in BAT. In these animals, pharmacological blockade of BMPR1A-SMAD signaling blunted the ability of BMP7 to increase energy expenditure or BAT SNA. Together, we demonstrated an important role for hypothalamic BMP signaling in the regulation of energy balance, including BMPR1A-mediated appetite regulation in POMC neurons as well as hypothalamic BMP-SMAD regulation of the sympathetic drive to BAT for thermogenesis
N=2 supersymmetric dynamics for pedestrians
No full textUnderstanding the dynamics of gauge theories is crucial, given the fact that all known interactions are based on the principle of local gauge symmetry. Beyond the perturbative regime, however, this is a notoriously difficult problem. Requiring invariance under supersymmetry turns out to be a suitable tool for analyzing supersymmetric gauge theories over a larger region of the space of parameters. Supersymmetric quantum field theories in four dimensions with extended N=2 supersymmetry are further constrained and have therefore been a fertile field of research in theoretical physics for quite some time. Moreover, there are far-reaching mathematical ramifications that have led to a successful dialogue with differential and algebraic geometry. These lecture notes aim to introduce students of modern theoretical physics to the fascinating developments in the understanding of N=2 supersymmetric gauge theories in a coherent fashion. Starting with a gentle introduction to electric-magnetic duality, the author guides readers through the key milestones in the field, which include the work of Seiberg and Witten, Nekrasov, Gaiotto and many others. As an advanced graduate level text, it assumes that readers have a working knowledge of supersymmetry including the formalism of superfields, as well as of quantum field theory techniques such as regularization, renormalization and anomalies. After his graduation from the University of Tokyo, Yuji Tachikawa worked at the Institute for Advanced Study, Princeton and the Kavli Institute for Physics and Mathematics of the Universe. Presently at the Department of Physics, University of Tokyo, Tachikawa is the author of several important papers in supersymmetric quantum field theories and string theory
Seven connection patterns between the author research areas.
No full textSeven connection patterns between the author research areas.</p
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