1,748 research outputs found
Methods for treating a tumor using an antibody that specifically binds HMW-MAA
No full textCombinations of agents that have a synergistic effect for the treatment of a tumor are disclosed herein. These combinations of agents can be used to treat tumors, wherein the cells of the cancer express a mutated BRAF. Methods are disclosed for treating a subject diagnosed with a tumor that expresses a mutated BRAF. The methods include administering to the subject (1) a therapeutically effective amount of an antibody or antigen binding fragment thereof that specifically binds high molecular weight melanoma associated antigen (HMW-MAA), also known as CSPG4; and (2) a therapeutically effective amount of a BRAF inhibitor. In some embodiments, the tumor is melanoma. In some embodiments the method includes selecting a subject with primary or secondary resistance to a BRAF inhibitor. In further embodiments, treating the tumor comprises decreasing the metastasis of the tumor. In additional embodiments, the BRAF inhibitor comprises PLX4032 or PLX4720
Supplemental Material - A Novel Nomogram for Identifying Candidates for Adjuvant Chemotherapy in Patients With Stage IB Non-small Cell Lung Cancer
No full textSupplemental Material for A Novel Nomogram for Identifying Candidates for Adjuvant Chemotherapy in Patients With Stage IB Non-small Cell Lung Cancer by Xue Song, Yangyang Xie, Haoran Deng, Fei Yu, Shiqiang Wang, and Yafang Lou in Cancer Control</p
Interleukin-1 mediated cell-type specific signaling in hippocampal neurons and astrocytes
No full textInterleukin-1β (IL-1β) is a pro-inflammatory cytokine that is implicated in immune and inflammatory responses. In the central nervous system (CNS), IL-1β is synthesized and released during injury, infection, and many neurodegenerative diseases, but also under physiological conditions. Several IL-1-mediated signaling pathways and effects have been identified in hippocampal neurons and astrocytes, but their mechanisms have not been fully defined. IL-1 signaling requires the type one IL-1 receptor (IL-1RI) as well as IL-1 receptor accessory protein (IL-1RAcP) as a receptor partner. A novel isoform of the IL-1 receptor accessory protein, AcPb, has also been found in the CNS, but its role remains unclear. This thesis examined AcPb function in regulating IL-1β signaling. The results showed that IL-1β activated p38 MAPK but not NFκB in neurons. In astrocytes, IL-1β induced both p38 and NFκB pathways in regulating inflammatory responses. AcPb was not involved in mediating either p38 or NFκB in either cell type. In contrast, a physiological level of IL-1β treatment (0.01ng/ml) activated p-Src in neurons via AcPb in vitro. In addition, overexpression of AcPb in astrocytes was sufficient to induce p-Src mediated by IL-1β. Taken together, these results suggest that the restricted expression of AcPb in CNS neurons may mediate neuronal specific IL-1 pathways and outcomes, and that physiological and pathophysiological levels of IL-1β mediate particular neuronal functions via separate pathways.Ph. D.Includes abstractIncludes bibliographical referencesby Yangyang Huan
sj-docx-1-aim-10.1177_09645284221085278 – Supplemental material for Manual acupuncture at ST36 attenuates rheumatoid arthritis by inhibiting M1 macrophage polarization and enhancing Treg cell populations in adjuvant-induced arthritic rats
No full textSupplemental material, sj-docx-1-aim-10.1177_09645284221085278 for Manual acupuncture at ST36 attenuates rheumatoid arthritis by inhibiting M1 macrophage polarization and enhancing Treg cell populations in adjuvant-induced arthritic rats by Nannan Yu, Fuming Yang, Xue Zhao, Yongming Guo, Yuan Xu, Guangchang Pang, Yinan Gong, Shenjun Wang, Yangyang Liu, Yuxin Fang, Kun Yu, Lin Yao, Hui Wang, Kuo Zhang, Baohu Liu, Zhenguo Wang, Yi Guo and Zhifang Xu in Acupuncture in Medicine</p
sj-docx-1-taj-10.1177_20406223221109651 – Supplemental material for Sarcopenia and frailty combined increases the risk of mortality in patients with decompensated cirrhosis
No full textSupplemental material, sj-docx-1-taj-10.1177_20406223221109651 for Sarcopenia and frailty combined increases the risk of mortality in patients with decompensated cirrhosis by Gaoyue Guo, Chaoqun Li, Yangyang Hui, Lihong Mao, Mingyu Sun, Yifan Li, Wanting Yang, Xiaoyu Wang, Zihan Yu, Xiaofei Fan, Kui Jiang and Chao Sun in Therapeutic Advances in Chronic Disease</p
Abstract 4390: Heat shock protein (HSP) Grp94-targeted combinatorial immunotherapy for pancreatic cancer
No full textMolecular simulations of rheological, mechanical and transport properties of solid-fluid systems:
No full textIn this dissertation, two distinct but relevant systems are chosen as representatives of interesting solid-fluid systems. Molecular dynamics (MD) and Monte Carlo techniques are applied to investigate the rheological, mechanical and transport properties of these systems.
Firstly, polyethylene melt embedded with silica nanoparticles is examined to be of our interest. Since it is computationally impractical to model a complex system with a molecular description, a multiscale modeling approach, which combines both atomistic and mesoscale simulations, is employed to efficiently represent and study the polymer nanoparticle systems. Based on a coarse-grained force field for polyethylene, a novel method is developed for determining the solid-fluid interaction at the spherical interface. Our coarse grained model is designed to mimic 4 nm silica nanoparticles in polyethylene melt at 423K. A series of MD simulations are performed to investigate the factors that control the homogeneity of nanofillers inside polymer matrix, also in the presence of nonionic surfactants (short chain alcohols). The effects of nanoparticle filling fraction, polymer chain length, and relative sizes between nanoparticles and polymer chains on the particle dispersion are explored. In addition, a fundamental relationship is pursued between the microstructure and macroscopic properties (transport and rheological) of polymer nanoparticle composites.
In this work another method for determining the solid-fluid interaction parameter is presented: the experimental adsorption isotherms are used to validate the potential parameters. The rapid expansion of silica nanoparticle agglomerates in supercritical carbon dioxide (RESS process) is chosen to be the system of interest. The simulations show that the effective attraction between two identical nanoparticles is most prominent for densely hydroxylated particle surfaces that interact strongly with CO2 via hydrogen bonds, while it is significantly weaker for dehydroxylated particles. We also explore the shearing forces necessary to break an agglomerate in supercritical fluid. The agglomerate experiences deformation followed by elongation, and finally break-up. The calculated diffusion coefficient of CO2 is expected to be smaller than the experimental value, because the nanoparticle agglomerate hinders fluid movement. In the direction of shearing forces, the diffusion of CO2 shows a steep increase after the breakup, confirming the rupture of the agglomerate.Ph.D.Includes bibliographical references (p. 136-142)by Yangyang She
The CSPG4-specific monoclonal antibody enhances and prolongs the effects of the BRAF inhibitor in melanoma cells
No full textSelf-Assembled Morphologies and Percolation Probability of Mixed Carbon Fillers in the Diblock Copolymer Template: Hybrid Particle-Field Molecular Dynamics Simulation
No full textThe self-assembly of polymer composites of mixed carbon fillers including single-walled carbon nanotube (SWCNT) and carbon black nanoparticles (CB NPs) in diblock copolymer (BCP) template are investigated using hybrid particle-field molecular dynamics simulations in this work. Simulations show, in agreement with experiments, that composites of BCP template with SWCNT have lower percolation threshold than that of BCP template with CB NPs. Moreover, the ratio between SWCNT and CB NPs has a strong influence on the percolation threshold of composites. The results of percolation probability show that adding more SWCNT (compared with CB NPs) to the BCP template could decrease the percolation threshold. However, a synergistic effect of percolation of the mixed carbon fillers in BCP template has been found. In particular, a nonlinear relation following the Boltzman function has been found, and the lowest percolation threshold exists with the volume ratio 4:1 (SWCNT/CB NPs) compared with the volume ratios of 1:1, 2:1, and 8:1 (SWCNT/CB NPs). The mixed carbon fillers also affect the morphologies of the BCP template, and the calculated radius of gyration of BCP shows that, in a higher concentration of the mixed fillers, the stretching of BCP is stronger, which results in the deformation of BCP template
Tumor Antigen-Specific Monoclonal Antibody-Based Immunotherapy, Cancer Initiating Cells and Disease Recurrence
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