5,192 research outputs found
Letter from Cy Donner to Michi Weglyn, June 2, 1967
No full textA letter from Cy Donner to Michi Weglyn encouraging her to come out to California to talk to producers about two shows called "Youthquake" and "Pretty Talk".These materials are from box 73 and 74 of the Frank Chin Papers. The Frank Chin Papers contain personal and professional correspondence between Frank Chin and Michi Weglyn relating to particular projects on which either author was working as well as files related to the Day of Remembrance Tribute to Michi Weglyn
CY-09 Alleviates the Depression-like Behaviors via Inhibiting NLRP3 Inflammasome-Mediated Neuroinflammation in Lipopolysaccharide-Induced Mice
No full textDepression
is a serious mental illness, mainly characterized
as
large mood swings and sleep, diet, and cognitive function disorders.
NLPR3, one of the inflammasomes that can be activated by a variety
of stimuli to promote the maturation and secretion of pro-inflammatory
cytokines, has been considered to be involved in the pathophysiology
of depression. In this study, the putative role of CY-09, a selective
and direct inhibitor of NLRP3, was evaluated in the lipopolysaccharide
(LPS)-induced mice. The results of the study indicated that CY-09
significantly decreased the levels of NLRP3 in the hippocampus of
LPS-induced mice. In addition, CY-09 increased the sucrose preference
and shortened the immobility time in LPS-induced mice, suggesting
the antidepressant-like effects of inhibiting NLRP3 inflammasome.
Biochemical analysis showed that LPS significantly activated the NLRP3/ASC/cytokine
signaling pathway and caused microglial activation, while CY-09 prevented
the changes. Moreover, CY-09 increased the brain-derived neurotrophic
factor (BDNF) only in microglia but not in the whole hippocampus.
Meanwhile, CY-09 did not promote neurogenesis in the hippocampus of
LPS mice. In conclusion, the results of the study showed that the
antidepressant-like effects of NLRP3 inhibitor CY-09 were mediated
by alleviating neuroinflammation in microglia and independent of the
neurotrophic function in the hippocampus
Magnetic resonance imaging detects intestinal barrier dysfunction in a rat model of acute mesenteric ischemia/reperfusion injury.
No full textOutcome of medium-dose VP-16/CY/TBI superior to CY/TBI as a conditioning regimen for allogeneic stem cell transplantation in adult patients with acute lymphoblastic leukemia
Full text linkThe choice of conditioning regimen before allogeneic stem cell transplantation (SCT) in patients with acute lymphoblastic leukemia (ALL) is important. We retrospectively compared outcomes of medium-dose VP-16/cyclophosphamide/total body irradiation (VP/CY/TBI) regimen and CY/TBI. Five hundred and twenty-nine patients (VP/CY/TBI: n = 35, CY/TBI: n = 494) who met all of the following criteria were compared: first time for SCT, aged 15-59 years; first or second complete remission at SCT; bone marrow or peripheral blood as stem cell source; and HLA phenotypically matched donor. Median age of the patients was 34 years, and patients who received VP/CY/TBI were younger (28 years vs. 34 years, P = 0.02). Cumulative incidences of relapse and non-relapse mortality (NRM) were higher for patients who received CY/TBI (P = 0.01 for relapse, P < 0.01 for NRM). After a median follow-up period of 36.9 months, 5-year overall survival (OS) rates were 82.2% in the VP/CY/TBI group and 55.2% in the CY/TBI group. OS, and disease-free survival (DFS) in the VP/CY/TBI group were shown to be significantly better by multivariate analysis [hazard ratio: 0.21 (95% confidence interval: 0.06-0.49) for DFS, hazard ratio: 0.25 (95% confidence interval: 0.08-0.59) for OS]. VP/CY/TBI was associated with a lower relapse rate and no increase in NRM, resulting in better survival than that in CY/TBI for adult ALL patients
A Recessive Lethal Gene, l-Cy, concealed in the Second Chromosome Balancer of Drosophila Melanogaster
Full text linkThe second chromosome balancer, SM 5[In(2(LR)SM 5)]Cy, has been used as a most useful tool to study the genetic variations in natural populations of Drosophila. melanogaster. The balancer suppresses recombination in almost whole region of the second chromosome since it has complicated inversions both in the right and left arms. It is lethal in the homozygous condition and it also has a dominant mutant, Cy, and several recessive mutations.Homozygous lethality has been explained by the presence of In(2 LR) or Cy itself. However, the cause of lethality is not necessarily clear. Recently, the author has found a recessive lethal gene in a natural population, which is allelic to these balancer chromosomes. In this short communication the author reports that the lethality of SM 5 chromosome in the homozygous condition is due to a recessive lethal gene, l-Cy (lethal Cy)
A Poetics of becoming: the mythography of Cy Twombly
No full textA Poetics of Becoming: The Mythography of Cy Twombly, centres upon Proteus, a painting made by the artist Cy Twombly in 1984. The chapter uses this particular work as a means of unpacking the artist's complex and manifold relationship with mythology. With regards to both the facture and the matiere of Proteus, the author argues that the visual poetics of the artist's work results from what is claimed to be the painting's "becoming
Calabi–Yau property under monoidal Morita–Takeuchi equivalence
No full textLet H and L be two Hopf algebras such that their comodule categories are monoidally equivalent. We prove that if H is a twisted Calabi–Yau (CY) Hopf algebra, then L is a twisted CY algebra when it is homologically smooth. In particular, if H is a Noetherian twisted CY Hopf algebra and L has finite global dimension, then L is a twisted CY algebra.The authors sincerely thank the referee for his/her valuable comments and suggestions that helped them to improve the paper quite a lot. Wang and Yu are grateful to the Department of Mathematics of Zhejiang Normal University for the hospitality they received during a visit in summer 2016. Wang is supported by AMS-Simons travel grant. Yu is supported by grants from NSFC (No. 11301126, No. 11571316, No. 11671351)
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