143,934 research outputs found
Parametric design of developable structure based on yoshimura origami pattern
No full textOrigami is an ancient art form and can be divided into rigid and non-rigid origami. Rigid origami is suitable for the design of building structures because the panels are not twisted and deformed during the folding process. Currently, rigid origami structures are generally built with steel. However, compared with natural, non-polluting wood, steel has a high energy consumption and a high environmental impact. Based on this situation, this paper designs a developable wooden building structure using the Yoshimura origami model. First, the Jacobian matrix method was used to analyze the degree of freedom of the basic unit of the Yoshimura origami pattern, following which the motion trajectory required by the target structure was obtained. Secondly, by analyzing the relationship between the plane angle α and dihedral angle θ, three interaction rules were obtained, and the formula for determining the structure size was established by using the plane angle α, dihedral angle θ, the number of valley folds n and the unit length l. Subsequently, two enhancement schemes, the quadrangle enhancement scheme and the triangle enhancement scheme, were proposed to increase the height of the structure. After comparing the deformation and failure types of origami structures based on Cross-Laminated Timber, a triangular reinforcement scheme was chosen to increase the height of the structure. Finally, a new connection method was developed that allowed the origami structure to be practically applied. This research demonstrates the possibility of developing a timber structure based on Yoshimura origami
Continuous assay of protein tyrosine phosphatases based on fluorescence resonance energy transfer
No full textAn assay method that continuously measures the protein tyrosine phosphatase (PTP)-catalyzed dephosphorylation reaction based on fluorescence resonance energy transfer (FRET) was developed as an improvement of our previously reported discontinuous version [M. Nishikata, K. Suzuki, Y. Yoshimura, Y. Deyama, A. Matsumoto, Biochem. J. 343 (1999) 385-391]. The assay uses oligopeptide substrates that contain Mca [(7-methoxycoumarin-4-yl)acetyl] group as a fluorescence donor and DNP (2,4-dinitrophenyl) group as a fluorescence acceptor, in addition to a phosphotyrosine residue located between these two groups. In the assay, a PTP solution is added to a buffer solution containing a FRET substrate and chymotrypsin. The PTP-catalyzed dephosphorylation of the substrate and subsequent chymotryptic cleavage of the dephosphorylated substrate results in a disruption of FRET, thereby increasing Mca fluorescence. In this study, we used FRET substrates that are much more susceptible to chymotryptic cleavage after dephosphorylation than the substrate used in our discontinuous assay, thus enabling the continuous assay without significant PTP inactivation by chymotrypsin. The rate of fluorescence increase strictly reflected the rate of dephosphorylation at appropriate chymotrypsin concentrations. Since the continuous assay allows the measurement of initial rate of dephosphorylation reaction, kinetic parameters for the dephosphorylation reactions of a FRET substrate by Yersinia, T-cell and LAR PTPs were determined. The continuous assay was compatible with the measurement of very low PTP activity in a crude enzyme preparation and was comparable in sensitivity to assays that use radiolabeled substrates
Motion analysis of a foldable barrel vault based on regular and irregular Yoshimura Origami
No full textThis paper investigates the geometry of a foldable barrel vault with Yoshimura Origami patterns during the motion. On the base of the geometry analysis of the origami unit, the radius, span, rise, and longitudinal length of the foldable barrel vault with regular Yoshimura Origami pattern in all configurations throughout the motion are determined. The results show that the radius of curvature and the span increase during deployment. But the rise increases first, followed by a decrease with increasing fold angle. Furthermore, the influence of the apex angle of the origami unit and the numbers of triangular plates in the span direction on the geometric parameters is also investigated. Finally, the method to obtain the rise and span of the barrel vault with irregular origami pattern is also given
DS_10.1177_0022034520913250 – Supplemental material for Effects of Sulfonylureas on Periodontopathic Bacteria-Induced Inflammation
No full textSupplemental material, DS_10.1177_0022034520913250 for Effects of Sulfonylureas on Periodontopathic Bacteria-Induced Inflammation by Y. Kawahara, T. Kaneko, Y. Yoshinaga, Y. Arita, K. Nakamura, C. Koga, A. Yoshimura and R. Sakagami in Journal of Dental Research</p
Newborn care practices in rural Bangladesh
No full textBackground: Neonatal mortality is high in Bangladesh. Most of the neonatal deaths are preventable through simple and cost-effective essential newborn care interventions. Studies to document the determinants of unhealthy newborn care practices are scarce.Objective: The objective of this study is to describe the pattern of neonatal care practices andtheir determinants in rural Bangladesh.Methodology: This study is based on baseline data of a community-based intervention to assess impact of limited postnatal care services on maternal and neonatal health-seeking behavior. Data from 510 women, who had a live birth at home 1 year prior to survey, of six randomly selected unions of an Upazila (subdistrict) were analyzed.Results: Majority of the respondents were at an age group of 20–34 years. Only 6% had delivery by skilled providers. Immediate drying and wrapping, and giving colostrums to newbornswere almost universal. Unhealthy practices, like unclean cord care (42%), delayed initiation of breastfeeding (60%), use of prelacteals (36%), and early bathing (71%) were very common. Muslims were more likely to give early bath (adjusted odds ratio [OR]: 2.01; 95% confidence interval [CI]: 1.13–3.59; P=0.018) and delay in initiating breastfeeding (adjusted OR: 1.45;95% CI: 1.18–1.78; P,0.001) to newborns. Practice of giving prelacteals was associated with teenage mothers (adjusted OR: 2.26; 95% CI: 1.19–4.28; P=0.013) and women’s lack of education (adjusted OR: 2.64; 95% CI: 1.46–4.77; P=0.001).Conclusion: Unhealthy neonatal care practices are widespread in rural Bangladesh. Continued education to the community and home delivery attendants on essential newborn care could benefit newborn survival in Banglades
Spatially-localized time dependent solutions including turbulence and their interactions in 2D Kolmogorov flow
No full textIn 2D Kolmogorov flow in small aspect ratio domains, spatially-localized solutions such as kink, traveling or time-dependent kink-antikink pars coexist. However, the conservation of the flow rate in the y direction strongly restrict combination of localized solutions and their positioning. We find that by adding a homogeneous flow U y their positioning is controlled and each of localized solutions including a spatially-localized chaos is isolated. Numerical results suggest that these isolated solutions can be elements constructing a whole flow
Characteristics of overlap region in high-Reynolds number turbulent channel flow
No full textDirect numerical simulation of the fully developed turbulent channel flows have been carried out at the Reynolds number based on the friction velocity and the channel half width, 2000, 4000 and 8000. A hybrid 10th order accurate finite difference scheme in the stream and spanwise directions, and a second-order scheme in the wall-normal direction is adapted as the spatial discretization method. We observed the plateau profiles in the indicator function corresponded to the von Karman constant. Furthermore, second peak of streamwise pre-multiplied spectra were appeared in the same wall normal height, 300 < y+ < 600, in case of Re = 4000. Nevertheless, the effects of the lager than the channel half height scale on the streamwise turbulent intensity are fixed contributions without dependence on Reynolds number. These results suggested that the new streamwise vortexes are formed between buffer layer and outer layer with increasing of Reynolds number
Evidence of carrier accumulation effects on the response enhancement in thin-film electrochromic devices
No full textLa 'circunstancia' de 'Herederos y Pretendientes
No full textIn June 2010, the Ortega y Gasset Foundation hosted a Conference about the “Spanish Philosophical Transition” in order to debate the book of Francisco Vázquez, La filosofía española. Herederos y Pretendientes. Una lectura sociológica (1963-1990), recently published. This paper is the author’s response to criticism raised in the Conference and to published reviews received by this book. First, the author summarized the argument of Herederos y pretendientes. Secondly he responds and takes into account the most important objections against the book’s hypothesis and methodology. Finally the author evaluates the favorable judgments received by the book and suggests the limits of the historian’s task.Fundación Ortega y Gasset-Marañó
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