52 research outputs found
DIMENSIONALITY REDUCTION TECHNIQUES FOR SEARCH RESULTS CLUSTERING by STANISŁAW OSIŃSKI Supervisor
No full textAll sentences or passages quoted in this dissertation from other people's work have been specifically acknowledged by clear cross-referencing to author, work and page(s). Any illustrations which are not the work of the author of this dissertation have been used with the explicit permission of the originator and are specifically acknowledged. I understand that failure to do this amounts to plagiarism and will be considered grounds for failure in this dissertation and the degree examination as a whole
CLINICAL OBSERVATIONS ON RENAL ARTERIOGRAPHY
No full textThe renal arteriography has four methods, i.e., translumbar aort o graphy, retrograde aortography, selective renal arteriography, and intravenous aortography. The author attempted clinical observations on 262 cases of translumbar aortography and 34 cases of intravenous aortography which he had performed at Kyoto Univ. during his stay there, the period of April 1953 through June 1961. Especially, the clinical value on the dynamic x-ray diagnosis by application of the seriography was discussed with given instances. 1. Clinical Observations on Renal Arteriography b y Translumbar Abdominal Aortography There were included not only urologic diseases as renal tumor and urolithiasis etc., but also renal hypertension etc., in 262 cases which the translumbar aortography had been employed. The single shoot was made on most cases, and the seriography was taken in 79 cases which included both methods the seriographic apparatus was used in 73 cases and ODELCA mirror camera was used in 6 cases. The 16 mm x-ray cinematography was taken in 8 cases for the purpose of dynamic x-ray diagnosis. Side reactions of the aortograph y were found only in 15 cases. The most of them were the irritative symptoms caused by the contrast media, and it was demonstrated that 76% Urografin (Schering) was most nonirritating. No such severe symptoms, as have been described in other references, were observed. The times of the appearances of the pictures which were shown by seriography were as follows : the shadow of the renal artery appeared during 1.0-3.0 sec., nephrogram during 2.0, -6.0 sec., renal vein during 4.0-6.0 sec., renal calyces and pelves during 50.0-60.0 sec. after the beginning of injection respectively. Some other arteries in the abdo m inal cavity as well as the renal artery appeared by this method. I n cases of renal tumor, irregular pooling pictures of contrast media in the neoplastic area appeared well, and it was shown that the picture appeared and disappeared later than the shadow of the renal artery by means of seriography. In a case of solitary cyst of the kidney, a v ascularity in the cystic area and bow-shaped blood vessels around the area appeared clearly by this method. In a cases of hydronephrosis, function of the dise a s ed kidney was well estimated and an aberrant artery obstructing the ureter was visualized by this method. A case of horse-shoe kidney was demonstrated, being one o f congenital anomalies of the kidney. In a cases of Goldblatt's hypertension a picture of the renal artery stenosis was demonstrated. In a case of abdominal aortic aneurysm, the slowed circulation in the aneurysmal part was shown but the renal arteries were normally demonstrated. 2. Clinical Observations on R e n a l A rteriography by Intravenous Abdominal Aortography This method was performed on 34 cases, mos t of whom were renal tuberculosis, urolithiasis and renal tumors etc. The single shoot was emplo y ed in most cases, and the seriography was taken in 5 cases and the 16 mm x-ray cinematography in 2 cases. The author hopes that applications of the seriography will be made in these cases to obtain clearer pictures of the renal artery. The appearance of the picture of the renal artery in seriography was during 7.0-15.0 sec. following the beginning of injection, and nephrogram appeared during 8.0-16.0 sec. and renal calyces and pelves at 90 sec. The pictures of renal artery and nephrogram in a case of ureteral calculus were demonstrated. It was shown by the seriographic method that pictures of the renal artery and nephrogram appeared late in case of the aortic aneurysm located above the renal arteryies. The intravenous aortography is more simple and more safe than the tr a n slumbar one, and has some other excellent clinical values. However, the former is somewhat inferior to the latter in a point of the contrast density of the picture. This research had been performed during the author's stay at the Kyoto University. Grateful acknowledgement is made to Prof. T. Inada for his constant interest and guidance, to the staff of the departmet of Urology and x-ray technicians of the Kyoto University for much assistance throughout this investigaiton. Thanks are also due to the NichidokuYakuhin Co., Ltd. and to the Shimadzu-seisaku Co., Ltd. for generous supply of materials and instruments
Studies on dysuria by urography : voiding cystourethrography
No full textThe author and others reported a part of results ab o ut studies of "Physiology and Pathology of Voiding" which was done by application of seriography and cineradiography to voiding cystourethrography. The c onclusions are as follows : 1) In normal cases, descending of the bladder base and opening of the internal meatus were shown. 2) In prostatic hypertrophy where patients could not void spontaneously descending of the bladder base was shown to a slight degree, but using the parasympathomimetic agent, Besacolin, the descent became more clear than before. After prostatectomy the descent of the bladder base and the opening of the internal meatus were clearly shown and urine was completely voided. 3) In p r ostatic cancer, descending of the bladder base and opening of the internal meatus were scarecely shown. The author believes that the above indications as well as the stiffness of the posterior urethra should be a help in differential diagnosis from the prostatic hypertrophy. 4) In neurogenic bladder, descending of the bladder base and opening of the internal meatus were clearly shown. 5) In urethral s t r icture, dilatation of the urethra as far as the strictural portion was shown with hard voiding
Effect of Daytime Grazing of Fresh Grass without Supplemental Feed on Serum and Milk α-Tocopherol Concentrations of Holstein Dairy Cows
No full textTrim17, novel E3 ubiquitin-ligase, initiates neuronal apoptosis
No full textAccumulating data indicate that the ubiquitin-proteasome system controls apoptosis by regulating the level and the function of key regulatory proteins. In this study, we identified Trim17, a member of the TRIM/RBCC protein family, as one of the critical E3 ubiquitin ligases involved in the control of neuronal apoptosis upstream of mitochondria. We show that expression of Trim17 is increased both at the mRNA and protein level in several in vitro models of transcription-dependent neuronal apoptosis. Expression of Trim17 is controlled by the PI3K/Akt/GSK3 pathway in cerebellar granule neurons (CGN). Moreover, the Trim17 protein is expressed in vivo, in apoptotic neurons that naturally die during post-natal cerebellar development. Overexpression of active Trim17 in primary CGN was sufficient to induce the intrinsic pathway of apoptosis in survival conditions. This pro-apoptotic effect was abolished in Bax(-/-) neurons and depended on the E3 activity of Trim17 conferred by its RING domain. Furthermore, knock-down of endogenous Trim17 and overexpression of dominant-negative mutants of Trim17 blocked trophic factor withdrawal-induced apoptosis both in CGN and in sympathetic neurons. Collectively, our data are the first to assign a cellular function to Trim17 by showing that its E3 activity is both necessary and sufficient for the initiation of neuronal apoptosis. Cell Death and Differentiation (2010) 17, 1928-1941; doi: 10.1038/cdd.2010.73; published online 18 June 201
Heritability of male mandible length in the stag beetle Cyclommatus metallifer
No full textNumerous coleopteran species express male-specific "weapon traits" that often show size variations among males, even within a single population. Many empirical studies have demonstrated that environmental conditions during development affect absolute weapon size. However, relatively few studies in horned beetles support the hypothesis that the relationship between weapon size and body size, also referred to as a "scaling relationship" or "static allometry", is largely determined by genetic factors. In this study, the heritability of absolute mandible length and static allometry between mandible length and body size were estimated in the stag beetle Cyclommatus metallifer. While no significant heritable variation was observed in absolute mandible length, high heritability (h2 = 0.57 ± 0.25) was detected in the static allometry between mandible length and body size. This is the first report on the genetic effect on male mandible size in Lucanidae, suggesting that absolute mandible size is largely determined by environmental conditions while the static allometry between weapon size and body size is primarily determined by genetic factors
Juvenile Hormone titre and vitellogenin gene expression related to ovarian development in primary reproductives compared with nymphs and nymphoid reproductives of the termite Reticulitermes speratus
No full textTo elucidate the reproductive cycle of termite queens, incipient colonies of Reticulitemes speratus (Isoptera: Rhinotermitidae) were established under laboratory conditions, and the transition of colony development was observed at 0.5, 1.5, 2.5, 3.5, and 7.5 months (stages I-V, respectively) after colony foundation. Ovarian development, vitellogenin gene expression, and Juvenile Hormone (JH) titres are examined in the queens and in non-physogastric nymphoids collected from natural colonies. A reproductive cycle in queens is observed, in which the oviposition rate is relatively higher during stages I and II, and then decreases during stages III and IV. Vitellogenic oocytes are not observed in the ovary during stages III and IV, and the expression level of the vitellogenin gene is low, suggesting that egg production in queens is repressed during these stages. However, vitellogen gene expression and egg deposition in queens resumes during stage V. Juvenile Hormone levels rise during the transition from nymphs to stage-I queens, and elevated JH titres are observed also during stages III and IV. The decrease in JH titre in queens at stage II precedes the decline in vitellogenesis at stages III and IV. Thus, JH titre and vitellogenesis are correlated in an offset pattern. However, non-physogastric nymphoid reproductives do not have vitellogenic oocytes in their ovaries, and their JH titre is two-fold higher than that of queens, suggesting that elevated JH titre precedes vitellogenesis as in queens
Comparative Ultrastructural Observation of the Cuticle and Muscle of an Enchytraeid (Enchytraeus japonensis) and an Oribatid species (Tectocepheus velatus) using Transmission Electron Microscopy
No full textWe observed internal tissue of wet soil meso animal, Enchytraeus japonensis and dry soil meso animal, Tectocepheus velatus using optical and transmission electron microscopes. Thin cuticle layer and thick epidermis covered the whole body, and there were epidermal gland cells of various forms in the cuticle of E. japonensis. The epidermis was formed of the bilayer, and thick body wall muscles of various travels were observed in the hypodermic. There were many lipid droplets (large and small size) under body wall muscles. On the other hand, the mite body of T. velatus was surrounded by thick sclerites. The sclerites formed a thin epidermis (outer layer), a thick epicuticle (middle layer) and a thick procuticle (inner layer). The procuticle was formed of 5-6 thin layers. However, there was the position with the impossible discriminate in other place. The hypodermic muscles were connected to the procuticle, and were surrounded by many lipid droplets. There were lipid droplets (large and small sizes) in various places. This study indicates that there are internal histological differences of soil animals according to different habitat and environment in soil
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