113 research outputs found
The effects of endothelial protein C receptor gene polymorphisms on sEPCR levels in venous thrombotic patients
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Letter to the Editor: Serum Superoxide Dismutase Levels of Beta Thalassemia Patients and Effects of High Dosage of Intravenous Desferrioxamine Treatment on Superoxide Dismutase Levels
No full textIncreased formation of free radicals as a result of iron overload plays an important role in the pathogenesis of beta thalassemia. Previous reports revealed controversial data on superoxide dismutase (SOD) levels in these patients [1]. Superoxide dismutase catalyzes superoxide to hydrogen peroxide and prevents further generation of free radicals. Manganese superoxide dismutase (MnSOD) is found mainly in mitochondria and copper-zinc superoxide dismutase (Cu/ZnSOD) in cytoplasm [2]. Desferrioxamine (DF) is the most efficient iron chelating agent. Although its regular daily dose is 25-60 mg/kg, high intravenous doses of DF such as 100-150 mg/kg per 24 hours have been proposed [3]. However, high doses of DF may cause side effects such as autotoxicity, retinopathy, and cataract [4]. The aim of this study is to determine MnSOD and Cu/ZnSOD levels in beta thalassemia patients and to assess further the effect of high-dose DF treatment
The Relation Between Cytokines, Soluble Endothelial Protein C Receptor, and Factor VIII Levels in Turkish Pediatric Stroke Patients
No full textProtein Z G79A polymorphism in Turkish pediatriccerebral infarct patients
No full textObjective: Protein Z (PZ) plays an enhancer role in coagulation as an anticoagulant. In this study G79A polymorphism was investigated in Turkish pediatric stroke patients. Material and Methods: Ninety-one pediatric stroke patients with cerebral ischemia and 70 control subjects were analyzed for PZ G79A and also factor V Leiden (FVL) and prothrombin (PT) mutations. Results: PZ 79 ‘A’ allele in homozygous state was found in five patients (5.5%), while it was found in only one control subject (1.4%), and it appeared to be a risk factor for pediatric ischemia [OR=3.94 (0.44-35.1)]. When patients and controls who had FVL and PT carriers were excluded, AA genotype carried a risk [OR=3.88 (0.41-36.5)]. In addition, plasma PZ levels were measured in 21 stroke patients and 52 controls. Plasma PZ levels were not different between stroke patients (501,0 ngml-1 ± 158,3 ngml-1) and controls (447,3 ngml-1 ± 166,0 ngml-1). However, the plasma levels of PZ were decreased in patients with AA genotype. This is the first study in which G79A polymorphism was investigated in Turkish pediatric stroke patientsConclusion: Our data showed that carrying 79 AA genotype could be a genetic risk factor for cerebral infarct in pediatric patients
SISTEM OPERASI PORTABLE BERBASIS LINUX UNTUK KEPERLUAN PENGEMBANGAN WEBSITE
No full textThis portable operating system is a Linux operating system called SLAX, which was written and developed by it’s creator, Tomas Matejicek from the Czech Republic. This Slax operating system does not need to be installed on the hard drive because it can run directly on a CD / DVD or USB flashdisk and can store data or configurations made permanently by the user, so that when the computer is turned off or restarted Slax will reload any changes done by the user, this feature is called Persistent Changes.
Because of the convenience offered by Slax, the author will make this operating system as a tool to develop websites where users can create or continue website projects that are being worked on all different computer devices, this is very useful for web developers or anyone who has high mobility because it’s doesn't have to carry a laptop that is heavy enough. Just with a small flashdisk the user can continue programming easily.
Keyword : Portable operating system, Slax linux, web developmen
The role of tumor necrosis factor-alpha -308 G/A and transforming growth factor-beta 1 -915 G/C polymorphisms in childhood idiopathic thrombocytopenic purpura
No full textEvaluation of the role of Nrf2/Keap1 pathway-associated novel mutations and gene expression on antioxidant status in patients with deep vein thrombosis
No full textDeep vein thrombosis (DVT) is a type of venous thromboembolism and a clinically complex vascular disease. Oxidative stress serves a key role in the pathogenesis of numerous cardiovascular diseases, particularly in endothelial dysfunction-associated syndromes. Nuclear factor erythroid-2-like 2(Nrf2) transcription factor is the primary regulator of antioxidant responses. The levels of reactive oxygen species (ROS) are regulated by Nrf2 and its suppressor protein Kelch-like ECH-associated protein 1 (Keap1). However, to the best of our knowledge, genetic abnormalites in the Nrf2/Keap1 pathway in DVT syndrome have not been thoroughly investigated. The aim of the present study was to investigate the association between the Nrf2/Keap1 pathway and antioxidant responses in DVT. Mutations and expression levels of genes involved in the Nrf2/Keap1 pathway were measured in 27 patients with DVT via DNA sequencing analysis and reverse transcription-quantitative PCR, respectively. The Polymorphism Phenotyping v2 program was used to identify the pathogenic mutations. Total antioxidant activity levels were determined by measuring the effect of serum samples from 27 patients with DVT on oxidation of the 2,2'-azino-bis (3-ethylbenz-thiazoline-6-sulfonic acid) system. A total of 23 mutations, including seven novel mutations, were detected in the Nrf2/Keap1 pathway in 24 (89%) of the 27 patients with DVT. Keap1 mRNA expression levels were significantly higher compared with Nrf2 expression levels in patients with DVT (P=0.02). Analysis of molecular characteristics and gene expression levels demonstrated that Nrf2/Keap1-associated mutations and total antioxidant levels can be used as precursor markers in the diagnosis of DVT
Contribution of clinical, metabolic, and genetic factors on hypertension in obese children and adolescents
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