1,721,540 research outputs found
Jing jing de Jialing Jiang.
No full text書名據封面."大江影業公司出品".Shu ming ju feng mian."Da jiang ying ye gong si chu pin"
Oral mucositis and periodontal disease in patients with primary or acquired immunodeficiencies
No full textThe infection and inflammation in the oral cavity are commonly related to the skewed interaction between host immunity and inhabiting microorganisms. Both primary and acquired immunodeficiency conditions are frequently associated with oral symptoms. In this thesis two oral manifestations, chronic periodontitis and oral mucositis, were investigated in patients with severe congenital neutropenia and in patients with malignant diseases respectively.In Paper I, a genotype-phenotype correlation between ELANE mutations and chronic periodontal disease was described in a group of patients with severe congenital neutropenia. Patients that harbor mutations in the gene ELANE, encoding neutrophil elastase, presented with poorer periodontal health as compared to those with HAX1 mutations or unknown mutations. The periodontal pockets of the patients with ELANE mutations displayed a skewed microflora and elevated levels of proinflammatory cytokine IL-1β.In Paper II and III we studied the oral mucositis, an acute side effect frequently encountered during cytostatic chemotherapy, in a group of pediatric patients diagnosed with various types of malignancies. In Paper II, we showed that at the time of malignancy diagnosis, patients with acute leukemia had highest risk of oral mucositis, presenting with high concentrations of inflammatory cytokines IL-6, IL- 8, IL-10, and TNF-α and low levels of pro-LL-37 (hCAP-18) in the blood plasma.In Paper III we conducted high-throughput sequencing of the oral mucosal bacterial community in an attempt to investigate the role of bacteria in the pathogenesis of oral mucositis development. At the time of malignancy diagnosis, patients who later developed oral mucositis were found to have higher oral mucosal microbial diversity and were more heterogeneous among one another compared to those that did not develop mucositis. A more pronounced modification of the bacterial community by chemotherapy was detected in patients that later developed oral mucositis, indicating a beneficial role of stable oral microbiota.In the last paper of this thesis, we investigated the variation of blood pro-LL-37 levels in a cohort of patients presenting with chronic neutropenia. The lower values of pro-LL-37 were found in cases with severe congenital neutropenia, as compared to autoimmune, idiopathic, and ethnic neutropenia. The findings support the view that benign forms of neutropenia could be distinguished from the severe forms at an early stage. Plasma pro-LL-37 levels may potentially work as a diagnostic parameter and this analysis could be developed for clinical use.Providing adequate and personalized oral care to the patients with immunodeficiencies has necessitated more knowledge regarding the predisposition and pathobiology of their oral manifestations. The findings in this thesis may benefit the clinical management and subsequently improves the patient’s quality of life.List of scientific papersI. YING YE, Göran Carlsson, Biniyam Wondimu, Annika Fahlén, Jenny Karlsson-Sjöberg, Mats Andersson, Lars Engstrand, Tülay Yucel-Lindberg, Thomas Modéer, Katrin Pütsep. Mutations in the ELANE gene are associated with development of periodontitis in patients with severe congenital neutropenia. Journal of Clinical Immunology. 2011; 31(6): 936-45. https://doi.org/10.1007/s10875-011-9572-0 II. YING YE, Göran Carlsson, Monica Barr Agholme, Jenny Karlsson-Sjöberg, Tülay Yucel-Lindberg, Katrin Pütsep, Thomas Modéer. Pretherapeutic plasma pro- and anti- inflammatory mediators are related to high risk of oral mucositis in pediatric patients with acute leukemia: a prospective cohort study. PLoS ONE. 2013; 8(5): e64918. https://doi.org/10.1371/journal.pone.0064918 III. YING YE, Göran Carlsson, Monica Barr Agholme, John A.L. Wilson, Annika Roos, Birgitta Henriques-Normark, Lars Engstrand, Thomas Modéer, Katrin Pütsep. Oral bacterial community dynamics in paediatric patients with malignancies in relation to chemotherapy-related oral mucositis: a prospective study. Clinical Microbiology and Infection. 2013 https://doi.org/10.1111/1469-0691.12287 IV. YING YE, Göran Carlsson, Jenny Karlsson-Sjöberg, Niels Borregaard, Thomas Modéer, Mats Andersson, Katrin Pütsep. Plasma pro-LL-37 level as a diagnostic tool in the evaluation of chronic neutropenia: a prospective study. [Manuscript]</p
sj-docx-1-tva-10.1177_15248380231185305 – Supplemental material for Childhood Maltreatment and Gratitude: A Multilevel, Meta-Analytic Review
No full textSupplemental material, sj-docx-1-tva-10.1177_15248380231185305 for Childhood Maltreatment and Gratitude: A Multilevel, Meta-Analytic Review by Ningzhe Zhu, Ying Ye, Chengcheng Li, Rixin Wang and Feng Kong in Trauma, Violence, & Abuse</p
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Activin signaling promotes the competence of the prothoracic gland during Drosophila metamorphosis
No full textUniversity of Minnesota Ph.D. dissertation. Major: Molecular, Cellular, Developmental Biology and Genetics. Advisor: Michael B. O’Connor. 1 computer file (PDF); vii, 167 pages, Ill., (some col.).In insects, the timing of metamorphosis is modulated by a large titer of the steroid hormone ecdysone produced by the prothoracic gland. However, the molecular mechanisms that control production of the ecdysone titer are not completely understood. Here we show that blocking Activin signaling in Drosophila prothoracic gland causes developmental arrest prior to metamorphosis. This defect is due to the absence of the ecdysone titer, a likely consequence of reduced expression of the ecdysone biosynthetic enzymes. We further demonstrate that Activin signaling may regulate the competence of the prothoracic gland to respond to prothoracicotropic hormone and insulin, two hormonal signals that have been shown to trigger ecdysone synthesis. These findings suggest that Activin signaling is required for insect metamorphosis by providing competence that allows tissue- and stage-specific response to metamorphic stimuli.Gibbens, Ying Ye. (2010). Activin signaling promotes the competence of the prothoracic gland during Drosophila metamorphosis. Retrieved from the University Digital Conservancy, https://hdl.handle.net/11299/96237
Dispelling the Myths Behind First-author Citation Counts
Get PDFWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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