19,238 research outputs found
Shen Ying Ji
No full text학위논문(석사)--아주대학교 일반대학원 :의학과,2006. 8ABSTRACT………………………………………………………….i
TABLE OF CONTENTS ………….…………………..…………iii
LIST OF FIGURES…………...…….……………………………..v
LIST OF TABLES..……..……………………………….…….…vi
ABBREVIATION……………..……………………...…………..vii
I. INTRODUCTION…...……………………………………………1
II. METEIRALS AND METHODS………………………………..3
A. ANIMALS AND TREATMENT……………………………….3
B. PHYSICAL MEASUREMENT………………………………..4
C. BIOCHEMICAL ANALYSIS………………………………….4
D. IMMUNOHISTOCHEMISTRY……………………………….5
E. STATISTICAL ANALYSIS…………………………………..6
III. RESULTS………………………………………………………7
IV. DISCUSSION……………………………………….………..10
V. CONCLUSION…………………………………….………….14
REFERENCES..…………………………………………………..19
국문요약…………………………………………………………….26MasterPurpose: OLETF rat is a model of Type II DM. Bone metabolism has influenced with hormones, growth factors, and cytokines that orchestrate the activities of both osteoclast and osteoblast cells. Type II DM influences bone metabolism and Neuropeptides-leptin and NPY2 receptor’s in hypothalamic control bone formation with osteoblast activity. We tried to distinct alteration of bone metabolism in OLETF rat from 8wks to 52wks.
Animals and treatment: Serum samples were collected in eleven male OLETF and LETO (control) rats, femoral BMD and percent body fat were measured in 8, 25, 40, 52wks of age. In 25wks of age, all the OLETF rats developed Type II DM. In 52wks of age, rats were sacrificed and brain sections were made for immunohistochemistry. Hormones, growth factors and bone markers were measured by radioimmunoassay.
Results: Body weight and percent body fat in OLETF rat were higher than that of LETO rat in whole time (p<0.001); but BMD was lower than control (p<0.05) from 40wks of age. OLETF rat hypothalamic arcuate neuron cell NPY2 receptor were strongly pattern expressed than LETO rat. OLETF rat testosterone was decreased in 25wks and significantly lower in 40 and 52wks (p<0.05); serum leptin and IGF-I levels were higher (p<0.05) in whole time; insulin levels were higher from 8wks to 40wks(p<0.05), but in 52wks lower (p<0.05) than LETO rat; free T4 were higher in 8wks and 25wks (p<0.05), but in 40wks there was no difference, in 52wks lower than LETO rat; corticosterone level was lower in 8wks (p<0.05), but higher in 25wks, 40wks, and 52wk (p<0.05). OLETF rat serum CTx was higher (p<0.05), but OPG was lower (p<0.05) in 40wks and 52wks.
Conclusion: OLETF rat had low bone density after 40wks of age and this finding could be correlated with low level of testosterone, high level of corticosterone and leptin in serum, and also NPY2-R over-expression in hypothalamic arcuate nuclei
Wan jia deng huo.
No full text陽翰笙[歐陽繼修], 沈浮著.電影劇本.Yang Hansheng [Ouyang Jixiu], Shen Fu zhu.Dian ying ju ben
Hydrophobic Targeting Ligand Modified Polyethyleneimine for Hepatic Cancer Gene Therapy
No full text<p>Mingzhuo Cao <sup>1,2*</sup>, Yong Gao <sup>3</sup>, Mengling Zhan<sup>2</sup>, Nasha Qiu <sup>1</sup>, Ying Piao<sup>1</sup>, Zhuxian Zhou<sup>1</sup>, Youqing Shen <sup>1</sup></p>
<p><sup>1</sup> Center for Bio-nanoengineering and Key Laboratory of Biomass Chemical Engineering, Ministry of Education, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310027, China;</p>
<p><sup>2</sup> Scientific Research and Experimental Center, Henan University of Chinese Medicine, Zhengzhou, 450058, China.</p>
<p><sup>3</sup> Henan province food and drug Administration, Food and Drug Evaluation and Inspection Center, Zhengzhou, 450018, China.</p>
<p><strong>*</strong> Corresponding Author: Mingzhuo Cao, E-mail: <a href="mailto:[email protected]">[email protected]</a></p>
Zhong guo ge min zu shen hua ha sa ke zu ke er ke zi zu wei wu er zu ta ji ke zu
No full textBen shu jiang ha sa ke zu de chuang shi shen hua,Tian ti shen hua,Da di shen hua,Ying xiong shen hua,Ke er ke zi zu de chuang shi shen hua,Hong shui shen hua,Tian ti shen hua,Da di shen hua,Ying xiong shen hua,Wei wu er zu de chuang shi shen hua,Tian ti shen hua,Da di shen hua,Ying xiong shen hua,Yi ji ta ji ke zu de da di shen hua,Ying xiong shen hua sou luo jing jin,Zhan shi le zhong guo gu lao shen hua de mian ma
Shen ren tong ju de shi jie Zhongguo ren yu Zhongguo ci shen wen hua
No full textBen shu fen xi le ci shen shi jie chan sheng de she hui li shi gen yuan yi ji ta dui zhong guo she hui li shi suo chan sheng de ying xiang, lun shu le yan jiu ci shen wen hua de xian shi yi y
Obtuse Music and Nebulous Males: The Haunting Presence of Taiwan in Hong Kong Films of the 1990s.
No full textStylistic Innovations and the Emergence of the Urban in Taiwan Cinema: A Study of Bai Jingrui's Early Films
No full textYou xian shen zhan de ju he wu dui shui ping ji chui zhi bian jie ceng liu zhong re liang chuan shu de ying xiang
No full textYu, Wilson = 有限伸展的聚合物對水平及垂直邊界層流中熱量傳輸的影響 / 余俊傑.Thesis M.Phil. Chinese University of Hong Kong 2014.Includes bibliographical references (leaves 73-75).Abstracts also in Chinese.Title from PDF title page (viewed on 01, November, 2016).Yu, Wilson = You xian shen zhan de ju he wu dui shui ping ji chui zhi bian jie ceng liu zhong re liang chuan shu de ying xiang / Yu Junjie
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