126,448 research outputs found
Ying Yao's Piano Recital 1
No full textSonata in G, Hoboken XVI No. 6, Franz Joseph Haydn
Fantasy-Pieces, Op. 12, Robert Schumann
Sonata Ill, Op. 46, Dmitri Kabalevsky
Memories in an Ancient Garden (1987), Alexina LouieRelated performance for this degree -- Ying Yao's Piano Recital 2: https://hdl.handle.net/2346/104181
Related performance for this degree -- Ying Yao's Piano Recital 3: https://hdl.handle.net/2346/104182
Related performance for this degree -- Ying Yao's Piano Recital 4: https://hdl.handle.net/2346/104183Recital recordings are archival copies for educational purposes only. Members of the TTU community may request to listen/view them for educational purposes via the PDF link to the left
Learning and adaptation in physical agents
No full textLearning and adaptation is fundamental for autonomous agents that operate in a physical world and not a computer network. The paper is providing a general framework of skills learning within behaviour logic framework of agents that communicate, sense and act in the physical world. It is advocated that playfulness can be important in learning and to improving skills of agents
Use of Fourier-Transform Infrared Spectroscopy for the Diagnosis of Failure of Transfer of Passive Immunity and Measurement of Immunoglobulin Concentrations in Horses
No full textBackground: The economic, accurate, and rapid screening of foals for failure of transfer of passive immunity (FPT) is essential to ensure timely intervention. Hypothesis: Infrared (IR) spectroscopy of foal sera and pattern recognition may be used to diagnose FPT and quantify serum IgG. Samples: Sera from 194 foals (24–72 hours) with serum immunoglobulin G (IgG) concentrations determined previously by radial immunodiffusion assay (RID) were used. Methods: IR spectra were recorded for the serum samples, and the data were randomly divided into training and independent test sets, each containing both FPT-positive (IgG <400 mg/dL) and non-FPT samples. A genetic optimal region selection algorithm and linear discriminant analysis were used to partition the training spectra, and the resulting classifier was then validated by comparing the IR-predicted FPT status for each of the test samples to that provided by the RID IgG assay. A quantitative IR-based assay for IgG was developed using partial least squares (PLS) and validated by testing its ability to predict IgG concentrations. Results: Specificity, sensitivity, and accuracy for the combined data were 92.5, 96.8, and 95.9%, respectively. Corresponding positive (88.1%) and negative predictive (98.0%) values determined a success rate of 95–97% as compared to RID-based IgG concentrations. The IR-based quantitative assay yielded correlation coefficients for IR spectroscopy versus RID-based IgG concentrations of 0.90 and 0.86 for the training and test sets, respectively. Conclusions and Clinical Importance: The overall performance of the IR-based test was similar to that of the colorimetric assay and was superior and more economic than other available tests.Christopher B. Riley, J.T. McClure, Sarah Low-Ying, and R. Anthony Sha
Religious pathways to coping with personal death anxiety among older adult British Christians and Chinese Buddhists: afterlife beliefs, psychosocial maturity and regret management
No full textReligion was proposed to account for the relatively low personal death anxiety found among older adults. This dissertation sought to examine the influence of religious afterlife beliefs, religiously enhanced psychosocial maturity and religious management of a past major regret on personal death anxiety in later life. Terror Management Theory and Erikson’s Psychosocial Theory were used to describe these three religious pathways to coping with personal death anxiety in later life. The cross-sectional postal survey samples consisted of 143 older adult British Christians and 141 older adult Chinese Buddhists. Structural Equation Modelling results from the British Christian survey study showed that intrinsic religiosity predicted lower personal death anxiety through: (a) fostering more benign afterlife beliefs; (b) enhancing psychosocial maturity; and (c) promoting emotional stability. No significant relationship between belief in reincarnation and personal death anxiety was found in the Chinese Buddhist survey study. Both survey studies failed to support the personal death anxiety buffering power of religious management of a past major life regret, although some religious coping strategies were associated with lower negative emotional appraisal towards the major life regret among older adults. The British survey study has been the first to demonstrate both the personal death anxiety buffering and psychosocial maturity enhancing power of religion in an increasingly secular society. The lack of relationship between Buddhist reincarnation beliefs and personal death anxiety suggests that not all religious afterlife beliefs have death anxiety buffering power as proposed by Terror Management Theory. The development of Buddhist reincarnation belief and Buddhist coping scales is a pioneering step towards developing research on under-explored Eastern non-theistic afterlife beliefs and coping measures. Implications for ways that help religious older adults cope with their personal death anxiety were discussed. Prospective cross cultural and cross-religion studies were recommended to replicate the present survey findings. Finally, self detachment (self negation) was proposed as the basis of an alternative death transcendence theory to be researched in future studies on personal death anxiety
Enantioselective capillary electrophoresis : fundamental aspects and application to the "in vitro" assessment of CYP3A4 mediated ketamine N-demethylation
No full textA large number of pharmaceutical substances are administered as racemates, consisting of two enantiomers with typically different pharmacodynamic and pharmacokinetic profiles. Thus, stereoselective analysis is important in drug development, therapeutic drug monitoring and research. Chiral separation by chromatographic methods such as HPLC and GC require expensive stationary phases. In contrast, in capillary electrophoresis (CE), enantioselective separation can be obtained using one or several chiral selectors which are added to the background electrolyte. Separation of enantiomers is based on different binding affinities with the enantiomers and/or different migration velocities of the formed analyte-selector complexes. High resolution can be achieved by varying type and concentration of chiral selector as well as buffer properties (pH, ionic strength, other additives etc.). Typical chiral selectors are neutral or charged cyclodextrins, proteins and bile acids. The simplicity of the technique makes enantioselective CE an attractive, promising and economic methodology for drug and metabolite analysis in pharmaceutical preparations, body fluids, tissues and microsomal preparations.
In the first part of this thesis, fundamental aspects of enantioselective CE were investigated using computer simulation. Dynamic computer simulators provide insight into the buffer system and improve understanding of the electrophoretic separation process. Simulation allows to predict proper separation and detection conditions for analytes prior to experiments. Using an extended version of the dynamic computer simulator GENTRANS, the interaction of methadone and its main metabolite EDDP with neutral chiral selectors were simulated. Experimentally determined complexation constants and mobilites of the formed complexes were employed as additional input parameters. Simulated electropherograms were qualitatively in good agreement with the experimental results.
In the second and third parts of the thesis, enantioselective CE was applied to study ketamine metabolism in an off-line study. Ketamine is a chiral phencyclidine derivative used in anesthesia. In vitro and also in vivo studies showed a higher affinity for the NMDA-receptors, higher anesthetic potency and shorter recovery time for S-ketamine compared to R-ketamine. The aims in this project were to characterize the kinetics of CYP 3A4 mediated ketamine N-demethylation in vitro including KM, Vmax and to investigate the stereoselective metabolism of this pathway. Furthermore, the inhibition kinetics of this pathway by ketoconazole, a potent CYP3A4 inhibitor, was investigated. Results showed a higher formation rate for S-norketamine after incubation of racemic ketamine as well as incubation of the single enantiomers. Data obtained in the absence of ketoconazole revealed that the N-demethylation occurred stereoselectively. Inhibition kinetics by ketoconazole fitted best to a one-site competitive model and no stereoselectivity could be demonstrated.
In the forth and final part of this thesis, an on-line method was developed to investigate the in vitro N-demethylation of ketamine via CYP3A4, with the incubation performed in-capillary with subsequent electrophoretic separation and detection of the ketamine enantiomers. Kinetic parameters obtained compared well with those of the off-line study mentioned above and the metabolic step was stereoselective, confirming the results of the off-line assay. After additional improvements, the in-capillary method should be widely applicable to assess enzymatic activity in a fast, low-cost and automated way
Phenotyping of the “G series” Vitis hybrids: First screening of the mineral composition
No full textGrapevine rootstocks affect the nutritional status of plants and thus the production and the quality of grape. In this study, a screening of mineral level in vine leaves is performed to a series of 35 Vitis hybrids for rootstock selection, in two different growing conditions at two sampling times. Mineral levels were determined by elemental analyzer (N) and ICP-MS (P; K; Mg; Ca; Na; Fe; Cu; Fe) in leave samples. Generally, the effect of growing conditions was predominant, whereas genotype effect and their interaction were significant for N, K, Ca, Mg, Na, Mn and Cu. A cluster analysis was used to identify the affinity of each genotypes to K, Mg and Ca. Furthermore, response of genotypes to the different environments was assessed by a plasticity index. An elastic behavior was shown by 14 genotypes. Within this group, genotypes G.05, G.21, G.71, G.76 and G.77 reported high potassium level, beside the already demonstrated tolerance to water stress
Bibliographie Hilarion G. Petzold 1958 – 2009 mit Anhang als Einführung
No full textDieses Archiv enthält die Gesamtbibliographie der Werke des Autors nebst einiger Texte „Über H. G. Petzold“ im Schlussteil der Bibliographie sowie einen Anhang mit einer Einführung in die Architektur des Werkes in seinem wissenslogischen Aufbau als Ausarbeitung seines „Tree of Science Modells“ (2007).This archive contains the complete bibliography of the author and some texts about H. G. Petzold, moreover an epilogue with an introduction to the architecture of the works in its epistemological structure and composition and as an elaborations of Petzold’s „Tree of Science Modell (2007).https://www.fpi-publikation.de/polyloge/01-2009-petzold-h-g-gesamtbibliographie-h-g-petzold-1958-2009-updating-november2009/peerReviewedpublishedVersio
Dispelling the Myths Behind First-author Citation Counts
No full textWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
Light-assisted domain engineering, waveguide fabrication and microstructuring of lithium niobate
No full textThe thesis is focussing on the interaction of lithium niobate with UV and ultrafast laser radiation to achieve 1) ferroelectric domain inversion, 2) waveguide fabrication, and 3) surface microstructuring. Preferential ferroelectric domain inversion has been demonstrated by 'latent light-assisted poling' and 'inhibition of poling' using ultrafast laser irradiation at 400 nm and CW highly absorbed UV radiation (305..244 nm) respectively. The characteristics of the resultant domains have been experimentally investigated as a function of the fabrication conditions and a theoretical model have been proposed to explain the experimental observations. UV radiation in the 305 nm to 244 nm range have been used for the fabrication of optical waveguides in lithium niobate. The waveguiding characteristics and electro-optic response of the UV written optical channel waveguides have been investigated experimentally. Inhibition of poling and post processing has been used for the fabrication of ridge waveguide structures with enhanced refractive index change. Finally, a method for the fabrication of ultra-smooth lithium niobate single crystal photonic microstructures has been proposed. The method is based on surface tension reshaping of surface microstructures which are produced by preferential poling and subsequent etching. Whispering gallery mode resonators have been fabricated and characterised here
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