345 research outputs found
Discussion on Relations between Depression Syndrome and Deficiency Pattern
No full text历代对郁证的认识,详于实证,而略于虚证。王彦晖教授擅长中医肝胆病治疗,对虚证与郁证的关系有独到的理解,认为肝肾阴虚是郁证的基础病因。治疗上,根据伤阴的层面不同,分为阴液不足,阴血亏虚证与阴精匮乏3类,分别采用凉润养阴、温养阴血和填补肾精之法,在临床取得了良好效果。
【英文摘要】 deficient pattern of depression syndrome were given less attention than excess patterns in traditional medical literature.As an experienced hepatology doctor of Chinese medicine,Professor Wang Yanhui has innovative understanding on deficient pattern of depression syndrome: liver-kidney yin deficiency is basic causal factor for depression syndrome.In clinical practice,there are 3 categories: deficiency of(yin) fluid,(yin) blood or(yin) essence,which are to be treated respectively with cooling-moistening meth..
Yue yu yu yin xin xi de ji yi jia gong: cong ji ben dan yuan dao Ya ci shui ping de gui lu gan zhi
No full textM.Phil.A sound can be represented in working memory by perceptual units at various levels along the linguistic hierarchy, ranging from distinctive features to units as large as phrases and sentences. Hence, where do we enter the linguistic hierarchy and whether there is a basic perceptual unit underlying the perceptual recoding of speech signals are fundamental questions in speech perception research. Available studies have converged on a number of pertinent factors, including the orientation of attention, the phonological and cognitive demands imposed by the task, the influence of linguistic experience, as well as the sound statistics in the surrounding context. However, there is still no consensus regarding the aforementioned questions. Disentangling the interplay among these factors while delineating how speech representations are selected during online processing can reveal a great deal about the way the human language capacity works.Experiment 1 of this project explored these issues by studying the language and memory interface, or rather, phonological similarity effects and related behavioral measures. Cantonese participants with and without congenital amusia were recruited and given sequences of real, pseudo, and reversed Cantonese words to recall. Significant detrimental effects were observed with increased phonological similarity, along with a rhyming advantage for pseudo words alone. Results of Experiment 1 thus pointed to the interplay between the holistic encoding strategy and the immediate context (specifically, the structural regularities of the context stimuli) as major determinants of unit priority during speech signal analysis.Moreover, with the abolishment of the similarity effects by high cognitive demands, Experiment 1 also ascertained the linguistic bases of the cognitive load and the phonological similarity effects with a tonal language. Manipulating phonological capacity at the subject level further allowed the present study to put forward the processing-based working memory deficit hypothesis to explain the symptoms of congenital amusia, a wide-spread neurodevelopmental disorder with negative consequences on speech processing.With results in Experiment 1 showing that the ranking of the perceptual units is both task- and context-dependent, Experiment 2 was carried out to further explore the human capacity to process context regularities using eletroencephalography. This experiment also examined whether influenced by holistic encoding tendency, subjects could form awareness at sublexical levels. Participants were instructed to attend to an adapted unimodal word matching task where the probe words may match or mismatch the context stimuli in terms of its subsyllabic components.Results showed that context regularities were extracted early during spoken word analysis, modulating both the amplitudes and the latencies of the N1 and P2 event-related potentials. P2 amplitude also appeared to be an electrophysiological marker of phonological processing load, thereby extending previous findings to the sublexical level as well as to a tonal language with much richer phoneme inventory and complex phonology. Furthermore, different from the view that N1 and P2 are indexes of low-level auditory processing, results in Experiment 2 revealed that the two components can capture processes higher on the linguistic hierarchy, the analysis of contextual sound regularities, for example.Taken together, the two experiments in this project highlighted the complex nature of human speech perception and the fact that decoding speech signals is a highly situated event: How one perceives speech signals is influenced by one’s perceptual experience on both long-term and short-term scales. They indicated that awareness of sublexical phonological components emerge early during spoken word perception, even when the holistic encoding tendency was simultaneously shaping subjects’ perceptual behaviors. The fact that language-specific knowledge was used to guide speech perception, and that impairments in working memory may have cascading effects on phonological processing also had practical implications for developing speech perception models and for researching phonological disorders, including that associated with congenital amusia.語音在大腦工作記憶中的轉碼是多樣的，因轉碼單元可以來自不同的語言層級，包括區別性特徵，亦包括詞語和句子。正因如此，語音轉碼發生在哪個層級，以及是否存在基本的感知單元是語音感知研究領域的兩個根本問題。已有研究表明聽者的語音處理機制會受到一系列因素的影響，例如注意力指向，語音和認知處理的需求，語言經驗，以及上下文中的音韻規則。然而，研究人員至今仍未就語音轉碼的基本單元及層級問題達成共識。探尋各種因素的相互作用以及語音感知單元的選擇機制可以讓我們更深入地瞭解人類語言能力的機制。實驗一利用語音類同效應及相關行爲數據,在語言和記憶的交界面進一步探究了以上問題。廣東話被試（對照組及有先天性失歌症組）按照指示回憶目標字在字串裏面的出現順序。結果表明語音相似度越高，目標詞的出現順序就越容易混淆。但不同於真詞，押韻可以有效提高假詞的回憶准確度。該對比說明，語音感知中轉碼單元的選取是受整體加工策略以及上下文中的音韻規則的交互所驅動的。鑒于高認知負荷可以消除語音類同效應，實驗一的結果也爲聲調語言處理中的負荷效應和語音類同效應的語言學基礎提供了經驗證據。通過對比被試的語音處理能力，本實驗進一步提出了工作記憶缺陷假說，將工作記憶的處理效力同失歌症患者的語言和非語言感知困難相聯系。實驗二進一步探究了規律感知的神經表徵，及被試是否能在整體加工的語音處理機制的影響下，形成亞詞水平的音韻覺識。該實驗控制了目標字和前行字串的一致性，並記錄了受試者在單模態詞語匹配任務中的腦波訊號。結果表明對上下文中的音韻規則處理可以影響早期的事件相關電位（N1和P2），並且P2也可以作爲聲調語言處理過程中語音加工負荷的電生理標志。因此，不同於早期的觀點，實驗二的結果表明N1和P2不僅能夠表徵低層的語音加工，例如對聲音訊號物理特性的感知，它們也能反映對上下文規律的提取。後者屬于更高層級的認知處理機制。綜合實驗一、二結果可見語音感知機制的複雜性，及其對情境（包括被試長期及短期語言經驗）的高度依賴性。兩實驗也表明盡管漢語母語者有較強的整體加工趨勢，在感知早期也可以形成亞詞結構意識。此外，實驗中觀察到的語言經驗的影響以及工作記憶缺陷可能帶來的級聯效應也對發展語音感知模型以及音韻處理障礙研究有實際指導意義。Wang, Xiao.Thesis M.Phil. Chinese University of Hong Kong 2017.Includes bibliographical references (leaves 95-103).Abstracts also in Chinese.Title from PDF title page (viewed on 12, February, 2020).Wang, Xiao
Cancer-testis antigen HCA587/MAGE-C2 interacts with BS69 and promotes its degradation in the ubiquitin-proteasome pathway
No full textHCA587, also known as MAGE-C2, belonging to the MAGE gene family which is characterized by a conserved MAGE Homology Domain, is active in various types of tumors and silent in normal tissues except in male germ-line cells. The biological function of HCA587 is largely unknown. To analyze it, we attempted to identify protein partners of HCA587. We immunopurified HCA587-containing complex from HEK293 cells and identified BS69, a potential tumor suppressor, as an associated protein by mass spectrometry, and the following Immunoprecipitation and GST pull-down assays confirmed HCA587 interaction with BS69. Interestingly, overexpression of HCA587 promoted ubiquitination and the proteasomal degradation of BS69 whereas knockdown of endogenous HCA587 increased the protein level of BS69. Consistent with a functional role for BS69 in negatively regulating LMP1-induced NF-kappa B activation, overexpression of HCA587 resulted in a significant enhancement of LMP1-induced IL-6 production. These data indicate that HCA587 is a new negative regulator of BS69. (C) 2014 Elsevier Inc. All rights reserved.Biochemistry & Molecular BiologyBiophysicsSCI(E)[email protected]
Environmental Protection or Development? Multiple Policy Effects Evaluation of the Resource Tax Collection Reform for Iron Ore Enterprises in China
No full textThe change from quantity-based taxation to price-based taxation of iron ore resources is an important measure for China to implement the goal of carbon peaking and carbon neutralization, and to achieve green economic recovery. To explore the policy’s effectiveness in playing its tax function, and improving the environment and production efficiency, this paper takes the reform of the method of resource tax collection as the “quasi natural experiment” object, and selects the balanced panel data of 16 provinces in China from 2011 to 2021. The double difference method is used to evaluate the policy effect of the reform of resource tax collection. The research shows that: (1) Changing the resource tax from a “volume-based tax” to an “ad valorem tax” can effectively increase the government’s resource tax revenue, and promote the upgrading of enterprise production technology. (2) The reform of resource tax collection will eliminate some small and medium-sized enterprises that are backward in production technology and bring more pollution to the environment. (3) The reform of resource tax collection mode will increase the number of large and medium-sized iron ore enterprises and promote the standardization of the whole iron ore industry
Study on the Integrated Model of Interfaces of Hub Project Based on Two Dimensional Frame
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Effect of coordination number of particle contact force on rutting resistance of asphalt mixture
No full textOptimizing asphalt mix design at the indoor stage is of significant importance for enhancing the rutting resistance of asphalt mixture, which is affected by its structural characteristics. In this work, the coordination number of particle contact force (CNpcf) was proposed as an indicator to represent contact characteristics of skeleton structure aggregates in asphalt mixture. Nine asphalt mixtures with different gradations were designed, and the relationship of CNpcf with the number of aggregate contact zones (CZ) was established by combining rutting tests and digital image processing technique (DIP). The Mann-Whitney U test was implemented to analyze the distribution properties of inter-particle contacts before and after the rutting test. In addition, the resistance to the further expansion of rutting was analyzed. The results revealed a significant positive correlation (PCCs = 0.843, R2 = 0.711) between CNpcf and CZ. The content of coarse aggregates in the dominant structure did not exhibit monotonic related to anti-rutting performance of the asphalt mixture. Therefore, an optimum aggregate content of 57% was utilized. The Mann-Whitney U test revealed that the mesoscale skeleton structure of the asphalt mixes before and after rutting exhibited excellent stability. This study further indicated the applicability of combining CNpcf to adjust the mix design to enhance the rutting resistance of asphalt mixture and to prevent rutting expansion in flexible pavement.Green Open Access added to TU Delft Institutional Repository ‘You share, we take care!’ – Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Pavement Engineerin
Study on electromagnetic propagation characteristics of two-layer media with CST software
No full textThe change in temporal trend and spatial distribution of CO<sub>2</sub> emissions of China's public and commercial buildings
No full textThe CO2 emission mitigation of the commercial and public building sector (P&C) is critical for achieving China's carbon peak and carbon neutrality. Analyzing changes in CO2 emissions and their driving factors from temporal and spatial perspective provides insights for developing equitable and effective decarbonization strategies. This study investigated the change in temporal trend and spatial distribution of CO2 emissions of China's P&C during period of 2005–2018 according to the Kaya identify and Gravity Center model. Meanwhile, combined with the Logarithmic Mean Divisia Index, this study proposed a decomposed method to identify the driving factor of the movement of the gravity center. The results showed that: 1) in the temporal dimension, China's P&C has still not achieved its CO2 emissions peak, arriving 820.68 MtCO2. The most positive and negative driving factors were per capita add value of tertiary industry and energy efficiency, respectively; 2) in the spatial dimension, during the 13th Five Year Plan period, the gravity center moved southwestward, and the most positive and negative driving factors were energy consumption unit area and energy efficiency, respectively; Besides, to accelerate the decarbonization of China's P&C, this study reviewed the main decarbonization strategies, divided them into six categories and provided policy implications. In summary, this study provides a completed assessment on CO2 emission changes of China's P&C, facilitating policy-makers to develop more reasonable implementation plans for emission mitigation.Green Open Access added to TU Delft Institutional Repository 'You share, we take care!' - Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Design & Construction Managemen
Effective contact texture region aware pavement skid resistance prediction via convolutional neural network
No full textThe surface texture of asphalt pavement has a significant effect on skid resistance performance. However, its contribution to the performance of skid resistance is non-homogeneous and subjects to local validity. There are also a few deep learning models that take into account the effective contact texture region. This paper proposes a convolutional neural network model based on the effective contact texture region, containing macro- and micro-scale awareness sub-modules. In this study, the asphalt mixture with varying gradations was designed to accurately obtain the effective contact texture region. Then, the textures were disentangled into macro- and micro-texture scales by applying the fast Fourier transform and fed into the model for training. Finally, the area of effective contact texture region was calculated, and the effective contact ratio parameter was then proposed using the triangulation algorithm. The results showed that the effective contact texture area of pavement varies by the asphalt mixture type. The effective contact ratio parameter exhibited a significant positive correlation (Pearson correlation coefficient is 0.901, R2= 0.8129) with skid resistance performance and was also influenced by key sieve aggregate content from 2.36 to 4.75 mm. The data of effective contact texture region following disentanglement significantly released the model performance (the relative error dropped to 1.81%). The model exhibited improved precision and performance, which can be utilized as an efficient, non-contact alternative method for skid resistance analysis.Green Open Access added to TU Delft Institutional Repository ‘You share, we take care!’ – Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Transport and Plannin
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