145,907 research outputs found
Review article: is non-alcoholic fatty liver disease a spectrum, or are steatosis and non-alcoholic steatohepatitis distinct conditions?
No full textBackground Non-alcoholic fatty liver disease (NAFLD) is currently conceptualised as a clinical spectrum that results from a 'multiple-hit' process which begins with simple steatosis and subsequently renders the hepatocytes susceptible to a variety of insults. Ultimately, more serious liver injuries like non-alcoholic steatohepatitis (NASH) and cirrhosis may develop. Although the metabolic syndrome is considered the crucial player in the pathogenesis of NAFLD, recent studies have highlighted novel pathophysiological mechanisms in this clinical entity. Aim To discuss the pathophysiology of NAFLD based on the hypothesis that simple steatosis and NASH are discrete entities rather than two points on a spectrum. Methods A literature search was conducted in August 2012 on PubMed, Ovid Embase, Ovid Medline and Scopus using the following search terms: steatosis, non-alcoholic steatohepatitis, pathophysiology, fatty liver, natural history and genetics. Results Simple steatosis and NASH appear as two distinct pathophysiological entities and progression from pure fatty liver to NASH appears to be so rare as to warrant publication. The possible pathogenetic pathways specifically related to NASH are highlighted. Conclusions Although simple steatosis and non-alcoholic steatohepatitis are currently viewed as two histological subtypes of the unique spectrum of non-alcoholic fatty liver disease, the two conditions are likely distinct not only from a histological but also from a pathophysiological standpoint. Efforts to distinguish simple steatosis from non-alcoholic steatohepatitis using non-invasive modalities should be informed by the current pathophysiology of these two clinical entities
Systematic review: caspase‐cleaved fragments of cytokeratin 18 – the promises and challenges of a biomarker for chronic liver disease
No full textP>Background Biomarkers hold great promise for detecting chronic liver disease without the use of liver biopsy. Aim To review the usefulness of cytokeratin (CK) 18 fragments, a marker of hepatocyte apoptosis, to predict the presence of chronic liver injury. Methods Available literature identified from PubMed was reviewed. Results Levels of CK18 fragments have been shown to be elevated in hepatocellular carcinoma, viral hepatitis, alcoholic hepatitis, nonalcoholic fatty liver disease and cholestatic liver disease. In the setting of nonalcoholic fatty liver disease, CK18 fragments may distinguish nonalcoholic steatohepatitis from simple fatty liver. Conclusions Undoubtedly, the most promising application of CK18 fragments is currently in nonalcoholic fatty liver disease, and especially for distinguishing patients with nonalcoholic steatohepatitis vs. those with simple steatosis. Further investigations and technical improvements are required to cross the boundary from research to the clinical application of CK18 fragments as a marker of chronic liver disease
The performance of the higher-order radiation condition method for the penetrable cylinder
No full textWe have considered the scattering of a plane wave by a penetrable acoustic circular cylinder. The boundary conditions are continuity of the total pressure and the total velocity. The wave speed and density of the target are different from that of the surrounding medium. We investigated the performance of higher-order SRCs up to L-4 operator in two dimensions. We assume that in the rectangular Cartesian system of axes, (x, y, z), the z axis coincides with the axis of the cylinder and an incident wave propagates in a direction perpendicular to the z axis. All the field quantities are then independent of z. Numerical results are added to present the change of the module of the total field and the magnitude of the far field with respect to theta. Copyright (c) 2007 Bulent Yilmaz
A step in the right direction! Critical assessment of forum selection agreements under the revised Brussels I: A comparative analysis with US law
No full textA step in the right direction! Critical assessment of forum selection agreements under the revised Brussels I: a comparative analysis with US law Youseph Farah and Anil Yilmaz-Vast…
Yilmaz Guney's Quick Files
No full textThe Quick Files feature was discontinued and it’s files were migrated into this Project on March 11, 2022. The file URL’s will still resolve properly, and the Quick Files logs are available in the Project’s Recent Activity
Yilmaz Güney y el cine turco o las contradicciones de un gran cineasta comprometido
No full textBasutçu, M. (1995). Yilmaz Güney y el cine turco o las contradicciones de un gran cineasta comprometido. Nosferatu. Revista de cine. (19):72-79. https://riunet.upv.es/handle/10251/40940.Importación Masiva72791
Is nonalcoholic fatty liver disease the hepatic expression of the metabolic syndrome?
No full textNonalcoholic fatty liver disease (NAFLD) is generally considered as the hepatic manifestation of the metabolic syndrome (MS). Although there is no doubt that NAFLD is tightly linked to the MS, the diagnosis of NAFLD encompasses a broad range of histological entities and as a composite phenotype may be hindering attempts to understand the mechanistic basis of these variants. The awareness that NAFLD is not solely and invariably associated with the MS is a useful means to help direct future studies. We should be aware that mechanisms other than insulin resistance may contribute to the chronic inflammatory processes that underpin the development of liver fat accumulation and the subsequent architectural distortion of the liver. Further studies with special focus on hemoglobin as a risk factor for the development of NAFLD in the absence of MS should be performed. © 2012 Baishideng. All rights reserved
Yilmaz Güney : le cinéaste révolté
No full textIl y a dix ans, Yilmaz Güney, le grand cinéaste kurde né en Turquie, est mort en exil à Paris, à l'âge de 47 ans. Il laisse derrière lui une vaste oeuvre cinématographique, témoignage poignant de la misère des paysans de son pays d'origine, mais aussi de leurs aspirations à la justice et au bonheur. Güney était l'exemple par excellence d'un artiste d'un certain type - l'artiste dont la vie et les convictions ne font qu'un avec son oeuvre. Son travail et sa vie sont aux antipodes de "l'object..
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