12 research outputs found
Perbedaan Kebutuhan Transfusi Darah Selama Fase Induksi pada Leukemia Limfoblastik Akut
No full textLatar belakang. Terapi transfusi adalah salah satu terapi kunci dalam pengelolaan kanker dan penyakit
darah pada anak. Hanya sedikit laporan tentang kuantitatif aspek transfusi sel darah merah dan trombosit
pada penyakit leukemia limfoblastik akut (LLA). Fase induksi sangat berbahaya pada terapi LLA, karena
sumsum tulang mengalami supresi yang diakibatkan oleh kemoterapi intensif. Fase induksi meliputi
pemberian obat-obat methotrexate, vincristine, L-asp, daunorubicin, dan kortikosteroid selama 6 minggu.
Protokol Indonesia 2006 terdiri dari 3 fase (induksi, konsolidasi, pemeliharaan) pada kelompok risiko standar
(standard risk/SR) dan ditambah fase re-induksi untuk kelompok risiko tinggi (high risk/HR).Kuantitas
transfusi dikaitkan dengan masalah efek samping dan biaya.
Tujuan. Menilai perbedaan kebutuhan transfusi darah pasien LLA risiko standar dan tinggi yang diterapi dengan Protokol Indonesia 2006.
Metode. Studi retrospektif dilakukan selama bulan Juli 2006 sampai Desember 2010 tentang kebutuhan transfusi selama fase induksi pada pasien baru LLA yang mendapat terapi dengan Protokol Indonesia 2006 di RS Dr Kariadi Semarang. Pasien diklasifikasikan menjadi kelompok risiko standar dan tinggi menurut kriteria NCI. Dibandingkan jumlah transfusi packed red cell(PRC) dan thrombocyte concentrate(TC) per luas permukaan tubuh (basal surface area/BSA).Analisis statistik menggunakan chi square(X2).
Hasil. Subyek 160 pasien, namun hanya 119 (74,3%) pasien yang dapat dievaluasi. Perbandingan kelompok
SR:HR 59,7:40,3. Rerata BSA pada kelumpok SR dan HR berturut turut 0,66 (SD±0,19)m2dan 0,77/m2 (SD±0,22), p<0,001. Selama fase induksi didapatkan rerata pemakaian PRC per pasien pada kelompok SR dan HR berturut turut 530 ml dan 420ml (p=0,79), pada TC 13 dan 11 unit (p= 0,19).Rasio penggunaan komponen PRC/BSA berturut turut untuk SR: HR 843:543 ml/m2untuk komponen TC 21:15 unit/m2.
Kesimpulan. Tidak terdapat perbedaan bermakna antara kebutuhan kelompok risiko standar dan tinggi terhadap
kebutuhan transfusi komponen darah PRC dan TC selama fase induksi
Event Free Survival Enam Bulan Kejadian Tumor Cachexia Syndrome pada Anak dengan Keganasan
No full textLatar belakang. Jumlah kasus kanker pada anak dengan komplikasi tumor cachexia syndrome (TCS) terus
meningkat. Penyebab TCS bersifat multifaktorial, yaitu asupan makanan yang kurang, malabsorbsi, dan
sitokin oleh tumor. Pengelolaan pasien anak dengan keganasan di rumah sakit tidak hanya dari terapi anti
kanker tetapi juga nutrisi. Nilai event free survival (EFS) terhadap kejadian TCS merupakan salah satu
indikator keberhasilan pengelolaan kanker di rumah sakit.
Tujuan. Menentukan EFS 6 bulan terhadap kejadian TCS pada pasien anak dengan keganasan.
Metode. Desain kohort retrospektif berdasarkan catatan medik pasien anak dengan keganasan yang dirawat
di RSUP Dr. Kariadi Semarang pada bulan Januari 2007 - Desember 2012. Kriteria inklusi adalah pasien
usia 0-14 tahun, dengan diagnosis keganasan baik tumor padat maupun hematologi, dan tidak mengalami
kakeksia pada saat diagnosis ditegakkan. Dilakukan pengamatan secara klinis dan laboratoris tiap bulan
selama 6 bulan untuk menentukan terjadinya TCS. Analisis statistik menggunakan uji Kaplan Meier.
Hasil. Didapatkan 83 subjek dengan keganasan, rerata umur pada kelompok tumor padat 61,2 (SD
48,37) bulan, dan keganasan hematologi 79,9 (SD 48,37) bulan p=0,032. Empatbelas dari 40 (35%) anak
tumor padat dan 10 dari 43(23,3%) anak dengan keganasan hematologi mengalami TCS. Kejadian TCS
didapatkan mulai pengamatan bulan kedua. Rerata terjadi TCS pada tumor padat 4,4 bulan dan pada
keganasan hematologi 4,9 bulan. Event free survival 6 bulan kejadian TCS pada tumor padat 65% dan
keganasan hematologi 76,7%, p= 0,207.
Kesimpulan. Event free survival 6 bulan kejadian TCS pada pasien tumor padat lebih rendah daripada
keganasan hematologi, tetapi tidak berbeda secara statisti
Pemeriksaan Bone Mineral Density dan Pelatihan Senam Osteoporosis sebagai Upaya Peningkatan Kewaspadaan Osteoporosis pada Penderita Talasemia Mayor
No full textThalassemia major patients with routine transfusions are at risk of experiencing iron overload and bone turn over disorders which will increase the risk of osteoporosis. Community training activities with BMD examinations and osteoporosis exercise training in thalassemia major patients are expected to identify the prevalence of bone fragility in thalassemia major patients, increase the awareness of thalassemia major patients and their families to the risk of osteoporosis in thalassemia major patients and osteoporosis exercise training as an effort to prevent osteroporosis. The results of BMD on the spine showed 57.1% osteoporosis, 28.6% normal and 14.3% osteopenia. The results of BMD examination on the cervical spine showed 71.4% osteopenia, 21.4% normal and 7.2% osteoporosis. The results of BMD examination on the femur found 50% normal, 42.8% osteopenia and 7.2% osteoporosis. The bone location with the highest percentage of osteoporosis was the spine (57%), and the bone location with the highest percentage of osteopenia was the neck bone (71.4%). The high percentage of osteopenia locations in the cervical spine of thalassemia major patients with repeated transfusions should be become a concern. Based on these findings, we held education and counselling on the risk of osteoporosis in thalassemia patients with repeated transfusions, osteoporosis exercise training and distribution of osteoporosis exercise compact disk (CD) for at home osteoporosis exercise training
Characteristics, attitudes, and the odds for positive attitude toward clinical trial: A study on Indonesian COVID-19 vaccine trial participants
No full textAims: This study was performed to understand the Indonesian population's characteristics and the factors that contribute to a more positive attitude toward participation in a clinical trial.
Methods: A cross-sectional survey was conducted involving 402 COVID-19 vaccine trial participants in Semarang, Indonesia, utilizing self-reporting questionnaires consisting of questions related to socio-demographic characteristics and statements in a 5-scaled Likert Scale to assess the attitude toward vaccine trial. The odds for positive attitude were analyzed using Ordinal Logistic Regression to obtain the odd-ratio and 95% confidence interval. The P < 0.05 was considered statistically significant.
Results: Most of the respondents were adults aged 22–64-year-old (89.30%), males (63.68%), married (77.61%), worked as an employee (59.70%), obtained information about the clinical trial from the Public Health Service (41.29%), had a low education level (40.80%), a low monthly income level (68.41%), with no previous participation in a clinical trial (90.80%). All respondents showed a good attitude toward the trial, with low education level, nonemployment status, fewer or no previous participation in clinical trials, and getting the information from the public health centers were the main predictors for better attitude toward vaccine trials.
Conclusion: There was a positive attitude toward vaccine trials in the Indonesian population. The positive attitude could be driven by having a low education level, nonemployment status, fewer or no previous participation in the clinical trial, and getting information from public health centers
Advancing access and equity: the vision of a new generation in cancer control
No full textWe must dramatically alter the current trajectory of cancer care to ensure that improvements are accessible by all in the global community. We must bridge the gap between what is achievable and what is accessible. We must act with urgency and precision, recognising the tremendous social and economic costs of inaction. The first priority should be to reframe cancer care. Second, we need to identify different measures of cancer outcomes. Third, we need to challenge extant priorities
The Global Retinoblastoma Outcome Study: a prospective, cluster-based analysis of 4064 patients from 149 countries
No full textBackground: Retinoblastoma is the most common intraocular cancer worldwide. There is some evidence to suggest that major differences exist in treatment outcomes for children with retinoblastoma from different regions, but these differences have not been assessed on a global scale. We aimed to report 3-year outcomes for children with retinoblastoma globally and to investigate factors associated with survival. Methods: We did a prospective cluster-based analysis of treatment-naive patients with retinoblastoma who were diagnosed between Jan 1, 2017, and Dec 31, 2017, then treated and followed up for 3 years. Patients were recruited from 260 specialised treatment centres worldwide. Data were obtained from participating centres on primary and additional treatments, duration of follow-up, metastasis, eye globe salvage, and survival outcome. We analysed time to death and time to enucleation with Cox regression models. Findings: The cohort included 4064 children from 149 countries. The median age at diagnosis was 23·2 months (IQR 11·0–36·5). Extraocular tumour spread (cT4 of the cTNMH classification) at diagnosis was reported in five (0·8%) of 636 children from high-income countries, 55 (5·4%) of 1027 children from upper-middle-income countries, 342 (19·7%) of 1738 children from lower-middle-income countries, and 196 (42·9%) of 457 children from low-income countries. Enucleation surgery was available for all children and intravenous chemotherapy was available for 4014 (98·8%) of 4064 children. The 3-year survival rate was 99·5% (95% CI 98·8–100·0) for children from high-income countries, 91·2% (89·5–93·0) for children from upper-middle-income countries, 80·3% (78·3–82·3) for children from lower-middle-income countries, and 57·3% (52·1–63·0) for children from low-income countries. On analysis, independent factors for worse survival were residence in low-income countries compared to high-income countries (hazard ratio 16·67; 95% CI 4·76–50·00), cT4 advanced tumour compared to cT1 (8·98; 4·44–18·18), and older age at diagnosis in children up to 3 years (1·38 per year; 1·23–1·56). For children aged 3–7 years, the mortality risk decreased slightly (p=0·0104 for the change in slope). Interpretation: This study, estimated to include approximately half of all new retinoblastoma cases worldwide in 2017, shows profound inequity in survival of children depending on the national income level of their country of residence. In high-income countries, death from retinoblastoma is rare, whereas in low-income countries estimated 3-year survival is just over 50%. Although essential treatments are available in nearly all countries, early diagnosis and treatment in low-income countries are key to improving survival outcomes. Funding: Queen Elizabeth Diamond Jubilee Trust. © 2022 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 licens
A personal COVID-19 dendritic cell vaccine made at point-of-care: Feasibility, safety, and antigen-specific cellular immune responses
No full textSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a world-wide pandemic. Internationally, because of availability, accessibility, and distribution issues, there is a need for additional vaccines. This study aimed to: establish the feasibility of personal dendritic cell vaccines to the SARS-CoV-2 spike protein, establish the safety of a single subcutaneous vaccine injection, and determine the antigen-specific immune response following vaccination. In Phase 1, 31 subjects were assigned to one of nine formulations of autologous dendritic cells and lymphocytes (DCL) incubated with 0.10, 0.33, or 1.0 µg of recombinant SARS-CoV-2 spike protein, and admixed with saline or 250 or 500 µg of granulocyte-macrophage colony-stimulating factor (GM-CSF) prior to injection, then assessed for safety and humoral response. In Phase 2, 145 subjects were randomized to one of three formulations defined by incubation with the same three quantities of spike protein without GM-CSF, then assessed for safety and cellular response. Vaccines were successfully manufactured for every subject at point-of-care. Approximately 46.4% of subjects had a grade 1 adverse event (AE); 6.5% had a grade 2 AE. Among 169 evaluable subjects, there were no acute allergic, grade 3 or 4, or serious AE. In Phase 1, anti-receptor binding domain antibodies were increased in 70% of subjects on day-28. In Phase 2, in the 127 subjects who did not have high levels of gamma interferon-producing cells at baseline, 94.4% had increased by day 14 and 96.8% by day 28. Point-of-care personal vaccine manufacturing was feasible. Further development of such subject-specific vaccines is warranted
0001
No full textTHE DAILY PALO AL~0 TIMES
MATRIMONY ON TRIAL
: If Unsuited,QuitIt,Advise8Mra.
Elsie Clews Parsons.
i BTABTLINQ BEFOBMS ADVOCATE]?
to Her *•*** Book Wl*> of U-*prraa->at-
Hti.r I'-rtmu *>•>»■ Thai YVctll-.rli
I* Xelthrr Sac-ran-cr-l Nor Pro^-irty
ItoldJa*-—Wamta llrlJr. IMorm-J.
IT WM 1 HT- Views of i 1-tk) men and OlOorta
11 WILL DC %^o Coadrmn Mr*. Parsons* Tba-
•*A Merry Christ ma*-." The New 017_wiT 0d« w*»s* rsvon li.
York Tribune believe*, that the next
four years are to see the greatest Try marriage, aud if the prospect is
-prosperity ln the history of this not bright for permanency break it
country—and it gives Ms reasons, off tn the absence of offspring, and
It Jus-ji!-** us in the belief that Ibis you ***H1 ■•-••*" no great degree of pub-
will be our "Merriest Christmas." »«- condemnation. If the experiment
Anyway we have prep-.red to make !»»***«■ successful, tbe bonds may be
merry as we have never done before,' continued for an Indefinite period.
and im ii-- our friends to look over
the choice Urn- nf thlr*s-s that we offer which arc the most oppro-frlat-*
for gift giving.
Weingartner <$- Co.
Prescription Druggists.
"Ml UNIVHRSITY AVTCNUE
•art**,** ■*.%»>>-to as^as<A*sie^asit^i^as*ka\
I
ELITE
MARKET
This rather striking view of matrimony Is taken by Mr*. Elsie Clews
Psrsous. wife of RepresenUtlve Herbert Parsons, chairman of the Republican county committee, snd daughter
of Henry Clews, banker. In a book entitled "The Family," say" -he New
York Herald.
No more radical declaration from tbe
pen of an author relating to matri-
mouy has been published. Mrs. Par-
sous favors tbe abolition of all laws
preventing recurrence of matrimonial
ventures and believes that remarriage
should be enrouraged. • One of the
must pointed paragraphs ln tbe coming
: if proved unsuccessful and, lu the nb-
*jI sence of offspring, without suffering
MEATS
I' any great degree of public condemna-
; tion."
Sirs. Parsons Is n doctor of philosophy and lectured for several year* on
-wdology In Barnard college. Her t>ook
Is really n lecture to elementary "tu-
f, .dents In sociology and Is Intended to
I All Put* Meet Products • „-Hsbt«n those who pursue a stud, of
9 sociological problems. It Is a fearless
CsrTT. I r* A R ¥*"• V £ treatise of a question at which tho
w cw. j. -w.#-i.r-.---.x m autnor MlMt tlmorwu dilettanti will
« ' look askance, bnt she recommends th*
Lsf ; Idea nevertheless lo home reading clr-
2 clos which are attended by young wo-
*-s**-,(**^(*T-'*K**m'em.1*^ mcn 0- coiicij-. age,
—---■ ■ -The dogma that marriage is on un-
j(*s*>'*'**Vi**V*fc*ViW'*^^ questlouahle sacrament" the author
•? declures, "and the dictum that It is
r
Telephone Main 35.
Hay, Grain,
Wood and Coal
Delivered at market rotes.
F. I,. WORRELL, Proprleta--r.
Corner Alms street and
LHamilton avenue, Palo, Alto.
Opposite Freight Depot i*?
s*nf*ns*ns* ns*ns*ns* ns*ns*ns*
r
HUDSON
The
Cp*to Dote
JEWELER
On The Circle
C Opposlt* tbs Depot
ft-*Ktaw,ta*a.ta ns*ns*nf*ns* nf* nf*n&
merely * survival of a past form of
0 property holding aro both sbnma.**
9 She farther state**:
' "If Individualism and oltrulsm or* to
•J- be reconciled In the view Hint child
1 bearing and rearing are tbe most Im-
-*: porta nt of all soclnl sen-Ices the doll sirabillty of change In many social re-
»■ latlous In and out of tbe family will
9 i bavii to be frankly faced nnd. If n**ces-
£ sary. new adaptations must be wal-
0 corned. Mlgbt It not t>e well to cm-
J uody In mnrrlogc licenses data about
■'tie- personul beallh nud character of
*- the bride and groom, likewise a e*r-
£ . tlflcate of tbe bride's previous training
0 In child care?
9: "Such a record would tie a partial
f- - proof of ihe matrimonial eligibility or
? . nonellglblllly of the license holder. A
favorable record would entitle the
holder to a place upon the matrimonial
white list In all civilisations divorce
Is Increasing. A large majority of dl-
voree-t nre obtained hy women. Legal
~0 ' causes for divorce t<-ud to multiply."
9 Mrs. Pamons, Intel-dine "Tbe Pom-
£ | lly" sb a text liook for students lu col-
e i leges, declares that "Inquiry, preaching
•» aud. for tb.nl matter, contempt breed
f j Ing knowledge nre dangerous debris
9 i choking up -rosslbic outlets for a stream
£ ' of pi*og~~e*~*!re and Inspiring moral the-
g ory." Mr*. Parsons believes that suc-
9 ' cessful child rearing Is an luiportaut
a • service to society. After showing that
9 > m*n and women bent upon marriage
£ | In tbe paBt gave no thought to society's
r ; wcirore the author says that she per-
9 celves a changing tendency in modern
f - time*.
[ "There are signs already," sbo an-
'' •jounces, "of the spread of the ld*a
' that tbe Individual I* bound to consider
' tbe effects upon society of his or her
i murrlnge. individuals tainted by «pl-
: lepsy. Insanity, Inebrlty, d*fluf-rautt-ism.
etc, are thought by many to be morally Ituilty !f they marry.
' "There Is a growing realisation of the
'■ cost to the state of reproduction by Its
I diseased or vicious subjects and a grow-
! Ing inclination to prevent these classes
i from reproducing themselve*.
j "If the biological knowledge of tbe
> future throws more light upon tbe
present day mysteries of heredity—
demonstrating tbe disastrous results of
ths making of those bondlrappcd by
minor as well as by more flagrant taints
or lacks—th* social obligations ln marriage will b* held more and more con-
YOUR CHRISTMAS TURKEY j «ldtrrable. The sodal demand for the
I* boond to lie a good one if Santn possession of progressive traits, -phys-
_ .. . .*. ,.,_ m. _, . k_, 1 leal, moral aad mental, as well as l*c*.
Clans gets It at the Lily Market but - rf ^^ ^ ^ Qf ^ j^
It wUl be an odvantage to yon to or-' tnd -.ag,.--*.,,, wIH „crt mon ano
dcr It In advance, as tbey may In* m0Tl, prtgsuro upon the Individual.
all gone before Sir SanU come* t» Eugenics, ss Profeasor Gatton sug
town. We hove them of all sixes; j goats, will become a religious dogma.
also choice *rec*e, ducks, chickens—i "Ths relation between married per-
ereryUUng in choice meats and poal- wns should t-e that -^J"1-1* tb*m
, •*"—"■» ^^ -~ ; fof tba-ir task or pareuthood. It should
try to make the best of Xmaa din*, ^ ^ ^^^ ,„ . „.,, d.„-opn)(IIll
. of their natures, for all their capsblll-
. ties shonld b* taxed in tb*tr roll of
parenthood It Is unfortunate that In
the emancipation of woman ngitntlon
of the past half century tbe refornwr*
railed to •mpti-ulss tb* social a* adequately ns the individual need of
cbnni*,-.
*T*mratbKi of maralag* ln tbe UfeUms
of tbs moi-riad persons sisms. to a
grsat extent, to lie dependent trpon It*
CITY MARKET
301 University Ave.
Phone Main 160
PISH EVERY FRIDAY
H. C. LAURIDSEN
Proprietor
form. Where monogamy prevails It
i- often accompanied by form* of
promiscuity or by readily obtained divorce. Polygamy satisfies, to a certain
extent, tbe desire for variety to which
transiency of relationship Is often due
"In this connection Sir John Lubbock make* in enlightening distinction
between lax and brittle marriage.
Where* nn cudurlug form of marriage
Is pi-escribed marriage tends to b* lax
—1. e„ polygamous ot accomplished by
promiscuity. Where se*-aratlon is more
or leas optional It tend* to be brittle,
"Incidentally let us note bete, la illustration of tbe brittle marriage, so
culled time and trial marriage*. In
time marriages n contract for marriage
for a stated time Is made. The time
may be for a fixed number of days
during thc week (part time marriage)
—this Is a lax rather than a brittle
arranger** en I—or for a stated continuous period. (Term marriage, bond
fasting.) At the end of the stated
perioJ the relation may or may not be
made j ,-ri....: en;. • • • Trial marriage
Is a variety uf time murrlnite. It belnt*
dlstluctly sfreed that tbe relationship
may be dlstolved at sny time"
Reside* advocating radical departures
lu the manner of contracting matrimonial toads, Mrs. Parsons pleads for
greater facility In severing them. Provision should be made by law for those
collide* who separate because of the
expiration of s time or trial marriage.
To this end is favored the abolition or
nil laws forbidding the remarriage of
divorced --eraons or those who hove
parted by mutual agreement.
The vole* of popular protest has been
quickly aroused agaln-*t the doctrine
of trinl marriage ns set forth In Mrs.
Herbert PlTSons' Imok. "The Family,"
'Here and iliere only c voice was raised
In favor of trial marriage as N-ing a
solctjou of the divorce problem.
Tlie Ilev. Mor-aiin Dlx. rector of Trinity church. In New- York, was outspoken ngnlnut trial marriage. He called It
■•nl-niHliiiiuli*" nnd "nu Imposition on
rivillied society."
"Tlie doclriaes set forth by Mrs. Parsons." he snld, "lire simply outrageous.
This Idea, if carried out. would place
civilized men and women In the same
position ns aulmnls, contracting for a
short time and sepiinttiug nl will to
form new alliance* nud leaving the
children to Im* nobody's children nud to
tie cured for by thu state. This would
be iMtrbiirlHin. It reverts back of man
to the beast
'The pro]i-Mlt1ou to reduce the number of children-and keep down the
progeny of married couples~*U also
mo*.t offensive and Is a menace to
rullty and the* stability of society,
consider Mrs. Parsons* theories outrageous aud will attack them wltb oil
the force In mo."
The Rev. Dr. Charles U. Parkhurst
of New York said he felt very much
alarmed because n woman of education and social ixwltlon should have
tnken It upon herself to assist lu
knocking down the bars tbat are falling fast enough as It Is.
"The fuinlly la the foundation or nil
our social, religious and political In'tl-
tutlons,** said Dr. Pst-khant "The
home Is tlie unit Anything which
tends to dlslutegrati* tbe home, which
tends to break the vital bond* of marriage. Is wholly bad. If you shake a
foundation stone, you may not bring
about the coIb|»se of tbe building, but
mauy cracks will api>ear In tbe walls.
"As to Mrs. Parsons' views on tho
remarriage of divorced persons, I can
soy I am partly In sympathy wltb bar.
I believe that where a woman haB Itccn
dlvoreed from nn erring husband she
should not lie punished by being forced
to remain single. Rut farther than
that I cannot go.
"The modern stage, the modern nov
el and other Indications of tbe popular
thought show there are many person*
who nre awaiting nn excuse to break
tbe conventions that society bas found
necessary to Impose. Anything that
will counteiioncc or appear to cotinte-
nnucc a rupture nf these conventions
Is Iiound to be seized upon by some of
these persons to their undoing. Such a
liook nt Mrs. Parsons lias written. *•
Ing from an authoritative source. Is
likely to tn-'t'iiie tin Instrument of evfl
In tlie manner I hnve indicated."
"That the Ideas set forth in Tho
Family.' by Mrs. Elsie Clews Parsons.
are acceptable to the members of the
women's clubs of Now York or other
cities of tbe United States must be set
aside as false." said Mrs. Dore Lyon,
honorary president of the City Federation of Women's Clubs. "So fnr from
that being the cos-*. It Is true that the
entire club world has striven to build
up (be status of woman throughout the
country, and thin Idea would mean the
tearing down of all we bare accomplished In that direction. The woman,
ln clubs, married or single, realizes, as
perhaps few others do. the Inherent ne-
co-i'lty of tbe faacredness of tbe nisr-
ringo tie and has fought for It and will
go ou fighting for It What Is this Idea
save an advocacy of tb* most on-
bridled license? It Is not only Immoral,
hut almost indecent, to sny nothing of
being widely Impracticable."
Mrs. Josrfa Ostorn of New York
ssld: "Trial marriages would probably
result In no more separation* than we
hav* now. and If such separation could
:>e effected quietly ond without public
scandal I bellev* it would be a very
rrTod thing for society,"
R*v. It He'-er Newton of New York
said: The recommendation of trial
marriage in the kind of iriiggestlon tbst
may be axp*cte<l from n person of academic mind who know* Unit- of real
Uf*. It Is n sngg-Mitlon that canuot bs
entertained for a moment try one wl
know* tbe world as it la It would bs
tbe legalli*atlon of llt-ertinlsm. We
sEnnld have nn unholy estate of matrimony, limited. The standing of 'JM
author-**-, alone make* tbe suggest >a
woT.*iv of comment. In Itself it
MORGANS ART TEMPLE
■*h».**i ns* ns* nf* ns* ns* ns*ns*ns* ns** ns* nf*ns* ns* ns*ns* ns* ns* ns* -a-t*
Features of tbe Financier's Costly Private Museum.
TO HOLD FRI0ELES8 TREA8U11EB
I ..iirrilim et Mr. Mor**-. S*M t* B«
Wortl! More Thai. a*""-. 1,1100,000—It*rr
nooks. Rare* and Tapoatrl** (iath-
rrcd From Cad* of E*svn*a—Woadrrs
ot thr Hokum.
The finishing touch to the Interior of
J. Plerpottt Morgan's private museum
of art was given recently by the lsylng
or 300,000 worth of oriental carpet*
lu ibe various rooms, says th* New
York World. Although the artisans
have ended their task, there.ls much
to t-e done before the museum will be
the remarkable thesaurus of art tbat
Its owner has designed. Wben Its purpose Is realized It will be the most
r*o*tly and artistically valuable private
n-.-emblage In the world of rare books,
piliitlugti of tbe old ond modern masters and antique manuscripts, tapestries and Scripture*. It Is estimated
by n friend familiar wltb Mr. Morgan's
inquisitions during the last decade tbat
his collection Is worth more than S20.-
000,000.
Itut many of these objects of art are
still in tbe conutrlr* of Europe where
tbey were ]>urehast*-d. and there tbey
'remain until the tariff laws are shnped
more to Mr, Morgan's view. Meantime
men are busy gathering from places
within tha duty lines the treasures tbat
are lo be stored lu his museum vaults,
hung upon It* walls or set upon Its
t-edetitals.
The building, which Is a model of
classic beauty, stands In East Tblrty-
slttfa street New York, a few yards
-.cross a lawn from the conservatory
of Mr. Morgan's home, which Is at tbe
rorner -jyf Madison nvenue. From his
: *:•■■ to the inuncum Mr. Morgan Is
n' '■• to go In stormy weather without
■ • thing the outer nlr. This Is accom-
II '■■*•! by nn underground passage that
: ■ U from a staircase In the conserva-
• »ry to the vaults tbat contain art
--,.'.,.-.., g.irnei-ed from tbe cndB of
Ihe .-*.-th.
" ::■ rsclts, made, of steel, nre In
• '.. -icuient. wblcnextends the entire
••h of the building. The celltog.
ir •heel vrlth moBonry. Is of good
he' hi, nnd the great spartment.
-'.iitiy cni-tit-h In a dim light can be
!e ebeerfnt ns day by electric 11-
'•• InatiOn. Hero arc stored portable
-ts tft-.i r-.ir.. and of value too great
- It I:ft lu the large open chambers
They are kept within the
•.I vaults except when their owner
ihei to hnve them brought ont for
• • r hlmseU or friends. There
i :i i>-..,.;'.i:t] miiiitiBCript of the Per-
| -i poet lunar Khayyam. On shelves
l .::.• vault are parchments covere-1
■*i the light, flowing strokes that de-
ite the oldest llrecl* manuscripts.
•:-vcr*l of them nre earlier than the
lrisllnn era. There are latin manu-
.-rlpls of tlie various periods— Roman
-.jiliiuc. Mcrovlir-itiu. I^mbardlan.Car
-*riSj|dan nnd G-dhlc, with Its nrtlfl
'.ally (sainted di-rar-ieia.
A massive dour swan-**, tho lights arc
-.yip-a, ami the vlnltor beholds Ilium!
I -"~.l mamiM-ript* tbat represent a for-
•:;■>. Etryptlnn pn|ior or screeds In tb.
B~***antinc styles. In other vsnlts ore
" -t-llsb or French parchments, with
".i^ir delicate tints of bine and green:
:i still others, ancient writings of Italy
and "Spain, wltb initial letters that de
pet animals and flowers ln bright col-
nrs nnd gold.
One of tbe rarest manuscripts of tht
..■ill.-eilon Is Chinese. It Is a thousand
-ratni old There Is no binding. Each
n**tMt Is detached. Tlie writing Is upon
blue paper. The characters are white.
On some of the shelves stand weir*'
figures corviKl In Ivory, ptnln for the
most part, but hen* uud there oue tbat
is known to tbe Greek antiquarian as
chryselephantine work. This Ib Ivory
overlaid with plates of gold. All along
the walla tlie vaults are ranged. On
one side there are priceless treasures
of paint und canvnss, works of tho old
masters. Some of these are to be
bong, but meet of Uiem wltl remain ln
thetr gloomy stronghold, to receive tbe
light ouly when some favored eye
wonld see.
Tbe main floor, tbe one entered from
ibe ntreet. ns the great bronze doom
open, has but one chamber on Its east
side. Tbls h thc library, u Is stocked
already with rare volnmns, bat there
are thousands more to como from over
seas, wben the tariff Is adjusted. At
present the shelves, which are of
bronze, rise only to n bright of six
fsot on all slues of the room. It Is Mr.
Morgan's plan to Increase tbe shelf
capacity as tbe Influx of books de
mnnds. All the volumes are -behind
glass, A ('obclln tapestry that coal
75,000 dc<- rates one wall above tbe
book shelves, and where the walls are
not covered they show a delicate buff.
The colling* nro of beautiful simplicity
In bloc snd green.
At the end of tho foyer there Is a
room devoted to books that by collcct-
ors ore regarded as some of the greatest prizes In the world. They are rarer
and lo other respects more valuable
than those In the main library. Many
books here are said to be worth s*
much as If each page were a ten dollai
hill, and they have three, sometime*
(ire hnndrcd pages
Aeror-i the foyer, westward from the
main library, a dour opens to tho red
room. Tbls In Mr. Morgnu's sanctum
It derives Its name from the walla,
which are covered with -raboased red
satin. A rwrtTalt of Mr. Morgan's r-i
ther hongs over a huge open flrepl*'*.*
Tbs room is t*nrnlsbed wltb snrl. u-
chalrs and tables set noon a Cbmo--
csrp-'t thai cos) | ft!
*• ns*ns*ns*^s*ns*ns* ns* ns*ns*ns&* ns* ns* ns* ns* ns* ns* ns* ns*ns* ns*
We '..ave just got in a
fresh supply of
Maine Corn
One of the best Sweet Corns
grown. Two cans
for a quarter
FULLER
& CO.
PHONE MAIN 61
c t*^e^*m^^e>n!*vr^*w« "... *Hf* 'WsvtfomW'nM -.« *.-. v.... v.*. v..
BasKet Perfumes
Fine Perfumes in elegant little Baskets.
Make nice work baskets after perfumes
are removed. Reasonable prices make
them desirable for small presents.
EAGLE DRUG CO.
Yellow
ajtsi front
PHONE^MAIN 36
t-v»^»^».l»*»*»'l.^M.«-SWW.O>-»«-a^-a»-a»-ai«-a;*-a^-al«-art>V* ?
Say.
We Have Lots of Things
To Sell
Can't sell unless you buy—to buy
you must come and see us. Once
here you are sure to buy, because
we make it your interest to do so.
Fine Butter and Eggs, and high
grade Coffee and Teas a specialty.
Earle & Company
Phone Main 37. 159 UnlvereltyAve.
Fashions and Fabrics
FOR MEN
The Latest Ideas Carefully Expressed
B. P. LAUSTEN
The Tailor
109 THE CIRCLE
Pacific Grove and Return.
Santa Cruz and Return.
Fare-and-a-thlrd for Round Trip.
Tlckou oa salt now aad will ce until Docr-niber 2Gih. Return limit
January 12th.
Holiday rata to all point, near by on sale December 2i. 23, 21,
IS, 23, 30, 31 and January 1.
Jteturn limit Jaouary 2.
A. A. HAPQOOD. AceDt. Palo Alto
E. SHILLINGGSBE.Ml, D. P. A„ Kan Jose.
For Sale
Just completed 8-room
house; all modern improvements; fine concrete base-
ment; lot 75x150 ft. Price
$3,700. Address
Box 14, Mountain View, CsL
PALO ALTO
Planing Hill
Wn. DEAN, Proprietor
Orrica: Corner High Street and
Cbonninp A**-emie.
Retinoblastoma in Asia: Clinical Presentation and Treatment Outcomes in 2112 Patients from 33 Countries
No full textPurpose: To describe the clinical presentation and treatment outcomes of children who received a diagnosis of retinoblastoma in 2017 throughout Asia. Design: Multinational, prospective study including treatment-naïve patients in Asia who received a diagnosis of retinoblastoma in 2017 and were followed up thereafter. Participants: A total of 2112 patients (2797 eyes) from 96 retinoblastoma treatment centers in 33 Asian countries. Interventions: Chemotherapy, radiotherapy, enucleation, and orbital exenteration. Main Outcome Measures: Enucleation and death. Results: Within the cohort, 1021 patients (48%) were from South Asia (SA), 503 patients (24%) were from East Asia (EA), 310 patients (15%) were from Southeast Asia (SEA), 218 patients (10%) were from West Asia (WA), and 60 patients (3%) were from Central Asia (CA). Mean age at presentation was 27 months (median, 23 months; range, < 1–261 months). The cohort included 1195 male patients (57%) and 917 female patients (43%). The most common presenting symptoms were leukocoria (72%) and strabismus (13%). Using the American Joint Committee on Cancer Staging Manual, Eighth Edition, classification, tumors were staged as cT1 (n = 441 [16%]), cT2 (n = 951 [34%]), cT3 (n = 1136 [41%]), cT4 (n = 267 [10%]), N1 (n = 48 [2%]), and M1 (n = 129 [6%]) at presentation. Retinoblastoma was treated with intravenous chemotherapy in 1450 eyes (52%) and 857 eyes (31%) underwent primary enucleation. Three-year Kaplan-Meier estimates for enucleation and death were 33% and 13% for CA, 18% and 4% for EA, 27% and 15% for SA, 32% and 22% for SEA, and 20% and 11% for WA (P < 0.0001 and P < 0.0001), respectively. Conclusions: At the conclusion of this study, significant heterogeneity was found in treatment outcomes of retinoblastoma among the regions of Asia. East Asia displayed better outcomes with higher rates of globe and life salvage, whereas Southeast Asia showed poorer outcomes compared with the rest of Asia. Financial Disclosure(s): The author(s) have no proprietary or commercial interest in any materials discussed in this article
The Global Retinoblastoma Outcome Study: a prospective, cluster-based analysis of 4064 patients from 149 countries
No full textBackground Retinoblastoma is the most common intraocular cancer worldwide. There is some evidence to suggest that major differences exist in treatment outcomes for children with retinoblastoma from different regions, but these differences have not been assessed on a global scale. We aimed to report 3-year outcomes for children with retinoblastoma globally and to investigate factors associated with survival. Methods We did a prospective cluster-based analysis of treatment-naive patients with retinoblastoma who were diagnosed between Jan 1,2017, and Dec 31,2017, then treated and followed up for 3 years. Patients were recruited from 260 specialised treatment centres worldwide. Data were obtained from participating centres on primary and additional treatments, duration of follow-up, metastasis, eye globe salvage, and survival outcome. We analysed time to death and time to enucleation with Cox regression models. Findings The cohort included 4064 children from 149 countries. The median age at diagnosis was 23.2 months (IQR 11.0-36.5). Extraocular tumour spread (cT4 of the cTNMH classification) at diagnosis was reported in five (0.8%) of 636 children from high-income countries, 55 (5.4%) of 1027 children from upper-middle-income countries, 342 (19. 7%) of 1738 children from lower-middle-income countries, and 196 (42.9%) of 457 children from low-income countries. Enudeation surgery was available for all children and intravenous chemotherapy was available for 4014 (98.8%) of 4064 children. The 3-year survival rate was 99.5% (95% CI 98.8-100.0) for children from high-income countries, 91.2% (89.5-93.0) for children from upper-middle-income countries, 80.3% (78.3-82.3) for children from lower-middle-income countries, and 57.3% (524-63-0) for children from low-income countries. On analysis, independent factors for worse survival were residence in low-income countries compared to high-income countries (hazard ratio 16.67; 95% CI 4.76-50.00), cT4 advanced tumour compared to cT1 (8.98; 4.44-18.18), and older age at diagnosis in children up to 3 years (1.38 per year; 1.23-1.56). For children aged 3-7 years, the mortality risk decreased slightly (p=0.0104 for the change in slope). Interpretation This study, estimated to include approximately half of all new retinoblastoma cases worldwide in 2017, shows profound inequity in survival of children depending on the national income level of their country of residence. In high-income countries, death from retinoblastoma is rare, whereas in low-income countries estimated 3-year survival is just over 50%. Although essential treatments are available in nearly all countries, early diagnosis and treatment in low-income countries are key to improving survival outcomes. Copyright (C) 2022 The Author(s). Published by Elsevier Ltd.Y
