1,721,004 research outputs found
Abstract 482: miRNAs involved in LY6K and estrogen receptor-α contribute to tamoxifen susceptibility in breast cancer
No full textAbstract
Estrogen receptor-alpha is a clinically important therapeutic target for breast cancer. However, tumors that lose ERα are less responsive to anti-estrogens such as tamoxifen. MicroRNAs are small RNAs that regulate expression of their target gene and dysregulations of miRNA has been identified in many diseases including human cancer. However, only a few miRNAs associated with tamoxifen resistance has been reported. In this study, we found that lymphocyte antigen 6 complex, which is a member of the Ly-6/μPAR superfamily and related to breast cancer progression and metastasis, is inversely correlated with ERα expression. We, for the first time, found miRNAs involved in the regulatory molecular mechanism between ERα and LY6K and related to tamoxifen susceptibility in breast cancer. miR-192-5p, induced by LY6K, downregulates ERα directly and induced tamoxifen resistance in ERα-positive breast cancer cells. In addition, re-expression of ERα in ERα-negative breast cancer cells increased miR-500a-3p expression and directly inhibits LY6K expression. Ectopic expression of miR-500a-3p sensitized ERα-negative cells to tamoxifen by increasing apoptosis. Finally, we observed an inverse correlation between LY6K and ERα in primary breast cancer samples. We found that patients with recurrence showed high expression of miR-192-5p after tamoxifen treatments. In addition, expression of miR-500a-3p was significantly correlated to survival outcome. As miRNAs involved in the regulatory mechanism between LY6K and ERα can affect tamoxifen resistance, downregulating miR-192-5p or re-expressing miR-500a-3p could be a potential therapeutic approach for treating tamoxifen resistant patients.
Citation Format: Yesol Kim, Dasom Son, Kyung Hyun Yoo, Jong Hoon Park. miRNAs involved in LY6K and estrogen receptor-α contribute to tamoxifen susceptibility in breast cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2017; 2017 Apr 1-5; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2017;77(13 Suppl):Abstract nr 482. doi:10.1158/1538-7445.AM2017-482</jats:p
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
대한해협 저층냉수의 유입에 미치는조석의 영향에 관한 수치실험
Full text linkThe Korea Strait Bottom Cold Water (KSBCW) indicates lower than 10 ℃ of sea water observed in the Western Channel of the Korea Strait. The intrusion of KSBCW is maximum in Summer (August or September) and second maximum in Winter (December or January). However, its mechanism and origin is not revealed yet.
This study investigates mechanisms of KSBCW intrusion using 3-dimensional high resolution ocean circulation model and focuses on effects of tides. ROMS(Regional Ocean Model System 3.4 version) is used for ocean model and study area covers the Korea Strait and part of East Sea, 126.9-132°E and 33.3-36.5°N.
Two experimental cases(considering tides or not) were compared. It could be seen that results from experiment involving tides showed better agreement with the observed temperature and velocity. Tides act to enhance the intrusion of KSBCW.
Additionally, we study main factors to simulate KSBCW intrusion in numerical ocean model. Firstly, we find semi-diurnal constituents (M2, S2) play important role in generating the intrusion of KSBCW. Because the amplitude of semi-diurnal tidal waves are larger than diurnal tidal wave(K1, O1), deep and cold water in the Ulleung Basin can flow into the Korea Strait. Secondly, numerical models need to exhibit bathymetry of the western channel trough to simulate KSBCW intrusion, which is associated with the resolution of model. After the cold waters in the Ulleung Basin cross over the Korea Strait shelf break, it flows along the Western Channel bottom slope.1. 서 론
2. 모델 및 입력자료
2.1 모델개요
2.2 입력자료
3. 결 과
3.1 모델 검증
3.1.1 모델 안정화
3.1.2 조석 검증
3.1.3 조류 검증
3.2 대한해협 수온 및 유속에 미치는 조석의 효과
3.2.1 수평 수온 분포
3.2.2 연직 수온 분포
3.2.3 연직 유속 분포
3.3 저층냉수 유입에 미치는 주요 요인
3.3.1 주요 분조별 영향
3.3.2 지형효과
3.3.3 모델 해상도
4. 결 론
참고문
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
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