102,501 research outputs found
Circadian modulation on T-wave alternans activity in chronic heart failure patients
No full textConference paper: Computing in Cardiology 2015; 42:845-848. Alba Martín-Yebra, Enrico G Caiani, Pablo Laguna, Violeta Monasterio, Juan Pablo Martíne
Most HIV type 1 non-B infections in the Spanish cohort of antiretroviral treatment-naïve HIV-infected patients (CoRIS) are due to recombinant viruses
No full textYebra, G., De Mulder, M., Martín, L., Rodríguez, C., Labarga, P., Viciana, I., Berenguer, J., Alemán, M.R., Pineda, J.A., García, F., Holguín, Á
Sensitivity of seven HIV subtyping tools differs among subtypes/recombinants in the Spanish cohort of naïve HIV-infected patients (CoRIS)
No full textYebra, G., de Mulder, M., Martín, L., Pérez-Cachafeiro, S., Rodríguez, C., Labarga, P., García, F., Tural, C., Jaén, À., Navarro, G., Holguín, Á
SORBITOL SYNTHESIS FROM A LACTOBACILLUS CASEI FOOD-GRADE STRAIN USING METABOLIC ENGINEERING
No full textSorbitol is a sugar alcohol that is assumed to have important physiological properties for human health. It could replace high-calorie sugars such as glucose, lactose or sucrose in food products with equivalent sweetness and taste. The synthesis of sorbitol in situ during fermentation of dairy products may result in a good strategy to obtain fermented products with extra health-promoting value. A food-grade recombinant strain of Lactobacillus casei (BL232) was constructed by the integration of a D-Sorbitol-6-phosphate dehydrogenase-encoding gene (gutF) in the chromosomal lactose operon. gutF expression followed the same regulation as that of the lac genes, that is, repressed by glucose and induced by lactose. BL232 cells were induced with lactose, and using 13C-nuclear magnetic resonance analysis, sorbitol was detected by addition of glucose to resting cells. Inactivation of the L-lactate dehydrogenase gene in BL232 led to higher sorbitol production, suggesting that the novel route provides an alternative pathway for NAD+ regeneration. Since sorbitol is not absorbed in the small intestine, it could reach the colon and there it could selectively stimulate the multiplication or activity of beneficial bacteria. Results showing the influence of sorbitol on the intestinal microbiota of rats will be presente
Evaluation of Cardiac Circadian Rhythm Deconditioning Induced by 5-to-60 Days of Head-Down Bed Rest
No full textHead-down tilt (HDT) bed rest elicits changes in cardiac circadian rhythms, generating possible adverse health outcomes such as increased arrhythmic risk. Our aim was to study the impact of HDT duration on the circadian rhythms of heart beat (RR) and ventricular repolarization (QTend) duration intervals from 24-h Holter ECG recordings acquired in 63 subjects during six different HDT bed rest campaigns of different duration (two 5-day, two 21-day, and two 60-day). Circadian rhythms of RR and QTend intervals series were evaluated by Cosinor analysis, resulting in a value of midline (MESOR), oscillation amplitude (OA) and acrophase (φ). In addition, the QTc (with Bazett correction) was computed, and day-time, night-time, maximum and minimum RR, QTend and QTc intervals were calculated. Statistical analysis was conducted, comparing: (1) the effects at 5 (HDT5), 21 (HDT21) and 58 (HDT58) days of HDT with baseline (PRE); (2) trends in recovery period at post-HDT epochs (R) in 5-day, 21-day, and 60-day HDT separately vs. PRE; (3) differences at R + 0 due to bed rest duration; (4) changes between the last HDT acquisition and the respective R + 0 in 5-day, 21-day, and 60-day HDT. During HDT, major changes were observed at HDT5, with increased RR and QTend intervals’ MESOR, mostly related to day-time lengthening and increased minima, while the QTc shortened. Afterward, a progressive trend toward baseline values was observed with HDT progression. Additionally, the φ anticipated, and the OA was reduced during HDT, decreasing system’s ability to react to incoming stimuli. Consequently, the restoration of the orthostatic position elicited the shortening of RR and QTend intervals together with QTc prolongation, notwithstanding the period spent in HDT. However, the magnitude of post-HDT changes, as well as the difference between the last HDT day and R + 0, showed a trend to increase with increasing HDT duration, and 5/7 days were not sufficient for recovering after 60-day HDT. Additionally, the φ postponed and the OA significantly increased at R + 0 compared to PRE after 5-day and 60-day HDT, possibly increasing the arrhythmic risk. These results provide evidence that continuous monitoring of astronauts’ circadian rhythms, and further investigations on possible measures for counteracting the observed modifications, will be key for future missions including long periods of weightlessness and gravity transitions, for preserving astronauts’ health and mission success
Report of the ICES Working Group on Zooplankton Ecology 2012. Málaga (Spain), 26-29/03/2012.
No full textThe ICES Working Group on Zooplankton Ecology (WGZE) met at the University of
Málaga, Spain from 26 to 29 March 2012. The meeting was hosted by Dr. Lidia Yebra
of the Instituto Español de Oceanografia (IEO) and chaired by Piotr Margonski. It
was attended by 32 scientists representing 13 nations. The objective of the meeting
was to discuss and address the 13 terms of reference (ToRs) and to exchange information on recent activities in zooplankton ecology.
The specific task for the 2012 meeting was to exchange information of mutual concern
and to discuss future collaborative plan with Working Group on Phytoplankton and
Microbial Ecology (WGPME). Both groups agreed on cooperation during the preparation and further development of the Zooplankton and the Phytoplankton and Microbial Plankton Status Reports (ToRs c and d). Moreover, both groups
recommended the joint workshop on synthesis of hydrographic, phytoplankton, microbial plankton and zooplankton time series to be held in late 2013..
Bibliographie Hilarion G. Petzold 1958 – 2009 mit Anhang als Einführung
No full textDieses Archiv enthält die Gesamtbibliographie der Werke des Autors nebst einiger Texte „Über H. G. Petzold“ im Schlussteil der Bibliographie sowie einen Anhang mit einer Einführung in die Architektur des Werkes in seinem wissenslogischen Aufbau als Ausarbeitung seines „Tree of Science Modells“ (2007).This archive contains the complete bibliography of the author and some texts about H. G. Petzold, moreover an epilogue with an introduction to the architecture of the works in its epistemological structure and composition and as an elaborations of Petzold’s „Tree of Science Modell (2007).https://www.fpi-publikation.de/polyloge/01-2009-petzold-h-g-gesamtbibliographie-h-g-petzold-1958-2009-updating-november2009/peerReviewedpublishedVersio
Dispelling the Myths Behind First-author Citation Counts
No full textWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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3346: Samuel G. Freedman, author, 2013
No full textPhotograph of author Samuel G. Freedman, at NT Daily Slash meeting in the Mayborn School of Journalism at UNT
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