1,721,062 research outputs found
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Clinical and biological impact of targeted therapies in digestive oncology : application in metastatic colorectal cancer
No full textLe traitement médical du cancer colorectal a connu ces dernières années d'importantes avancées avec l'arrivée notamment des thérapies ciblées anti-angiogéniques et anti-EGFR. Néanmoins ces molécules ne bénéficient pas à tous les patients et il est à ce jour impossible de bien individualiser leur utilisation. Mon travail de thèse s'est donc intéressé à d'une part à identifier de nouveaux facteurs prédictifs de réponse en particulier au bévacizumab, d'autre part à rechercher et antagoniser de nouvelles cibles ou des mécanismes participant à la résistance aux molécules disponibles notamment pour les patients non répondeurs aux anti-EGFR. Premièrement, nous avons montré que le sorafenib améliorait l'activité anti-tumorale de l'irinotecan in vitro et in vivo sur des lignées cellulaires de cancer du colon rendues résistantes au SN38 indépendamment de leur statut K-ras. Pour expliquer ce phénomène, nous avons mis en évidence que le sorafenib inhibait la pompe d'efflux ABCG2 et favorisait l'accumulation intra-cellulaire de l'irinotecan et donc sa cytotoxicité. De plus, nous avons vérifié la faisabilité d'une telle association chez l'homme et confirmé son efficacité chez des patients K-ras mutés lourdement prétraités. Deuxièmement, nous avons développé un nouveau score radiologique objectif combinant l'évolution de la taille et la densité tumorale normalisée à celle du foie qui pourrait être utilisé comme marqueur de substitution pour déterminer précocément les bons répondeurs à une chimiothérapie à base de bevacizumab chez des patients présentant des métastases hépatiques.The medical treatment of colorectal cancer has made significant progresses in recent years including the arrival of targeted therapies: anti-angiogenic and anti-EGFR. However, these molecules don't benefit all patients and their use is not well personalized. My thesis is therefore aimed, on one hand, to identify new predictors of response especially to bevacizumab and, on the other hand, to find and antagonize new targets or mechanisms involved in chemo-resistance, especially for K-ras mutated patients. Firstly, we have showed that sorafenib improved the anti-tumoral activity of irinotecan, both in vitro and in vivo, in SN-38 resistant colon adenocarcinoma cell lines independently of their K-ras status. To explain this phenomenon, we have demonstrated that sorafenib inhibited the efflux pump ABCG2 and promoted the intracellular accumulation of irinotecan and thus its cytotoxicity. In addition, we have checked the feasibility of such an association in human and confirmed its efficacy in K-ras mutated heavily pretreated patients. Secondly, we have developed a new objective radiological score combining both tumor size and density normalized to the liver that could be used as objective surrogate markers to determine early good responders after bevacizumab-containing chemotherapy in patients with colorectal liver metastases
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Get PDFWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
Author Under Sail The Imagination of Jack London, 1893-1902
No full textIn Author Under Sail, Jay Williams offers the first complete literary biography of Jack London as a professional writer engaged in the labor of writing. It examines the authorial imagination in London's work, the use of imagination in both his fiction and nonfiction, and the ways he defined imagination in the creative process in his business dealings with his publishers, editors, and agents. In this first volume of a two-volume biography, Williams traverses the years 1893 to 1902, from London's "Story of a Typhoon" to The People of the Abyss. The Jack London who emerges in the pages of Author Under Sail is a writer whose partnership with publishers, most notably his productive alliance with George Brett of Macmillan, was one of the most formative in American literary history. London pioneered many author models during the heyday of realism and naturalism, blurring the boundaries of these popular genres by focusing on absorption and theatricality and the representation of the seen and unseen. London created an impassioned, sincere, and extremely personal realism unlike that of other American writers of the time. Author Under Sail is a literary tour de force that reveals the full range of London as writer, creative citizen, and entrepreneur at the same time it sheds light on the maverick side of machine-age literature.Intro -- Title Page -- Copyright Page -- Dedication -- Contents -- Acknowledgments -- Introduction -- 1. Spirit Truth -- 2. From Absorption to Theatricality and Back Again -- 3. "I Will Build a New Present" -- 4. Sons as Authors -- 5. Fathers as Publishers -- 6. The Daughter as Author -- 7. Lovers as Authors -- 8. At Sea with the Family -- 9. Yellow News, Yellow Stories -- 10. The Return Home -- Notes -- Bibliography -- Index -- About Jay WilliamsIn Author Under Sail, Jay Williams offers the first complete literary biography of Jack London as a professional writer engaged in the labor of writing. It examines the authorial imagination in London's work, the use of imagination in both his fiction and nonfiction, and the ways he defined imagination in the creative process in his business dealings with his publishers, editors, and agents. In this first volume of a two-volume biography, Williams traverses the years 1893 to 1902, from London's "Story of a Typhoon" to The People of the Abyss. The Jack London who emerges in the pages of Author Under Sail is a writer whose partnership with publishers, most notably his productive alliance with George Brett of Macmillan, was one of the most formative in American literary history. London pioneered many author models during the heyday of realism and naturalism, blurring the boundaries of these popular genres by focusing on absorption and theatricality and the representation of the seen and unseen. London created an impassioned, sincere, and extremely personal realism unlike that of other American writers of the time. Author Under Sail is a literary tour de force that reveals the full range of London as writer, creative citizen, and entrepreneur at the same time it sheds light on the maverick side of machine-age literature.Description based on publisher supplied metadata and other sources.Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, YYYY. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries
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