40,427 research outputs found
A Study of the Classical Landscape at the Wang River Villa of Wang Wei
No full textThe landscape of Wang Wei's Wang River Villa is examined by reviewing the essays and papers written about the poetical collaboration, the “Wang River Collection.” The purpose of this paper is to clarify the meaning of villa architecture in China. The author expects that this research will contribute to a mutual understanding between cultures. The villa was a Utopia for Wang. On the other hand, he was a pious Buddhist and Buddhistic concepts are reflected in the landscape. I consider the features of the classical landscape of Xie Lingyun and "Chu Ci," as written in “The Collection,” a reflection of the Buddhistic concept. When considering what the classics meant to Wang Wei, it is apparent that his villa is a representation of the classical landscape. It is not an imitation of the classical landscape, but a unique and original creation of art by Wang.departmental bulletin pape
First person – Yihua Wang
No full textFirst Person is a series of interviews with the first authors of a selection of papers published in Journal of Cell Science, helping early-career researchers promote themselves alongside their papers. Yihua Wang is the first author on ‘Nuclear entry and export of FIH are mediated by HIF1α and exportin1, respectively’, published in Journal of Cell Science. Yihua is a Lecturer in Biological Sciences at the University of Southampton, studying cell signalling in lung fibrosis and cancer, drug target validation and gene function analysis
Using Ensemble Streamflow Forecasts to Inform Seasonal Outlooks for Water Allocations in the Murray Darling Basin
No full textAbstract not availableTristan D. J. Graham, Quan J. Wang, Yating Tang, Andrew Western, Wenyan Wu, Guy Ortlipp, Mark Bailey, Senlin Zhou, Kirsti Hakala, and Qichun Yan
Ultra-high-sensitivity refractive index sensor based on dual-microfiber coupler structure with the Vernier effect
No full textWe demonstrate a novel, to the best of our knowledge, refractive index (RI) sensor based on the Vernier effect in dual-microfiber coupler (MFC) structures. The sensor sensitivity was studied both theoretically and experimentally. The numerical results show that by tracing the wavelength shifts of the envelope formed by the Vernier effect, the sensitivity can be improved by several times compared to that obtained for normal coupler-based sensors. In this Letter, two MFCs with a width and free spectral range (FSR) of ~3.5µm and 6 nm, respectively, were fabricated. Based on the sensitivity of 5820 nm/RIU for a single coupler, we experimentally achieved an ultra-high sensitivity of 126,540 nm/RIU using dual MFCs by the Vernier effect in the RI range of 1.3350 to 1.3455, which shows good agreement with numerical simulations. The proposed all-fiber RI sensor has the advantages of high sensitivity and low cost and can find applications in chemical and biological detection as well as electronic/magnetic field measurement
Role of WD domain-containing proteins in cell cycle progression
No full textIn the eukaryotic proteome, WD domain is one of the most abundant protein motifs. The structure of WD domain allows it to interact with diverse protein partners and proteins containing WD domain have been shown to function in various cellular processes. In this thesis, I describe how two WD domain-containing proteins, LRWD1/ORCA and RFWD3, regulate different aspects of cell cycle progression.
In eukaryotic cells, the duplication of the genome starts from the loading of a six-subunit complex, Origin Recognition Complex (ORC), onto replication origins on the chromosome. The loading of ORC triggers the assembly of the pre-replicative complex (pre-RC) at origins, which licensed the origins prior to entering S phase. Unlike yeast, replication origins in higher eukaryotes do not have consensus sequence and metazoan ORC does not bind to DNA in a specific manner. Thus, a long-standing question in the field has been, how are origins specified and how are ORCs recruited to origins? Studies suggest that ORC loading may be facilitate by ORC-associated proteins. LRWD1/ORCA is an ORC-associated protein that stabilizes ORC on chromatin. We have previously characterized ORCA’s role in replication initiation and heterochromatin organization. In Chapter 2, I describe my work to map the binding sites of ORCA genome-wide by ChIP- seq method at specific time points of G1. ORCA associates with chromatin in a dynamic manner and ORCA binding regions are enriched for heterochromatic marks, including H3K9me3 and methylated-CpGs. ORCA co-localizes with a subset of origins that are enriched for repressive marks, consistent with the fact that these origins replicate late during S phase. Further, ORCA directly associates with the repressive marks and interacts with the enzymes that catalyze these marks. ORCA regulates the level of H3K9me3 and methylated-CpG at its binding sites, suggesting a role of ORCA in maintaining the repressive chromatin marks at its binding sites. Importantly, repressive marks are required for ORCA’s association on chromatin. I propose that ORCA localizes to a subset of origins by association with repressive marks and recruits the enzymes to maintain the repressive chromatin environment.
In Chapter 3, I focus on another WD domain containing protein, RFWD3, and describe how RFWD3 regulates cell cycle progression. Unlike previous studies that described how RFWD3 regulates DNA damage response, I focus on how RFWD3 regulate unperturbed cell cycle progression. I show that RFWD3 is required for proper cell cycle progression. Depletion of RFWD3 causes S phase defects including slower replication fork progression and prolonged S phase. There is also increased loading of replication fork proteins on S phase chromatin in the absence of RFWD3, potentially due to stalled replication fork. RFWD3 associates with the replication fork component, PCNA, via a PIP box motif. I purpose that RFWD3 localizes to replication fork by interacting with PCNA and regulate proper replication fork progression.
In Chapter 4, I summarize my findings on the regulation of DNA replication, chromatin organization and S phase progression. I also discussed interesting areas of research that my work has opened up.Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2019-08-01The student, Yating Wang, accepted the attached license on 2017-07-07 at 10:35.The student, Yating Wang, submitted this Dissertation for approval on 2017-07-07 at 10:47.This Dissertation was approved for publication on 2017-07-09 at 16:22.DSpace SAF Submission Ingestion Package generated from Vireo submission #11332 on 2017-09-29 at 11:14:35Made available in DSpace on 2017-09-29T16:39:20Z (GMT). No. of bitstreams: 2
WANG-DISSERTATION-2017.pdf: 2379470 bytes, checksum: 8df5906ffa8dfc73ce9ad20d8705e304 (MD5)
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Supporting the research process through expanded library data services
No full textPurpose – The purpose of this paper is to describe how the authors gained a better understanding of the variety of library users' data needs, and how gradually some new data services were established based on current capabilities.Design/methodology/approach – This paper uses a case study of the new data services at the John Cotton Dana Library, at Rutgers, The State University of New Jersey, Newark campus, to demonstrate the possible ways to extend data reference services and provide data computing services. A content analysis of services records shows how each user group falls into the multiple data services levels and subcategories.Findings – Library users can be classified into many different categories, and each of these may have different needs. Research centers might have big projects involving data gathering and applications where a librarian can mainly provide consultation; while an individual faculty member or student might need the librarians as research partners, with help for their specific problems. Computing data services can involve group training and statistical analysis assistance, where researchers need emergent help. Data librarians can take various opportunities for data management education, thereby gradually raising awareness and cultivating better research habits among researchers.Originality/value – Library data computing services can make unique contributions to faculty and students' research and study. Institution, library and users' interaction determines the levels and extent of data services and is generalized from the description and analysis of typical data service examples. Classic concept of data services levels is applied to a concrete case of data services program, and sub-categories of each data services level and user types are developed based on the authors' services record.This article is (c) Emerald Group Publishing and permission has been granted for this version to appear here at the RUcore: Rutgers University Community Repository . Emerald does not grant permission for this article to be further copied/distributed or hosted elsewhere without the express permission from Emerald Group Publishing Limited.Peer reviewe
The supporting information for Spatial Changes of Late Quaternary Slip Rates along the Gyaring Co Fault: Implications for Strain Partitioning and Deformation Modes in Central Tibet
No full textAuthor: Wang Duo, Hong Chang, Gongming Yin, Fei Han, Zebin Mao, Jinhua Du Wenjun Zheng and Xulong Wang
Corresponding author: Xulong Wang ([email protected])
Contents of this file
Text S1
Figures S1 to S3
Table S1
Introduction
The supporting information including sampling, pretreatments, all details of Optically Stimulated Luminescence (OSL) dating and collected rates and ages along strike-slip and normal faults in central Tibet.
Text S1 shows detailed OSL dating processing and analysis procedures.
Figures S1, S2 and S3 show OSL dating details at Kong Co, Aruo and Nacha site, respectively.
Table S1 shows the rates and ages of strike-slip and normal faults and their corresponding references in central Tibet
The supporting information for Spatial Changes of Late Quaternary Slip Rates along the Gyaring Co Fault: Implications for Strain Partitioning and Deformation Modes in Central Tibet
No full textAuthor: Wang Duo, Hong Chang, Gongming Yin, Fei Han, Zebin Mao, Jinhua Du Wenjun Zheng and Xulong Wang
Corresponding author: Xulong Wang ([email protected])
Contents of this file
Text S1
Figures S1 to S3
Table S1
Introduction
The supporting information including sampling, pretreatments, all details of Optically Stimulated Luminescence (OSL) dating and collected rates and ages along strike-slip and normal faults in central Tibet.
Text S1 shows detailed OSL dating processing and analysis procedures.
Figures S1, S2 and S3 show OSL dating details at Kong Co, Aruo and Nacha site, respectively.
Table S1 shows the rates and ages of strike-slip and normal faults and their corresponding references in central Tibet
The Supporting Information for Spatial Changes in Late Quaternary Slip Rates along the Gyaring Co Fault: Implications for Strain Partitioning and Deformation Modes in Central Tibet
No full textAuthor: Wang Duo, Hong Chang, Gongming Yin, Fei Han, Zebin Mao, Jinhua Du Wenjun Zheng and Xulong Wang
Corresponding author: Xulong Wang ([email protected])
Contents of this file
Text S1
Figures S1 to S3
Table S1
Introduction
The supporting information including sampling, pretreatments, all details of Optically Stimulated Luminescence (OSL) dating and collected rates and ages along strike-slip and normal faults in central Tibet.
Text S1 shows detailed OSL dating processing and analysis procedures.
Figures S1, S2 and S3 show OSL dating details at Kong Co, Aruo and Nacha site, respectively.
Table S1 shows the rates and ages of strike-slip and normal faults and their corresponding references in central Tibet
Serving the Future E-Science Researchers: Library Computing Data Services for Graduate Students on the Rutgers Newark Campus
No full textThis article was published in Synergy: News from ARL Diversity Programs, Issue 7, and can be accessed at http://www.arl.org/bm~doc/synergy1011.pd
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