3,139 research outputs found
Information systems auditing and computer fraud / Yap May Lin
No full text"EDP auditing is defined as the process of collecting and evaluating evidence to determine whether a computer system safeguards assets, maintains data integrity, achieves organizational goals effectively, and consumes resources efficiently. " [Weber, 1988]. The issue of computer fraud has been given a considerable amount of space in most books devoted to the subject of EDP or Information Systems (IS) auditing. Studies have shown that the monetary amounts
misappropriated in the average fraud involving EDP or IS
substantially exceed the corresponding monetary amounts in the average fraud situation that does not involve automated services. Hence, the subsequent establishment or expansion of existing IS audit departments by management primarily as a defense against material fraud. The purpose of this paper is to focus on two issues. One, the occurrence of computer fraud in the IT environment, and secondly, IS auditing as a deterrent to discourage the commission of fraud
IT auditing in institutes of higher learning / Jasber Kaur Gian Singh and Yap May Lin
No full textInformation technology (IT) has become an essential tool for businesses in performing daily operations and processes. Realizing this fact, business practitioners must make sure that business information transmitted via the IT medium is kept confidential with the integrity and availability of information resources being well preserved (Posthumus & von Solms, 2004), Numerous threats and vulnerabilities exposed in using IT have posed concerns over issues like confidentiality, integrity and availability. One way to ensure that business information retains its value is through the conduct of IT auditing. The same scenario of the pervasiveness of IT may be witnessed in the education sector where the traditional classroom teaching and learning process is not only strongly supported by IT tools but in the case of electronic learning (e-learning), vast amounts of IT tools coupled with Internet technology are used to facilitate and enhance the learning process. And, just as in the business sector, there is the need for IT audit in the academic sector as academic institutions increasingly employ the use of IT to carry out its organization processes. Literature in the area of IT audit in academic institutions, particularly in Malaysia, is very scarce despite intensive IT advancement in this sector. A study on IT audit practice in Malaysian institutes of higher learning (IHLs) was conducted. This paper reports on the study which was conducted to determine IT audit practices in the IHLs, focusing on those with MSC status located within the Klang Valley region. The primary data was collected through the use of questionnaires in interviews as well as distributed to IT personnel from each IHL A five-point Likert scale (of very significant, significant, moderate, least significant and not significant) was also used in this questionnaire to determine factors influencing the use of IT audit. Out of 29 IHLs, 15 questionnaires were collected and analyzed. The results of the study indicated that the level of IT auditing in IHL is satisfactory (71%) with most of the respondents reporting positively to conducting IT audit in their premises, either annually or bi-annually, and with a few even practicing compliancy to some standards. This study further determines some influential factors in IT audit implementation in IHLs. Findings from the study indicate that the significant factors are (from most to least significant): IT infrastructure, system performance, security support, organization compliance and top management support
Perceived successfulness of e-learning curriculum development / Yap May Lin, Noor Habibah Arshad, Mohd. Aliff Sarjani
No full textE-learning may become one of the most prominent technology enabler of providing education to the masses. However, if its curriculum is inadequately planned and poorly managed, Institutions of Higher Learning (IHLs) may require some re-engineering to make it right and in doing so, tie up management resources. This study seeks to determine the perceived successfulness of e-learning curriculum development in the Malaysian environment from the perspectives of the learner, instructor and institution, respectively. Six factors (needs analysis, collaborative development, consistency and standardization, attention to the delivery mode, expertise, and training support) associated with curriculum development are used for this determination. The primary data for this study was collected by means of a questionnaire survey conducted among 14 Malaysian private and public IHLs. Returned questionnaires totaled 140 from institutions, 145 from instructors and 180 from learners. Findings from the survey indicate that, from the perspectives of the learner, instructor and institution, all six factors exhibit significant association with the level of perceived successfulness in e-learning curriculum development. Through the findings, IHLs would be better able to focus on strengthening some crucial aspects of curriculum development that would contribute to a better planned e-learning curriculum
Inhibitors Targeting YAP in Gastric Cancer: Current Status and Future Perspectives
No full textJiaxin Yong, Yuan Li, Sihan Lin, Zhenning Wang, Yan Xu Department of Surgical Oncology and General Surgery, Key Laboratory of Precision Diagnosis and Treatment of Gastrointestinal Tumors, Ministry of Education, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning Province, 110001, People’s Republic of ChinaCorrespondence: Zhenning Wang; Yan XuDepartment of Surgical Oncology and General Surgery, Key Laboratory of Precision Diagnosis and Treatment of Gastrointestinal Tumors, Ministry of Education, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning Province, 110001, People’s Republic of ChinaEmail [email protected]; [email protected]: Gastric cancer (GC) is one of the most common cancers globally, threatening global health. The deregulation of the Hippo signaling pathway has been discovered in GC and may be related to cancer development, proliferation, metastasis, and drug resistance. Yes-associated protein (YAP), as a downstream effector of the Hippo signaling pathway and a crucial co-transcription factor in the nucleus, is a promising and vital potential drug target for the treatment of GC. A series of drugs or compounds that inhibit YAP has been developed or confirmed. Therefore, this review will focus on summarizing the drugs and small-molecule inhibitors that have been reported to inhibit YAP and discuss the clinical prospects of YAP inhibitors in GC.Keywords: gastric adenocarcinoma, Yes-associated protein, Hippo pathway, small molecule inhibitor, targeted therap
Investigating the extent of information technology usage in Malaysian batik industry / Yap May Lin, Yap Bee Wah and Jasber Kaur Gian Singh
No full textIn this new information technology era, business enterprises in Malaysia should capitalize on the use of information technology (IT) to gain competitive advantage
and bring their businesses to the global forefront. This paper discusses the extent of IT usage in the Malaysian Batik Industry. A survey study involving eleven batik
companies in the Klang Valley was carried out. Information was also gathered via interviews with four related organization. Survey results indicated that communication via telephone is still the major mode of communication with
suppliers, producers and customers Payment by cheque is still the most favored mode of payment and very few batik companies provide online payment facilities. Only four batik companies have set up their own websites. The services they wish to add to their websites are shopping cart, online payment and immediate credit card validation
services. The main benefits they gain from their websites are faster and more efficient communication with customers while the two main problems they face are funding and lack of expertise in their company to maintain the website. Results of this study also show that improved sales, profitability, competitive position and recognition of
market brand are significantly correlated with the batik company commitment to using IT in their business
Investigating the extent of Information Technology (IT) usage in Malaysian Batik industry / Yap May Lin, Yap Bee Wah and Jasber Kaur Gian Singh
No full textIn this new information technology era, business enterprises in Malaysia should capitalize on the use of information technology (IT) to gain the competitive advantage and bring their businesses to the global forefront. The recent advancement of information technology enables a community network portal to provide faster and more efficient communication, dissemination of information and business transactionsfor organizations. This paper discusses the extent of IT usage in the Malaysian Batik Industry and then proposes a community net portal (CNP) reference model for the Malaysian batik industry
Appropriate Similarity Measures for Author Cocitation Analysis
No full textWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
William E. Hoy, letter to Mr. Ralph Elliot Lin Weber, July 8, 1943, with envelope and newspaper articles
No full textThis letter was sent from William E. Hoy to Mr. Ralph Elliot Lin Weber and is dated July 8, 1943. The letter recounts information about the only baseball game where Hoy, a deaf athlete, was at-bat against Taylor, also a deaf athlete. Mentioned in the letter is a typewritten play by play of the same game, copied from the Enquirer of May 17, 1902. Also included is an envelope and newspaper articles. The envelope, from International League Information, is addressed to Ralph E Lin Weber and has handwritten lists of players of N.Y. and Cincinnati. The newspaper articles are from the Dayton Daily News and the Cincinnati Enquirer and feature pictures of William E. Hoy, the author of the letter
Activated platelets and antibody opsonization as tumor markers: novel avenues for cancer diagnosis, targeted therapy and monitoring therapeutic outcomes
No full text© 2018 Dr. May Lin YapWith over 100 types of cancer known, the study presented in this thesis introduces novel means of targeting a wide range of cancers, rather than a specific cancer antigen. Here, unique cancer targets, such as components of the tumor microenvironment and monoclonal antibody opsonization are investigated as new approaches for cancer diagnosis and targeted therapy. The first part of the study investigates the possibility of targeting activated platelets in the tumor microenvironment as a novel cancer diagnostic target. I showed the feasibility of using a single-chain antibody, which targets the activated form of GPIIb/IIIa, the most abundant platelet-specific receptor on the platelet surface as a possible tool for cancer diagnosis using PET/CT, fluorescence imaging and ultrasound. The second part of the investigation aims to further expand the utility of the single-chain antibody as an antibody-drug conjugate for cancer therapy. Using a mouse metastasis model of triple negative breast cancer, I showed that the activated platelet targeting single-chain antibody, conjugated to Auristatin E, a clinically available chemotherapy agent, was successful in reducing tumor growth and preventing metastasis development. The final part of the thesis describes the development of an FcγRIIIa receptor dimer, which has been engineered to selectively bind avidly to multimeric Fc complexes. This binding mimics the engagement of FcγRIIIa on effector cells, such as on NK cells, with antibody-coated cells that leads to antibody-mediated target killing. Here, using a mouse xenograft model of B cell lymphoma treated with Rituximab and triple negative breast cancer adenocarcinoma, treated with an EGFR receptor antibody, I show that the FcγRIIIa receptor dimer, labeled with a near-infrared contrast agent, could be used to specifically image antibody opsonization of tumor cells in vivo
YAP Regulates the Expression of Hoxa1 and Hoxc13 in Mouse and Human Oral and Skin Epithelial Tissues
No full textYes-associated protein (YAP) is a Hippo signaling transcriptional coactivator that plays pivotal roles in stem cell proliferation, organ size control, and tumor development. The downstream targets of YAP have been shown to be highly context dependent. In this study, we used the embryonic mouse tooth germ as a tool to search for the downstream targets of YAP in ectoderm-derived tissues. Yap deficiency in the dental epithelium resulted in a small tooth germ with reduced epithelial cell proliferation. We compared the gene expression profiles of embryonic day 14.5 (E14.5) Yap conditional knockout and YAP transgenic mouse tooth germs using transcriptome sequencing (RNA-Seq) and further confirmed the differentially expressed genes using real-time PCR and in situ hybridization. We found that YAP regulates the expression of Hoxa1 and Hoxc13 in oral and dental epithelial tissues as well as in the epidermis of skin during embryonic and adult stages. Sphere formation assay suggested that Hoxa1 and Hoxc13 are functionally involved in YAP-regulated epithelial progenitor cell proliferation, and chromatin immunoprecipitation (ChIP) assay implies that YAP may regulate Hoxa1 and Hoxc13 expression through TEAD transcription factors. These results provide mechanistic insights into abnormal YAP activities in mice and humans.Biochemistry & Molecular BiologyCell BiologySCI(E)[email protected]
- …
