5,309 research outputs found
Vacuum Insulation Panels Applied in Building Constructions
No full textDue to sustainability and due to international treaties, it is desired and required to reduce greenhouse gas emissions drastically. One contributor to these emissions is the burning of fossil fuels for generating power and electricity to be used in and for buildings. Buildings and building-related processes are responsible for about 40% of the primary energy consumption in the European Union. More than half of this energy is applied for heating systems in dwellings and commercial buildings. The European Union therefore has laid down new energy performance requirements for buildings in the European Directive on the Energy Performance of Buildings. Moreover, a reduction of energy losses of buildings during their occupational phase is important for facilitating the implementation of sustainable energy sources in the built environment. Increasing the insulation value of the envelope of buildings may contribute to this reduction of primary energy use. Two strategies can be followed. The first strategy is to increase the thickness of the thermal insulation layer. Until recently, this strategy has primarily been adopted. If, however, German or Swiss Passivhaus standard is applied, the thickness of this insulation layer would increase to beyond 30 cm, resulting in very thick building enclosures. The second, more innovative, strategy for reducing energy losses through the building skin would be the application of more effective thermal insulators. One such more effective thermal insulator is a vacuum insulation panel, abbreviated as VIP. A VIP consists of an open-celled core material which is evacuated and then tightly sealed into a barrier envelope to maintain this vacuum. The vacuum inside the pores of the core material reduces the thermal conductivity of the product significantly, as a result of which the thickness of the insulation layer can be reduced to obtain a certain performance. This reduction of thickness is among the most promising features for large-scale application of VIPs in the building industry. However, integration of VIPs into buildings must be performed very meticulously for several reasons; first, due to its nature a VIP cannot be processed on site and needs careful planning in advance; second, it is very sensitive to mechanical damage thus requiring careful handling; third, thermal bridges along the panel’s edges reduce its performance; fourth, the composite system is highly subjected to aging. This dissertation therefore looks into many of these aspects, presents several calculation tools and shows how VIPs can be applied in façade panels, EPS insulation boards and as under-floor insulation. With the wide-spread proliferation of VIPs in buildings a more sustainable and healthy environment can then be achieved.Building TechnologyArchitectur
YAP regulates an SGK1/mTORC1/SREBP-dependent lipogenic program to support proliferation and tissue growth
No full textadditional pages e1-e8The coordinated regulation of growth control and metabolic pathways is required to meet the energetic and biosynthetic demands associated with proliferation. Emerging evidence suggests that the Hippo pathway effector Yes-associated protein 1 (YAP) reprograms cellular metabolism to meet the anabolic demands of growth, although the mechanisms involved are poorly understood. Here, we demonstrate that YAP co-opts the sterol regulatory element-binding protein (SREBP)-dependent lipogenic program to facilitate proliferation and tissue growth. Mechanistically, YAP stimulates de novo lipogenesis via mechanistic target of rapamcyin (mTOR) complex 1 (mTORC1) signaling and subsequent activation of SREBP. Importantly, YAP-dependent regulation of serum- and glucocorticoid-regulated kinase 1 (SGK1) is required to activate mTORC1/SREBP and stimulate de novo lipogenesis. We also find that the SREBP target genes fatty acid synthase (FASN) and stearoyl-CoA desaturase (SCD) are conditionally required to support YAP-dependent proliferation and tissue growth. These studies reveal that de novo lipogenesis is a metabolic vulnerability that can be targeted to disrupt YAP-dependent proliferation and tissue growth.Srimayee Vaidyanathan, Talhah M. Salmi, Rasan M. Sathiqu, MalcolmJ.McConville, AndrewG.Cox, Kristin K. Brow
Book Review: Reginald M.J. Oduor’s Introduction to Ethics
No full textTITLE OF BOOK: Introduction to Ethics
AUTHOR: Reginald M.J. Oduor
Nairobi: Sophia Publications Ltd., 2009, 116 pages
COVER: Paperback
ISBN: 9966-7457-0-X
This book is a product of more than a decade of Oduor’s experience in teaching ethics (moral philosophy) at the University of Nairobi. In the course of this introduction, the reader gets to see the techniques of philosophic reflection in action, as they are employed to scrutinise various pertinent moral questions
Targeting the YAP/TAZ pathway in uveal and conjunctival melanoma with verteporfin
No full textPURPOSE. The purpose of this study was to determine whether YAP/TAZ activation in uveal melanoma (UM) and the susceptibility of melanoma cell lines to YAP/TAZ inhibition by verteporfin (VP) is related to the tumor's genetic background.METHODS. Characteristics of 144 patients with enucleated UM were analyzed together with mRNA expression levels of YAP/TAZ-related genes (80 patients from the The Cancer Genome Atlas [TCGA] project and 64 patients from Leiden, The Netherlands). VP was administered to cell lines 92.1, OMM1, Mel270, XMP46, and MM28 (UM), CRMM1 and CRMM2 (conjunctival melanoma), and OCM3 (cutaneous melanoma). Viability, growth speed, and expression of YAP1-related proteins were assessed.RESULTS. In TCGA data, high expression of YAP1 and WWTR1 correlated with the presence of monosomy 3 (P = 0.009 and P < 0.001, respectively) and BAP1-loss (P = 0.003 and P = 0.001, respectively) in the primary UM; metastasis development correlated with higher expression of YAP1 (P = 0.05) and WWTR1 (P = 0.003). In Leiden data, downstream transcription factor TEAD4 was increased in cases with M3/BAP1-loss (P = 0.002 and P = 0.006) and related to metastasis (P = 0.004). UM cell lines 92.1, OMM1, and Mel270 (GNAQ/11-mutation, BAP1-positive) and the fast-growing cell line OCM3 (BRAF-mutation) showed decreased proliferation after exposure to VP. Two slow-growing UM cell lines XMP46 and MM28 (GNAQ/11-mutation, BAP1-negative) were not sensitive to VP, and neither were the two conjunctival melanoma cell lines (BRAF/NRAS-mutation).CONCLUSIONS. High risk UM showed an increased expression of YAP/TAZ-related genes. Although most UM cell lines responded in vitro to VP, BAP1-negative and conjunctival melanoma cell lines did not. Not only the mutational background, but also cell growth rate is an important predictor of response to YAP/TAZ inhibition by VP.Ophthalmic researc
Numerical analysis of the radial force produced by the Medtronic-CoreValve and Edwards-SAPIEN after transcatheter aortic valve implantation (TAVI)
No full textA better understanding of the mechanisms producing the radial force in transcatheter heart valves is essential in order to reduce the reported cases of migration and atrio-ventricular block and improve the effectiveness of the treatment. This paper presents a numerical study of the different mechanisms responsible for the radial force exerted on the aortic annulus by self-expanding and balloon-expandable prostheses. The behavior of the Medtronic CoreValve (self-expanding) and the Edwards SAPIEN (balloon-expandable) devices, both of size 26, has been simulated and compared. The results indicate that, for both prostheses, the radial force may vary considerably within the recommended functional range for the valve implantation and is substantially higher at the smallest annular sizes. In particular, in the case of the self-expanding valve the radial force is essentially dependent on the diameter of the left ventricular outflow tract, while for the balloon-expandable valve the radial force produced is influenced by both the geometry and stiffness of the host tissue. The outcomes of this study provide a better insight into the phenomenon and useful information that could support the development of improved solutions. © 2012 IPEM
Comments on “Precipitation kinetics of Al–1.12Mg2Si–0.35Si and Al–1.07Mg2Si–0.33Cu alloys”
No full textIt is shown that in analysing DSC data of precipitation reactions in Al–1.12Mg2Si–0.35Si, Al–1.07Mg2Si–0.33Cu and Al–1.0Mg2Si–0.5Ag alloys in work by Gaber et al., accurate values for the activation energies are obtained by applying the method derived by the present author (the Type B-1.92 method). Values obtained from other analysis methods reported by Gaber et al. are less accurate. Averaging activation energies obtained by different methods introduces inaccuracies and obscures these inaccuracies, especially if the set of methods applied includes highly inaccurate ones, such as the Ozawa and Takhor methods
Optical Flow Based State Estimation for an Indoor Micro Aerial Vehicle
No full textThis work addresses the problem of indoor state estimation for autonomous flying vehicles with an optic flow approach. The paper discusses a sensor configuration using six optic flow sensors of the computer mouse type augmented by a three-axis accelerometer to estimate velocity, rotation, attitude and viewing distances. It is shown that the problem is locally observable for a moving vehicle. A Kalman filter is used to extract these states from the sensor data. The resulting approach is tested in a simulation environment evaluating the performance of three Kalman filter algorithms under various noise conditions. Finally, a prototype of the sensor hardware has been built and tested in a laboratory setup. Paper published: Verveld, M.J., Chu, Q.P., De Wagter, C. and Mulder, J.A. “Optic Flow Based State Estimation for an Indoor Micro Air Vehicle” AIAA Guidance, Navigation, and Control Conference, August 2010, Toronto, Canada AIAA 2010-8209, DOI: 10.2514/6.2010-8209Aerospace EngineeringControl & Simulatio
Transient time-averaged spectra of rapidly-modulated semiconductor lasers
No full textUsing the computed solution of multimode rate equations, and including wavelength-chirping effects via the dependence of the refractive index on carrier concentration, it is possible to calculate time-averaged spectra of rapidly-modulated lasers. The averaging time may be used to simulate the effects of measuring equipment with a specific time response. The results show a characteristic line structure within the dominant longitudinal mode spectrum, and are in qualitative agreement with experimental measurements reported by other author
Gift inscription in Minions of the Moon: a little book of song and story
No full textThis edition includes a gift inscription possibly penned by the author, Madison Julius Cawein, "Frank on Valentines Day, 1914. M.J." Madison Julius Cawein (1865-1914).Cawein, Madison Julius, 1865-1914
Cooling and heating rate dependence of precipitation in an Al-Cu alloy
No full textDifferential scanning calorimetry and X-ray diffraction were used to study the cooling and heating rate dependence of precipitation in an Al-1.66 at.% Cu alloy. After homogenizing, cooling at a rate of 22 K min?1 (SC22) is sufficient to retain all copper in solid solution. GP-zone formation during subsequent heat treatment is hindered; this is ascribed to an insufficient number of (excess) vacancies. After a water quench (WQ) a large number of GP zones are formed during subsequent storage at room temperature for 1 h. The heat content of the GP-zone dissolution effect can quantitatively be described in terms of the heat of precipitation of GP I zones and the solid solubilities as derived from the GP I zone solvus. The heat content of the combined ??-/?-phase precipitation effect appeared to be proportional to the number of copper atoms precipitated, yielding an average value for the heat of copper precipitation of 36 kJ mol?1 copper. The activation energy for ??-phase formation is 0.75 eV for SC22 specimens and 1.10 ± 0.10 eV for WQ specimens. The differences in reported activation energies for ??-phase formation are discussed in terms of mobility of dissolve atoms (related to the vacancy concentration), interfacial energy and direction of growth (normal or perpendicular to the ??-phase plate)
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