416 research outputs found
Author response image 1. Author response
No full textAnkyrin adaptors together with their spectrin partners coordinate diverse ion channels and cell adhesion molecules within plasma membrane domains and thereby promote physiological activities including fast signaling in the heart and nervous system. Ankyrins specifically bind to numerous membrane targets through their 24 ankyrin repeats (ANK repeats), although the mechanism for the facile and independent evolution of these interactions has not been resolved. Here we report the structures of ANK repeats in complex with an inhibitory segment from the C-terminal regulatory domain and with a sodium channel Nav1.2 peptide, respectively, showing that the extended, extremely conserved inner groove spanning the entire ANK repeat solenoid contains multiple target binding sites capable of accommodating target proteins with very diverse sequences via combinatorial usage of these sites. These structures establish a framework for understanding the evolution of ankyrins' membrane targets, with implications for other proteins containing extended ANK repeat domains.</p
Digital Phenotyping of Sensation Seeking: A Machine Learning Approach Using Gait Analysis
No full textSensation seeking represents a significant risk factor for various mental health disorders and maladaptive behaviors, highlighting the need for objective assessment methods that circumvent the limitations of traditional self-report measures. This study introduces an innovative digital phenotyping approach that combines computational gait analysis with machine learning (ML) to quantify sensation-seeking traits and examines its validity. Natural gait sequences (using a Sony camera at 25 FPS) and self-report measures (Brief Sensation-Seeking Scale for Chinese, BSSS-C) were collected from 233 healthy adults. Computer vision processing through OpenPose extracted 25 skeletal keypoints, which were subsequently transformed into a hip-centered coordinate system and denoised using Gaussian filtering. From these kinematic data, 300 temporospatial gait features capturing various aspects of movement dynamics were derived. Using a supervised ML approach with feature selection, three ML models (SMO Regression, Multilayer Perceptron, and Bagging) were developed and compared through 10-fold cross-validation. The SMO Regression model demonstrated superior performance (r = 0.60, MAE = 3.50, RMSE = 4.59, R2 = 0.26), outperforming the other approaches. These results establish proof-of-concept for gait-based digital phenotyping of sensation seeking, offering a scalable, objective assessment paradigm with potential applications in clinical screening and behavioral research. The methodological framework presented here advances the field of behavioral biometrics by demonstrating how computer vision and ML can transform basic movement patterns into meaningful psychological indicators
Fluid Inclusion Re‐equilibration in Carbonate Rock Caused by Freezing during Microthermometric Analysis
No full text
Analysis on the Transition of Resource-based Rural Land Use in the Context of Rural Revitalization: A Case Study of Taolingou Village, Yangquan City, Shanxi Province
No full textThe key to the transformation of resource-based rural economy lies in the land use transition, which has important theoretical and practical significance for the reconstruction of rural values and the promotion of rural revitalization. Taking Taolingou Village in Yangquan City, Shanxi Province as an example, on the basis of expounding the concept and connotation of land use transition, this paper analyzes the evolution trend of resource-based rural land use transition, explores the driving force of resource-based rural land use transition and clearly puts forward the measures to strengthen the transformation of resource-based rural land use in the context of rural revitalization. The analysis shows that the land use of Taolingou Village is transforming towards the trend of sustainability, putting people first and multi-function, which is consistent with the strategic goal of rural revitalization; The driving force of land use transition in Taolingou Village includes four aspects, namely, industrial structure, economic factors, development policy and contradiction between human and land; Adjusting and optimizing the industrial structure, protecting the ecological environment, perfecting relevant policies and regulations, and controlling the overall population are the effective measures for Taolingou Village to realize the land use transition. This case study is expected to provide a useful reference for the land use transition in other resource-based rural areas
Ji yu jin chang sheng xue xuan fu de zi yun xing he zi fu dong er wei zhi dong qi
No full textM.Phil.Acoustic radiation force in the near-field of a vibrating source can be utilized to lift and transport objects, which provides a non-contact driving technology in addition to maglev. This research presents a novel self-running planar motion stage utilizing near-field acoustic transportation phenomenon and coupled resonant vibration of the device.Finite element analysis models have been established to find the needed resonant modes and optimize the design of the structure. The first longitudinal and the second bending modes are designed to have an identical frequency to create elliptical vibration of the structure, which can provide vertical levitation force as well as the propulsion force. A dynamic model based on the Reynolds Equation has been established to study the levitation and driving mechanism of the proposed device. The levitation and driving forces are analyzed; and the relationship between the driving force and the input phase difference is investigated to optimize the following position control. A capacitance surface encoder is proposed to provide the levitation height and two dimensional position feedback for the stage. The encoder design is based on the measurement of capacitance change between the driving stage and the metal sensing plates embedded in the ground. The lateral position (in the XY plane) of the circular stage can be uniquely determined based on the capacitance values.A prototype including the stage, encoder, and controller is implemented and characterized to demonstrate the performance of the proposed design. Two motion characteristics of the stage are first tested: one is the influence of the excitation voltage amplitude on the levitation height, and the other is the influence of the amplitude and phase angles of the excitation signals on the velocity and thrust force. In the calibration of the encoder, the calculated coordinates are firstly compensated for the scaling and the misalignment of the encoder axis and the precision stage. And the systematic errors from the nonlinear features are identified and fitted to a third-order polynomial equation in each axis. In the control scheme, the capacitance encoder works as the feedback module, and a LabVIEW program is used for date acquisition and processing. The stage is tested and demonstrated to follow a circular trajectory with a radius of 3.5mm.This work investigates a novel self-floating and self-running two-dimensional actuator using near-field acoustic levitation and coupled resonant vibration of the device. Compared with the conventional designs based on near-field acoustic levitation, the proposed design eliminates any external component such as guide rail, which contributes to bigger working space. This design also has two-dimensional motion capability with higher load capacity and energy efficiency. A dynamic model based on the Reynolds Equation is established to study the driving mechanism. A capacitance surface encoder is proposed to provide the two dimensional position feedback for the stage. A prototype including the stage, encoder, and controller is implemented and characterized to demonstrate the capability of the proposed design.振動源在近場中產生的輻射力可以用於提升和運輸物體，這現象可用於非接觸驅動技術，並有別於磁懸浮技術。本研究提出了一種新型的自運行平面運動機構，該機構利用了近場聲學傳播現象和裝置的耦合諧振。通過有限元分析可以找到機構的共振模態，並且用於指導結構的優化設計。通過結構設計，使得一階縱向模態和二階橫向模態具有相同的振動頻率，以產生橢圓振動，橢圓振動同時提供懸浮立和前進驅動力。建立了基於雷諾方程的運動模型，來分析機構的懸浮和運動機制。通過分析懸浮力和驅動力，獲得驅動力與輸入信號相位差之間的關係，用於之後定位平臺的位置控制。基於表面電容的編碼器被用於定位平臺的位置反饋，這個反饋包括了平臺的懸浮高度以及它的二維平面位置。編碼器可以測量懸浮平臺和固定在地上的金屬感應板間的電容。基於測得的電容值，通過相應的計算，可以得出平臺在XY平面內的確定位置。建立了包括運動器，編碼器和控制器在內的實驗模型，用於驗證設計的性能。首先是關於驅動器運動性能的測定，第一個是電壓大小對懸浮高度的影響，第二個是電壓大小以及電壓相位角對於運動速度和驅動力的影響。在編碼器的校準過程中，首先補償了由於編碼器和精密平臺錯位以及縮放而引起的誤差， 然後運用三階多項式來擬合每個軸的非線性系統誤差。在控制方案中，電容式編碼器起反饋作用，一個LabVIEW程序用於對電信號的處理。在運動測試中，平臺行走了一個半徑為3.5mm的圓形軌跡。這項研究成功研發了一種新型的自懸浮和自運動的二維運動機構，這個機構運用了近場超聲懸浮和耦合共振效應。與傳統的近場超聲懸浮裝置相比，新的設計不需要導軌之類的任何外部部件，這有助於提供更大的工作空間。該設計具有二維運動能力，並有更高的負載能力和能量效率。建立了基於雷諾方程的運動模型來研究其運動機制。用電容編碼器來當作二維定位平臺的位置反饋。包括運動機構，編碼器和控制器在內的實驗模型被建立，用於驗證設計的性能。Chen, Keyu.Thesis M.Phil. Chinese University of Hong Kong 2017.Includes bibliographical references (leaves 56-60).Abstracts also in Chinese.Title from PDF title page (viewed on 06, February, 2020).Chen, Keyu
A Mean Field Game Approach to Relative Investment-Consumption Games with Habit Formation
No full textThis paper studies an optimal investment-consumption problem for competitive
agents with exponential or power utilities and a common finite time horizon.
Each agent regards the average of habit formation and wealth from all peers as
benchmarks to evaluate the performance of her decision. We formulate the
n-agent game problems and the corresponding mean field game problems under the
two utilities. One mean field equilibrium is derived in a closed form in each
problem. In each problem with n agents, an approximate Nash equilibrium is then
constructed using the obtained mean field equilibrium when n is sufficiently
large. The explicit convergence order in each problem can also be obtained. In
addition, we provide some numerical illustrations of our results.Comment: arXiv admin note: substantial text overlap with arXiv:2206.13341 by
other author
ANALLSIS KETEBALAN KAYU LAMBUNG KAPAL IKAN NELAYAN TRADISONAL YANG MENGALAMI PEMBENGKOKAN PAKSA DENGAN PEMANASAN
No full textBangsa Indonesia telah menggenal teknologi pembangunan kapal kayu secara tradisional sejak ratiman tahun silam, amnia, sampai sekarang para pengrajin kapal kayu terscbut belum memamfaatkan kemajuan ilmu pengetahuan dan teknologi modern, selaingga dalam pembaugunan kapal kayu tersebut tidak mengindatikan faktor teknis, keselantatan manusia dan barang di taut ntauptm faktor non Minns lainnya.
Delman mempertabankan teknologi tradisional pada pembangunan kapal kayu, berdampak pada pemakaian balm baku kayu yang berlebihan + 20 ski 50 m3 anti& kapal dengan ukuran limas 10 std 20 in. Hal ini tnerupalsan sumo pemboresan terhadap bahan baku kayu. Sementara produksi kayu hutan terutama untuk kayu jati mengalami penumnan drastis, yang disebabkan karena tidak dapat dikondalikannya penebangan kayu liar dan lamanya proses produksi untuk satu pohon kayu jati yaitu + 50 tahun. Dengan demikian menyebabkan ketangkaan kayu jail di pasaran dim mejadikan harga kayu jati melambung fmggi, sehingga ongkos produksi untuk satu unit kapal kayo nelayan tradisional sangat tinngi.
Salah satu penggimaim kayu jati adalah untuk kulit lambung kapal, pada proses pembangunan kapal kayu tradisional kulit kapal int memiliki ketebalan antara 4 ski 5 cm untuk bagian }ambling kapal yang lercelup air, sedangkan untuk bagian iambus kapal yang berada di alas saris air 3 skI 4 cm. Untuk rnenentukan tebal bahan kayn yang di pakai terscbut tampa mempertimbangkan kekuatan whits dmi kayu dan besamya beban yang akan di tanggung oleh lambing kapal secara keseluruhan, Minya berdasarkan install; dan pengalaman dalam pembangunan kapal sebeIumnya. Sehingga pengrajin kapal kayu perkt di bet; pengertian dan pengetahuan tentang kekutan bahan kayu terutama untuk bagian buritan dan baluan kapal, biasanya pada bagian buritan dan haluan kapal bahan kayunya dilengkungkan ter/chili dahulu dan untuk mempertabankan kelengkungan terscbut dengan jalan penaanasan, serta besamya beban yang beketja pada lambing kapal, agar pengrajin kapal kayu dapat mementukan tebal bahan kayu yang akan digunakan pada /ambling kaput tersebut.Dalian rangka pengembangan teknologi tmdisional yang digunakan oloh pant pengrajin kapal kayu perlu dilakukan serangkaian eksperimen terhadap teknologi tmdisional pembangunan kapal kayu tersebut, salah satunya adalah percobaan analisis ketebalan kayu lambung kapal ikon nelayan tmdisional yang mengalami pembengkokkan paksa. Pada eksperimen ini diambil beberapa bagian badan kapal kayu di haluan dan buritan kapal, sena salah sam bahan alternative yaitu kayo merbau, yang diperlakukan sama dengan teknologi tradisonal pembangunan kapal kart, yarm pembengkokkan dan pemanasan dengan Mho diasapkan. Eksperimen ini dilakukukan pada ketebalan kayu 2, 3, 4 den 5 cm dengan lama pemauasan 2, 4 den 6 jam.
Hasil yang diperoleh melalui eksperimen tersebut adalah untuk kayu dengan tebal 2 cm memiliki kekutan tekan rata-rata 410,2 x 102 kg/cm2, kayu dengan tebal 3 cm : 550,6 x 102 kg/cm2, 4 an : 574 x 102 kg/cm2 dan 5 cm : 620,7 x 102kg/em2. Untuk lama pemanasan dengan jalan pengasapan 2 s/d 6 jam mengalami penurunim kekutan tekan dan Ionia rata-rota 20,8 x 1021m/cm2
Karmen kayu yang dipersyaratkan untuklambtmg kapal adalah berkisar antara 500 x 102 s/d 850 x 102 kg/cm2 untuk berbagai jails kayu, sehingga keyu merbau dapat menjadi alternative bahan baku dalam pembanguna kapal kayu dengan tebal minimal 3 cm. Dengan demilcian diharapkan ongkos produksi dari bahan balm dapat dihemat hingga 30 %
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