444 research outputs found
Characterization of a basic phospholipase A2-homologue myotoxin isolated from the venom of the snake Bothrops neuwiedii (yarará chica) from Argentina
No full textFil: Geoghegan, Patricia A. ANLIS Dr.C.G.Malbrán. Centro Nacional de Control de Calidad de Biológicos. Servicio de Inmunoterapéuticos; Argentina.Fil: Angulo, Yamileth. Universidad de Costa Rica. Facultad de Microbiología. Instituto Clodomiro Picado; Costa Rica.Fil: Cangelosi, Adriana. ANLIS Dr.C.G.Malbrán. Centro Nacional de Control de Calidad de Biológicos. Servicio de Inmunoterapéuticos; Argentina.Fil: Díaz, Mónica. ANLIS Dr.C.G.Malbrán. Centro Nacional de Control de Calidad de Biológicos. Servicio de Inmunoterapéuticos; Argentina.Fil: Lomonte, Bruno. Universidad de Costa Rica. Facultad de Microbiología. Instituto Clodomiro Picado; Costa Rica.A basic protein was isolated by CM-Sephadex C-25 chromatography from the venom of Bothrops neuwiedii from Argentina, and named B. neuwiedii myotoxin I. This protein exerted local myotoxic and edema-forming effects in mice, with potencies comparable to other myotoxins isolated from Bothrops spp. venoms. When injected by i.v. route at doses up to 4.7 mg/kg of body weight, the toxin was not lethal. In vitro, the toxin had no detectable phospholipase A2 activity on egg yolk phospholipids. B. neuwiedii myotoxin I appeared as a homodimer in sodium dodecylsulphate-polyacrylamide gel electrophoresis, with a subunit molecular weight of 15 kD. Gel immunodiffusion revealed a pattern of partial antigenic identity between the newly isolated myotoxin and myotoxin II from Bothrops asper venom. The sequence of B. neuwiedii myotoxin I was determined for the first 40 amino acid residues, showing high homology to several class II phospholipase A2 myotoxins of the Lys-49 family from crotalids. Altogether, results suggest that this toxin is a new member of the Lys-49 phospholipase A2-homologues with myotoxic, cytolytic, and edema-inducing activities
El Tlacuache Núm. 523 (2012). 523 Año 13 (2012) junio. El Tlacuache
No full textOtra vez los Mayas... La falacia del fin del mundo De los Mayas? por Jorge Angulo Villaseñor. -Programa liberal: El Clero, Juárez, y Maximiliano por Erick Alvarado Tenorio
Efecto in vivo de las disintegrinas de Bothrops asper y Crotalus simus en el proceso hemorrágico
No full textTesis (licenciatura en microbiología y química clínica)--Universidad de Costa Rica. Facultad de Microbiología, 2024Las disintegrinas, son péptidos de bajo peso molecular con enlaces disulfuro que forman parte de las proteínas que conforman los venenos de serpientes. Tienen la capacidad de interactuar con integrinas en las membranas celulares, desencadenando diversos efectos en procesos como la adhesión celular, agregación plaquetaria, reacciones inflamatorias, migración celular y angiogénesis, entre otros. Las investigaciones indican que las disintegrinas tienen propiedades antiagregantes de plaquetas, contribuyendo al proceso hemorrágico en pacientes afectados. Este proyecto busca determinar si las disintegrinas aisladas de los venenos de serpiente de Bothrops asper y Crotalus simus tienen un impacto en el tiempo de sangrado in vivo, debido a la inhibición de la agregación plaquetaria. En este proyecto se purificó y se caracterizó ambas disintegrinas. Se evaluó el efecto in vivo en el tiempo de sangrado mediante dosis respuesta y tiempo respuesta con ratones. Se determinó una dosis respuesta que no sufre variaciones significativas a partir de 5 a 20 μg . El desarrollo del efecto de las disintegrinas en el tiempo se determinó que persistente desde 1 hasta las 6 horas sin mostrar diferencias significativas. En conclusión, se demostró que ambas disintegrinas de ambas especies, al ser inyectadas de manera intravenosa producen la inhibición de la agregación plaquetaria in vivo.UCR::Docencia::Salud::Facultad de Microbiologí
Stories of emotional experiences throughout theatrical approaches during the confinement
No full textRelatos de la vivencia emocional desde la experiencia teatral en medio del confinamiento, es una investigación desde la práctica pedagógica virtual, a través del teatro, en los énfasis específicos de los títeres y el clown. Se recoge la experiencia de 3 niños, que se vinculan a la Fundación Pastoral Social Manos Unidas, por medio del proyecto “Creando mi Teatro”, ganador del Programa Distrital de Estímulos-Arte Para la Transformación Social, creado por el IDARTES en medio de la pandemia causada por el covid-19. En la investigación se analiza la percepción que tiene cada uno de ellos con respecto a su propia práctica y cómo ella se convierte en un vehículo para transitar por sus emociones en medio del encierro.Stories of emotional experiences throughout theatrical approaches during the confinement, is an investigation from the online pedagogical practice through theater and its practices such as clown and puppets.
The experience of three children who are participants of the foundation: Fundación Pastoral Social Manos unidas as part of the project “creando mi teatro” (building my own theater), is analyzed and is awarded as part of the program of distrital incentives for arts in times of the pandemic . (Idartes). The investigation centers itself in the analysis of each of the participants in terms of their perception upon the confinement and the use of this experience as a way of expressing their emotions in the middle of the lockdown
An Homage to Jaime de Angulo: A North American Ovid
No full textPurpose of the Study: Linguist, story-teller, poet, novelist, illustrator, scholar, homesteader, vaquero, wild-man, sorcerer's apprentice, Jaime de Angulo was a legendary figure in his own time. The scholars and artists he associated with and influenced, such as Carl Jung, Franz Boas, Carl Sauer, Bronislaw Malinowski, Robinson Jeffers and Ezra Pound, make up a veritable "Who's Who" of the first half of this century. But, because of his fame as a linguist rather than an author and poet, his eccentricities, and a self-imposed public silence between 1936 and 1949, his literary achievements remain relatively unknown. The purpose of this study is to collate the various and disparate biographical material written about de Angulo, separating fact from legend where it's possible, presenting the reader with an accurate chronology, and to present the first major book-length critical examination of de Angulo's literary wriiting. Procedure: To present a biography of Jaime de Angulo, as well as a serious critical examination of his literary work, all available biographical material concerning de Angulo, along with pertinent anthropological, historical and critical materials relevant to the many contexts from which de Angulo's work derived, was researched. Findings: Jaime de Angulo was one of a kind. He was a brilliant scholar and extraordinary writer who lived the most colorful of lives. His work, study and life with American Indian societies, especially those of northern California. led to a unique contribution to North American letters. His novel. The Lariat. has been compared with The Scarlet Letter. and justly so. And the quality of his entire oeuvre is comparable with the most notable writings from the twentieth century Big Sur-Carmel milieu, literature of the North American West. and the internationalist Modernist movement of his era. Conclusions: A close examination of de Angulo's life and literary work leaves an even stronger impression of extraordinary quality than a first glance, even at the remarkable cast of characters, European, European-American, an American Indian, associated with him. His virtuosity and passion as a writer simply cannot be overemphasized.Eisenberg, Barry. 1989. An Homage to Jaime de Angulo: A North American Ovid. Department of English, Sonoma State University
Identificación, aislamiento y caracterización parcial de componentes del veneno de Bothrops asper (terciopelo) que inhiben la agregación plaquetaria
No full textTesis (licenciatura en microbiología y química clínica)--Universidad de Costa Rica. Facultad de Mircobiología, 2000UCR::Docencia::Salud::Facultad de Microbiologí
An Homage to Jaime de Angulo: A North American Ovid
No full textPurpose of the Study:\ud
Linguist, story-teller, poet, novelist, illustrator, scholar, homesteader, vaquero, wild-man, sorcerer's apprentice, Jaime de Angulo was a legendary figure in his own time. The scholars and artists he associated with and influenced, such as Carl Jung, Franz Boas, Carl Sauer, Bronislaw Malinowski, Robinson Jeffers and Ezra Pound, make up a veritable "Who's Who" of the first half of this century. But, because of his fame as a linguist rather than an author and poet, his eccentricities, and a self-imposed public silence between 1936 and 1949, his literary achievements remain relatively unknown.\ud
The purpose of this study is to collate the various and disparate biographical material written about de Angulo, separating fact from legend where it's possible, presenting the reader with an accurate chronology, and to present the first major book-length critical examination of de Angulo's literary wriiting.\ud
Procedure: \ud
To present a biography of Jaime de Angulo, as well as a serious critical examination of his literary work, all available biographical material concerning de Angulo, along with pertinent anthropological, historical and critical materials relevant to the many contexts from which de Angulo's work derived, was researched.\ud
Findings:\ud
Jaime de Angulo was one of a kind. He was a brilliant scholar and extraordinary writer who lived the most colorful of lives. His work, study and life with American Indian societies, especially those of northern\ud
California. led to a unique contribution to North American letters. His novel. The Lariat. has been compared with The Scarlet Letter. and justly so. And the quality of his entire oeuvre is comparable with the most notable writings from the twentieth century Big Sur-Carmel milieu, literature of the North American West. and the internationalist Modernist movement of his era.\ud
Conclusions:\ud
A close examination of de Angulo's life and\ud
literary work leaves an even stronger impression of extraordinary quality than a\ud
first glance, even at the remarkable cast of\ud
characters, European, European-American, an\ud
American Indian, associated with him. His\ud
virtuosity and passion as a writer simply cannot be overemphasized
Cuban and Afro-Cuban Musical Elements in the Classical Guitar Compositions by Héctor Angulo
No full textHéctor Angulo, one of the most versatile Cuban composers, had a musical style that combines Afro-Cuban music elements with 20th and 21st-century compositional techniques. His musical discourse includes elements from the African musical heritage. This paper proposes a conscious reconsideration of the approach to non-Western musical traditions which require different analytical techniques. An analytical study will reveal the musical content that defines both the Afro-Cuban and the contemporary styles. Some of the analytical techniques used in this study include musical ambiguities (polytonal, polyrhythmic, pitch ambiguity, bi-modal, Poly-meter, Dual texture, phenomenal and agogic accents) and music temporalities which are defined by non-directed linear dynamic, texture, timbre, density, range, progressions, and gestures. From a historical background, the research provides a complete description of Angulo’s innovative musical style, which comports with a Nationalist trend in Classical Guitar idiomatic writing. This study explores the approach of a non-guitarist composer who brings new sonorities to the guitar, transcending the range of musical options traditionally limited by standard performance modes. Héctor Angulo’s musical compositions display an outstanding balance between the premise of collective participation of the artist with his individual artistic distinctiveness. The educational goal of this research is to provide a detailed analysis of these works, offering alternative approaches to them and support for the performer's musical choices. In addition, the author is opening the path for further investigations into other Cuban guitarist and non-guitarist composers.</p
Read and edit Góngora in the Golden Century: Martín de Angulo or the forge (frustrated) of a song of author
No full textEl presente estudio ofrece un análisis monográfico del manuscrito inédito
Varias poesías y casi todas las que compuso… D. Luis de Góngora, de Martín de Angulo
y Pulgar, custodiado en la Fundación Bartolomé March (B87-V3-10). Con fecha de 1639-
1640, constituye una suerte de cancionero de poesías varias o antología preparada por este
autor con la voluntad de difundir la obra de Góngora, canonizarlo y de paso posicionarse él
mismo, respecto a la nutrida galería o elenco de eruditos comentaristas, en un lugar privilegiado
de la república de las letras. Sin embargo, pese a desafiar a los editores precedentes
de Góngora e incluso entrar en discordia interpretativa con otros destacados actantes de
la polémica literaria, por su ambicioso fuste, el proyecto acabaría inconcluso y sin llegar
a buen puerto editorial.The present study offers a monographic analysis of the unpublished manuscript
Varias poesías y casi todas las que compuso… D. Luis de Góngora, Martín de Angulo y
Pulgar, guarded at the Fundación Bartolomé March (B87-V3-10). With a date of 1639-
1640, it constitutes a kind of poetry songbook or anthology prepared by this author with
the aim of spreading the work of Góngora, canonizing it and, in turn, position himself,
with respect to the large gallery or cast of commentator scholars, in a privileged place of
the Republic of letters. However, despite challenging the previous editors of Góngora and
even enter into interpretative discord with other prominent actants of the literary polemic,
for its ambitious fuste, the project would end unfinished and without reaching a good
publishing port
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Cuban and Afro-Cuban Musical Elements in the Classical Guitar Compositions by Héctor Angulo
No full textHéctor Angulo, one of the most versatile Cuban composers, had a musical style that combines Afro-Cuban music elements with 20th and 21st-century compositional techniques. His musical discourse includes elements from the African musical heritage. This paper proposes a conscious reconsideration of the approach to non-Western musical traditions which require different analytical techniques. An analytical study will reveal the musical content that defines both the Afro-Cuban and the contemporary styles. Some of the analytical techniques used in this study include musical ambiguities (polytonal, polyrhythmic, pitch ambiguity, bi-modal, Poly-meter, Dual texture, phenomenal and agogic accents) and music temporalities which are defined by non-directed linear dynamic, texture, timbre, density, range, progressions, and gestures. From a historical background, the research provides a complete description of Angulo’s innovative musical style, which comports with a Nationalist trend in Classical Guitar idiomatic writing. This study explores the approach of a non-guitarist composer who brings new sonorities to the guitar, transcending the range of musical options traditionally limited by standard performance modes. Héctor Angulo’s musical compositions display an outstanding balance between the premise of collective participation of the artist with his individual artistic distinctiveness. The educational goal of this research is to provide a detailed analysis of these works, offering alternative approaches to them and support for the performer's musical choices. In addition, the author is opening the path for further investigations into other Cuban guitarist and non-guitarist composers.</p
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