5,700 research outputs found
ko-ax photo [Selected by Tate Curator of Photography, Simon Baker]
No full textko-ax photo was an open submission competition selected by Simon Baker (Curator of Photography, Tate), Sue Steward (Photography critic, Telegraph, Observer, Guardian, BBC) and John Gill (Curator Brighton Photo Biennial and Founder Photoworks). The 10 artists selected all presented fascinating artworks that conceal narratives and ask questions of the viewer. Questions of beauty, family, decay and fantasy were all explored across over 50 works.</p
The people behind the papers – Jason Ko and Daniel Lobo
No full textPlanarians grow when they are fed and shrink during periods of starvation. However, it is unclear how they maintain appropriate body proportions as their size changes. A new paper in Development investigates the differences between growth and shrinkage dynamics and builds a mathematical model to explore the mechanisms underpinning these two processes. To learn more about the story behind the paper, we caught up with first author, Jason Ko, and corresponding author, Daniel Lobo, Associate Professor at the University of Maryland.https://doi.org/10.1242/dev.20298
Organizational Learning and Marketing Capability Development: A Study of Charity Retailing Operation of British Social Enterprises
No full textSocial enterprise is a hybrid form of profit- and social benefit-seeking organization whereby traditional nonprofit organizations pursue both their social mission and business opportunities. To embrace this new strategic direction shift, the nonprofit organizations need to develop new competences that will enable them to respond to the changes in the business model. The article investigates the learning mechanisms through which social enterprises develop a marketing capability to deploy their resources in the marketplace as the drivers of competitive advantage in their commercial practice. We study eight cases of UK-based charity retailers, in order to address the role of knowledge accumulation, articulation and codification process in the evolution of marketing capability development. We identify, amongst other things that the critical process of organizational learning for social enterprise is to transfer the experience into organization specific knowledge under the social aspects of constraints
Yamamoto Masao = Nippon Girls: fotografia al femminile. Hiromix, Mika Ninagawa, Yurie Nagashima, Maki Miyashita
No full textCinque fotografi che rappresentano in maniera differente la produzione fotografica giapponese contemporanea. Yamamoto con un racconto legato alla tradizione e per questo apprezzato dal pubblico straniero. Le onna no ko shashinka, che invece danno vita a un nuovo filone fotografico tutto femminile e rivolto al privato
Ko au te whenua, te whenua ko au – I am the land, the land is me: An autoethnographic investigation of a secondary school teacher’s experience seeking to enrich learning in outdoor education for Māori students.
No full textThis thesis is my story as an outdoor educator, as a researcher, and a co-participant reflecting on my own actions and experiences as well as those of my students. In this autoethnography I share my revelations and tensions in my role as an outdoor education teacher seeking to enrich the experiences of Māori students. Māori culture and history have largely been ignored in the outdoor education classrooms and environments of Aotearoa New Zealand. After teaching the subject for ten years I didn’t perceive that I was perpetuating the same invisibility in my own outdoor education course. Over this time a number of questions that had fermented at the back of my mind came to the fore; ‘why are so few Māori students opting to take outdoor education as a senior secondary school subject?’ and ‘how can I make the subject of outdoor education more desirable and appealing to Māori?’ A place-responsive approach incorporates and values traditional ways of learning through the notion of place and the stories attached to them. The cultural context of learning about and through place has the potential to provide learning opportunities that are relevant and meaningful to all learners but particularly Māori. Place-responsive pedagogies allow outdoor educators to create an environment where language, knowledge, culture and values are normal, valid and legitimate – contexts where Māori students can be themselves. Through this research I have found that the implementation of a place responsive approach has had significant implications for Year twelve outdoor education at Mount Maunganui College. The improvement in Māori student achievement and numbers selecting the subject have been affirming.
Ko au te whenua, te whenua ko au – I am the land, the land is m
KNOWLEDGE ACCUMULATION IN ASIAN PUBLIC ADMINISTRATION RESEARCH: A CRITICAL REVIEW
No full textGiven the growing controversy over the relevance of Anglo-Saxon style public administration to developing countries and a greater demand for more context-relevant theories of public administration in Asia, we should expect that Asian scholars achieve a certain level of knowledge growth in line with this controversy and demand. On the basis of the review of 8810 articles published in nine major international journals during 1990-2011, the author found that the number of articles on Asian public administration is very small, and there is no strong pattern of growth in this regard. In addition, there are very few studies adopting a comparative approach covering multiple Asian countries. Copyright (c) 2013 John Wiley & Sons, Ltd.N
Book-in-Common Conversation - Lisa Ko
No full textLisa Ko, author of The Leavers, will speak about her book and writing career in a virtual presentation on Tuesday, March 23 at 7 pm. Lisa Ko is the recipient of the 2016 PEN/Bellwether Prize and the 2017 Barnes and Noble Discover Great New Writers Award. The Leavers was also named best book of the year by NPR
PALEOLIMNOLOGICAL STUDY ON LACUSTRINE SEDIMENTS OF LAKE BIWA-KO
No full textIn this paper, the writers dealt with the developmental history of Lake Biwa-ko during thelateglacial and the postglacial time. The purpose of the writero are to clarify paleohydrology, paleoclimate, and to establish the late-Pleistocene chronology which is comparable to Europeanand American chronological time table. Discussion was done from chemical, mathematical, physi-cal, and palynological points of view about the various features of core sample of nearly 12 mlong.On the basis of p9llen analytical data, former temperature during the lateglacial time is regard-ed as several degrees in centigrade lower than present one. Although the correlation betweencalcium carbonate amount as an indicator of former temperature and the amount of nutrient saltand of organic matter is indistinct, temperature rise since the lateglacial time is clear. The reasonmight be complicated combination between water environments, organic production and decomposi-tion, turn over rate, source of organic material, and turbidity current in such large lake as Biwa.Because of the existence of thick lacustrine sediments in Lake Biwa-ko, they afford unique in-formation on the fluctuation of the Pleistocene climate in Japan. The writers intend to analyse thefeature of the combination composed by various elements and to accomplish the purpose mentionedabove.In this paper, the writers dealt with the developmental history of Lake Biwa-ko during thelateglacial and the postglacial time. The purpose of the writero are to clarify paleohydrology,paleoclimate, and to establish the late-Pleistocene chronology which is comparable to Europeanand American chronological time table. Discussion was done from chemical, mathematical, physi-cal, and palynological points of view about the various features of core sample of nearly 12 mlong.On the basis of p9llen analytical data, former temperature during the lateglacial time is regard-ed as several degrees in centigrade lower than present one. Although the correlation betweencalcium carbonate amount as an indicator of former temperature and the amount of nutrient saltand of organic matter is indistinct, temperature rise since the lateglacial time is clear. The reasonmight be complicated combination between water environments, organic production and decomposi-tion, turn over rate, source of organic material, and turbidity current in such large lake as Biwa.Because of the existence of thick lacustrine sediments in Lake Biwa-ko, they afford unique in-formation on the fluctuation of the Pleistocene climate in Japan. The writers intend to analyse thefeature of the combination composed by various elements and to accomplish the purpose mentionedabove
Differentially altered social dominance- and cooperative-like behaviors in Shank2- and Shank3-mutant mice
No full textBackground: Recent progress in genomics has contributed to the identification of a large number of autism spectrum disorder (ASD) risk genes, many of which encode synaptic proteins. Our understanding of ASDs has advanced rapidly, partly owing to the development of numerous animal models. Extensive characterizations using a variety of behavioral batteries that analyze social behaviors have shown that a subset of engineered mice that model mutations in genes encoding Shanks, a family of excitatory postsynaptic scaffolding proteins, exhibit autism-like behaviors. Although these behavioral assays have been useful in identifying deficits in simple social behaviors, alterations in complex social behaviors remain largely untested. Methods: Two syndromic ASD mouse models—Shank2 constitutive knockout [KO] mice and Shank3 constitutive KO mice—were examined for alterations in social dominance and social cooperative behaviors using tube tests and automated cooperation tests. Upon naïve and salient behavioral experience, expression levels of c-Fos were analyzed as a proxy for neural activity across diverse brain areas, including the medial prefrontal cortex (mPFC) and a number of subcortical structures. Findings: As previously reported, Shank2 KO mice showed deficits in sociability, with intact social recognition memory, whereas Shank3 KO mice displayed no overt phenotypes. Strikingly, the two Shank KO mouse models exhibited diametrically opposed alterations in social dominance and cooperative behaviors. After a specific social behavioral experience, Shank mutant mice exhibited distinct changes in number of c-Fos+ neurons in the number of cortical and subcortical brain regions. Conclusions: Our results underscore the heterogeneity of social behavioral alterations in different ASD mouse models and highlight the utility of testing complex social behaviors in validating neurodevelopmental and neuropsychiatric disorder models. In addition, neural activities at distinct brain regions are likely collectively involved in eliciting complex social behaviors, which are differentially altered in ASD mouse models. © 2020, The Author(s).1
Comparison of skin barrier abnormalities and epidermal ceramide profiles among three ω-O-acylceramide synthesis-deficient mouse strains
No full textBackground: The epidermis contains many structurally diverse ceramides, which form the skin permeability barrier (skin barrier). Mutations in genes involved in the synthesis of omega-O-acylceramides (acylceramides) and protein-bound ceramides cause ichthyosis. Objective: We aimed to elucidate the relationship between the degree of skin barrier impairment and changes in epidermal ceramide profiles caused by mutations in acylceramide synthesis genes. Methods: Knockout (KO) mice of three genes-fatty acid (FA) omega-hydroxylase Cyp4f39 (human CYP4F22 ortholog), FA elongase Elovl1, and acyl-CoA synthetase Fatp4-were subjected to transepidermal water loss measurement, toluidine blue staining, and epidermal ceramide profiling via liquid chromatography coupled with tandem mass spectrometry. Results: Transepidermal water loss was highest in Cyp4f39 KO mice, followed by Elovl1 KO and Fatp4 KO mice, and Cyp4f39 KO mice also showed the strongest degree of toluidine blue staining. In Cyp4f39 KO, Elovl1 KO, and Fatp4 KO mice, acylceramide levels were 0.6%, 1.6%, and 12%, respectively, of those in wildtype mice. Protein-bound ceramide levels were 0.2%, 30%, and 33%, respectively, of those in wild-type mice. We also observed a near-complete absence of omega-hydroxy ceramides in Cyp4f39 KO mice, reduced total ceramide levels and shortened FA moieties in Elovl1 KO mice, and increased hydroxylated ceramide levels and slightly shortened FA moieties in Fatp4 KO mice. Conclusions: The degree of reduction in protein-bound ceramide levels is probably related to the severity of skin barrier defects in these three strains. However, reduced acylceramide levels and other changes in ceramide composition unique to each KO strain are also involved
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