501 research outputs found
Is Human Atrial Natriuretic Peptide (hANP) Effective as an Additive to Cardioplegic Solution During Cardiac Surgery?
No full text
Erratum: The histone demethylase JMJD2B regulates endothelial-to-mesenchymal transition (Proceedings of the National Academy of Sciences of the United States of America (2020) 117 (4180-4187) DOI: 10.1073/pnas.1913481117)
No full textCorrection for “The histone demethylase JMJD2B regulates endothelial-to-mesenchymal transition,” by Simone F. Glaser, Andreas W. Heumüller, Lukas Tombor, Patrick Hofmann, Marion Muhly-Reinholz, Ariane Fischer, Stefan Günther, Karoline E. Kokot, David Hassel, Sandeep Kumar, Hanjoong Jo, Reinier A. Boon, Wesley Abplanalp, David John, Jes-Niels Boeckel, and Stefanie Dimmeler, which was first published February 7, 2020; 10.1073/pnas.1913481117 (Proc. Natl. Acad. Sci. U.S.A. 117, 4180-4187). The authors note that Hitoshi Okada should be added to the author list between Karoline E. Kokot and David Hassel. Hitoshi Okada should be credited with providing mice. The corrected author line, affiliation line, and author contributions appear below. The online version has been corrected
Development of an in vivo tissue-engineered, autologous heart valve (the biovalve) : preparation of a prototype model
No full textObjective: This study aimed to develop an autologous heart valve without using traditional in vitro tissue-engineering methods, which necessitate complicated cell management protocols under exceptionally clean laboratory facilities. Methods: An autologous heart valve construct composed of trileaflets was prepared using a specially designed mold. The mold was prepared by covering a silicone rod with a crown-shaped tubular polyurethane scaffold containing 3 horns. The mold was implanted in the dorsal subcutaneous space in Japan White rabbits for 4 weeks. After harvesting, the implanted trileaflet valve-shaped structure with an internal diameter of either 5 or 20 mm was obtained by trimming the membranous tissue formed between the horns located around the silicone rod. The valve substitute was examined both macroscopically and histologically. The tensile strength of the leaflets was measured to rupture. The degree of regurgitation in valve function was evaluated using a flow circuit by calculating the ratio of the regurgitation volume to the forward flow volume. Results: After implantation, the mold was completely covered with connective tissue consisting mostly of collagen and fibroblasts. Harvesting of the mold was straightforward, because there was little adhesion between the formed tissue and the native skin tissue. The trileaflet heart valve construct was obtained after withdrawing the inserted rods and trimming the membranous tissues formed between the horns of the scaffold. It was firmly attached to the scaffold, the interstices and surface of which revealed connective tissues composed of components similar to those of the leaflet tissue. Although the mechanical properties of the leaflet tissue were less efficient than those of the native porcine aortic valve leaflets, satisfactory valvular functions were demonstrated under pulsatile conditions using a flow circuit. No regurgitation was observed under retrograde hydrostatic pressures of up to 60 mm Hg, the physiologic pressure acting on the aortic valves during retrograde aortic flow. Conclusions: The biovalve, an autologous, in vivo tissue-engineered, trileaflet, valve-shaped construct, was developed using our novel in-body tissue architecture technology. The biovalve has the potential to be an ideal prosthetic heart valve, with excellent biocompatibility to the growth of the recipient’s heart
ERRATA
No full textVolume and issue: Vol.6, No.7 (2011)Page: pp.317-322Title: Contribution of Slip and Cleavage in Friction and Wear at (10-14) Surface of Magnesite (MgCO3) CrystalAuthor(s): Kaori Niki, Mai Kobayashi and Hitoshi ShindoVolume and issue: Vol.7, No.1 (2012)Page: pp.8-12Title: Frictional Asymmetry and Wear Pattern Formation by Slip and Cleavage Detected at Directional r {10-14} Face of Calcite (CaCO3)Author(s): Kaori Niki, Mai Kobayashi and Hitoshi Shind
Letter from John Lancaster, Unit President, A.I.F.D., January 29, 1970
No full textLetter from John Lancaster, Chairman, American Institute of Floral Designers (A.I.F.D) addressed to the florists who are interested in attending the Yoke Kuromi Memorial Dinner.This collection contains two photograph albums and material related to Hitoshi "Yoke" Kuromi and Corrine Nobuko Nishimura Kuromi. Subjects in the collection include the Kuromi family, the Gila River incarceration camp, and hot rods, and classic cars
- …
