1,720,981 research outputs found
A prospective, multicenter, clinical study to evaluate the safety, pharmacokinetics, and efficacy of bleed outcomes, with HemoRel-A® in severe hemophilia A patients
No full textPurpose: To evaluate efficacy for an on-demand treatment of acute bleeding events, pharmacokinetics, safety, and tolerability of HemoRel-A® in severe hemophilia A. Methods: A total of 44 male subjects with severe hemophilia A with an annualized bleed rate of 12 while on-demand treatment with factor VIII (FVIII) were enrolled in the study and received HemoRel-A® for bleed treatment. The efficacy of HemoRel-A® was evaluated based on a four-point scale (excellent, good, moderate, or none). Six-point pharmacokinetic (PK) assessment was performed following a single dose of 50 IU/kg in 12 subjects after a 7-day wash-out period. Safety evaluations were performed at each visit and inhibitor testing was performed in all patients at screening and end of study. Results: Forty-four male subjects received at least a single dose of the study medication and were included in the intent-to-treat (ITT) analysis and safety outcome. In 23 (7.52%) out of the 306 bleeding events, HemoRel-A® efficacy was rated as excellent, in 272 (88.89 %) bleeds it was rated as good, and in 11 (3.68%) bleeding events it was rated as moderate. No failure of efficacy was noted in any of the bleeding events. Thus overall out of 306 bleeding events, 295 (96.41%) showed excellent or good efficacy. Pharmacokinetic assessment based on plasma FVIII activity measured by the chromogenic assay in 12 patients showed comparative results similar to FVIII preparations. A total of 12 adverse events (AEs) were reported in this study. There was no inhibitor development in this previously treated patients (PTP) cohort. Conclusion: HemoRel-A® was established to be efficacious and safe in the treatment of acute bleeding events in subjects with severe hemophilia A.</p
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Innovation in Marketing Management
No full textThis research aims at exploring the relationship between a firm's strategic orientation, marketing
management in terms of marketing mix tactics, and innovation performance. We examine three types of
strategic orientations: customer, technology, and combined customer/technology orientation. We analyze
their direct effect on innovation performance as well as the moderating effect of marketing management in
terms of the marketing mix on this relationship. We test our hypotheses on a sample of 1603 French
manufacturing firms and show that organizations with a combined customer/technology orientation
outperform those with a customer or technology orientation alone. We also show that the moderating effect
of marketing management in boosting innovation success is positive for all orientations, but greatest for
organizations with a technology orientation. Finally, we find that the moderating effect of marketing
management on the relationship between orientation and performance increases as more elements of the
marketing mix are deployed simultaneously. We are pleased to introduce this special issue on marketing of
high-technology products and innovations. High-technology industries are distinguished by increasing
turbulence, and time-and information-intensive environments (Mohr, Sengupta, & Slater, in press).
Additionally, issues related to unique characteristics like network effects, dominant design, and
technological standards increase complexity in identifying, implementing, and evaluating marketing
strategies in such environments (Hills & Sarin, 2003). This special issue features papers that contribute
theoretically, methodologically, and substantively to enhancing our understanding of marketing strategies
in high-tech environments.
The effects of exploratory and exploitative market learning on management innovation are contingent on
technological and marketing capabilities. Specifically, technological capabilities enhance the positive
effect of exploratory market learning and weaken the positive effect of exploitative market learning on
management innovation. Marketing capabilities enhance the positive effect of exploitative market learning
and weaken the positive effect of exploratory market learning on management innovation. This study
contributes to the literature by integrating organizational learning theory with the absorptive capacity
perspective to explain management innovation
Recommended from our members
Novel Physical Phenomena in Oxide Superlattices
Full text linkIt is historically proven that artificial heterostructures are of paramount importance for both fundamental research and technological application. One distinguishable example is superlattices and quantum-well heterostructures of conventional semiconductors (III-V). Several fundamental observations such as two-dimensional electron gas, quantum confinement effect, quantum Hall effect and fractional quantum Hall effect, were first realized in artificial heterostructures of conventional semiconductors. On the technological front, artificial heterostructures of conventional semiconductors were found to revolutionize optoelectronic and high-speed electronic industry. Given the capability of artificial heterostructures to enable new physical phenomena, with an appropriate choice of material system, these heterostructures hold the potential to uncover hidden physical phenomena and exotic phases, which are otherwise not observed in bulk systems. One choice of such a system could be a strongly correlated material where the presence of strong electronic correlations has been known to enable unique electronic and magnetic properties. Complex oxides, in particular, are known to exhibit a strong interaction between various degrees of freedom available such as spin, charge, orbital and lattice degree, and thus offer a suitable choice of material system. In literature, one can find plenty of examples from different areas of research such as superconductivity, magnetism, ferroelectricity and thermoelectricity, where artificial superlattices led to the observation of fundamentally different behavior, compared to bulk superlattice constituents. These artificial superlattices and heterostructures continue to be the most promising candidate for exploring new phenomena and enhancing physical properties in complex oxide material systems. In this dissertation, artificial superlattices of complex oxides were synthesized in a thin-film geometry to enable the observation of fundamentally new physical phenomena, compared to their bulk counterparts, in few selected areas of investigation.First, I will present the experimental results on heat transport across superlattice structures composed of insulating perovskite oxides. The measured thermal conductivity of these artificial superlattices exhibited a unique phonon transport, i.e. coherent phonon transport, phenomenon that is extremely rare to observe in bulk form. The key element for enabling the coherent transport of phonon in these superlattice systems is the range of phonon wavelengths, which carry most of the heat in the material. The critical range being between 1-3 nanometers, the size of the system needs to reduce to this length scale in order to observe the effect of the wave nature of phonons on heat transport. Thus, superlattice structures offer an ideal candidate to search for this novel phenomenon. Several theoretical studies predicted the existence of these phenomena, but the experimental evidence of their existence remained largely absent or inconclusive. By synthesizing the superlattice of perovskite oxides, I’ve observed unambiguous evidence of the coherent transport of phonons at short-period superlattices of SrTiO3-CaTiO3 and BaTiO3-SrTiO3. In contrast to conventional heat conduction mechanisms, where phonon transport can be described by energy-carrying particles, the uniqueness of this phenomenon is highlighted by the fact that the wave aspect of phonons needs to be invoked to understand their transport behavior. After observing the wave nature of phonons in dictating heat conduction across periodic superlattices, other artificial heterostructures were studied to understand the nature of coherent phonon transport at the superlattice interfaces. Designed superlattice-like sequences, where the structural order can be controlled from a periodic sequence to a completely random sequence, were synthesized to further understand the role of the coherent scattering of phonons in thermal transport across superlattice structures.Next, I will discuss the experimental observation of another unique phenomenon, which was enabled by artificial superlattices of complex oxides in a different subject of research, i.e. ferroelectricity. Several theoretical studies on nanostructured ferroelectric systems such as nanodisc, nanocomposites, superlattices etc., predicted the stabilization of novel ferroelectric ground states. A number of different topologies of electrical polarization such as vortices and skyrmions, were predicted in ferroelectric nanostructures, which showed a strong resemblance to spin topologies such as skyrmion, merons etc. found in magnetic systems. Experimental confirmation for the existence of these exotic polarization states, however, remained absent. By leveraging the competition among charge, orbital and lattice degrees of freedom in superlattices of a paraelectric (SrTiO3) and ferroelectric (PbTiO3) material, vortex-antivortex structures of electrical polarization were stabilized in ferroelectric (PbTiO3) layers of PbTiO3-SrTiO3 superlattice. Only for a narrow range of superlattice periods, the polarization vortices are stabilized with a balance between one gradient energy associated with the non-uniform polarization profile of the vortex structure and the other’s electrostatic and elastic energies associated with depolarization fields and epitaxial constraints from the substrate, respectively.In the last section, I will describe unique and unusual phenomena associated with the existence of polarization vortices in paraelectric/ferroelectric superlattices. Superlattices of PbTiO3-SrTiO3 with varying periodicity showed a rich spectrum of characteristically different ferroelectric domains. Specifically, in the short-period regime, domain size was observed to evolve with a negative scaling coefficient, which is unusual for typical ferroelectrics. When the superlattice periodicity was increased, the average domain size decreased, suggesting an opposite behavior to the universal Kittel’s Law, where in the latter, an increase in ferroelectric thickness leads to an increase in the average domain size. Second, I will present intriguing results on the fundamental characteristics of polarization vortices as revealed from X-ray circular dichroism studies. The finite difference in absorption spectra of left-circular vs. right-circular polarized light from vortex structures, suggested that vortex-antivortex arrays are chiral in nature. The presence of chirality in polarization vortex structures is a characteristically different behavior compared to bulk ferroelectric systems where uniformly polarized regions are expected to exhibit a linear X-ray dichroism (i.e. a difference in the absorption spectra of linearly polarized light in a direction parallel and perpendicular to ferroelectric order). Lastly, a possibility of manipulating phonon dispersion using vortex ordering or vortex “lattice” is discussed, along with a hypothesis of inducing localization in propagative phonons
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