1,720,979 research outputs found
The effect of epidermal growth factor applied to the anostomosis safety in rats undergoing sleeve gastrectomy
No full textSleeve gastrektomi günümüzde oldukça sık yapılan bir cerrahi yöntemdir ve önemli komplikasyonlarından biri kesi hattından kaçak meydana gelmesidir. Günümüzde kesi hattını güçlendirmek için çeşitli yöntemler denenmektedir. EGF hücrelerin bölünmesi, farklılaşması, yaşaması, çoğalması, büyümesi ve hücre göçünü uyaran protein yapıda bir büyüme faktörü olup, organizmadaki pek çok fizyolojik ve patolojik süreçte rol almaktadır. Bu etkilerinden dolayı EGF'nin anastomoz iyileşmesine katkı sağlayıp, stapler hattını güçlendireceği düşünülerek böyle bir çalışma planlanmıştır. Bu çalışmada ratlar üzerinde uygulanan deneysel sleeve gastrektomi modelinde, suturasyonun(klinik uygulamada stapler hattına kanama durdurucu ve stapler hattını destekleme amaçlı uygulanan suturasyon) ve yara iyileşmesinde kullanılan EGF'nin anastomoz iyileşmesine etkisi ve birbirlerine üstünlükleri araştırılmıştır. Çalışmada, ağırlıkları 300-350 gram arasında değişen, 16 haftalık 30 adet dişi Wistar türü albino rat kullanıldı. Ratlar randomize 3 gruba ayrıldı. Üç gruba da 30mm'lik lineer stapler yardımıyla sleeve gastrektomi uygulandı. A grubunda stapler hattına herhangi bir destekleyici madde uygulanmadı. B grubunda anastomoz hattına suturasyon uygulandı. C grubunda anastomoz hattına Rekombinant Human Epidermal Growth Faktör (rhEGF) uygulandı. Ratlar 6.gün de sakrifiye edildi ve anastomoz patlama basınçları ölçüldü, anastomoz üzerinden alınan doku örneğinden histopatolojik inceleme yapıldı. Veriler PASW 22 (SPSS/IBM, Chicago, IL, USA) eşliğinde incelendi. EGF'nin mide anastomoz iyileşmesi üzerine etkisi; anastomoz patlama basıncı, histopatolojik skorlamalar üzerinden değerlendirilmiştir. Gruplar doku histopatolojik inceleme açısından değerlendirildiğinde istatistiksel olarak anlamlı fark gözlenmedi. Ancak, anostomoz basıncı açısından değerlendirildiğinde A ve B gruplarının ortalama basınçları birbirine yakın ve C grubundan daha düşük olduğu gözlendi ve istatiksel olarak anlamlı veri elde edildi. Bu verilere göre EGF'nin mide anastomoz iyileşmesi üzerine olumlu etkileri olduğunu söyleyebiliriz. Bu sonuçlar sleeve gastrektomide stapler hattına destekleyici olarak EGF'nin kullanılabileceği yönünde güçlü veriler sağlamaktadır. Çalışmamızda patlama basıncı ve histopatolojik olarak yara iyileşmesinin değerlendirilmesiyle, EGF'nin kontrol grubuna göre stapler hattında yara iyileşmesini ve patlama basıncını artırdığı dolayısıyla doku direnci ve dayanıklılığını sağladığı görüldü. Sonuç olarak sleeve gastrektomide stapler hattı üzerine EGF kullanımının stapler hattı iyileşmesini arttıracağı görülmüş ve bu çalışmanın klinik prospektif çalışmalarla desteklenmesi gerektiği düşünülmüştür.Sleeve gastrectomy is a very common surgical method today and one of its important complications is leakage from the incision line. Today, various methods are being tried to strengthen the incision line. EGF is a protein-structured growth factor that stimulates cell division, differentiation, survival, proliferation, growth and cell migration, and plays a role in many physiological and pathological processes in the organism. Due to these effects, such a study was planned considering that EGF will contribute to anastomosis healing and strengthen the stapler line. In this study, in the experimental sleeve gastrectomy model applied on rats, the effect of suturing- suturing applied to the stapler line in clinical practice to stop the hemorrhage and to support the stapler line- and EGF used in wound healing on anastomosis healing and their advantages over each other were investigated. In the study, 30 female Wistar type albino rats weighing between 300-350 grams, 16 weeks old, were used. Rats were randomly divided into 3 groups. Sleeve gastrectomy was performed with the help of a 30mm linear stapler in all three groups. supporting substance was not applied to the stapler line in group A. In group B, suturing was applied to the anastomosis line. Recombinant Human Epidermal Growth Factor (rhEGF) was applied to the anastomosis line in group C. The rats were sacrificed on the 6th day and their anastomotic bursting pressures were measured, and histopathological examination was performed from the tissue sample taken from the anastomosis. The data were analyzed with PASW 22 (SPSS / IBM, Chicago, IL, USA). The effect of EGF on stomach anastomosis healing; The anastomotic bursting pressure was evaluated by histopathological scores. When the groups were evaluated in terms of tissue histopathological examination, statistically significant difference was not observed. However, when evaluated in terms of anostomosis pressure, it was observed that the mean pressures of groups A and B were close to each other and lower than group C, and statistically significant data were obtained. According to these data, we can say that EGF has positive effects on stomach anastomosis healing. These results provide strong data that EGF can be used to support the stapler line in sleeve gastrectomy. As a result of our study, it was observed that EGF increased wound healing in the stapler line compared to the control group, by evaluating the burst pressure and histopathological wound healing. As a result, it was seen that the use of EGF on the stapler line in sleeve gastrectomy would increase the stapler line healing and it was thought that this should be supported by clinical prospective studies on humans.Bu araştırma Selçuk Üniversitesi Bilimsel Araştırma Projeleri Koordinatörlüğü tarafından 20122022 proje numarası ile desteklenmiştir
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
The Effects of Contrast Agent Administration Rate and Intraductal Pressure Increase in an Experimental Ercp Model in Rats
No full textAmaç: Bu çalışmanın amacı ERCP işlemi sonrası akut pankreatit gelişiminde biliopankreatik kanaldaki basınç artışının ve opak madde verilme hızının etkilerini belirlemektir.
Gereç ve Yöntem: Çalışmamızda 24 adet rat 4 gruba ayrıldı. Grup 1 de sadece biliopankreatik kanal kanülasyonu yapıldı. Diğer gruplara biliopankreatik kanal içerisine farklı hızlarda opak madde infüzyonu uygulandı ve kanal içinde oluşan basınç ölçüldü.
Bulgular: Deney sonrası sıçanlar takibe alındı. 24 saat sonra akut pankreatit gelişimi ve şiddetinin değerlendirilmesi amacıyla sıçanlar
sakrifiye edilerek kan ve doku örnekleri alındı. Alınan kan örneğinden lökosit sayısı, amilaz, lipaz, üre, kreatinin, glukoz, AST, ALT,
ALP, LDH, kalsiyum, CRP, albümin, total protein, MDA, TAS, TOS değerleri çalışıldı. Pankreas dokuları akut pankreatit gelişimi
açısından histopatolojik olarak değerlendirildi.
Sonuç: Kanal içi hidrostatik basınç artışın akut pankreatit gelişmesine neden olmaktadır ve biliopankreatikkanal içerisindeki hidrostatik basınç arttıkça, pankreatitin şiddetinin de arttığı gözlenmiştir.Objective: In this experimental study, we investigated the possible correlation between the increase in the hydrostatic pressure within
the pancreatic duct caused by opaque substance given during ERCP procedure and the development of acute pancreatitis.
Material and Methods: In our study, 24 rats were divided into 4 groups. The first of these groups was designated as the control group
and only biliopancreatic duct cannulation was performed. In other groups, the opaque substance was infused into the biliopancreatic
duct at various rates and the resulting intra-ductal pressure was measured.
Results: After the experiment, the rats were followed up. 24 hours later, the rats were sacrificed, and blood and tissue samples were
taken to evaluate the development and severity of acute pancreatitis. Leukocyte (WBC) count, amylase, lipase, urea, creatinine, glucose, AST, ALT, ALP, LDH, calcium, CRP, albumin, total protein, MDA, TAS and TOS were studied from the blood samples taken.
The pancreatic tissues were histopathologically evaluated for the development of acute pancreatitis.
Conclusion: it has been concluded that an increase in the intra-ductal hydrostatic pressure led to acute pancreatitis. As the hydrostatic
pressure in the biliopancreatic duct increased, the severity of acute pancreatitis was observed to have increase
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
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