1,257 research outputs found
Premio BBVA 2016 a los pioneros de la modelización climática Manabe y Hansen
No full textLa reciente concesión del Premio Fundación BBVA Fronteras del Conocimiento 2016 en la categoría de Cambio Climático a Syukuro Manabe y James Hansen, que crearon de manera independiente dos de los primeros modelos tridimensionales de circulación general para simular el comportamiento del clima, nos sirve de excelente excusa para revisar su trabajo pionero que sentó las bases de los actuales modelos climáticos y que constituyen una de las principales, si no la principal, fuente de información para comprender el sistema climático y estimar su posible evolució
Chemical Synthesis of Sialyl N-Glycans and Analysis of Their Recognition by Neuraminidase
No full textThe chemical synthesis of a fully sialylated tetraantennary N-glycan has been achieved for the first time by using the diacetyl strategy, in which NHAc is protected as NAc2 to improve reactivity by preventing intermolecular hydrogen bonds. Another key was the glycosylation to the branched mannose in an ether solvent, which promoted the desired glycosylation by stabilizing the oxocarbenium ion intermediate. Furthermore, high α-selectivity of these glycosylation reactions was realized by utilizing remote participation. Two asymmetrically deuterium labeled sialyl N-glycans were also synthesized by the same strategy. The synthesized N-glycans were used to probe the molecular basis of H1N1 neuraminidase recognition. The asymmetrically deuterated N-glycans revealed a difference in the recognition of sialic acid on each branch. Meanwhile, the tetraantennary N-glycan was used to evaluate the effects of multivalency and steric hinderance by forming branching structures
Issue 1. Bamboo Ridge, The Hawaii Writers' Quarterly
No full textAnthology of short stories. Issue 1. Editors: Eric Chock & Darrell H. Y. Lum. Contributors’ Notes: Jody Manabe. Cover & Design: Darrell H.Y. Lum. Digitized by InfoGridPacific Publisher, http://www.infogridpacific.com/DigitalPublisher.html
Spontaneous improvement of hematologic abnormalities in patients having juvenile myelomonocytic leukemia with specific RAS mutations
No full textThis research was originally published in Blood. Authors.Matsuda, K; Shimada, A; Yoshida, N; Ogawa, A; Watanabe, A; Yajima, S; Iizuka, S; Koike, K; Yanai, F; Kawasaki, K; Yanagimachi, M; Kikuchi, A; Ohtsuka, Y; Hidaka, E; Yamauchi, K; Tanaka, M; Yanagisawa, R; Nakazawa, Y; Shiohara, M; Manabe, A; Kojima, S; Koike, K Title. Blood. 2007;109(12):5477-5480. © by the American Society of Hematology.ArticleBLOOD. 109(12): 5477-5480 (2007)journal articl
Spontaneous improvement of hematologic abnormalities in patients having juvenile myelomonocytic leukemia with specific RAS mutations
No full textThis research was originally published in Blood. Authors.Matsuda, K; Shimada, A; Yoshida, N; Ogawa, A; Watanabe, A; Yajima, S; Iizuka, S; Koike, K; Yanai, F; Kawasaki, K; Yanagimachi, M; Kikuchi, A; Ohtsuka, Y; Hidaka, E; Yamauchi, K; Tanaka, M; Yanagisawa, R; Nakazawa, Y; Shiohara, M; Manabe, A; Kojima, S; Koike, K Title. Blood. 2007;109(12):5477-5480. © by the American Society of Hematology.Articleapplication/pdfBLOOD. 109(12): 5477-5480 (2007)journal articl
Structural Determination and Chemical Synthesis of the N-Glycan from the Hyperthermophilic Archaeon Thermococcus kodakarensis
No full textAsparagine-linked protein glycosylations (N-glycosylations) are one of the most abundant post-translational modifications and are essential for various biological phenomena. Herein, we describe the isolation, structural determination, and chemical synthesis of the N-glycan from the hyperthermophilic archaeon Thermococcus kodakarensis. The N-glycan from the organism possesses a unique structure including myo-inositol, which has not been found in previously characterized N-glycans. In this structure, myo-inositol is highly glycosylated and linked with a disaccharide unit through a phosphodiester. The straightforward synthesis of this glycan was accomplished through diastereoselective phosphorylation and phosphodiester construction by SN2 coupling. Considering the early divergence of hyperthermophilic organisms in evolution, this study can be expected to open the door to approaching the primitive function of glycan modification at the molecular level
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