234 research outputs found
Effect of the shell proximity on confinement characteristics in a reversed-field pinch device, TPE-1RM20
No full textRheb is a Critical Regulator of Autophagy During Myocardial Ischemia Pathophysiological Implications in Obesity and Metabolic Syndrome
No full textBackground-Rheb is a GTP-binding protein that promotes cell survival and mediates the cellular response to energy deprivation (ED). The role of Rheb in the regulation of cell survival during ED has not been investigated in the heart. Methods and Results-Rheb is inactivated during cardiomyocyte (CM) glucose deprivation (GD) in vitro, and during acute myocardial ischemia in vivo. Rheb inhibition causes mTORC1 inhibition, because forced activation of Rheb, through Rheb overexpression in vitro and through inducible cardiac-specific Rheb overexpression in vivo, restored mTORC1 activity. Restoration of mTORC1 activity reduced CM survival during GD and increased infarct size after ischemia, both of which were accompanied by inhibition of autophagy, whereas Rheb knockdown increased autophagy and CM survival. Rheb inhibits autophagy mostly through Atg7 depletion. Restoration of autophagy, through Atg7 reexpression and inhibition of mTORC1, increased cellular ATP content and reduced endoplasmic reticulum stress, thereby reducing CM death induced by Rheb activation. Mice with high-fat diet-induced obesity and metabolic syndrome (HFD mice) exhibited deregulated cardiac activation of Rheb and mTORC1, particularly during ischemia. HFD mice presented inhibition of cardiac autophagy and displayed increased ischemic injury. Pharmacological and genetic inhibition of mTORC1 restored autophagy and abrogated the increase in infarct size observed in HFD mice, but they failed to protect HFD mice in the presence of genetic disruption of autophagy. Conclusions-Inactivation of Rheb protects CMs during ED through activation of autophagy. Rheb and mTORC1 may represent therapeutic targets to reduce myocardial damage during ischemia, particularly in obese patients. (Circulation. 2012;125:1134-1146.
The Lamperti transformation for self-similar processes
No full textIn this paper we establish the uniqueness of the Lamperti transformation leading from self-similar to stationary processes, and conversely. We discuss alpha-stable processes, which allow to understand better the difference between the Gaussian and non-Gaussian cases. As a by-product we get a natural construction of two distinct alpha-stable Ornstein–Uhlenbeck processes via the Lamperti transformation for 0Lamperti transformation; Self-similar process; Stationary process; Stable distribution;
Does This Code Change Affect Program Behavior? Identifying Nonbehavioral Changes with Bytecode
No full textA. Maejima, Y. Higo, J. Matsumoto and S. Kusumoto, "Does This Code Change Affect Program Behavior? Identifying Nonbehavioral Changes with Bytecode," 2020 IEEE 44th Annual Computers, Software, and Applications Conference (COMPSAC), Madrid, Spain, 2020, pp. 1103-1104, doi: 10.1109/COMPSAC48688.2020.0-119.2020 IEEE 44th Annual Computers, Software, and Applications Conference (COMPSAC) [13-17 July 2020, Madrid, Spain]Developers occasionally conduct some source code changes that do not affect program behavior. We call such changes nonbehavioral changes. In this research, we propose a technique for determining whether a given commit includes only nonbehavioral changes or not by checking the differences of bytecode on the commit. If the bytecode is not affected by the commit, the proposed technique determines that the commit includes only nonbehavioral changes. As a result of experiments on six Java open source projects, out of the commits in which Java source files were changed, the commits of 8.6~22.4% consisted of only nonbehavioral changes. We also found new 25 patterns of nonbehavioral changes compared to a previous study
Confinement Characteristics of the TPE Reversed Field Pinch Plasmas and Effects of the Boundary Configuration
No full textmTORC2 regulates cardiac response to stress by inhibiting MST1.
No full textThe mTOR and Hippo pathways have recently emerged as the major signaling transduction cascades regulating organ size and cellular homeostasis. However, direct crosstalk between two pathways is yet to be determined. Here, we demonstrate that mTORC2 is a direct negative regulator of the MST1 kinase, a key component of the Hippo pathway. mTORC2 phosphorylates MST1 at serine 438 in the SARAH domain, thereby reducing its homodimerization and activity. We found that Rictor/mTORC2 preserves cardiac structure and function by restraining the activity of MST1 kinase. Cardiac-specific mTORC2 disruption through Rictor deletion leads to a marked activation of MST1 that, in turn, promotes cardiac dysfunction and dilation, impairing cardiac growth and adaptation in response to pressure overload. In conclusion, our study demonstrates the existence of a direct crosstalk between mTORC2 and MST1 that is critical for cardiac cell survival and growth
P1021 TBA in urine as an indicator of exposure to MTBE(Poster Presentation,Occupational Health in the Age of Decentralization Reform in Japan,The 79th Annual Meeting of Japan Society for Occupational Health)
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Effect of mixed cropping with lupin (Lupinus albus L.) on growth and nitrogen uptake in pasture grasses grown under manure application
No full textThe use of organic fertilizer is essential to ensure sustainable agricultural production. Because organic fertilizer normally acts as a slow-release fertilizer, improving its nutrient-use efficiency is important, particularly in terms of nitrogen (N) nutrition. In the present study, we attempted to increase the N-use efficiency of cattle farmyard manure (CM) in the cultivation of pasture grasses by mixed cropping with white lupin (Lupinus albus), which has been reported to decompose organic N in its rhizosphere. Timothy (Phleum pratense) and orchard grass (Dactylis glomerata) were cultivated with or without either lupin or soybean (Glycine max) in pots under three different N treatments (CM, ammonium sulfate, or no N). In the CM treatment, growth was higher in grasses cultivated with lupin than in those cultivated alone or with soybean. Moreover, decomposition of soluble organic N and protease activity in the rhizosphere soil of grasses with CM treatment were enhanced by mixed cropping with lupin. Analyses of microbial activity and bacterial community structure using Biolog EcoPlates suggested that the enhanced decomposition of soluble organic N was facilitated by lupin roots rather than by rhizosphere microorganisms
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