1,242 research outputs found
Sex differences in the prediction of the effectiveness of paroxetine for patients with major depressive disorder identified using a receiver operating characteristic curve analysis for early response [Corrigendum]
No full textTomita T, Norio YF, Sato Y, et al. Neuropsychiatr Dis Treat. 2014;10:599–606.On page 599, there is an error in the author list "Yasui-Furukori Norio" should read "Norio Yasui-Furukori".Read the original articl
Search for missing charmonium states in B-meson decays
No full textThe recent progress in experiments at B-factories suggests an opportunity to search for the missing charmonium states eta'(c)(2(1)S(0)) and h(c)(1 P-1(1)). The feasibility of such a search in B-meson decays are discussed. (C) 2002 Elsevier Science B.V All rights reserved.http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000176725100002&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701Physics, MultidisciplinarySCI(E)6ARTICLE1-26-1053
Genome-wide association study identifies a variant in HDAC9 associated with large vessel ischemic stroke
No full textGenetic factors have been implicated in stroke risk, but few replicated associations have been reported. We conducted a genome-wide association study (GWAS) for ischemic stroke and its subtypes in 3,548 affected individuals and 5,972 controls, all of European ancestry. Replication of potential signals was performed in 5,859 affected individuals and 6,281 controls. We replicated previous associations for cardioembolic stroke near PITX2 and ZFHX3 and for large vessel stroke at a 9p21 locus. We identified a new association for large vessel stroke within HDAC9 (encoding histone deacetylase 9) on chromosome 7p21.1 (including further replication in an additional 735 affected individuals and 28,583 controls) (rs11984041; combined P = 1.87 × 10<sup>−11</sup>; odds ratio (OR) = 1.42, 95% confidence interval (CI) = 1.28–1.57). All four loci exhibited evidence for heterogeneity of effect across the stroke subtypes, with some and possibly all affecting risk for only one subtype. This suggests distinct genetic architectures for different stroke subtypes
Connection between the closeness of classical orbits and the factorization of the radial Schrodinger equation
No full textIt is shown that the Runge-Lenz vector of a hydrogen atom is equivalent to the raising and lowering operators derived from the factorization of the radial Schrodinger equation. A similar situation exists for an isotropic harmonic oscillator. It is seen that there exists an intimate relation between the conserved quantities responsible for the closeness of classical orbits on the one side and the quantum-mechanical raising and lowering operators on the other side, which is physically connected with the dynamical symmetry of the system considered. Some discussions are made about the factorization of a one-dimensional system. [S1050-2947(98)06308-2].http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000075386200016&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701OpticsPhysics, Atomic, Molecular & ChemicalSCI(E)5ARTICLE2862-8685
MOLECULAR LINE STUDIES OF DENSE CORE MOTIONS
No full textMolecular lines have revealed various supporting motions in dense cores. Line widths and emission region sizes of NH3 and CS in the same kind of cores or of the same line in cores with or without sources are different and can not be explained with the line width- size relationship. Outflows in dense cores show rich characteristics which can account for the NH3 emission difference between the two kinds of the cores; CS emission is consistent with the chemical effects in shocked regions. Rotation exists in both kinds of cores and may be related to the observed polarities and collimations of outflows.Astronomy & AstrophysicsSCI(E)0ARTICLE150217-22
A mathematical model for describing the mechanical behaviour of root canal instruments
No full textZhang EW, Cheung GSP, Zheng YF. A mathematical model for describing the mechanical behaviour of root canal instruments. International Endodontic Journal, 44, 72-76, 2011.Aim The purpose of this study was to establish a general mathematical model for describing the mechanical behaviour of root canal instruments by combining a theoretical analytical approach with a numerical finite-element method.Method Mathematical formulas representing the longitudinal (taper, helical angle and pitch) and cross-sectional configurations and area, the bending and torsional inertia, the curvature of the boundary point and the (geometry of) loading condition were derived. Torsional and bending stresses and the resultant deformation were expressed mathematically as a function of these geometric parameters, modulus of elasticity of the material and the applied load. As illustrations, three brands of NiTi endodontic files of different cross-sectional configurations (ProTaper, Hero 642, and Mani NRT) were analysed under pure torsion and pure bending situation by entering the model into a finite-element analysis package (ANSYS).Results Numerical results confirmed that mathematical models were a feasible method to analyse the mechanical properties and predict the stress and deformation for root canal instruments during root canal preparation.Conclusions Mathematical and numerical model can be a suitable way to examine mechanical behaviours as a criterion of the instrument design and to predict the stress and strain experienced by the endodontic instruments during root canal preparation. © 2010 International Endodontic Journal.link_to_subscribed_fulltex
Stable suppression of gene expression in murine embryonic stem cells by RNAi directed from DNA vector-based short hairpin RNA
No full textMurine embryonic stem (ES) cells are an ideal system for the research of directed differentiation in vitro. Long double-stranded RNA, which can induce RNA interference (RNAi) effectively in many organisms, has been shown to suppress target gene expression efficiently and specifically in undifferentiated ES cells. However, it cannot be used in differentiated ES cells due to unspecific inhibition of gene expression resulting from the activation of interferon pathway following differentiation. Using green fluorescent protein (GFP) as a reporter system, we show here that a short hairpin RNA (shRNA) expression vector driven by the murine U6 small nuclear RNA promoter can specifically induce potent gene knockdown effect (i.e., inhibit GFP expression specifically) when transfected transiently into ES cells. Furthermore, when the expression vector is stably integrated into the genome of the cell, it can still show specific RNAi effect, which can be maintained at least for 10 days. These transfected ES cells showed no obvious differences in the morphology or growth rate in culture compared with untransfected cells, suggesting that the activation of shRNA-directed RNAi did not affect the properties of ES cells and that the RNAi effect in ES cells is specific and persistent. Our results prove the feasibility of the U6 promoter-driven shRNA expression technique to be used to study the function of genes expressed in ES cells. These ES cells, after integration of the U6-based RNAi vector into their genome, could be used to generate gene knockdown mice.Cell & Tissue EngineeringBiotechnology & Applied MicrobiologyOncologyCell BiologyHematologySCI(E)PubMed0ARTICLE193-992
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