1,723,691 research outputs found
In conversation with Xin Lu
Full text linkXin Lu is Professor of Cancer Biology at the University of Oxford, UK, and Director of the Oxford Branch of the Ludwig Institute for Cancer Research, Co‐director of the Cancer Research UK Oxford Centre, NIHR Oxford Biomedical Research Centre Multi‐Modal Cancer Therapies Theme Lead and Director of the Oxford Centre for Early Cancer Detection. She has a long‐standing interest in mechanisms of tumour suppression and cellular plasticity, centred on studies of p53 and the ASPP family of proteins (apoptosis‐stimulating protein of p53; ankyrin repeats, SH3 domain and proline‐rich sequence‐containing proteins). Her laboratory's discovery of ASPPs, regulators or ‘molecular switches’ of the apoptotic function of p53 led to key insights into the role of cell plasticity in cancer and other diseases, and these could pave the way to new diagnostic and therapeutic interventions. Xin has received many awards and honours in recognition of her significant contributions to cancer biology, including being elected as a Fellow of the Royal Society in 2020. Here, she outlines how her breakthrough discovery of ASPPs came about and its impact on the cancer field, as well as highlighting the importance of mentors including Min Wu, Birgit Lane and Sir David Lane in shaping her early career and helping her to navigate a new research world, having moved to the UK from China in the 80s
Shanghai Yü ying tang zheng xin lu.
No full textCaption title.; Special collection from London Missionary Society.; On double leaves, oriental style, in case.; Also available in an electronic version via the Internet at http://nla.gov.au/nla.gen-vn389180.880-02 Yü ying tang zheng xin lu
Shanghai Qi liu jü, Tong ren tang, Yü ying tang shang chuan jüan zheng xin lu.
No full textCover title.; Special collection from London Missionary Society.; On double leaves, oriental style, in case.; Also available in an electronic version via the Internet at http://nla.gov.au/nla.gen-vn389068.880-02 Shang chuan jüan zheng xin lu
To the Graduate Council: I am submitting herewith a thesis written by Xin Lu entitled “The Effects of Calpain on the Degradation of Amyloid Beta (Aβ) Protein”. I have examined the final electronic copy of this thesis for form and content and recommend that it be accepted in partial fulfillment of the requirements for the degree of Master of Science, with a major in Comparative and Experimental Medicine
ENERGY LOSS MECHANISM FOR HOT ELECTRONS IN GaAs
No full textWe have systematically investigated the energy loss mechanisms for hot electrons injected into a thin doped GaAs layer. Incident energies are kept below the threshold for intervalley scattering. We find for carrier densities typical of those used in many GaAs devices, the energy losses are dominated by pure electron- like excitation processes
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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