121,637 research outputs found
Near-capacity code design for entanglement-assisted classical communication over quantum depolarizing channels
No full textWe have conceived a near-capacity code design for entanglement-assisted classical communication over the quantum depolarizing channel. The proposed system relies on efficient near-capacity classical code designs for approaching the entanglement-assisted classical capacity of a quantum depolarizing channel. It incorporates an Irregular Convolutional Code (IRCC), a Unity Rate Code (URC) and a soft-decision aided Superdense Code (SD), which is hence referred to as an IRCC-URC-SD arrangement. Furthermore, the entanglement-assisted classical capacity of an N-qubit superdense code transmitted over a depolarizing channel is invoked for benchmarking. It is demonstrated that the proposed system operates within 0.4 dB of the achievable noise limit for both 2-qubit as well as 3-qubit SD schemes. More specifically, our design exhibits a deviation of only 0.062 and 0.031 classical bits per channel use from the corresponding 2-qubit and 3-qubit capacity limits, respectively. The proposed system is also benchmarked against the classical convolutional and turbo codes
A new directory map of Shanghai = Xin Shanghai di tu /
No full textMap of Shanghai, China.; Cover title.; Title within neat lines: A new map of Shanghai.; Map folded in booklet, accompanied by text titled "A description of the Shanghai Municipality".; Includes 4 insets ([environs of Shanghai, scale approximately 1:350,000]; [continuation north, scale approximatley 1:70,000],[Shanghai civic centre, scale approximately 1:18,500] and [enlargement of commercial district of the International Settlement, scale not given]), legend, and panoramic view of the Bund, Shanghai.; Also available online http://nla.gov.au/nla.map-vn6374656.New map of Shanghai880-03 Xin Shanghai di t
Letter, [Author unclear] to Paulina T. Merritt
No full textHandwritten letter to Paulina Merritt from an unknown author, October 1, 1876.
Xin repeats define a novel actin-binding motif
No full textXin is a protein that is expressed during early developmental stages of cardiac and skeletal muscles. Immunolocalization studies indicated a peripheral localization in embryonic mouse heart, where Xin localizes with beta- catenin and N-cadherin. In adult tissues, Xin is found primarily in the intercalated discs of cardiomyocytes and the myotendinous junctions of skeletal muscle cells, both specialized attachment sites of the myofibrillar ends to the sarcolemma. A large part of the Xin protein consists of unique 16 amino acid repeats with unknown function. We have investigated the characteristics of the Xin repeats by transfection experiments and actin-binding assays and ascertained that, upon expression in cultured cells, these repeats bind to and stabilize the actin-based cytoskeleton. In vitro co- sedimentation assays with skeletal muscle actin indicated that they not only directly bind actin filaments, but also have the capability of arranging microfilaments into networks that sediment upon low-speed centrifugation. Very similar repeats were also found in Xin-repeat protein 2' (XIRP2), a novel protein that seems to be expressed mainly in striated muscles. Human XIRP2 contains 28 Xin repeats with properties identical to those of Xin. We conclude that the Xin repeats define a novel, repetitive actin-binding motif present in at least two different muscle proteins. These Xin- repeat proteins therefore constitute the first two members of a novel family of actin-binding protein
Abstract 618: Toll-like receptor 2 costimulation potentiates the antitumor efficacy of CAR T cells
No full textAbstract
Chimeric antigen receptor (CAR) T cell immunotherapies have shown unprecedented success in treating leukemia but lack efficacy in solid tumors. Here, we generated 1928zT2 and m28zT2, targeting CD19 and mesothelin, respectively, by introducing the Toll/interleukin-1 receptor (TIR) domain of Toll-like receptor 2 (TLR2) to 1928z and m28z. T cells expressing 1928zT2 or m28zT2 showed enhanced effector function, expansion and persistency against CD19+ leukemic or mesothelin+ lung cancer cells in vitro and in vivo. In a patient with relapsed B cell acute lymphoblastic leukemia, a single dose of 5×104/kg 1928zT2 T cells resulted in robust expansion and leukemia eradication and led to complete remission. Hence, our results demonstrate that TLR2 signaling is a contributing component to CAR T cells for both leukemia and solid tumors and is capable of increasing the efficacy of CAR T cells and facilitating low dose clinical usage.
Citation Format: Peng Li, Xin Du, Yun Xin, Jianyu Weng, Peilong Lai. Toll-like receptor 2 costimulation potentiates the antitumor efficacy of CAR T cells [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2017; 2017 Apr 1-5; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2017;77(13 Suppl):Abstract nr 618. doi:10.1158/1538-7445.AM2017-618</jats:p
Handwritten biographical information on Paulina T. McClung Merritt
No full textA handwritten biography of Paulina T. McClung Merritt by an unknown author, 1892.
Heterogeneous and tissue-specific regulation of effector T cell responses by IFN-gamma during Plasmodium berghei ANKA infection.
No full textIFN-γ and T cells are both required for the development of experimental cerebral malaria during Plasmodium berghei ANKA infection. Surprisingly, however, the role of IFN-γ in shaping the effector CD4(+) and CD8(+) T cell response during this infection has not been examined in detail. To address this, we have compared the effector T cell responses in wild-type and IFN-γ(-/-) mice during P. berghei ANKA infection. The expansion of splenic CD4(+) and CD8(+) T cells during P. berghei ANKA infection was unaffected by the absence of IFN-γ, but the contraction phase of the T cell response was significantly attenuated. Splenic T cell activation and effector function were essentially normal in IFN-γ(-/-) mice; however, the migration to, and accumulation of, effector CD4(+) and CD8(+) T cells in the lung, liver, and brain was altered in IFN-γ(-/-) mice. Interestingly, activation and accumulation of T cells in various nonlymphoid organs was differently affected by lack of IFN-γ, suggesting that IFN-γ influences T cell effector function to varying levels in different anatomical locations. Importantly, control of splenic T cell numbers during P. berghei ANKA infection depended on active IFN-γ-dependent environmental signals--leading to T cell apoptosis--rather than upon intrinsic alterations in T cell programming. To our knowledge, this is the first study to fully investigate the role of IFN-γ in modulating T cell function during P. berghei ANKA infection and reveals that IFN-γ is required for efficient contraction of the pool of activated T cells
Dispelling the Myths Behind First-author Citation Counts
No full textWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
Pelevin’s Trinity in the novel “t”: author – protagonist – reader
No full textThe article attempts to interpret Pelevin's artistic strategy in the novel "T" by exploring its subject organization and addressing the key problems of the author, the protagonist, and the reader as they are seen by the researcher. The article analyzes the peculiarities of constructing the narrative reality in the novel "T", and goes on to discuss Pelevin's philosophic models of the development of the humankind, and the emergence of his new anthropology
Detached-eddy simulation of flow around a circular cylinder in ground effect
No full textIn this study we performed a detached-eddy simulation (DES) of flow around a circular cylinder placed near and parallel to a moving ground, on which no boundary layer developed to interfere with the cylinder. The results were compared with experiments previously reported by the authors, and also with two-dimensional unsteady RANS computations. The DES correctly predicted the cessation of the Kármán-type vortex shedding behind the cylinder, whereas the unsteady RANS also predicted it but at a much smaller ‘gap ratio’ (i.e. the ratio of the gap between the cylinder and the ground, h, to the cylinder diameter d) compared with the experiments. Time-averaged force coefficients, separation angles and velocity profiles in the near wake region predicted by the DES were in good agreement with the experiments. The major features of instantaneous wake structures were well reproduced in both large- and small-gap regimes, and also in the intermediate-gap regime, where the DES predicted a temporary formation of a small dead-fluid zone behind the cylinder
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