179,907 research outputs found
Yue zhou zhu ji xian xiang yan si jing zang ji 越 州 諸 暨 縣 香 嚴 寺 經 藏 記 par le śramaṇa Zhi xian 志 閑.
No full textShou qing 守 清. Zhi xian 志 閑. Cao tang (si ?) 草 堂 (寺 ?). Yue zhou zhu ji xian xiang yan si jing zang ji 越 州 諸 暨 縣 香 嚴 寺 經 藏 記Numérisation effectuée à partir d'un document original.Déb. seulement. Inédit. Titre initial suivi de l'indication : calligraphié (shu 書) par le moine Shou qing 守 清 du Cao tang [si ?] 草 堂 [寺 ?]. Pour une copie plus complète du même texte, cf. Pelliot chinois 2804. L'auteur, Zhi xian, est mort en 895 (cf. T . 2076, vol. 51, j. 12, p. 294 c). Écr. kai call. Encre foncée un peu irrégulière. 13 col., les 2 dernières mutilées. 15 à 17 car. par col. Marges tracées, sup. 0,4 à 0,6 cm, inf. 0,6 cm. Réglures
An agent-based model of cardiac allograft vasculopathy: toward a better understanding of chronic rejection dynamics
No full textCardiac allograft vasculopathy (CAV) is a coronary artery disease affecting 50% of heart transplant (HTx) recipients, and it is the major cause of graft loss. CAV is driven by the interplay of immunological and non-immunological factors, setting off a cascade of events promoting endothelial damage and vascular dysfunction. The etiology and evolution of tissue pathology are largely unknown, making disease management challenging. So far, in vivo models, mostly mouse-based, have been widely used to study CAV, but they are resource-consuming, pose many ethical issues, and allow limited investigation of time points and important biomechanical measurements. Recently, agent-based models (ABMs) proved to be valid computational tools for deciphering mechanobiological mechanisms driving vascular adaptation processes at the cell/tissue level, augmenting cost-effective in vivo lab-based experiments, at the same time guaranteeing richness in observation time points and low consumption of resources. We hypothesize that integrating ABMs with lab-based experiments can aid in vivo research by overcoming those limitations. Accordingly, this work proposes a bidimensional ABM of CAV in a mouse coronary artery cross-section, simulating the arterial wall response to two distinct stimuli: inflammation and hemodynamic disturbances, the latter considered in terms of low wall shear stress (WSS). These stimuli trigger i) inflammatory cell activation and ii) exacerbated vascular cell activities. Moreover, an extensive analysis was performed to investigate the ABM sensitivity to the driving parameters and inputs and gain insights into the ABM working mechanisms. The ABM was able to effectively replicate a 4-week CAV initiation and progression, characterized by lumen area decrease due to progressive intimal thickening in regions exposed to high inflammation and low WSS. Moreover, the parameter and input sensitivity analysis highlighted that the inflammatory-related events rather than the WSS predominantly drive CAV, corroborating the inflammatory nature of the vasculopathy. The proof-of-concept model proposed herein demonstrated its potential in deepening the pathology knowledge and supporting the in vivo analysis of CAV
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Building On and Honoring Forty Years of PBL Scholarship from Howard Barrows: A Scientometric, Large-Scale Data, and Visualization-based Analysis
No full textOver the past forty years, Howard Barrows’ contributions to PBL research have influenced and guided educational research and practice in a diversity of domains. It is necessary to make visible to all PBL scholars what has been accomplished, what is perceived as significant, and what is the scope of applicability for Barrows’ groundbreaking findings. As more disciplines recognize Barrows’ efforts and adopt PBL in education, it becomes crucial but challenging to sustain community memory so that PBL scholars are kept well informed of research innovations in various domains. In this paper, we review Barrows’ scholarly efforts in PBL and reveal the impacts on subsequent studies in various domains. A bibliometrics analysis is conducted on Barrows’ PBL publications and the corresponding citations to quantitatively measure Barrows’ impact. Our findings demonstrate Barrows’ exceptional contributions to PBL and the disciplinary differences in conducting PBL studies based on Barrows’ work. It is also revealed that PBL scholars who share similar interests have rarely collaborated with each other. The PBL research community has a real opportunity to connect isolated research groups and reduce the fragmentation so that research innovations in one domain can be disseminated to inform other scholars
Comibaena campolinea Pan & Xian & Han 2022, sp. nov.
No full textComibaena campolinea Xian & Han sp. nov. (Figs 1–4, 13–14, 19) Type material. Holotype ♂ (TAAHU), CHINA: Tibet, Hanmi, 29.VI.2021, STS 34898, leg. Pan Zhaohui. Paratype (TAAHU): Tibet, 1♀, Mêdog 80k, 19.VII.2017, STS 6927, leg. Pan Zhaohui. Diagnosis. On the wing pattern, C. campolinea is similar to Comibaena tibetensis Han, Galsworthy & Xue, 2012 (Figs 9–12) for sharing the slightly concave, white and broad postmedial line, and the whitish basal area on the forewing. However, the tornal patch on both wings and the apical patch on hind wing are much smaller than in C. tibetensis, and the forewing postmedial line below vein CuA 2 is distinct and separate from the tornal patch in C. campolinea but merges with the tornal patch in C. tibetensis. The male genitalia are also different: the dorsal process of the costal lobe is absent in C. campolinea but present in C. tibetensis (Fig. 17), the apical part of the costal lobe is pointed in C. campolinea but blunt in C. tibetensis, and the vinculum of C. campolinea is more deeply concave than in C. tibetensis. Description. Head. Antenna in male bipectinate for about basal two-thirds, filiform terminally, outer rami longer than inner rami; antenna filiform in female. Frons green. Labial palpus with first segment brown, second and third segments white. Vertex green. Thorax. Dorsal side of thorax green, white ventrally. Patagia yellow-green. Tegula green, yellow-green sub-basally, corresponding with costal area of forewing. Hind tibia with two pairs of spurs in both sexes, that of male dilated with hair-pencil and terminal extension. Forewing length: ♂ 15 mm, ♀ 16 mm. Wings green, diffused with white scales and short and white transverse stripes. Forewing with costal area a straw-yellow band, tapering towards apex; antemedial line white, oblique, almost straight; area between wing base and antemedial line green diffused with white scales; postmedial line white, broad, slightly concave, almost parallel to antemedial line above CuA 2, turning inwards at a blunt angle below CuA 2, then straight to inner margin; outside postmedial line tinged with white scales, which extends to apex; submarginal line weak, white and wavy; terminal line white; two dark rubineous patches present near tornal angle, the anterior one larger; discal spot a tiny dark-brown dot, very weak. Hind wing with two elongate reddish-brown patches at apex and tornal angle respectively; transverse lines absent, but terminal line white. Fringes on both fore- and hind wings with basal half green, terminal half paler, median part a narrow dull white band. Underside whitish, forewing discal spot clearer than on upperside. Abdomen. Dorsal side of abdomen green in fresh specimen, with white intersegments and white dorsal line; ventral side of abdomen white. Characters of third sternite and eighth segment in male unknown. Male genitalia. Uncus well divided, tapered. Socii longer than uncus, basal part broad, terminal part tapering and hooked. Costal lobe petal-like, terminal part pointed decorated with small spines; ventral margin strongly sclerotized, with two small teeth. Valva blunt and slightly expanded at apex, with setae, ventral margin concave. Vinculum concave at middle, lateral branches broad and blunt. Aedeagus slender, spinulose; cornutus absent. Female genitalia. Ovipositor lobes short and wide. Apophyses posteriores and anteriores almost in same length. Sterigma large, quadrate and solid, with posterior margin flat. Ductus bursae long and slender. Corpus bursae small and weak, signum absent. Distribution. China (Tibet). Etymology. The specific name is from the Latin prefix campo- and Latin word linea, referring to the infolding postmedial line.Published as part of Pan, Zhaohui, Xian, Chunlan & Han, Hongxiang, 2022, Two new species of the genus Comibaena Hübner, 1823 (Lepidoptera: Geometridae) from China, pp. 147-150 in Zootaxa 5190 (1) on pages 147-148, DOI: 10.11646/zootaxa.5190.1.8, http://zenodo.org/record/712002
MicroRNAs in epithelial immunity to C. parvum
No full textJuly 1, 2006$333,000National Institutes of Healt
Mitomycin C in highly myopic eyes - Author reply
No full textOphthalmology. 2005 Feb;112(2):208-18; discussion 219.
Mitomycin C modulation of corneal wound healing after photorefractive keratectomy in highly myopic eyes.
Gambato C, Ghirlando A, Moretto E, Busato F, Midena E.
SourceRefractive Surgery Service and Antimetabolite Therapy Research Unit, Department of Ophthalmology, University of Padova, Padova, Italy.
Abstract
PURPOSE: To evaluate the role of topical mitomycin C in corneal wound healing (CWH) after photorefractive keratectomy (PRK) in highly myopic eyes.
DESIGN: Prospective, double-masked, randomized clinical trial.
PARTICIPANTS: Seventy-two eyes of 36 patients affected by high (>7 diopters) myopia.
METHODS: In each patient, one eye was randomly assigned to PRK with intraoperative topical 0.02% mitomycin C application, and the fellow eye was treated with a placebo. Postoperatively, mitomycin C-treated eyes received artificial tears (3 times daily, tapered in 3 months), whereas the fellow eye was treated with fluorometholone sodium 2% and artificial tears (3 times daily, tapered in 3 months).
MAIN OUTCOME MEASURES: Uncorrected visual acuity (UCVA) and best-corrected visual acuity (BCVA), contrast sensitivity, manifest refraction, and biomicroscopy. Contrast sensitivity was determined using the Pelli-Robson chart. Corneal confocal microscopy documented CWH.
RESULTS: Mean follow-up was 18 months (range, 12-36). No side effects or toxic effects were documented. At 12-month follow-up examination, UCVAs (logarithm of the minimum angle of resolution) were 0.4+/-0.48 and 0.5+/-0.53 (P = .03) in mitomycin C-treated eyes and corticosteroid-treated eyes, respectively. At 1 year, corneal haze developed in 20% of corticosteroid-treated eyes, versus 0% of mitomycin C-treated eyes. At 12, 24, and 36 months, corneal confocal microscopy showed activated keratocytes and extracellular matrix significantly more evident in untreated eyes (Ps = 0.004, 0.024, and 0.046, respectively).
CONCLUSION: Topical intraoperative application of 0.02% mitomycin C can reduce haze formation in highly myopic eyes undergoing PRK.
Comment in
Ophthalmology. 2006 Feb;113(2):357; author reply 357-8
Syriac Onomastica in the Xian Fu Inscriptions
No full textDiscusses the Syriac proper names listed on the Xian Fu stele, pointing out the Persian origins of several of the names, thus indicating the ethnicity of some of the monks at the Church of the East monastery at Chang'an
Phanerosorus Copel., Philipp. J. Sci., C
No full text12.2. Phanerosorus Copel., Philipp. J. Sci., C 3: 344 (1909). T.: Phanerosorus sarmentosus (Baker) Copel. (Matonia sarmentosa Baker)Published as part of Christenhusz, Maarten J. M., Zhang, Xian-Chun & Schneider, Harald, 2011, A linear sequence of extant families and genera of lycophytes and ferns, pp. 7-54 in Phytotaxa 19 on page 43, DOI: 10.11646/phytotaxa.19.1.2, http://zenodo.org/record/489399
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